Guanosine inhibits LPS-induced pro-inflammatory response and oxidative stress in hippocampal astrocytes through the heme oxygenase-1 pathway

2′,3′-cAMP, 3′-AMP, 2′-AMP and adenosine inhibit TNF-α and CXCL10 production from activated primary murine microglia via A2A receptors

(2015) Elizabeth A. Newell et al.   BRAIN RESEARCH

Resveratrol Protects Hippocampal Astrocytes Against LPS-Induced Neurotoxicity Through HO-1, p38 and ERK Pathways

(2015) Bruna Bellaver et al.   NEUROCHEMICAL RESEARCH

Lipoic acid and N-acetylcysteine prevent ammonia-induced inflammatory response in C6 astroglial cells: The putative role of ERK and HO1 signaling pathways

(2015) Camila Leite Santos et al.   TOXICOLOGY IN VITRO

Activation and Regulation of Cellular Inflammasomes: Gaps in Our Knowledge for Central Nervous System Injury

(2014) Juan Pablo de Rivero Vaccari et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Guanosine protects C6 astroglial cells against azide-induced oxidative damage: a putative role of heme oxygenase 1

(2014) André Quincozes-Santos et al.   JOURNAL OF NEUROCHEMISTRY

Tumor Necrosis Factor Alpha: A Link between Neuroinflammation and Excitotoxicity

(2014) Gabriel Olmos et al.   MEDIATORS OF INFLAMMATION

Isolation of glia from Alzheimer's mice reveals inflammation and dysfunction

(2014) Marie Orre et al.   NEUROBIOLOGY OF AGING

The Potential Therapeutic Effect of Guanosine after Cortical Focal Ischemia in Rats

(2014) Gisele Hansel et al.   PLoS One

Resveratrol increases antioxidant defenses and decreases proinflammatory cytokines in hippocampal astrocyte cultures from newborn, adult and aged Wistar rats

(2014) Bruna Bellaver et al.   TOXICOLOGY IN VITRO

Cellular therapy to target neuroinflammation in amyotrophic lateral sclerosis

(2013) Federica Rizzo et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Guanosine controls inflammatory pathways to afford neuroprotection of hippocampal slices under oxygen and glucose deprivation conditions

(2013) Tharine Dal-Cim et al.   JOURNAL OF NEUROCHEMISTRY

Characterization of Adult Rat Astrocyte Cultures

(2013) Débora Guerini Souza et al.   PLoS One

Induction of an Inflammatory Loop by Interleukin-1β and Tumor Necrosis Factor-α Involves NF-kB and STAT-1 in Differentiated Human Neuroprogenitor Cells

(2013) Subbiah Pugazhenthi et al.   PLoS One

Gliopreventive effects of guanosine against glucose deprivation in vitro

(2013) André Quincozes-Santos et al.   Purinergic Signalling

Extracellular guanosine regulates extracellular adenosine levels

(2012) Edwin K. Jackson et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Glial cells in (patho)physiology

(2012) Vladimir Parpura et al.   JOURNAL OF NEUROCHEMISTRY

Cholinergic Precursors Modulate the Expression of Heme Oxigenase-1, p21 During Astroglial Cell Proliferation and Differentiation in Culture

(2012) V. Bramanti et al.   NEUROCHEMICAL RESEARCH

Guanosine protects human neuroblastoma SH-SY5Y cells against mitochondrial oxidative stress by inducing heme oxigenase-1 via PI3K/Akt/GSK-3β pathway

(2012) Tharine Dal-Cim et al.   NEUROCHEMISTRY INTERNATIONAL

Resveratrol Inhibits LPS-Induced MAPKs Activation via Activation of the Phosphatidylinositol 3-Kinase Pathway in Murine RAW 264.7 Macrophage Cells

(2012) Yi Zong et al.   PLoS One

Systemic administration of guanosine promotes functional and histological improvement following an ischemic stroke in rats

(2011) Michel P. Rathbone et al.   BRAIN RESEARCH

Brain Energy Metabolism: Focus on Astrocyte-Neuron Metabolic Cooperation

(2011) Mireille Bélanger et al.   Cell Metabolism

The metabolism and toxicity of hemin in astrocytes

(2011) Theresa N. Dang et al.   GLIA

Lipopolysaccharide modulates astrocytic S100B secretion: a study in cerebrospinal fluid and astrocyte cultures from rats

(2011) Maria Guerra et al.   Journal of Neuroinflammation

The ageing systemic milieu negatively regulates neurogenesis and cognitive function

(2011) Saul A. Villeda et al.   NATURE

Effects of chronic guanosine treatment on hippocampal damage and cognitive impairment of rats submitted to chronic cerebral hypoperfusion

(2011) Marcelo Ganzella et al.   NEUROLOGICAL SCIENCES

Depletion of GSH in glial cells induces neurotoxicity: relevance to aging and degenerative neurological diseases

(2010) Moonhee Lee et al.   FASEB JOURNAL

Adenosine A1 Receptor Activation as a Brake on the Microglial Response after Experimental Traumatic Brain Injury in Mice

(2010) M. Lee Haselkorn et al.   JOURNAL OF NEUROTRAUMA

Neuroinflammation in Parkinson's disease: a target for neuroprotection?

(2009) Etienne C Hirsch et al.   LANCET NEUROLOGY

NADPH oxidase is the primary source of superoxide induced by NMDA receptor activation

(2009) Angela M Brennan et al.   NATURE NEUROSCIENCE

Glucose and NADPH oxidase drive neuronal superoxide formation in stroke

(2008) Sang Won Suh et al.   ANNALS OF NEUROLOGY

Heme Oxygenase-1 as a Therapeutic Target in Neurodegenerative Diseases and Brain Infections

(2008) Antonio Cuadrado et al.   CURRENT PHARMACEUTICAL DESIGN

The NMDA antagonist MK-801 induces hyperalgesia and increases CSF excitatory amino acids in rats: Reversal by guanosine

(2008) André P. Schmidt et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

The undertow of sulfur metabolism on glutamatergic neurotransmission

(2008) Ruma Banerjee et al.   TRENDS IN BIOCHEMICAL SCIENCES

Glial toll-like receptor signaling in central nervous system infection and autoimmunity

(2007) Pamela A. Carpentier et al.   BRAIN BEHAVIOR AND IMMUNITY

Mechanism of guanosine-induced neuroprotection in rat hippocampal slices submitted to oxygen–glucose deprivation

(2007) Scheyla P.B. Oleskovicz et al.   NEUROCHEMISTRY INTERNATIONAL

Neuroprotective effects of guanosine on stroke models in vitro and in vivo

(2007) Ruby Chang et al.   NEUROSCIENCE LETTERS