Review
Cell Biology
Iason Psilopatis, Kleio Vrettou, Florian Nima Fleckenstein, Stamatios Theocharis
Summary: Preeclampsia is a common hypertensive disorder in pregnancy, and PPARs play a significant role in its pathophysiology. Studies have shown contradictory conclusions regarding PPAR expression in preeclamptic placentae, but PPAR gamma agonists have been identified as a novel and potent anti-preeclamptic treatment option.
Review
Biochemistry & Molecular Biology
Iason Psilopatis, Kleio Vrettou, Constantinos Troungos, Stamatios Theocharis
Summary: Endometrial carcinoma is the most common malignant tumor of the female genital tract in the United States. Peroxisome proliferator-activated receptors (PPARs) are nuclear receptor proteins which regulate gene expression. In our literature review of 27 relevant studies published between 2000 and 2023, it was found that PPAR alpha and PPAR beta/delta isoforms were upregulated in endometrial cancer cells, while PPAR gamma levels were significantly lower. Interestingly, PPAR agonists were found to be potent anti-cancer therapeutic alternatives. Overall, PPARs seem to play a significant role in endometrial cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Oncology
Gang Huang, Wei Jiang, Weiyong Xie, Wei Lu, Weimin Zhu, Zhenhan Deng
Summary: PPARs regulate cartilage homeostasis and reduce inflammation in OA, deficiency of PPARs may accelerate OA progression. PPAR agonists can inhibit catabolic and inflammatory factors synthesis, reducing cartilage lesions development in OA.
MOLECULAR MEDICINE REPORTS
(2021)
Review
Cell Biology
In Soo Kim, Prashanta Silwal, Eun-Kyeong Jo
Summary: This review discusses the roles of peroxisome proliferator-activated receptors (PPARs) alpha, beta, and gamma in transcriptional regulation, energy metabolism, inflammation regulation, cellular development, and differentiation. PPAR signaling pathways play important roles in the development of viral, bacterial, and parasitic infectious diseases. The review also explores the potential therapeutic uses of PPAR agonists/antagonists in infectious disease treatment.
Article
Biochemistry & Molecular Biology
Ye Liu, Yan Duan, Nan Zhao, Xinxin Zhu, Xiaoting Yu, Shiyu Jiao, Yanting Song, Li Shi, Yutao Ma, Xia Wang, Baoqi Yu, Aijuan Qu
Summary: The study reveals that PPAR alpha plays a critical protective role in Ang II-induced hypertension by attenuating ROS production in VSMCs, providing a potential therapeutic target for hypertensive diseases.
Article
Biochemistry & Molecular Biology
Chang Ho Lee, So Min Lee, So Young Kim
Summary: The study demonstrated that telmisartan has a protective effect against kanamycin-induced ototoxicity in rats, reducing hearing loss and attenuating the overexpression of PPAR gamma and HO1 in the cochlea.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Weibei Sheng, Qichang Wang, Haotian Qin, Siyang Cao, Yihao Wei, Jian Weng, Fei Yu, Hui Zeng
Summary: Osteoarthritis (OA) is a common degenerative joint disease that is exacerbated by population aging, resulting in a significant economic burden. Current therapies are inadequate, but research on peroxisome proliferator-activated receptors (PPARs) shows promise in slowing OA progression. PPARs have emerged as potential targets for effective OA treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Medicine, General & Internal
Iason Psilopatis, Kleio Vrettou, Eleni Nousiopoulou, Kostas Palamaris, Stamatios Theocharis
Summary: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of reproductive age, causing severe menstrual irregularities, skin conditions, and insulin resistance-associated health problems. Peroxisome proliferator-activated receptors (PPARs) have been investigated for their role in PCOS, but studies have reached contradictory conclusions about PPAR expression in PCOS. However, natural agents have shown promise as alternative treatments for PCOS. Overall, PPARs appear to play a significant role in PCOS.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Nutrition & Dietetics
Jia Liu, Qinyu Yao, Xinya Xie, Qi Cui, Tingting Jiang, Ziwei Zhao, Xiong Du, Baochang Lai, Lei Xiao, Nanping Wang
Summary: This study demonstrates that PCB2 attenuates nicotine-induced hepatocyte pyroptosis and liver damage by activating PPAR gamma.
Article
Biochemistry & Molecular Biology
Ariana Julia B. Gayban, Lucas A. C. Souza, Silvana G. Cooper, Erick Regalado, Robert Kleemann, Yumei Feng Earley
Summary: Non-alcoholic fatty liver disease (NAFLD) is closely related to diabetes, obesity, and metabolic syndrome. In this study, it was found that the (pro)renin receptor (PRR) plays a role in the development of diet-induced hepatic steatosis and fibrosis. The PRR antagonist, PRO20, showed potential therapeutic effects in reducing liver fat accumulation and damage in NAFLD.
Review
Biochemistry & Molecular Biology
Elena Valeria Fuior, Evangelia Zvintzou, Theodosios Filippatos, Katerina Giannatou, Victoria Mparnia, Maya Simionescu, Anca Violeta Gafencu, Kyriakos E. Kypreos
Summary: Peroxisome proliferator-activated receptors (PPARs) are ligand-binding transcription factors that regulate energetic metabolism, immune responses, and cell proliferation and differentiation. PPAR alpha receptors play a crucial role in modulating plasma lipid and lipoprotein metabolism, with pluripotent effects on atherogenic and antiatherogenic lipoproteins. Clinical evidence supports the use of PPAR alpha agonists in the treatment of hypertriglyceridemia and/or low high-density lipoprotein cholesterol levels.
Review
Cell Biology
Yaqin Zhao, Huabing Tan, Xiaoyu Zhang, Jing Zhu
Summary: This article summarizes the role of PPARs in the occurrence and development of HCC, as well as their value in the diagnosis, treatment, and prognosis of HCC.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Shi Fang, M. Christine Livergood, Pablo Nakagawa, Jing Wu, Curt D. Sigmund
Summary: This review focuses on the mechanisms by which nuclear receptors mediate transcriptional responses, with a specific emphasis on the role of PPARγ in regulating blood pressure. Genetic and clinical trial data demonstrate the importance of PPARγ in hypertension, and the tissue- and cell-specific molecular mechanisms by which PPARs modulate blood pressure and related phenotypes are detailed. The role of placental PPARs in preeclampsia is also discussed, along with future research directions and implications for novel therapies.
CIRCULATION RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Chang Wang, Fei Peng, Bohua Zhong, Ying Shi, Xiaomei Wang, Xueyuan Jin, Junqi Niu
Summary: The study showed that MBT1805 has therapeutic effects on ANIT-induced cholestasis, improving abnormal biochemical indicators, gallbladder enlargement, and histopathological changes. By regulating bile acid synthesis, biotransformation, and transport, MBT1805 helps relieve cholestasis.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Yanhao Qiu, Mailin Gan, Xingyu Wang, Tianci Liao, Qiuyang Chen, Yuhang Lei, Lei Chen, Jinyong Wang, Ye Zhao, Lili Niu, Yan Wang, Shunhua Zhang, Li Zhu, Linyuan Shen
Summary: Excessive expansion of adipocytes can lead to ectopic fat deposition, increasing the risk of metabolic diseases. Peroxisome proliferator-activated receptor gamma (PPARγ) plays a crucial role in fat cell differentiation and adipogenesis.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Biochemistry & Molecular Biology
Eu Leong Yong, Jun Li, Mei Hui Liu
CURRENT OPINION IN LIPIDOLOGY
(2008)
Article
Biochemistry & Molecular Biology
You Fu Pan, K. D. Senali Abayratna Wansa, Mei Hui Liu, Bing Zhao, Shu Zhen Hong, Peck Yean Tan, Kar Sian Lim, Guillaume Bourque, Edison T. Liu, Edwin Cheung
JOURNAL OF BIOLOGICAL CHEMISTRY
(2008)
Article
Endocrinology & Metabolism
Amelia Li Min Tan, Sarah R. Langley, Chee Fan Tan, Jin Fang Chai, Chin Meng Khoo, Melvin Khee-Shing Leow, Eric Yin Hao Khoo, Aida Moreno-Moral, Michal Pravenec, Maxime Rotival, Suresh Anand Sadananthan, S. Sendhil Velan, Kavita Venkataraman, Yap Seng Chong, Yung Seng Lee, Xueling Sim, Walter Stunkel, Mei Hui Liu, E. Shyong Tai, Enrico Petretto
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2019)
Review
Cell Biology
Mei Hui Liu, Edwin Cheung
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2014)
Article
Multidisciplinary Sciences
Melissa J. Fullwood, Mei Hui Liu, You Fu Pan, Jun Liu, Han Xu, Yusoff Bin Mohamed, Yuriy L. Orlov, Stoyan Velkov, Andrea Ho, Poh Huay Mei, Elaine G. Y. Chew, Phillips Yao Hui Huang, Willem-Jan Welboren, Yuyuan Han, Hong Sain Ooi, Pramila N. Ariyaratne, Vinsensius B. Vega, Yanquan Luo, Peck Yean Tan, Pei Ye Choy, K. D. Senali Abayratna Wansa, Bing Zhao, Kar Sian Lim, Shi Chi Leow, Jit Sin Yow, Roy Joseph, Haixia Li, Kartiki V. Desai, Jane S. Thomsen, Yew Kok Lee, R. Krishna Murthy Karuturi, Thoreau Herve, Guillaume Bourque, Hendrik G. Stunnenberg, Xiaoan Ruan, Valere Cacheux-Rataboul, Wing-Kin Sung, Edison T. Liu, Chia-Lin Wei, Edwin Cheung, Yijun Ruan
Article
Biochemistry & Molecular Biology
Christopher E. Mason, Feng-Jue Shu, Cheng Wang, Ryan M. Session, Roland G. Kallen, Neil Sidell, Tianwei Yu, Mei Hui Liu, Edwin Cheung, Caleb B. Kallen
NUCLEIC ACIDS RESEARCH
(2010)
Article
Biochemistry & Molecular Biology
Zhizhuo Zhang, Kern Rei Chng, Shreyas Lingadahalli, Zikai Chen, Mei Hui Liu, Huy Hoang Do, Shaojiang Cai, Nicola Rinaldi, Huay Mei Poh, Guoliang Li, Ying Ying Sung, Charlie L. Heng, Leighton J. Core, Si Kee Tan, Xiaoan Ruan, John T. Lis, Manolis Kellis, Yijun Ruan, Wing-Kin Sung, Edwin Cheung
Review
Nutrition & Dietetics
Jun Leong Sean Ou, Dimeng Yang, Mei Hui Liu
Article
Food Science & Technology
Yuanhang Yao, Jiaxing Jansen Lin, Xin Yi Jolene Chee, Mei Hui Liu, Saif A. Khan, Jung Eun Kim
Summary: The study demonstrates that microfluidic technology can effectively encapsulate lutein in food products, and both the type of oil and device do not affect the bioaccessibility of lutein.
Article
Chemistry, Applied
Sean Jun Leong Ou, Jingying Yu, Weibiao Zhou, Mei Hui Liu
Summary: This study showed that incorporating black rice anthocyanin extract (BRAE) into bread significantly reduces starch digestibility by decreasing gelatinization and increasing crystallinity of starch, as well as altering the microstructural characteristics of the food, leading to a reduction in digestibility.
Article
Food Science & Technology
Sean Jun Leong Ou, Dimeng Yang, Hanny Putri Pranata, E. Shyong Tai, Mei Hui Liu
Summary: This study investigates the metabolic effects of fortification with black rice anthocyanin extract in commonly consumed foods. It found that this fortification can reduce the glycemic index of wheat bread and alter lipid metabolism in a starch- and fat-rich composite meal.
NPJ SCIENCE OF FOOD
(2023)