Autophagy promotes mammalian survival by suppressing oxidative stress and p53

Targeted therapy based on p53 reactivation reduces both glioblastoma cell growth and resistance to temozolomide

(2019) Iris Forte et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

LC3-Associated Endocytosis Facilitates β-Amyloid Clearance and Mitigates Neurodegeneration in Murine Alzheimer’s Disease

(2019) Bradlee L. Heckmann et al.   CELL

Role of tumor and host autophagy in cancer metabolism

(2019) Laura Poillet-Perez et al.   GENES & DEVELOPMENT

Cancer Cells Upregulate NRF2 Signaling to Adapt to Autophagy Inhibition

(2019) Christina G. Towers et al.   DEVELOPMENTAL CELL

Cellular quality control by the ubiquitin-proteasome system and autophagy

(2019) Christian Pohl et al.   SCIENCE

Nutlin-3, A p53-Mdm2 Antagonist for Nasopharyngeal Carcinoma Treatment

(2018) Voon Yee-Lin et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Autophagy protein ATG16L1 prevents necroptosis in the intestinal epithelium

(2017) Yu Matsuzawa-Ishimoto et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Census and evaluation of p53 target genes

(2017) M Fischer   ONCOGENE

Intrinsic Autophagy Is Required for the Maintenance of Intestinal Stem Cells and for Irradiation-Induced Intestinal Regeneration

(2017) Jumpei Asano et al.   Cell Reports

Autophagy provides metabolic substrates to maintain energy charge and nucleotide pools in Ras-driven lung cancer cells

(2016) Jessie Yanxiang Guo et al.   GENES & DEVELOPMENT

p62/Sqstm1 promotes malignancy of HCV-positive hepatocellular carcinoma through Nrf2-dependent metabolic reprogramming

(2016) Tetsuya Saito et al.   Nature Communications

Sequential cancer mutations in cultured human intestinal stem cells

(2015) Jarno Drost et al.   NATURE

Molecular characterization of LC3-associated phagocytosis reveals distinct roles for Rubicon, NOX2 and autophagy proteins

(2015) Jennifer Martinez et al.   NATURE CELL BIOLOGY

p53 in survival, death and metabolic health: a lifeguard with a licence to kill

(2015) Flore Kruiswijk et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Autophagy at the crossroads of catabolism and anabolism

(2015) Jasvinder Kaur et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Inhibition of autophagy attenuates pancreatic cancer growth independent ofTP53/TRP53status

(2014) Annan Yang et al.   Autophagy

Redox regulation of antioxidants, autophagy, and the response to stress: Implications for electrophile therapeutics

(2014) Anna-Liisa Levonen et al.   FREE RADICAL BIOLOGY AND MEDICINE

Functional Role of Autophagy-Mediated Proteome Remodeling in Cell Survival Signaling and Innate Immunity

(2014) Robin Mathew et al.   MOLECULAR CELL

Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy

(2014) Joseph D. Mancias et al.   NATURE

Autophagy Is Critical for Pancreatic Tumor Growth and Progression in Tumors with p53 Alterations

(2014) A. Yang et al.   Cancer Discovery

Autophagy Is Required for Glucose Homeostasis and Lung Tumor Maintenance

(2014) G. Karsli-Uzunbas et al.   Cancer Discovery

Noncanonical Autophagy Promotes the Visual Cycle

(2013) Ji-Young Kim et al.   CELL

Global genomic profiling reveals an extensive p53-regulated autophagy program contributing to key p53 responses

(2013) D. Kenzelmann Broz et al.   GENES & DEVELOPMENT

Autophagy suppresses progression of K-ras-induced lung tumors to oncocytomas and maintains lipid homeostasis

(2013) J. Y. Guo et al.   GENES & DEVELOPMENT

Phosphorylation of p62 Activates the Keap1-Nrf2 Pathway during Selective Autophagy

(2013) Yoshinobu Ichimura et al.   MOLECULAR CELL

p53 status determines the role of autophagy in pancreatic tumour development

(2013) Mathias T. Rosenfeldt et al.   NATURE

Autophagy Opposes p53-Mediated Tumor Barrier to Facilitate Tumorigenesis in a Model of PALB2-Associated Hereditary Breast Cancer

(2013) Y. Huo et al.   Cancer Discovery

Autophagy Sustains Mitochondrial Glutamine Metabolism and Growth of BrafV600E-Driven Lung Tumors

(2013) A. M. Strohecker et al.   Cancer Discovery

DRAM-1 encodes multiple isoforms that regulate autophagy

(2012) Li Yen Mah et al.   Autophagy

P53 Mdm2 Inhibitors

(2012) Kareem Khoury et al.   CURRENT PHARMACEUTICAL DESIGN

Autophagy: Renovation of Cells and Tissues

(2011) Noboru Mizushima et al.   CELL

Pancreatic cancers require autophagy for tumor growth

(2011) S. Yang et al.   GENES & DEVELOPMENT

Autophagy machinery mediates macroendocytic processing and entotic cell death by targeting single membranes

(2011) Oliver Florey et al.   NATURE CELL BIOLOGY

Microtubule-associated protein 1 light chain 3 alpha (LC3)-associated phagocytosis is required for the efficient clearance of dead cells

(2011) J. Martinez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The role of the Atg1/ULK1 complex in autophagy regulation

(2010) Noboru Mizushima   CURRENT OPINION IN CELL BIOLOGY

Molecular mechanism and physiological role of pexophagy

(2010) Ravi Manjithaya et al.   FEBS LETTERS

A Noncanonical Mechanism of Nrf2 Activation by Autophagy Deficiency: Direct Interaction between Keap1 and p62

(2010) A. Lau et al.   MOLECULAR AND CELLULAR BIOLOGY

The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1

(2010) Masaaki Komatsu et al.   NATURE CELL BIOLOGY

Autophagy and Metabolism

(2010) J. D. Rabinowitz et al.   SCIENCE

p53 mediates mitochondria dysfunction-triggered autophagy activation and cell death in rat striatum

(2009) Xing-Ding Zhang et al.   Autophagy

Autophagy Suppresses Tumorigenesis through Elimination of p62

(2009) Robin Mathew et al.   CELL

Mdm2-mediated ubiquitylation: p53 and beyond

(2009) J-C Marine et al.   CELL DEATH AND DIFFERENTIATION

PUMA- and Bax-induced autophagy contributes to apoptosis

(2009) K S Yee et al.   CELL DEATH AND DIFFERENTIATION

A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells

(2008) Ken Cadwell et al.   NATURE