The interaction between microbiome and host central nervous system: the gut-brain axis as a potential new therapeutic target in the treatment of obesity and cardiometabolic disease

Treatment with Anaerobutyricum soehngenii: a pilot study of safety and dose–response effects on glucose metabolism in human subjects with metabolic syndrome

(2020) Pim W. Gilijamse et al.   npj Biofilms and Microbiomes

Expansion of Bacteriophages Is Linked to Aggravated Intestinal Inflammation and Colitis

(2019) Lasha Gogokhia et al.   Cell Host & Microbe

Phage Therapy: A Renewed Approach to Combat Antibiotic-Resistant Bacteria

(2019) Kaitlyn E. Kortright et al.   Cell Host & Microbe

Bacteriophages of the Human Gut: The “Known Unknown” of the Microbiome

(2019) Andrey N. Shkoporov et al.   Cell Host & Microbe

Multi-omics of the gut microbial ecosystem in inflammatory bowel diseases

(2019) Jason Lloyd-Price et al.   NATURE

Donor metabolic characteristics drive effects of faecal microbiota transplantation on recipient insulin sensitivity, energy expenditure and intestinal transit time

(2019) Pieter de Groot et al.   GUT

Correlation between Disease Severity and the Intestinal Microbiome in Mycobacterium tuberculosis-Infected Rhesus Macaques

(2019) Sivaranjani Namasivayam et al.   mBio

Short-chain fatty acids and microbiota metabolites attenuate ghrelin receptor signaling

(2019) Cristina Torres-Fuentes et al.   FASEB JOURNAL

Disbiome database: linking the microbiome to disease

(2018) Yorick Janssens et al.   BMC MICROBIOLOGY

Fiber-Mediated Nourishment of Gut Microbiota Protects against Diet-Induced Obesity by Restoring IL-22-Mediated Colonic Health

(2018) Jun Zou et al.   Cell Host & Microbe

Augmented capacity for peripheral serotonin release in human obesity

(2018) Richard L. Young et al.   INTERNATIONAL JOURNAL OF OBESITY

The prebiotic inulin improves substrate metabolism and promotes short-chain fatty acid production in overweight to obese men

(2018) Christina M. van der Beek et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Differential metabolic effects of oral butyrate treatment in lean versus metabolic syndrome subjects

(2018) KEC Bouter et al.   Clinical and Translational Gastroenterology

Energy intake is associated with endotoxemia in apparently healthy men

(2018) Jacques Amar et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Microbiome: Focus on Causation and Mechanism

(2018) Michael A. Fischbach   CELL

Environment dominates over host genetics in shaping human gut microbiota

(2018) Daphna Rothschild et al.   NATURE

Depicting the composition of gut microbiota in a population with varied ethnic origins but shared geography

(2018) Mélanie Deschasaux et al.   NATURE MEDICINE

Regional variation limits applications of healthy gut microbiome reference ranges and disease models

(2018) Yan He et al.   NATURE MEDICINE

Effect of the prebiotic fiber inulin on cholesterol metabolism in wildtype mice

(2018) Rima H. Mistry et al.   Scientific Reports

Long-term colonisation with donor bacteriophages following successful faecal microbial transplantation

(2018) L. A. Draper et al.   Microbiome

The Diverse Metabolic Roles of Peripheral Serotonin

(2017) Alyce M. Martin et al.   ENDOCRINOLOGY

The Gut Microbiome in Irritable Bowel Syndrome and Other Functional Bowel Disorders

(2017) Yehuda Ringel   GASTROENTEROLOGY CLINICS OF NORTH AMERICA

Butyrate reduces appetite and activates brown adipose tissue via the gut-brain neural circuit

(2017) Zhuang Li et al.   GUT

Meta-analysis of gut microbiome studies identifies disease-specific and shared responses

(2017) Claire Duvallet et al.   Nature Communications

Cohort profile: the Healthy Life in an Urban Setting (HELIUS) study in Amsterdam, The Netherlands

(2017) Marieke B Snijder et al.   BMJ Open

Acetate mediates a microbiome–brain–β-cell axis to promote metabolic syndrome

(2016) Rachel J. Perry et al.   NATURE

Diet–microbiota interactions as moderators of human metabolism

(2016) Justin L. Sonnenburg et al.   NATURE

Genome-wide association analysis identifies variation in vitamin D receptor and other host factors influencing the gut microbiota

(2016) Jun Wang et al.   NATURE GENETICS

Oral treatment with Eubacterium hallii improves insulin sensitivity in db/db mice

(2016) Shanthadevi Udayappan et al.   npj Biofilms and Microbiomes

Short Chain Fatty Acids Prevent High-fat-diet-induced Obesity in Mice by Regulating G Protein-coupled Receptors and Gut Microbiota

(2016) Yuanyuan Lu et al.   Scientific Reports

Probability of an Obese Person Attaining Normal Body Weight: Cohort Study Using Electronic Health Records

(2015) Alison Fildes et al.   AMERICAN JOURNAL OF PUBLIC HEALTH

Obese-type Gut Microbiota Induce Neurobehavioral Changes in the Absence of Obesity

(2015) Annadora J. Bruce-Keller et al.   BIOLOGICAL PSYCHIATRY

Indigenous Bacteria from the Gut Microbiota Regulate Host Serotonin Biosynthesis

(2015) Jessica M. Yano et al.   CELL

Interactions between Gut Microbiota, Host Genetics and Diet Modulate the Predisposition to Obesity and Metabolic Syndrome

(2015) Siegfried Ussar et al.   Cell Metabolism

Regulation of energy balance by a gut–brain axis and involvement of the gut microbiota

(2015) Paige V. Bauer et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The role of immunomodulators on intestinal barrier homeostasis in experimental models

(2015) Maria Emília Rabelo Andrade et al.   CLINICAL NUTRITION

Short-Chain Fatty Acids Protect Against High-Fat Diet–Induced Obesity via a PPARγ-Dependent Switch From Lipogenesis to Fat Oxidation

(2015) Gijs den Besten et al.   DIABETES

Brain reward-system activation in response to anticipation and consumption of palatable food is altered by glucagon-like peptide-1 receptor activation in humans

(2015) L. van Bloemendaal et al.   DIABETES OBESITY & METABOLISM

Endogenous GLP-1 mediates postprandial reductions in activation in central reward and satiety areas in patients with type 2 diabetes

(2015) Jennifer S. ten Kulve et al.   DIABETOLOGIA

Gut Serotonin Is a Regulator of Obesity and Metabolism

(2015) Richard L. Young et al.   GASTROENTEROLOGY

Fecal Microbiota Transplantation forClostridium difficileInfection

(2015) Matthew J. Armstrong et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Role of gastrointestinal hormones in feeding behavior and obesity treatment

(2015) Timothy Sean Kairupan et al.   JOURNAL OF GASTROENTEROLOGY

Loss of FFA2 and FFA3 increases insulin secretion and improves glucose tolerance in type 2 diabetes

(2015) Cong Tang et al.   NATURE MEDICINE

Host microbiota constantly control maturation and function of microglia in the CNS

(2015) Daniel Erny et al.   NATURE NEUROSCIENCE

Feeding the brain and nurturing the mind: Linking nutrition and the gut microbiota to brain development

(2015) Manu S. Goyal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The gut microbiota in human energy homeostasis and obesity

(2015) Michael Rosenbaum et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Bifidobacterium pseudocatenulatum CECT 7765 Reduces Obesity-Associated Inflammation by Restoring the Lymphocyte-Macrophage Balance and Gut Microbiota Structure in High-Fat Diet-Fed Mice

(2015) Angela Moya-Pérez et al.   PLoS One

Microbiota-Generated Metabolites Promote Metabolic Benefits via Gut-Brain Neural Circuits

(2014) Filipe De Vadder et al.   CELL

Meta-analyses of human gut microbes associated with obesity and IBD

(2014) William A. Walters et al.   FEBS LETTERS

Effects of targeted delivery of propionate to the human colon on appetite regulation, body weight maintenance and adiposity in overweight adults

(2014) Edward S Chambers et al.   GUT

Evidence for greater production of colonic short-chain fatty acids in overweight than lean humans

(2014) S Rahat-Rozenbloom et al.   INTERNATIONAL JOURNAL OF OBESITY

Overfeeding increases postprandial endotoxemia in men: Inflammatory outcome may depend on LPS transporters LBP and sCD14

(2014) Fabienne Laugerette et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Inhibiting peripheral serotonin synthesis reduces obesity and metabolic dysfunction by promoting brown adipose tissue thermogenesis

(2014) Justin D Crane et al.   NATURE MEDICINE

The short-chain fatty acid acetate reduces appetite via a central homeostatic mechanism

(2014) Gary Frost et al.   Nature Communications

Adiposity, gut microbiota and faecal short chain fatty acids are linked in adult humans

(2014) J Fernandes et al.   Nutrition & Diabetes

Gut-derived short-chain fatty acids are vividly assimilated into host carbohydrates and lipids

(2013) Gijs den Besten et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

CYTOKINE TARGETS IN THE BRAIN: IMPACT ON NEUROTRANSMITTERS AND NEUROCIRCUITS

(2013) Andrew H. Miller et al.   DEPRESSION AND ANXIETY

Increased brain uptake and oxidation of acetate in heavy drinkers

(2013) Lihong Jiang et al.   JOURNAL OF CLINICAL INVESTIGATION

The abundance and variety of carbohydrate-active enzymes in the human gut microbiota

(2013) Abdessamad El Kaoutari et al.   NATURE REVIEWS MICROBIOLOGY

Commensal microbiota modulate murine behaviors in a strictly contamination-free environment confirmed by culture-based methods

(2013) R. Nishino et al.   NEUROGASTROENTEROLOGY AND MOTILITY

BifidobacteriumCECT 7765 improves metabolic and immunological alterations associated with obesity in high-fat diet-fed mice

(2013) Paola Gauffin Cano et al.   Obesity

Gut Microbiota from Twins Discordant for Obesity Modulate Metabolism in Mice

(2013) V. K. Ridaura et al.   SCIENCE

Tributyrin attenuates obesity-associated inflammation and insulin resistance in high-fat-fed mice

(2012) Marco Aurélio Ramirez Vinolo et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Critical role of gut microbiota in the production of biologically active, free catecholamines in the gut lumen of mice

(2012) Yasunari Asano et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Inflammation and Lipid Signaling in the Etiology of Insulin Resistance

(2012) Christopher K. Glass et al.   Cell Metabolism

Inhibition of Hypothalamic Inflammation Reverses Diet-Induced Insulin Resistance in the Liver

(2012) M. Milanski et al.   DIABETES

Intravenous acetate elicits a greater free fatty acid rebound in normal than hyperinsulinaemic humans

(2012) J Fernandes et al.   EUROPEAN JOURNAL OF CLINICAL NUTRITION

Transfer of Intestinal Microbiota From Lean Donors Increases Insulin Sensitivity in Individuals With Metabolic Syndrome

(2012) Anne Vrieze et al.   GASTROENTEROLOGY

Human gut microbiome viewed across age and geography

(2012) Tanya Yatsunenko et al.   NATURE

Neuropeptide Y, peptide YY and pancreatic polypeptide in the gut–brain axis

(2012) Peter Holzer et al.   NEUROPEPTIDES

Butyrate and Propionate Protect against Diet-Induced Obesity and Regulate Gut Hormones via Free Fatty Acid Receptor 3-Independent Mechanisms

(2012) Hua V. Lin et al.   PLoS One

The impact of obesity on the immune response to infection

(2012) J. Justin Milner et al.   PROCEEDINGS OF THE NUTRITION SOCIETY

Responses of Gut Microbiota and Glucose and Lipid Metabolism to Prebiotics in Genetic Obese and Diet-Induced Leptin-Resistant Mice

(2011) Amandine Everard et al.   DIABETES

Bacterial Endotoxin Activity in Human Serum Is Associated With Dyslipidemia, Insulin Resistance, Obesity, and Chronic Inflammation

(2011) Mariann I. Lassenius et al.   DIABETES CARE

Intestinal mucosal adherence and translocation of commensal bacteria at the early onset of type 2 diabetes: molecular mechanisms and probiotic treatment

(2011) Jacques Amar et al.   EMBO Molecular Medicine

Probiotics and dietary counselling targeting maternal dietary fat intake modifies breast milk fatty acids and cytokines

(2011) Ulla Hoppu et al.   EUROPEAN JOURNAL OF NUTRITION

Kinetic modelling of lactate utilization and butyrate production by key human colonic bacterial species

(2011) Rafael Muñoz-Tamayo et al.   FEMS MICROBIOLOGY ECOLOGY

Toll-like receptors are key players in neurodegeneration

(2011) Daniela S. Arroyo et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Progress in genomics, metabolism and biotechnology of bifidobacteria

(2011) Michelle Cronin et al.   INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY

Effects of specific lactic acid bacteria species on biogenic amine production by foodborne pathogen

(2011) Fatih Özogul   INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY

Depletion of Murine Intestinal Microbiota: Effects on Gut Mucosa and Epithelial Gene Expression

(2011) Dag Henrik Reikvam et al.   PLoS One

Normal gut microbiota modulates brain development and behavior

(2011) R. D. Heijtz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Linking Long-Term Dietary Patterns with Gut Microbial Enterotypes

(2011) G. D. Wu et al.   SCIENCE

Effects of the enteric bacterial metabolic product propionic acid on object-directed behavior, social behavior, cognition, and neuroinflammation in adolescent rats: Relevance to autism spectrum disorder

(2010) Derrick F. MacFabe et al.   BEHAVIOURAL BRAIN RESEARCH

Differential Adaptation of Human Gut Microbiota to Bariatric Surgery-Induced Weight Loss: Links With Metabolic and Low-Grade Inflammation Markers

(2010) J.-P. Furet et al.   DIABETES

Evaluation of Cerebral Acetate Transport and Metabolic Rates in the Rat Brain in vivo Using 1H-[13C]-NMR

(2010) Anant B Patel et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

The endocannabinoid system links gut microbiota to adipogenesis

(2010) Giulio G Muccioli et al.   Molecular Systems Biology

Reward circuitry responsivity to food predicts future increases in body mass: Moderating effects of DRD2 and DRD4

(2010) Eric Stice et al.   NEUROIMAGE

From the gut to the peripheral tissues: the multiple effects of butyrate

(2010) P. Guilloteau et al.   NUTRITION RESEARCH REVIEWS

Inverted-U-shaped correlation between dopamine receptor availability in striatum and sensation seeking

(2010) Albert Gjedde et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Which comes first: atypical antipsychotic treatment or cardiometabolic risk?

(2009) S. M. Stahl et al.   ACTA PSYCHIATRICA SCANDINAVICA

Weight loss during oligofructose supplementation is associated with decreased ghrelin and increased peptide YY in overweight and obese adults

(2009) Jill A Parnell et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Gut microbiota fermentation of prebiotics increases satietogenic and incretin gut peptide production with consequences for appetite sensation and glucose response after a meal

(2009) Patrice D Cani et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Amine neuromediators, their precursors, and oxidation products in the culture of Escherichia coli K-12

(2009) V. A. Shishov et al.   APPLIED BIOCHEMISTRY AND MICROBIOLOGY

Vinegar Intake Reduces Body Weight, Body Fat Mass, and Serum Triglyceride Levels in Obese Japanese Subjects

(2009) Tomoo KONDO et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Mood and gut feelings

(2009) Paul Forsythe et al.   BRAIN BEHAVIOR AND IMMUNITY

Acute effects of intravenous and rectal acetate on glucagon-like peptide-1, peptide YY, ghrelin, adiponectin and tumour necrosis factor-α

(2009) Kristin R. Freeland et al.   BRITISH JOURNAL OF NUTRITION

Butyrate Improves Insulin Sensitivity and Increases Energy Expenditure in Mice

(2009) Z. Gao et al.   DIABETES

Induction of IDO by Bacille Calmette-Guerin Is Responsible for Development of Murine Depressive-Like Behavior

(2009) J. C. O'Connor et al.   JOURNAL OF IMMUNOLOGY

Cerebral Microglia Recruit Monocytes into the Brain in Response to Tumor Necrosis Factor  Signaling during Peripheral Organ Inflammation

(2009) C. D'Mello et al.   JOURNAL OF NEUROSCIENCE

Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites

(2009) W. R. Wikoff et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Signaling mechanisms involved in altered function of macrophages from diet-induced obese mice affect immune responses

(2009) Q. Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation of Central Nervous System Inflammatory Pathways by Interferon-Alpha: Relationship to Monoamines and Depression

(2008) Charles L. Raison et al.   BIOLOGICAL PSYCHIATRY

Effect of inulin on the human gut microbiota: stimulation of Bifidobacterium adolescentis and Faecalibacterium prausnitzii

(2008) Carlett Ramirez-Farias et al.   BRITISH JOURNAL OF NUTRITION

Changes in Gut Microbiota Control Metabolic Endotoxemia-Induced Inflammation in High-Fat Diet-Induced Obesity and Diabetes in Mice

(2008) P. D. Cani et al.   DIABETES

Activation of G Protein-Coupled Receptor 43 in Adipocytes Leads to Inhibition of Lipolysis and Suppression of Plasma Free Fatty Acids

(2008) Hongfei Ge et al.   ENDOCRINOLOGY

Chylomicrons promote intestinal absorption of lipopolysaccharides

(2008) Sarbani Ghoshal et al.   JOURNAL OF LIPID RESEARCH

Increased uptake of non-pathogenicE. coli via the follicle-associated epithelium in longstanding ileal Crohn's disease

(2008) ÅV Keita et al.   JOURNAL OF PATHOLOGY

The probiotic Bifidobacteria infantis: An assessment of potential antidepressant properties in the rat

(2008) Lieve Desbonnet et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Attenuation of the cardiovascular and metabolic complications of obesity in CD14 knockout mice

(2008) Roberto Roncon-Albuquerque et al.   LIFE SCIENCES

A core gut microbiome in obese and lean twins

(2008) Peter J. Turnbaugh et al.   NATURE

Low dopamine striatal D2 receptors are associated with prefrontal metabolism in obese subjects: Possible contributing factors

(2008) Nora D. Volkow et al.   NEUROIMAGE

Tlr-4 Deficiency Selectively Protects Against Obesity Induced by Diets High in Saturated Fat

(2008) Jeremy E. Davis et al.   Obesity

The convergence of carbohydrate active gene repertoires in human gut microbes

(2008) C. A. Lozupone et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients

(2008) H. Sokol et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effects of the gut microbiota on host adiposity are modulated by the short-chain fatty-acid binding G protein-coupled receptor, Gpr41

(2008) B. S. Samuel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Circulating cell wall components derived from gram-negative, not gram-positive, bacteria cause a profound induction of the gene-encoding Toll-like receptor 2 in the CNS

(2003) Nathalie Laflamme et al.   JOURNAL OF NEUROCHEMISTRY