Engineered antibody Fc variant with selectively enhanced Fc RIIb binding over both Fc RIIaR131 and Fc RIIaH131

A neutron-diffraction study of the low-cycle fatigue behaviour of an austenitic stainless steel 316

(2015) Adelaide Dubreuil et al.   ACTA CRYSTALLOGRAPHICA SECTION A

FcγRΙΙB controls the potency of agonistic anti-TNFR mAbs

(2013) Ann L. White et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Suppression of mast cell degranulation through a dual-targeting tandem IgE–IgG Fc domain biologic engineered to bind with high affinity to FcγRIIb

(2012) Saso Cemerski et al.   IMMUNOLOGY LETTERS

Antibodies against growth factor receptors can inhibit the proliferation of transformed cells via a cis-interaction with inhibitory FcR

(2012) Odile Malbec et al.   IMMUNOLOGY LETTERS

Reduction of total IgE by targeted coengagement of IgE B-cell receptor and FcγRIIb with Fc-engineered antibody

(2012) Seung Y. Chu et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

CD19 as an attractive target for antibody-based therapy

(2012) Ohad Hammer   mAbs

Apoptotic and antitumor activity of death receptor antibodies require inhibitory Fc  receptor engagement

(2012) F. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mouse model recapitulating human Fc  receptor structural and functional diversity

(2012) P. Smith et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An Fcγ Receptor-Dependent Mechanism Drives Antibody-Mediated Target-Receptor Signaling in Cancer Cells

(2011) Nicholas S. Wilson et al.   CANCER CELL

Immune complex enhances tolerogenecity of immature dendritic cells via FcγRIIb and promotes FcγRIIb-overexpressing dendritic cells to attenuate lupus

(2011) Yan Zhang et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Structural Basis for Fc RIIa Recognition of Human IgG and Formation of Inflammatory Signaling Complexes

(2011) P. A. Ramsland et al.   JOURNAL OF IMMUNOLOGY

Antibody-Mediated Coengagement of FcγRIIb and B Cell Receptor Complex Suppresses Humoral Immunity in Systemic Lupus Erythematosus

(2011) Holly M. Horton et al.   JOURNAL OF IMMUNOLOGY

Interaction with Fc RIIB Is Critical for the Agonistic Activity of Anti-CD40 Monoclonal Antibody

(2011) A. L. White et al.   JOURNAL OF IMMUNOLOGY

Inhibitory Fc  Receptor Engagement Drives Adjuvant and Anti-Tumor Activities of Agonistic CD40 Antibodies

(2011) F. Li et al.   SCIENCE

2-Bromopyridine-3-carboxylic acid

(2010) R. Alan Howie et al.   ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE

Increasing the efficacy of CD20 antibody therapy through the engineering of a new type II anti-CD20 antibody with enhanced direct and immune effector cell-mediated B-cell cytotoxicity

(2010) E. Mossner et al.   BLOOD

Divergent Intracellular Sorting of FcγRIIA and FcγRIIB2

(2010) Christine Y. Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Anti-CD40L Immune Complexes Potently Activate Platelets In Vitro and Cause Thrombosis in FCGR2A Transgenic Mice

(2010) L. Robles-Carrillo et al.   JOURNAL OF IMMUNOLOGY

Non-classical binding of a polyreactive α-type anti-idiotypic antibody to B cells

(2010) Tays Hernández et al.   MOLECULAR IMMUNOLOGY

Reduced elimination of IgG antibodies by engineering the variable region

(2010) T. Igawa et al.   PROTEIN ENGINEERING DESIGN & SELECTION

xia2: an expert system for macromolecular crystallography data reduction

(2009) G. Winter   JOURNAL OF APPLIED CRYSTALLOGRAPHY

High throughput thermostability screening of monoclonal antibody formulations

(2009) Feng He et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Fc RIIB signals inhibit BLyS signaling and BCR-mediated BLyS receptor up-regulation

(2008) J. E. Crowley et al.   BLOOD

The impact of Fc engineering on an anti-CD19 antibody: increased Fc  receptor affinity enhances B-cell clearing in nonhuman primates

(2008) J. Zalevsky et al.   BLOOD

Intravenous immunoglobulins induce CD32-mediated platelet aggregationin vitro

(2008) A. Pollreisz et al.   BRITISH JOURNAL OF DERMATOLOGY

Bevacizumab immune complexes activate platelets and induce thrombosis in FCGR2A transgenic mice

(2008) T. MEYER et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Optimization of antibody binding to Fc RIIa enhances macrophage phagocytosis of tumor cells

(2008) J. O. Richards et al.   MOLECULAR CANCER THERAPEUTICS

Inhibition of B cell receptor-mediated activation of primary human B cells by coengagement of CD19 and FcγRIIb with Fc-engineered antibodies

(2008) Seung Y. Chu et al.   MOLECULAR IMMUNOLOGY