Inhibition of PAD2 Improves Survival in a Mouse Model of Lethal LPS-Induced Endotoxic Shock

Cutting Edge: Protein Arginine Deiminase 2 and 4 Regulate NLRP3 Inflammasome–Dependent IL-1β Maturation and ASC Speck Formation in Macrophages

(2019) Neha Mishra et al.   JOURNAL OF IMMUNOLOGY

Inhibition of peptidylarginine deiminase alleviates LPS-induced pulmonary dysfunction and improves survival in a mouse model of lethal endotoxemia

(2018) Yingjian Liang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Neutrophil Activation During Septic Shock

(2018) Laure Stiel et al.   SHOCK

Protective Effect of Tubastatin A in CLP-Induced Lethal Sepsis

(2018) Qiufang Deng et al.   INFLAMMATION

Neutrophil dysregulation during sepsis: an overview and update

(2017) Xiao-Fei Shen et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Deficiency of Phosphatidylinositol 3-Kinase δ Signaling Leads to Diminished Numbers of Regulatory T Cells and Increased Neutrophil Activity Resulting in Mortality Due to Endotoxic Shock

(2017) Emeka B. Okeke et al.   JOURNAL OF IMMUNOLOGY

Development of a Selective Inhibitor of Protein Arginine Deiminase 2

(2017) Aaron Muth et al.   JOURNAL OF MEDICINAL CHEMISTRY

Host DNases prevent vascular occlusion by neutrophil extracellular traps

(2017) Miguel Jiménez-Alcázar et al.   SCIENCE

Evidence of Netosis in Septic Shock-Induced Disseminated Intravascular Coagulation

(2017) Xavier Delabranche et al.   SHOCK

Lipopolysaccharide-induced neutrophil extracellular trap formation in canine neutrophils is dependent on histone H3 citrullination by peptidylarginine deiminase

(2017) Ronald H.L. Li et al.   VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY

CitH3: a reliable blood biomarker for diagnosis and treatment of endotoxic shock

(2017) Baihong Pan et al.   Scientific Reports

Cl-Amidine Prevents Histone 3 Citrullination and Neutrophil Extracellular Trap Formation, and Improves Survival in a Murine Sepsis Model

(2016) Bethany M. Biron et al.   Journal of Innate Immunity

The role of neutrophils and NETosis in autoimmune and renal diseases

(2016) Sarthak Gupta et al.   Nature Reviews Nephrology

Sepsis: pathophysiology and clinical management

(2016) Jeffrey E Gotts et al.   BMJ-British Medical Journal

Sepsis: pathophysiology and clinical management

(2016) Jeffrey E Gotts et al.   BMJ-British Medical Journal

Neutrophil Isolation and Analysis to Determine their Role in Lymphoma Cell Sensitivity to Therapeutic Agents

(2016) Taghreed Hirz et al.   Jove-Journal of Visualized Experiments

Neutrophils Discriminate between Lipopolysaccharides of Different Bacterial Sources and Selectively Release Neutrophil Extracellular Traps

(2016) Elmar Pieterse et al.   Frontiers in Immunology

Neutrophil Extracellular Traps in Pulmonary Diseases: Too Much of a Good Thing?

(2016) Bárbara Nery Porto et al.   Frontiers in Immunology

Neutrophil Extracellular Traps Induce Organ Damage during Experimental and Clinical Sepsis

(2016) Paula Giselle Czaikoski et al.   PLoS One

PAD4-deficiency does not affect bacteremia in polymicrobial sepsis and ameliorates endotoxemic shock

(2015) K. Martinod et al.   BLOOD

Diabetes primes neutrophils to undergo NETosis, which impairs wound healing

(2015) Siu Ling Wong et al.   NATURE MEDICINE

Molecular mechanisms of NET formation and degradation revealed by intravital imaging in the liver vasculature

(2015) Elzbieta Kolaczkowska et al.   Nature Communications

Peptidylarginine deiminase inhibition disrupts NET formation and protects against kidney, skin and vascular disease in lupus-prone MRL/lprmice

(2014) Jason S Knight et al.   ANNALS OF THE RHEUMATIC DISEASES

Citrullinated Autoantigens: From Diagnostic Markers to Pathogenetic Mechanisms

(2014) Sylviane Muller et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

Neutrophil Extracellular Traps in Sepsis

(2014) Gabriela Camicia et al.   SHOCK

Peptidylarginine deiminases in citrullination, gene regulation, health and pathogenesis

(2013) Shu Wang et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

NETosis: how vital is it?

(2013) B. G. Yipp et al.   BLOOD

Peptidylarginine deiminase 2-catalyzed histone H3 arginine 26 citrullination facilitates estrogen receptor   target gene activation

(2012) X. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PAD4 mediated histone hypercitrullination induces heterochromatin decondensation and chromatin unfolding to form neutrophil extracellular trap-like structures

(2012) Marc Leshner et al.   Frontiers in Immunology

Activation of PAD4 in NET formation

(2012) Amanda S. Rohrbach et al.   Frontiers in Immunology

Biological Functions and Biogenesis of Secreted Bacterial Outer Membrane Vesicles

(2010) Adam Kulp et al.   Annual Review of Microbiology

PAD4 is essential for antibacterial innate immunity mediated by neutrophil extracellular traps

(2010) Pingxin Li et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Lipopolysaccharide-induced experimental immune activation does not impair memory functions in humans

(2010) Jan-Sebastian Grigoleit et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Histone hypercitrullination mediates chromatin decondensation and neutrophil extracellular trap formation

(2009) Yanming Wang et al.   JOURNAL OF CELL BIOLOGY

Role of MCP-1 in endotoxemia and sepsis

(2008) Raina Devi Ramnath et al.   INTERNATIONAL IMMUNOPHARMACOLOGY