Mechanism of Diol Dehydration by a Promiscuous Radical‐SAM Enzyme Homologue of the Antiviral Enzyme Viperin (RSAD2)

The Elusive 5′-Deoxyadenosyl Radical: Captured and Characterized by Electron Paramagnetic Resonance and Electron Nuclear Double Resonance Spectroscopies

(2019) Hao Yang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Trapping and Electron Paramagnetic Resonance Characterization of the 5′dAdo• Radical in a Radical S-Adenosyl Methionine Enzyme Reaction with a Non-Native Substrate

(2019) Richard I. Sayler et al.   ACS Central Science

Evidence for the synthesis of an unusual high spin (S = 7/2) [Cu–3Fe–4S] cluster in the radical-SAM enzyme RSAD2 (viperin)

(2018) K. Honarmand Ebrahimi et al.   CHEMICAL COMMUNICATIONS

Decarboxylation involving a ferryl, propionate, and a tyrosyl group in a radical relay yields hemeb

(2018) Bennett R. Streit et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

1,2-Diol Dehydration by the Radical SAM Enzyme AprD4: A Matter of Proton Circulation and Substrate Flexibility

(2018) Wan-Qiu Liu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Paradigm Shift for Radical S-Adenosyl-l-methionine Reactions: The Organometallic Intermediate Ω Is Central to Catalysis

(2018) Amanda S. Byer et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A naturally occurring antiviral ribonucleotide encoded by the human genome

(2018) Anthony S. Gizzi et al.   NATURE

The radical-SAM enzyme Viperin catalyzes reductive addition of a 5′-deoxyadenosyl radical to UDP-glucose in vitro

(2017) Kourosh Honarmand Ebrahimi et al.   FEBS LETTERS

Expanding Radical SAM Chemistry by Using Radical Addition Reactions and SAM Analogues

(2016) Xinjian Ji et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

RadicalS-Adenosylmethionine Enzymes in Human Health and Disease

(2016) Bradley J. Landgraf et al.   Annual Review of Biochemistry

Approved Antiviral Drugs over the Past 50 Years

(2016) Erik De Clercq et al.   CLINICAL MICROBIOLOGY REVIEWS

Fragmentation reactions using electrospray ionization mass spectrometry: an important tool for the structural elucidation and characterization of synthetic and natural products

(2016) Daniel P. Demarque et al.   NATURAL PRODUCT REPORTS

Radical SAM catalysis via an organometallic intermediate with an Fe-[5'-C]-deoxyadenosyl bond

(2016) M. Horitani et al.   SCIENCE

Synthesis of 2,6-Dihalogenated Purine Nucleosides by Thermostable Nucleoside Phosphorylases

(2015) Xinrui Zhou et al.   ADVANCED SYNTHESIS & CATALYSIS

Substrate-Tuned Catalysis of the RadicalS-Adenosyl-L-Methionine Enzyme NosL Involved in Nosiheptide Biosynthesis

(2015) Xinjian Ji et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Auxiliary iron–sulfur cofactors in radical SAM enzymes

(2015) Nicholas D. Lanz et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The Phyre2 web portal for protein modeling, prediction and analysis

(2015) Lawrence A Kelley et al.   Nature Protocols

Recent Advances in Radical SAM Enzymology: New Structures and Mechanisms

(2014) Jiarui Wang et al.   ACS Chemical Biology

Mechanistic Studies of the RadicalS-Adenosylmethionine Enzyme DesII with TDP-D-Fucose

(2014) Yeonjin Ko et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Radical S-Adenosylmethionine Enzymes

(2014) Joan B. Broderick et al.   CHEMICAL REVIEWS

Opsin, a Structural Model for Olfactory Receptors?

(2013) Jung Hee Park et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

New insights on nucleoside 2′-deoxyribosyltransferases: a versatile Biocatalyst for one-pot one-step synthesis of nucleoside analogs

(2013) A. Fresco-Taboada et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

A Conserved Tyrosine in Ferritin Is a Molecular Capacitor

(2013) Kourosh Honarmand Ebrahimi et al.   CHEMBIOCHEM

Cordycepin: A bioactive metabolite with therapeutic potential

(2013) Hardeep S. Tuli et al.   LIFE SCIENCES

Advances in the development of nucleoside and nucleotide analogues for cancer and viral diseases

(2013) Lars Petter Jordheim et al.   NATURE REVIEWS DRUG DISCOVERY

Spectroscopic Studies of the Iron and Manganese Reconstituted Tyrosyl Radical in Bacillus Cereus Ribonucleotide Reductase R2 Protein

(2012) Ane B. Tomter et al.   PLoS One

Developing a Collection of Immobilized Nucleoside Phosphorylases for the Preparation of Nucleoside Analogues: Enzymatic Synthesis of Arabinosyladenine and 2′,3′-Dideoxyinosine

(2012) Immacolata Serra et al.   ChemPlusChem

Prediction of a Ligand-Binding Niche within a Human Olfactory Receptor by Combining Site-Directed Mutagenesis with Dynamic Homology Modeling

(2011) Lian Gelis et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Radical SAM enzymes in the biosynthesis of sugar-containing natural products

(2011) Mark W. Ruszczycky et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

The antiviral protein viperin is a radical SAM enzyme

(2010) Kaitlin S. Duschene et al.   FEBS LETTERS

Straightforward synthesis of 3′-deoxy-3′,4′-didehydronucleoside-5′-aldehydes via 2′,3′-O-orthoester group elimination: a simple route to 3′,4′-didehydronucleosides

(2010) Magdalena Petrová et al.   TETRAHEDRON LETTERS

Tyrosyl radicals in proteins: a comparison of empirical and density functional calculated EPR parameters

(2009) Dimitri A. Svistunenko et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

The antiviral protein, viperin, localizes to lipid droplets via its N-terminal amphipathic  -helix

(2009) E. R. Hinson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Radical SAM Superfamily

(2008) Perry A. Frey et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

DNA Repair and Free Radicals, New Insights into the Mechanism of Spore Photoproduct Lyase Revealed by Single Amino Acid Substitution

(2008) Alexia Chandor-Proust et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The N-terminal Amphipathic α-Helix of Viperin Mediates Localization to the Cytosolic Face of the Endoplasmic Reticulum and Inhibits Protein Secretion

(2008) Ella R. Hinson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY