Harnessing the immune system via FcγR function in immune therapy: a pathway to next‐gen mAbs

Signaling through the Inhibitory Fc Receptor FcγRIIB Induces CD8+ T Cell Apoptosis to Limit T Cell Immunity

(2020) Anna B. Morris et al.   IMMUNITY

Human neutrophils express low levels of FcγRIIIA, which plays a role in PMN activation

(2019) Josée Golay et al.   BLOOD

A stable engineered human IgG3 antibody with decreased aggregation during antibody expression and low pH stress

(2019) Seiji Saito et al.   PROTEIN SCIENCE

An Anti-CD3 Antibody, Teplizumab, in Relatives at Risk for Type 1 Diabetes

(2019) Kevan C. Herold et al.   NEW ENGLAND JOURNAL OF MEDICINE

TRIM21—From Intracellular Immunity to Therapy

(2019) Stian Foss et al.   Frontiers in Immunology

Antibodies to watch in 2020

(2019) Hélène Kaplon et al.   mAbs

The Immunological Organ Environment Dictates the Molecular and Cellular Pathways of Cytotoxic Antibody Activity

(2019) Sina Gordan et al.   Cell Reports

Complex Interplay between Epitope Specificity and Isotype Dictates the Biological Activity of Anti-human CD40 Antibodies

(2018) Xiaojie Yu et al.   CANCER CELL

The binding of an anti-PD-1 antibody to FcγRΙ has a profound impact on its biological functions

(2018) Tong Zhang et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Size-Dependent Segregation Controls Macrophage Phagocytosis of Antibody-Opsonized Targets

(2018) Matthew H. Bakalar et al.   CELL

Transmembrane Pickets Connect Cyto- and Pericellular Skeletons Forming Barriers to Receptor Engagement

(2018) Spencer A. Freeman et al.   CELL

Update on Fc receptor-like (FCRL) family: new immunoregulatory players in health and diseases

(2018) Davood Rostamzadeh et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Market watch: Top drugs and companies by sales in 2017

(2018) Lisa Urquhart   NATURE REVIEWS DRUG DISCOVERY

The Contribution of Non-Professional Antigen-Presenting Cells to Immunity and Tolerance in the Liver

(2018) Christina Mehrfeld et al.   Frontiers in Immunology

Picket-fences in the plasma membrane: functions in immune cells and phagocytosis

(2018) Sivakami M. Mylvaganam et al.   Seminars in Immunopathology

Targeting FcRn to Generate Antibody-Based Therapeutics

(2018) E. Sally Ward et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

The Rare Anaphylaxis-Associated FcγRIIa3 Exhibits Distinct Characteristics From the Canonical FcγRIIa1

(2018) Jessica C. Anania et al.   Frontiers in Immunology

Immune Checkpoints as Therapeutic Targets in Autoimmunity

(2018) Christopher Paluch et al.   Frontiers in Immunology

CD32 Ligation Promotes the Activation of CD4+ T Cells

(2018) María Pía Holgado et al.   Frontiers in Immunology

Antibody Distance from the Cell Membrane Regulates Antibody Effector Mechanisms

(2017) Kirstie L. S. Cleary et al.   JOURNAL OF IMMUNOLOGY

A new mouse expressing human Fcγ receptors to better predict therapeutic efficacy of human anti-cancer antibodies

(2017) E Casey et al.   LEUKEMIA

Characterization of the Anti–PD-1 Antibody REGN2810 and Its Antitumor Activity in Human PD-1 Knock-In Mice

(2017) Elena Burova et al.   MOLECULAR CANCER THERAPEUTICS

CD32a is a marker of a CD4 T-cell HIV reservoir harbouring replication-competent proviruses

(2017) Benjamin Descours et al.   NATURE

Nivolumab as Programmed Death-1 (PD-1) Inhibitor for Targeted Immunotherapy in Tumor

(2017) Liting Guo et al.   Journal of Cancer

Fcγ Receptor Heterogeneity in Leukocyte Functional Responses

(2017) Carlos Rosales   Frontiers in Immunology

Mouse Liver Sinusoidal Endothelium Eliminates HIV-Like Particles from Blood at a Rate of 100 Million per Minute by a Second-Order Kinetic Process

(2017) Jessica M. Mates et al.   Frontiers in Immunology

Atezolizumab: A PD-L1–Blocking Antibody for Bladder Cancer

(2016) Brant A. Inman et al.   CLINICAL CANCER RESEARCH

Harnessing Fc receptor biology in the design of therapeutic antibodies

(2016) Peter Sondermann et al.   CURRENT OPINION IN IMMUNOLOGY

Immunoglobulin isotype knowledge and application to Fc engineering

(2016) Randall J Brezski et al.   CURRENT OPINION IN IMMUNOLOGY

Targeting B cells in treatment of autoimmunity

(2016) S Elizabeth Franks et al.   CURRENT OPINION IN IMMUNOLOGY

Fc Engineering Approaches to Enhance the Agonism and Effector Functions of an Anti-OX40 Antibody

(2016) Di Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Therapeutic CD38 Monoclonal Antibody Daratumumab Induces Programmed Cell Death via Fcγ Receptor–Mediated Cross-Linking

(2016) Marije B. Overdijk et al.   JOURNAL OF IMMUNOLOGY

Dimeric FcγR Ectodomains as Probes of the Fc Receptor Function of Anti-Influenza Virus IgG

(2016) Bruce D. Wines et al.   JOURNAL OF IMMUNOLOGY

Conformation of the Human Immunoglobulin G2 Hinge Imparts Superagonistic Properties to Immunostimulatory Anticancer Antibodies

(2015) Ann L. White et al.   CANCER CELL

Differential Fc-Receptor Engagement Drives an Anti-tumor Vaccinal Effect

(2015) David J. DiLillo et al.   CELL

Of ITIMs, ITAMs, and ITAMis: revisiting immunoglobulin Fc receptor signaling

(2015) Andrew Getahun et al.   IMMUNOLOGICAL REVIEWS

The biology of the classical Fcγ receptors in non-hematopoietic cells

(2015) Clark L. Anderson et al.   IMMUNOLOGICAL REVIEWS

Fcγ receptors: genetic variation, function, and disease

(2015) Chantal E. Hargreaves et al.   IMMUNOLOGICAL REVIEWS

Mouse and human FcR effector functions

(2015) Pierre Bruhns et al.   IMMUNOLOGICAL REVIEWS

Trastuzumab Triggers Phagocytic Killing of High HER2 Cancer Cells In Vitro and In Vivo by Interaction with Fcγ Receptors on Macrophages

(2015) Yun Shi et al.   JOURNAL OF IMMUNOLOGY

A Complement-Optimized EGFR Antibody Improves Cytotoxic Functions of Polymorphonuclear Cells against Tumor Cells

(2015) Stefanie Derer et al.   JOURNAL OF IMMUNOLOGY

Inhibitory FcγRIIb-Mediated Soluble Antigen Clearance from Plasma by a pH-Dependent Antigen-Binding Antibody and Its Enhancement by Fc Engineering

(2015) Yuki Iwayanagi et al.   JOURNAL OF IMMUNOLOGY

Comprehensive Analysis of the Therapeutic IgG4 Antibody Pembrolizumab: Hinge Modification Blocks Half Molecule Exchange In Vitro and In Vivo

(2015) Xiaoyu Yang et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Obinutuzumab as frontline treatment of chronic lymphocytic leukemia: updated results of the CLL11 study

(2015) V Goede et al.   LEUKEMIA

Structural basis for binding of human IgG1 to its high-affinity human receptor FcγRI

(2015) Masato Kiyoshi et al.   Nature Communications

Identification and Characterization of MEDI4736, an Antagonistic Anti-PD-L1 Monoclonal Antibody

(2015) R. Stewart et al.   Cancer Immunology Research

Reformatting Rituximab into Human IgG2 and IgG4 Isotypes Dramatically Improves Apoptosis Induction In Vitro

(2015) Jennifer D. Könitzer et al.   PLoS One

Dynamics of Inter-heavy Chain Interactions in Human Immunoglobulin G (IgG) Subclasses Studied by Kinetic Fab Arm Exchange

(2014) Theo Rispens et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fcγ Receptor Dependency of Agonistic CD40 Antibody in Lymphoma Therapy Can Be Overcome through Antibody Multimerization

(2014) Ann L. White et al.   JOURNAL OF IMMUNOLOGY

Structural Definition of an Antibody-Dependent Cellular Cytotoxicity Response Implicated in Reduced Risk for HIV-1 Infection

(2014) P. Acharya et al.   JOURNAL OF VIROLOGY

Endocytosis and Recycling of Immune Complexes by Follicular Dendritic Cells Enhances B Cell Antigen Binding and Activation

(2013) Balthasar A. Heesters et al.   IMMUNITY

The mechanism of anti-CD20–mediated B cell depletion revealed by intravital imaging

(2013) Fabricio Montalvao et al.   JOURNAL OF CLINICAL INVESTIGATION

Impact of Immune Complex Size and Glycosylation on IgG Binding to Human Fc Rs

(2013) A. Lux et al.   JOURNAL OF IMMUNOLOGY

Polymorphisms and Interspecies Differences of the Activating and Inhibitory Fc RII of Macaca nemestrina Influence the Binding of Human IgG Subclasses

(2013) H. M. Trist et al.   JOURNAL OF IMMUNOLOGY

High-Throughput IgG Fc N-Glycosylation Profiling by Mass Spectrometry of Glycopeptides

(2013) Maja Pučić Baković et al.   JOURNAL OF PROTEOME RESEARCH

Increasing FcγRIIa affinity of an FcγRIII-optimized anti-EGFR antibody restores neutrophil-mediated cytotoxicity

(2013) Stefanie Derer et al.   mAbs

Clinical targeting of the TNF and TNFR superfamilies

(2013) Michael Croft et al.   NATURE REVIEWS DRUG DISCOVERY

Engineered antibody Fc variant with selectively enhanced Fc RIIb binding over both Fc RIIaR131 and Fc RIIaH131

(2013) F. Mimoto et al.   PROTEIN ENGINEERING DESIGN & SELECTION

EGFR expression levels affect the mode of action of EGFR-targeting monoclonal antibodies

(2013) Stefanie Derer et al.   OncoImmunology

Results of a Phase 1 Study of AME-133v (LY2469298), an Fc-Engineered Humanized Monoclonal Anti-CD20 Antibody, in FcγRIIIa-Genotyped Patients with Previously Treated Follicular Lymphoma

(2012) Andres Forero-Torres et al.   CLINICAL CANCER RESEARCH

Reduction of total IgE by targeted coengagement of IgE B-cell receptor and FcγRIIb with Fc-engineered antibody

(2012) Seung Y. Chu et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Fc RIIb on Liver Sinusoidal Endothelium Clears Small Immune Complexes

(2012) L. P. Ganesan et al.   JOURNAL OF IMMUNOLOGY

Avidity confers FcγR binding and immune effector function to aglycosylated immunoglobulin G1

(2012) Thomas C. Nesspor et al.   JOURNAL OF MOLECULAR RECOGNITION

Fc receptor-targeted therapies for the treatment of inflammation, cancer and beyond

(2012) P. Mark Hogarth et al.   NATURE REVIEWS DRUG DISCOVERY

Apoptotic and antitumor activity of death receptor antibodies require inhibitory Fc  receptor engagement

(2012) F. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interaction with Fc RIIB Is Critical for the Agonistic Activity of Anti-CD40 Monoclonal Antibody

(2011) A. L. White et al.   JOURNAL OF IMMUNOLOGY

Pertuzumab plus Trastuzumab plus Docetaxel for Metastatic Breast Cancer

(2011) José Baselga et al.   NEW ENGLAND JOURNAL OF MEDICINE

Functional Expression of IgG-Fc Receptors in Human Airway Smooth Muscle Cells

(2010) YuXiu C. Xia et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Increasing the efficacy of CD20 antibody therapy through the engineering of a new type II anti-CD20 antibody with enhanced direct and immune effector cell-mediated B-cell cytotoxicity

(2010) E. Mossner et al.   BLOOD

Long-lasting antitumor protection by anti-CD20 antibody through cellular immune response

(2010) R. Abes et al.   BLOOD

Superior In vivo Efficacy of Afucosylated Trastuzumab in the Treatment of HER2-Amplified Breast Cancer

(2010) Teemu T. Junttila et al.   CANCER RESEARCH

Reciprocal Regulation of Activating and Inhibitory Fc  Receptors by TLR7/8 Activation: Implications for Tumor Immunotherapy

(2010) J. P. Butchar et al.   CLINICAL CANCER RESEARCH

B-Cell Depletion In Vitro and In Vivo with an Afucosylated Anti-CD19 Antibody

(2010) R. Herbst et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Rituximab immunotherapy results in the induction of a lymphoma idiotype-specific T-cell response in patients with follicular lymphoma: support for a "vaccinal effect" of rituximab

(2009) S. P. Hilchey et al.   BLOOD

Lymphoma depletion during CD20 immunotherapy in mice is mediated by macrophage Fc RI, Fc RIII, and Fc RIV

(2008) V. Minard-Colin et al.   BLOOD

Specificity and affinity of human Fc  receptors and their polymorphic variants for human IgG subclasses

(2008) P. Bruhns et al.   BLOOD

The clinical pharmacology of therapeutic monoclonal antibodies in the treatment of malignancy; have the magic bullets arrived?

(2008) Barrett W. Newsome et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Potent In vitro and In vivo Activity of an Fc-Engineered Anti-CD19 Monoclonal Antibody against Lymphoma and Leukemia

(2008) H. M. Horton et al.   CANCER RESEARCH

Human IgG2 Antibodies Display Disulfide-mediated Structural Isoforms

(2008) Jette Wypych et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of B cell receptor-mediated activation of primary human B cells by coengagement of CD19 and FcγRIIb with Fc-engineered antibodies

(2008) Seung Y. Chu et al.   MOLECULAR IMMUNOLOGY