Loss of the co-repressor GPS2 sensitizes macrophage activation upon metabolic stress induced by obesity and type 2 diabetes

Molecular control of activation and priming in macrophages

(2016) Christopher K Glass et al.   NATURE IMMUNOLOGY

Irf5 deficiency in macrophages promotes beneficial adipose tissue expansion and insulin sensitivity during obesity

(2015) Elise Dalmas et al.   NATURE MEDICINE

limma powers differential expression analyses for RNA-sequencing and microarray studies

(2015) Matthew E. Ritchie et al.   NUCLEIC ACIDS RESEARCH

Inflammation-sensitive super enhancers form domains of coordinately regulated enhancer RNAs

(2015) Nasun Hah et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

LXRs link metabolism to inflammation through Abca1-dependent regulation of membrane composition and TLR signaling

(2015) Ayaka Ito et al.   eLife

Tissue-Resident Macrophage Enhancer Landscapes Are Shaped by the Local Microenvironment

(2014) Yonit Lavin et al.   CELL

Adipose Tissue Macrophages Promote Myelopoiesis and Monocytosis in Obesity

(2014) Prabhakara R. Nagareddy et al.   Cell Metabolism

Metabolic Dysfunction Drives a Mechanistically Distinct Proinflammatory Phenotype in Adipose Tissue Macrophages

(2014) Mario Kratz et al.   Cell Metabolism

Macrophage Activation and Polarization: Nomenclature and Experimental Guidelines

(2014) Peter J. Murray et al.   IMMUNITY

Epigenomics of macrophages

(2014) David Gosselin et al.   IMMUNOLOGICAL REVIEWS

Regulation of RNA polymerase II activation by histone acetylation in single living cells

(2014) Timothy J. Stasevich et al.   NATURE

Identification of nuclear hormone receptor pathways causing insulin resistance by transcriptional and epigenomic analysis

(2014) Sona Kang et al.   NATURE CELL BIOLOGY

Signaling by IL-6 promotes alternative activation of macrophages to limit endotoxemia and obesity-associated resistance to insulin

(2014) Jan Mauer et al.   NATURE IMMUNOLOGY

Transcription Factor Cooperativity in Early Adipogenic Hotspots and Super-Enhancers

(2014) Rasmus Siersbæk et al.   Cell Reports

GPS2/KDM4A Pioneering Activity Regulates Promoter-Specific Recruitment of PPARγ

(2014) M. Dafne Cardamone et al.   Cell Reports

NCoR Repression of LXRs Restricts Macrophage Biosynthesis of Insulin-Sensitizing Omega 3 Fatty Acids

(2013) Pingping Li et al.   CELL

Obesity Activates a Program of Lysosomal-Dependent Lipid Metabolism in Adipose Tissue Macrophages Independently of Classic Activation

(2013) Xiaoyuan Xu et al.   Cell Metabolism

HDL and Glut1 inhibition reverse a hypermetabolic state in mouse models of myeloproliferative disorders

(2013) Emmanuel L. Gautier et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Deacetylase-Independent Function of HDAC3 in Transcription and Metabolism Requires Nuclear Receptor Corepressor

(2013) Zheng Sun et al.   MOLECULAR CELL

Remodeling of the Enhancer Landscape during Macrophage Activation Is Coupled to Enhancer Transcription

(2013) Minna U. Kaikkonen et al.   MOLECULAR CELL

Genome engineering using the CRISPR-Cas9 system

(2013) F Ann Ran et al.   Nature Protocols

Pathophysiology of Human Visceral Obesity: An Update

(2013) André Tchernof et al.   PHYSIOLOGICAL REVIEWS

The Health Risk of Obesity--Better Metrics Imperative

(2013) R. S. Ahima et al.   SCIENCE

Genomic and epigenomic regulation of adipose tissue inflammation in obesity

(2013) Amine Toubal et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

The Bcl6-SMRT/NCoR Cistrome Represses Inflammation to Attenuate Atherosclerosis

(2012) Grant D. Barish et al.   Cell Metabolism

Inflammation and Lipid Signaling in the Etiology of Insulin Resistance

(2012) Christopher K. Glass et al.   Cell Metabolism

SMRT-GPS2 corepressor pathway dysregulation coincides with obesity-linked adipocyte inflammation

(2012) Amine Toubal et al.   JOURNAL OF CLINICAL INVESTIGATION

A Protective Strategy against Hyperinflammatory Responses Requiring the Nontranscriptional Actions of GPS2

(2012) M. Dafne Cardamone et al.   MOLECULAR CELL

A High-Throughput Chromatin Immunoprecipitation Approach Reveals Principles of Dynamic Gene Regulation in Mammals

(2012) Manuel Garber et al.   MOLECULAR CELL

Insights into Negative Regulation by the Glucocorticoid Receptor from Genome-wide Profiling of Inflammatory Cistromes

(2012) N. Henriette Uhlenhaut et al.   MOLECULAR CELL

Differential expression analysis of multifactor RNA-Seq experiments with respect to biological variation

(2012) Davis J. McCarthy et al.   NUCLEIC ACIDS RESEARCH

Requirement for the histone deacetylase Hdac3 for the inflammatory gene expression program in macrophages

(2012) X. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells

(2012) C. Schulz et al.   SCIENCE

Inflammatory Mechanisms in Obesity

(2011) Margaret F. Gregor et al.   Annual Review of Immunology

Adipocyte NCoR Knockout Decreases PPARγ Phosphorylation and Enhances PPARγ Activity and Insulin Sensitivity

(2011) Pingping Li et al.   CELL

Differential Lipid Partitioning Between Adipocytes and Tissue Macrophages Modulates Macrophage Lipotoxicity and M2/M1 Polarization in Obese Mice

(2011) Xavier Prieur et al.   DIABETES

Histone deacetylase 3 is an epigenomic brake in macrophage alternative activation

(2011) S. E. Mullican et al.   GENES & DEVELOPMENT

Adipose tissue remodeling and obesity

(2011) Kai Sun et al.   JOURNAL OF CLINICAL INVESTIGATION

Structural basis for the assembly of the SMRT/NCoR core transcriptional repression machinery

(2011) Jasmeen Oberoi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Defining macrophage phenotype and function in adipose tissue

(2011) Elise Dalmas et al.   TRENDS IN IMMUNOLOGY

A framework for oligonucleotide microarray preprocessing

(2010) Benilton S. Carvalho et al.   BIOINFORMATICS

GPS2-dependent corepressor/SUMO pathways govern anti-inflammatory actions of LRH-1 and LXR  in the hepatic acute phase response

(2010) N. Venteclef et al.   GENES & DEVELOPMENT

Simple Combinations of Lineage-Determining Transcription Factors Prime cis-Regulatory Elements Required for Macrophage and B Cell Identities

(2010) Sven Heinz et al.   MOLECULAR CELL

Tumor Necrosis Factor α and Regulation of Adipose Tissue

(2010) Erik Arner et al.   NEW ENGLAND JOURNAL OF MEDICINE

Retinoid X receptor   controls innate inflammatory responses through the up-regulation of chemokine expression

(2010) V. Nunez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

edgeR: a Bioconductor package for differential expression analysis of digital gene expression data

(2009) M. D. Robinson et al.   BIOINFORMATICS

Cooperative NCoR/SMRT interactions establish a corepressor-based strategy for integration of inflammatory and anti-inflammatory signaling pathways

(2009) S. Ghisletti et al.   GENES & DEVELOPMENT

ChIP-seq: Using high-throughput sequencing to discover protein–DNA interactions

(2009) Dominic Schmidt et al.   METHODS

c-Jun Controls Histone Modifications, NF- B Recruitment, and RNA Polymerase II Function To Activate the ccl2 Gene

(2008) S. Wolter et al.   MOLECULAR AND CELLULAR BIOLOGY