ddhCTP produced by the radical‐SAM activity of RSAD2 (viperin) inhibits the NAD + ‐dependent activity of enzymes to modulate metabolism

Interactions between Viperin, Vesicle-Associated Membrane Protein A, and Hepatitis C Virus Protein NS5A Modulate Viperin Activity and NS5A Degradation

(2020) Soumi Ghosh et al.   BIOCHEMISTRY

Mechanism of Diol Dehydration by a Promiscuous Radical‐SAM Enzyme Homologue of the Antiviral Enzyme Viperin (RSAD2)

(2020) Kourosh Honarmand Ebrahimi et al.   CHEMBIOCHEM

Viperin, through its radical‐SAM activity, depletes cellular nucleotide pools and interferes with mitochondrial metabolism to inhibit viral replication

(2020) Kourosh H. Ebrahimi et al.   FEBS LETTERS

The antiviral protein viperin regulates chondrogenic differentiation via CXCL10 protein secretion

(2019) Mandy M. F. Steinbusch et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Viperin interacts with the kinase IRAK1 and the E3 ubiquitin ligase TRAF6,  coupling innate immune signaling to antiviral ribonucleotide synthesis

(2019) Arti B. Dumbrepatil et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Intrinsic expression of viperin regulates thermogenesis in adipose tissues

(2019) John Eom et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metabolomics reveals diet-derived plant polyphenols accumulate in physiological bone

(2019) Isabelle Alldritt et al.   Scientific Reports

Viperin Restricts Zika Virus and Tick-Borne Encephalitis Virus Replication by Targeting NS3 for Proteasomal Degradation

(2018) Christakis Panayiotou et al.   JOURNAL OF VIROLOGY

A naturally occurring antiviral ribonucleotide encoded by the human genome

(2018) Anthony S. Gizzi et al.   NATURE

Viperin Deficiency Promotes Polarization of Macrophages and Secretion of M1 and M2 Cytokines

(2018) John Eom et al.   Immune Network

The radical-SAM enzyme Viperin catalyzes reductive addition of a 5′-deoxyadenosyl radical to UDP-glucose in vitro

(2017) Kourosh Honarmand Ebrahimi et al.   FEBS LETTERS

Temporal Tracking of Microglia Activation in Neurodegeneration at Single-Cell Resolution

(2017) Hansruedi Mathys et al.   Cell Reports

A Highly Efficient Human Pluripotent Stem Cell Microglia Model Displays a Neuronal-Co-culture-Specific Expression Profile and Inflammatory Response

(2017) Walther Haenseler et al.   Stem Cell Reports

Viperin is an important host restriction factor in control of Zika virus infection

(2017) Kylie H. Van der Hoek et al.   Scientific Reports

C9orf72 Hexanucleotide Expansions Are Associated with Altered Endoplasmic Reticulum Calcium Homeostasis and Stress Granule Formation in Induced Pluripotent Stem Cell-Derived Neurons from Patients with Amyotrophic Lateral Sclerosis and Frontotemporal Demen

(2016) Ruxandra Dafinca et al.   STEM CELLS

NAD+ Metabolism and the Control of Energy Homeostasis: A Balancing Act between Mitochondria and the Nucleus

(2015) Carles Cantó et al.   Cell Metabolism

In vivo NAD assay reveals the intracellular NAD contents and redox state in healthy human brain and their age dependences

(2015) Xiao-Hong Zhu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Guanosine inhibits LPS-induced pro-inflammatory response and oxidative stress in hippocampal astrocytes through the heme oxygenase-1 pathway

(2015) Bruna Bellaver et al.   Purinergic Signalling

Proteasome Regulation by ADP-Ribosylation

(2013) Park F. Cho-Park et al.   CELL

Guanosine controls inflammatory pathways to afford neuroprotection of hippocampal slices under oxygen and glucose deprivation conditions

(2013) Tharine Dal-Cim et al.   JOURNAL OF NEUROCHEMISTRY

Molecular Profiling of Multiple Human Cancers Defines an Inflammatory Cancer-Associated Molecular Pattern and Uncovers KPNA2 as a Uniform Poor Prognostic Cancer Marker

(2013) Saleh M. Rachidi et al.   PLoS One

Efficient, Long Term Production of Monocyte-Derived Macrophages from Human Pluripotent Stem Cells under Partly-Defined and Fully-Defined Conditions

(2013) Bonnie van Wilgenburg et al.   PLoS One

Viperin Regulates Cellular Lipid Metabolism during Human Cytomegalovirus Infection

(2013) Jun-Young Seo et al.   PLoS Pathogens

NAD-dependent lactate dehydrogenase catalyses the first step in respiratory utilization of lactate by Lactococcus lactis

(2013) Rui Zhao et al.   FEBS Open Bio

The Pentose Phosphate Pathway Is a Metabolic Redox Sensor and Regulates Transcription During the Antioxidant Response

(2011) Antje Krüger et al.   ANTIOXIDANTS & REDOX SIGNALING

Viperin: A Multifunctional, Interferon-Inducible Protein that Regulates Virus Replication

(2011) Jun-Young Seo et al.   Cell Host & Microbe

The antiviral protein viperin inhibits hepatitis C virus replication via interaction with nonstructural protein 5A

(2011) Karla J. Helbig et al.   HEPATOLOGY

Viperin inhibits hepatitis C virus replication by interfering with binding of NS5A to host protein hVAP-33

(2011) S. Wang et al.   JOURNAL OF GENERAL VIROLOGY

Human Cytomegalovirus Directly Induces the Antiviral Protein Viperin to Enhance Infectivity

(2011) J.-Y. Seo et al.   SCIENCE

Taurine Reduces Inflammatory Responses after Spinal Cord Injury

(2009) Yasuhiro Nakajima et al.   JOURNAL OF NEUROTRAUMA

Intracellular NAD levels regulate tumor necrosis factor protein synthesis in a sirtuin-dependent manner

(2009) Frédéric Van Gool et al.   NATURE MEDICINE

The antiviral protein, viperin, localizes to lipid droplets via its N-terminal amphipathic  -helix

(2009) E. R. Hinson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TNF/iNOS-producing dendritic cells are the necessary evil of lethal influenza virus infection

(2009) J. R. Aldridge et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Viperin is required for optimal Th2 responses and T-cell receptor-mediated activation of NF- B and AP-1

(2008) L.-Q. Qiu et al.   BLOOD

The N-terminal Amphipathic α-Helix of Viperin Mediates Localization to the Cytosolic Face of the Endoplasmic Reticulum and Inhibits Protein Secretion

(2008) Ella R. Hinson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY