Comprehensive Analysis of the Therapeutic IgG4 Antibody Pembrolizumab: Hinge Modification Blocks Half Molecule Exchange In Vitro and In Vivo

Published 2015 View Full Article

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Title
Comprehensive Analysis of the Therapeutic IgG4 Antibody Pembrolizumab: Hinge Modification Blocks Half Molecule Exchange In Vitro and In Vivo
Authors
Keywords
half molecule (Fab arm) exchange analysis, IgG4, bispecific antibody, pembrolizumab, cancer immunotherapy, analytical biochemistry, bioanalysis, glycoprotein, immunology, biotechnology
Journal
JOURNAL OF PHARMACEUTICAL SCIENCES
Volume 104, Issue 12, Pages 4002-4014
Publisher
Elsevier BV
Online
2015-08-27
DOI
10.1002/jps.24620

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