Existing bitter medicines for fighting 2019‐nCoV‐associated infectious diseases

Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro

(2020) Manli Wang et al.   CELL RESEARCH

The novel Chinese coronavirus (2019‐nCoV) infections: Challenges for fighting the storm

(2020) Matteo Bassetti et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Yohimbine ameliorates lipopolysaccharide-induced acute kidney injury in rats

(2020) Takaomi Shimokawa et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Pneumonia of unknown aetiology in Wuhan, China: potential for international spread via commercial air travel

(2020) Isaac I Bogoch et al.   JOURNAL OF TRAVEL MEDICINE

Reducing mortality from 2019-nCoV: host-directed therapies should be an option

(2020) Alimuddin Zumla et al.   LANCET

A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster

(2020) Jasper Fuk-Woo Chan et al.   LANCET

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

(2020) Chaolin Huang et al.   LANCET

A novel coronavirus outbreak of global health concern

(2020) Chen Wang et al.   LANCET

Importation and Human-to-Human Transmission of a Novel Coronavirus in Vietnam

(2020) Lan T. Phan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Wuhan: Britons to be evacuated as scientists estimate 44 000 cases of 2019-nCOV in the city

(2020) Jane Parry   BMJ-British Medical Journal

Drug treatment options for the 2019-new coronavirus (2019-nCoV)

(2020) Hongzhou Lu   BioScience Trends

Infection by the parasitic helminthTrichinella spiralisactivates a Tas2r-mediated signaling pathway in intestinal tuft cells

(2019) Xiao-Cui Luo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immunometabolism and Pulmonary Infections: Implications for Protective Immune Responses and Host-Directed Therapies

(2019) Martin Rao et al.   Frontiers in Microbiology

Momordica charantia, a Nutraceutical Approach for Inflammatory Related Diseases

(2019) Massimo Bortolotti et al.   Frontiers in Pharmacology

Gingival solitary chemosensory cells are immune sentinels for periodontitis

(2019) Xin Zheng et al.   Nature Communications

Bitter Taste Receptors (TAS2Rs) in Human Lung Macrophages: Receptor Expression and Inhibitory Effects of TAS2R Agonists

(2019) Stanislas Grassin-Delyle et al.   Frontiers in Physiology

High versus standard dose caffeine for apnoea: a systematic review

(2018) Roos Vliegenthart et al.   Archives of Disease in Childhood-Fetal and Neonatal Edition

Current and Future Use of Chloroquine and Hydroxychloroquine in Infectious, Immune, Neoplastic, and Neurological Diseases: A Mini-Review

(2018) Domenico Plantone et al.   CLINICAL DRUG INVESTIGATION

Activation of intestinal tuft cell-expressed Sucnr1 triggers type 2 immunity in the mouse small intestine

(2018) Weiwei Lei et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ethnobotany of the genus Taraxacum -Phytochemicals and antimicrobial activity

(2018) Mehdi Sharifi-Rad et al.   PHYTOTHERAPY RESEARCH

Adverse events in IBD therapy: the 2018 update

(2018) Sandra M. Quezada et al.   Expert Review of Gastroenterology & Hepatology

Fine Tuning the Cytokine Storm by IFN and IL-10 Following Neurotropic Coronavirus Encephalomyelitis

(2018) Carine Savarin et al.   Frontiers in Immunology

Human T2R38 Bitter Taste Receptor Expression in Resting and Activated Lymphocytes

(2018) Hoai T. T. Tran et al.   Frontiers in Immunology

A Review of Pharmacogenetics of Antimalarials and Associated Clinical Implications

(2017) Hazem Elewa et al.   EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS

Current and future developments in the treatment of virus-induced hypercytokinemia

(2017) Jonathan P Wong et al.   Future Medicinal Chemistry

Extraoral bitter taste receptors in health and disease

(2017) Ping Lu et al.   JOURNAL OF GENERAL PHYSIOLOGY

Anti-cancer stemness and anti-invasive activity of bitter taste receptors, TAS2R8 and TAS2R10, in human neuroblastoma cells

(2017) Yoona Seo et al.   PLoS One

Pathogenic human coronavirus infections: causes and consequences of cytokine storm and immunopathology

(2017) Rudragouda Channappanavar et al.   Seminars in Immunopathology

The genetics of the bitter taste receptor T2R38 in upper airway innate immunity and implications for chronic rhinosinusitis

(2016) Noam A. Cohen   LARYNGOSCOPE

Coronaviruses — drug discovery and therapeutic options

(2016) Alimuddin Zumla et al.   NATURE REVIEWS DRUG DISCOVERY

Dextromethorphan: An update on its utility for neurological and neuropsychiatric disorders

(2016) Linda Nguyen et al.   PHARMACOLOGY & THERAPEUTICS

Tuft cells, taste-chemosensory cells, orchestrate parasite type 2 immunity in the gut

(2016) M. R. Howitt et al.   SCIENCE

Biodistribution of diphenhydramine in reproductive organs in an overdose case

(2016) Shigeki Oritani et al.   Human Cell

The bitter truth about bitter taste receptors: beyond sensing bitter in the oral cavity

(2015) B. Avau et al.   Acta Physiologica

Fatal diphenidol poisoning: a case report and a retrospective study of 16 cases

(2015) Lin Zhang et al.   Forensic Science Medicine and Pathology

Seizures due to high dose camphor ingestion

(2015) Hande Gazeteci Tekin et al.   TURK PEDIATRI ARSIVI-TURKISH ARCHIVES OF PEDIATRICS

Sinonasal Solitary Chemosensory Cells “Taste” the Upper Respiratory Environment to Regulate Innate Immunity

(2014) Robert J Lee et al.   American Journal of Rhinology & Allergy

Cecropin P1 inhibits porcine reproductive and respiratory syndrome virus by blocking attachment

(2014) Chunhe Guo et al.   BMC MICROBIOLOGY

Taste receptors in innate immunity

(2014) Robert J. Lee et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Bitter and sweet taste receptors regulate human upper respiratory innate immunity

(2014) Robert J. Lee et al.   JOURNAL OF CLINICAL INVESTIGATION

The bitter pill: clinical drugs that activate the human bitter taste receptor TAS2R14

(2013) Anat Levit et al.   FASEB JOURNAL

Relaxant effect of chloroquine in rat ileum: possible involvement of nitric oxide and BKCa

(2013) Fangmiao Jing et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Diet Shapes the Evolution of the Vertebrate Bitter Taste Receptor Gene Repertoire

(2013) Diyan Li et al.   MOLECULAR BIOLOGY AND EVOLUTION

Systemic diphenidol reduces neuropathic allodynia and TNF-alpha overexpression in rats after chronic constriction injury

(2013) Yu-Wen Chen et al.   NEUROSCIENCE LETTERS

Artemisinins: Pharmacological actions beyond anti-malarial

(2013) Wanxing Eugene Ho et al.   PHARMACOLOGY & THERAPEUTICS

Extraoral bitter taste receptors as mediators of off-target drug effects

(2012) Adam A. Clark et al.   FASEB JOURNAL

Amino Acids and Peptides Activate at Least Five Members of the Human Bitter Taste Receptor Family

(2012) Susann Kohl et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

T2R38 taste receptor polymorphisms underlie susceptibility to upper respiratory infection

(2012) Robert J. Lee et al.   JOURNAL OF CLINICAL INVESTIGATION

Bitter taste receptor research comes of age: From characterization to modulation of TAS2Rs

(2012) Maik Behrens et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

The Molecular Receptive Ranges of Human TAS2R Bitter Taste Receptors

(2009) Wolfgang Meyerhof et al.   CHEMICAL SENSES