Crosstalk between GSK-3β-actuated molecular cascades and myocardial physiology

Cardiomyocyte-GSK-3α promotes mPTP opening and heart failure in mice with chronic pressure overload

(2019) Firdos Ahmad et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

The protective effect of kaempferol on heart via the regulation of Nrf2, NF-κβ, and PI3K/Akt/GSK-3β signaling pathways in isoproterenol-induced heart failure in diabetic rats

(2019) Long Zhang et al.   DRUG DEVELOPMENT RESEARCH

Plantamajoside attenuates isoproterenol-induced cardiac hypertrophy associated with the HDAC2 and AKT/ GSK-3β signaling pathway

(2019) Linlin Shang et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Targeted disruption of glycogen synthase kinase-3β in cardiomyocytes attenuates cardiac parasympathetic dysfunction in type 1 diabetic Akita mice

(2019) Yali Zhang et al.   PLoS One

Modeling Hypertrophic Cardiomyopathy: Mechanistic Insights and Pharmacological Intervention

(2019) Diogo Mosqueira et al.   TRENDS IN MOLECULAR MEDICINE

Qishen granule attenuates cardiac fibrosis by regulating TGF-β /Smad3 and GSK-3β pathway

(2019) Zifan Zeng et al.   PHYTOMEDICINE

Severe Cardiac Dysfunction and Death Caused by Arrhythmogenic Right Ventricular Cardiomyopathy Type 5 Are Improved by Inhibition of Glycogen Synthase Kinase-3β

(2019) Laura Padrón-Barthe et al.   CIRCULATION

Vagal stimulation mimics preconditioning and postconditioning of ischemic myocardium in mice by activating different protection mechanisms

(2018) Bruno Buchholz et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Inhibiting Glycogen Synthase Kinase 3 Reverses Obesity-Induced White Adipose Tissue Inflammation by Regulating Apoptosis Inhibitor of Macrophage/CD5L-Mediated Macrophage Migration

(2018) Li Wang et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Antiproliferative and apoptotic effect of LY2090314, a GSK-3 inhibitor, in neuroblastoma in vitro

(2018) Selvi Kunnimalaiyaan et al.   BMC CANCER

Cardiomyocyte-specific deletion of GSK-3β leads to cardiac dysfunction in a diet induced obesity model

(2018) Manisha Gupte et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

SB-216763, a GSK-3β inhibitor, protects against aldosterone-induced cardiac, and renal injury by activating autophagy

(2018) Yi-De Zhang et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Exercise preconditioning and low dose copper nanoparticles exhibits cardioprotection through targeting GSK-3β phosphorylation in ischemia/reperfusion induced myocardial infarction

(2018) Arun K. Sharma et al.   MICROVASCULAR RESEARCH

Combined and individual strategy of exercise generated preconditioning and low dose copper nanoparticles serve as superlative approach to ameliorate ISO-induced myocardial infarction in rats

(2018) Arun K. Sharma et al.   Pharmacological Reports

Rhein protects the myocardiac cells against hypoxia/reoxygention-induced injury by suppressing GSK3β activity

(2018) Jing Liu et al.   PHYTOMEDICINE

Stage-specific Effects of Bioactive Lipids on Human iPSC Cardiac Differentiation and Cardiomyocyte Proliferation

(2018) Arun Sharma et al.   Scientific Reports

Unraveling the Inconsistencies of Cardiac Differentiation Efficiency Induced by the GSK3β Inhibitor CHIR99021 in Human Pluripotent Stem Cells

(2018) Filip Laco et al.   Stem Cell Reports

Sitagliptin attenuates myocardial apoptosis via activating LKB-1/AMPK/Akt pathway and suppressing the activity of GSK-3β and p38α/MAPK in a rat model of diabetic cardiomyopathy

(2018) Nouf T. Al-Damry et al.   BIOMEDICINE & PHARMACOTHERAPY

Inhibition of GSK-3 to induce cardiomyocyte proliferation-a recipe for in situ cardiac regeneration

(2018) Anand Prakash Singh et al.   CARDIOVASCULAR RESEARCH

GSK-3 inhibitors enhance TRAIL-mediated apoptosis in human gastric adenocarcinoma cells

(2018) Yi-Ying Wu et al.   PLoS One

Lithium Chloride Increases COX-2 Expression and PGE2 Production in a Human Granulosa-Lutein SVOG Cell Line Via a GSK-3β/β-Catenin Signaling Pathway

(2017) Long Bai et al.   ENDOCRINOLOGY

Role of PI3K in myocardial ischaemic preconditioning: mapping pro-survival cascades at the trigger phase and at reperfusion

(2017) Xavier Rossello et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Entanglement of GSK-3β, β-catenin and TGF-β1 signaling network to regulate myocardial fibrosis

(2017) Yuanjun Guo et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Cyclosporine-A induces endoplasmic reticulum stress and influences pro-apoptotic factors in human gingival fibroblasts

(2017) Suresh Ranga Rao et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Pharmacological postconditioning with atorvastatin calcium attenuates myocardial ischemia/reperfusion injury in diabetic rats by phosphorylating GSK3β

(2017) Linyan Chen et al.   Experimental and Therapeutic Medicine

Silymarin Ameliorates Diabetes-Induced Proangiogenic Response in Brain Endothelial Cells through a GSK-3β Inhibition-Induced Reduction of VEGF Release

(2017) Ahmed Alhusban et al.   Journal of Diabetes Research

GSK-3 Inhibitors: Anti-Diabetic Treatment Associated with Cardiac Risk?

(2016) Miranda Nabben et al.   CARDIOVASCULAR DRUGS AND THERAPY

Loss of Adult Cardiac Myocyte GSK-3 Leads to Mitotic Catastrophe Resulting in Fatal Dilated CardiomyopathyNovelty and Significance

(2016) Jibin Zhou et al.   CIRCULATION RESEARCH

Signaling Pathways in Cardiac Myocyte Apoptosis

(2016) Peng Xia et al.   Biomed Research International

GSK-3β/NFAT Signaling Is Involved in Testosterone-Induced Cardiac Myocyte Hypertrophy

(2016) Javier Duran et al.   PLoS One

AKT/GSK3β signaling pathway is critically involved in human pluripotent stem cell survival

(2016) Leonardo Romorini et al.   Scientific Reports

Inhibition of glycogen synthase kinase-3β prevents sympathetic hyperinnervation in infarcted rats

(2015) Tsung-Ming Lee et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Morphine Reduces Myocardial Infarct Size via Heat Shock Protein 90 in Rodents

(2015) Bryce A. Small et al.   Biomed Research International

G Protein-Coupled Estrogen Receptor 1 Mediates Acute Estrogen-Induced Cardioprotection via MEK/ERK/GSK-3β Pathway after Ischemia/Reperfusion

(2015) Mohammad E. Kabir et al.   PLoS One

Low-dose dipyridamole treatment partially prevents diabetes mellitus-induced vascular endothelial and renal abnormalities in rats

(2014) Arun Kumar Sharma et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Cardiomyocyte-Specific Deletion of Gsk3α Mitigates Post–Myocardial Infarction Remodeling, Contractile Dysfunction, and Heart Failure

(2014) Firdos Ahmad et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Accelerated Recovery of Mitochondrial Membrane Potential by GSK-3β Inactivation Affords Cardiomyocytes Protection from Oxidant-Induced Necrosis

(2014) Daisuke Sunaga et al.   PLoS One

Inhibition of GSK-3 Induces Differentiation and Impaired Glucose Metabolism in Renal Cancer

(2013) K. Pal et al.   MOLECULAR CANCER THERAPEUTICS

Glycogen synthase kinase-3β controls autophagy during myocardial ischemia and reperfusion

(2012) Peiyong Zhai et al.   Autophagy

Activation of Akt/protein kinase B mediates the protective effects of mechanical stretching against myocardial ischemia-reperfusion injury

(2012) Chan-Hyung Kim et al.   Journal of Veterinary Science

Molecular basis of physiological heart growth: fundamental concepts and new players

(2012) Marjorie Maillet et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The  -Catenin Destruction Complex

(2012) J. L. Stamos et al.   Cold Spring Harbor Perspectives in Biology

Phosphorylation of GSK-3β Mediates Intralipid-induced Cardioprotection against Ischemia/Reperfusion Injury

(2011) Siamak Rahman et al.   ANESTHESIOLOGY

Differential Roles of GSK-3β During Myocardial Ischemia and Ischemia/Reperfusion

(2011) Peiyong Zhai et al.   CIRCULATION RESEARCH

Myocardial AKT: The Omnipresent Nexus

(2011) Mark A. Sussman et al.   PHYSIOLOGICAL REVIEWS

GSK-3: Functional Insights from Cell Biology and Animal Models

(2011) Oksana Kaidanovich-Beilin et al.   Frontiers in Molecular Neuroscience

Allosteric Regulation of Glycogen Synthase Kinase 3β: A Theoretical Study

(2010) Idit Buch et al.   BIOCHEMISTRY

Emodin, a natural product, selectively inhibits 11β-hydroxysteroid dehydrogenase type 1 and ameliorates metabolic disorder in diet-induced obese mice

(2010) Ying Feng et al.   BRITISH JOURNAL OF PHARMACOLOGY

Cardioprotection by GSK-3 inhibition: role of enhanced glycogen synthesis and attenuation of calcium overload

(2010) Mohamed A. Omar et al.   CARDIOVASCULAR RESEARCH

Glycogen Synthase Kinase-3β Regulates Post–Myocardial Infarction Remodeling and Stress-Induced Cardiomyocyte Proliferation In Vivo

(2010) Kathleen C. Woulfe et al.   CIRCULATION RESEARCH

Targeting GSK-3 family members in the heart: A very sharp double-edged sword

(2010) Hui Cheng et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

14-3-3 inhibits insulin-like growth factor-I-induced proliferation of cardiac fibroblasts via a phosphatidylinositol 3-kinase-dependent pathway

(2009) Jian-Yong Qi et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Possible interactions between dietary fibres and 5-aminosalicyclic acid

(2009) Camilla Henriksen et al.   Therapeutic Advances in Gastroenterology

Glycogen synthase kinase 3 (GSK3) in the heart: a point of integration in hypertrophic signalling and a therapeutic target? A critical analysis

(2008) P H Sugden et al.   BRITISH JOURNAL OF PHARMACOLOGY

Inhibition of Glycogen Synthase Kinase-3β Is Sufficient for Airway Smooth Muscle Hypertrophy

(2008) Huan Deng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY