Genome‐wide interaction screen for Mycobacterium tuberculosis ClpCP protease reveals toxin–antitoxin systems as a major substrate class

TASmania: A bacterial Toxin-Antitoxin Systems database

(2019) Hatice Akarsu et al.   PLoS Computational Biology

Toxins, Targets, and Triggers: An Overview of Toxin-Antitoxin Biology

(2018) Alexander Harms et al.   MOLECULAR CELL

Toxin–antitoxin systems and regulatory mechanisms in Mycobacterium tuberculosis

(2018) Richard A Slayden et al.   Pathogens and Disease

ClpAP protease is a universal factor that activates the parDE toxin-antitoxin system from a broad host range RK2 plasmid

(2018) Andrzej Dubiel et al.   Scientific Reports

Mycobacterium tuberculosis ClpC1 N-Terminal Domain Is Dispensable for Adaptor Protein-Dependent Allosteric Regulation

(2018) Justin Marsee et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Crystal structure of Mycobacterium tuberculosis VapC20 toxin and its interactions with cognate antitoxin, VapB20, suggest a model for toxin-antitoxin assembly

(2017) Amar Deep et al.   FEBS Journal

Regulatory coiled-coil domains promote head-to-head assemblies of AAA+ chaperones essential for tunable activity control

(2017) Marta Carroni et al.   eLife

Acyldepsipeptide antibiotics kill mycobacteria by preventing the physiological functions of the ClpP1P2 protease

(2016) Kirsten Famulla et al.   MOLECULAR MICROBIOLOGY

The Mycobacterium tuberculosis relBE toxin:antitoxin genes are stress-responsive modules that regulate growth through translation inhibition

(2015) Shaleen B. Korch et al.   JOURNAL OF MICROBIOLOGY

The Mycobacterium tuberculosis ClpP1P2 Protease Interacts Asymmetrically with Its ATPase Partners ClpX and ClpC1

(2015) Julia Leodolter et al.   PLoS One

Distinct type I and type II toxin-antitoxin modules control Salmonella lifestyle inside eukaryotic cells

(2015) Damián Lobato-Márquez et al.   Scientific Reports

Lassomycin, a Ribosomally Synthesized Cyclic Peptide, Kills Mycobacterium tuberculosis by Targeting the ATP-Dependent Protease ClpC1P1P2

(2014) Ekaterina Gavrish et al.   CHEMISTRY & BIOLOGY

Role of Adaptor TrfA and ClpPC in Controlling Levels of SsrA-Tagged Proteins and Antitoxins in Staphylococcus aureus

(2014) N. P. Donegan et al.   JOURNAL OF BACTERIOLOGY

Substrate delivery by the AAA+ ClpX and ClpC1 unfoldases activates the mycobacterial ClpP1P2 peptidase

(2014) Karl R. Schmitz et al.   MOLECULAR MICROBIOLOGY

Crystal structure of Mycobacterium tuberculosis ClpP1P2 suggests a model for peptidase activation by AAA+ partner binding and substrate delivery

(2014) K. R. Schmitz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multiple Toxin-Antitoxin Systems in Mycobacterium tuberculosis

(2014) Ambre Sala et al.   Toxins

The Mtb Proteome Library: A Resource of Assays to Quantify the Complete Proteome of Mycobacterium tuberculosis

(2013) Olga T. Schubert et al.   Cell Host & Microbe

Roles of adaptor proteins in regulation of bacterial proteolysis

(2013) Aurelia Battesti et al.   CURRENT OPINION IN MICROBIOLOGY

Structural Dynamics of the MecA-ClpC Complex

(2013) Jing Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mycobacterium tuberculosis ClpP Proteases Are Co-transcribed but Exhibit Different Substrate Specificities

(2013) Yoann Personne et al.   PLoS One

VapC20 of Mycobacterium tuberculosis cleaves the Sarcin–Ricin loop of 23S rRNA

(2013) Kristoffer S. Winther et al.   Nature Communications

The active ClpP protease fromM. tuberculosisis a complex composed of a heptameric ClpP1 and a ClpP2 ring

(2012) Tatos Akopian et al.   EMBO JOURNAL

The bacterial two-hybrid system based on adenylate cyclase reconstitution in Escherichia coli

(2012) Aurélia Battesti et al.   METHODS

The Crystal Structure of the Intact E. coli RelBE Toxin-Antitoxin Complex Provides the Structural Basis for Conditional Cooperativity

(2012) Andreas Bøggild et al.   STRUCTURE

Mycobacterium tuberculosis ClpP1 and ClpP2 Function Together in Protein Degradation and Are Required for Viability in vitro and During Infection

(2012) Ravikiran M. Raju et al.   PLoS Pathogens

AAA+ Proteases: ATP-Fueled Machines of Protein Destruction

(2011) Robert T. Sauer et al.   Annual Review of Biochemistry

High-Resolution Phenotypic Profiling Defines Genes Essential for Mycobacterial Growth and Cholesterol Catabolism

(2011) Jennifer E. Griffin et al.   PLoS Pathogens

The Three RelE Homologs of Mycobacterium tuberculosis Have Individual, Drug-Specific Effects on Bacterial Antibiotic Tolerance

(2010) R. Singh et al.   JOURNAL OF BACTERIOLOGY

The MycoBrowser portal: A comprehensive and manually annotated resource for mycobacterial genomes

(2010) Adamandia Kapopoulou et al.   TUBERCULOSIS

TubercuList – 10 years after

(2010) Jocelyne M. Lew et al.   TUBERCULOSIS

Integrating Protein Homeostasis Strategies in Prokaryotes

(2010) A. Mogk et al.   Cold Spring Harbor Perspectives in Biology

Controlled destruction: AAA+ ATPases in protein degradation from bacteria to eukaryotes

(2009) Frank Striebel et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Structural basis of N-end rule substrate recognition in Escherichia coli by the ClpAP adaptor protein ClpS

(2009) Verena J Schuenemann et al.   EMBO REPORTS

Proteolytic Regulation of Toxin-Antitoxin Systems by ClpPC in Staphylococcus aureus

(2009) N. P. Donegan et al.   JOURNAL OF BACTERIOLOGY

Structure and Function of a Novel Type of ATP-dependent Clp Protease

(2009) Fredrik I. Andersson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Enzymatic assembly of DNA molecules up to several hundred kilobases

(2009) Daniel G Gibson et al.   NATURE METHODS

Adapting the machine: adaptor proteins for Hsp100/Clp and AAA+ proteases

(2009) Janine Kirstein et al.   NATURE REVIEWS MICROBIOLOGY

Principles of general and regulatory proteolysis by AAA+ proteases in Escherichia coli

(2009) Ronny Schmidt et al.   RESEARCH IN MICROBIOLOGY

Clp chaperone–proteases: structure and function

(2009) Wolfgang Kress et al.   RESEARCH IN MICROBIOLOGY

The role of proteolysis in the Caulobacter crescentus cell cycle and development

(2009) Urs Jenal   RESEARCH IN MICROBIOLOGY

Comprehensive Functional Analysis of Mycobacterium tuberculosis Toxin-Antitoxin Systems: Implications for Pathogenesis, Stress Responses, and Evolution

(2009) Holly R. Ramage et al.   PLoS Genetics

The Flexible Attachment of the N-Domains to the ClpA Ring Body Allows their Use On Demand

(2008) Susanne Cranz-Mileva et al.   JOURNAL OF MOLECULAR BIOLOGY

An Intrinsic Degradation Tag on the ClpA C-Terminus Regulates the Balance of ClpAP Complexes with Different Substrate Specificity

(2008) Željka Maglica et al.   JOURNAL OF MOLECULAR BIOLOGY