Melanoma epigenetics: novel mechanisms, markers and medicines

Global 5-hydroxymethylcytosine content is significantly reduced in tissue stem/progenitor cell compartments and in human cancers

(2015) Michael Christoph Haffner et al.   Oncotarget

Genetic and epigenetic loss of microRNA-31 leads to feed-forward expression of EZH2 in melanoma

(2015) Irfan A Asangani et al.   Oncotarget

Desmoplastic Melanoma

(2013) Maria Concepción Garrido et al.   AMERICAN JOURNAL OF DERMATOPATHOLOGY

Enzyme-Promoted Base Flipping Controls DNA Methylation Fidelity

(2013) Douglas M. Matje et al.   BIOCHEMISTRY

A Switch in the Expression of Embryonic EMT-Inducers Drives the Development of Malignant Melanoma

(2013) Julie Caramel et al.   CANCER CELL

BRD4 Sustains Melanoma Proliferation and Represents a New Target for Epigenetic Therapy

(2013) M. F. Segura et al.   CANCER RESEARCH

MicroRNA-Antagonism Regulates Breast Cancer Stemness and Metastasis via TET-Family-Dependent Chromatin Remodeling

(2013) Su Jung Song et al.   CELL

miR-22 in tumorigenesis

(2013) Su Jung Song et al.   CELL CYCLE

The Oncogenic MicroRNA miR-22 Targets the TET2 Tumor Suppressor to Promote Hematopoietic Stem Cell Self-Renewal and Transformation

(2013) Su Jung Song et al.   Cell Stem Cell

Epigenetic regulation ofREG1Aand chemosensitivity of cutaneous melanoma

(2013) Yusuke Sato et al.   Epigenetics

Epithelial stem cell mutations that promote squamous cell carcinoma metastasis

(2013) Ruth A. White et al.   JOURNAL OF CLINICAL INVESTIGATION

Selection of Immunostimulant AS15 for Active Immunization With MAGE-A3 Protein: Results of a Randomized Phase II Study of the European Organisation for Research and Treatment of Cancer Melanoma Group in Metastatic Melanoma

(2013) Wim H.J. Kruit et al.   JOURNAL OF CLINICAL ONCOLOGY

Safety, Efficacy, and Biomarkers of Nivolumab With Vaccine in Ipilimumab-Refractory or -Naive Melanoma

(2013) Jeffrey S. Weber et al.   JOURNAL OF CLINICAL ONCOLOGY

5-Hydroxymethylcytosine as a useful marker to differentiate between malignant melanomas and benign melanocytic nevi

(2013) Ryuhei Uchiyama et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

miR-612 suppresses the invasive-metastatic cascade in hepatocellular carcinoma

(2013) Zhong-Hua Tao et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Non-Coding RNA Llme23 Drives the Malignant Property of Human Melanoma Cells

(2013) Chuan-Fang Wu et al.   Journal of Genetics and Genomics

The Hematopoietic Stem Cell Regulatory Gene Latexin Has Tumor-Suppressive Properties in Malignant Melanoma

(2013) Viswanathan Muthusamy et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

The Role of miR-18b in MDM2-p53 Pathway Signaling and Melanoma Progression

(2013) Altaf A Dar et al.   JNCI-Journal of the National Cancer Institute

The antimelanoma activity of the histone deacetylase inhibitor panobinostat (LBH589) is mediated by direct tumor cytotoxicity and increased tumor immunogenicity

(2013) David M. Woods et al.   MELANOMA RESEARCH

Loss of 5-hydroxymethylcytosine and ten-eleven translocation 2 protein expression in malignant melanoma

(2013) Thilo Gambichler et al.   MELANOMA RESEARCH

Succinate dehydrogenase deficiency is associated with decreased 5-hydroxymethylcytosine production in gastrointestinal stromal tumors: implications for mechanisms of tumorigenesis

(2013) Emily F Mason et al.   MODERN PATHOLOGY

TET enzymes, TDG and the dynamics of DNA demethylation

(2013) Rahul M. Kohli et al.   NATURE

A new world of Polycombs: unexpected partnerships and emerging functions

(2013) Yuri B. Schwartz et al.   NATURE REVIEWS GENETICS

Gene amplification of the histone methyltransferase SETDB1 contributes to human lung tumorigenesis

(2013) M Rodriguez-Paredes et al.   ONCOGENE

miR in melanoma development: miRNAs and acquired hallmarks of cancer in melanoma

(2013) Paige E. Bennett et al.   PHYSIOLOGICAL GENOMICS

Decrease of 5-Hydroxymethylcytosine Is Associated with Progression of Hepatocellular Carcinoma through Downregulation of TET1

(2013) Chungang Liu et al.   PLoS One

Fidelity Index Determination of DNA Methyltransferases

(2013) Janine G. Borgaro et al.   PLoS One

HMGA2/TET1/HOXA9 signaling pathway regulates breast cancer growth and metastasis

(2013) M. Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Xist lncRNA Exploits Three-Dimensional Genome Architecture to Spread Across the X Chromosome

(2013) J. M. Engreitz et al.   SCIENCE

PI(4,5)P2 5-phosphatase A regulates PI3K/Akt signalling and has a tumour suppressive role in human melanoma

(2013) Yan Ye et al.   Nature Communications

Succinate Dehydrogenase Mutation Underlies Global Epigenomic Divergence in Gastrointestinal Stromal Tumor

(2013) J. Keith Killian et al.   Cancer Discovery

Predictors of BRAF Mutation in Melanocytic Nevi

(2012) Sarah Karram et al.   AMERICAN JOURNAL OF DERMATOPATHOLOGY

miR-200c Inhibits Melanoma Progression and Drug Resistance through Down-Regulation of Bmi-1

(2012) Shujing Liu et al.   AMERICAN JOURNAL OF PATHOLOGY

Safety and efficacy of decitabine in combination with temozolomide in metastatic melanoma: a phase I/II study and pharmacokinetic analysis

(2012) H. A. Tawbi et al.   ANNALS OF ONCOLOGY

Epigenetic biomarkers in skin cancer

(2012) Edward S. Greenberg et al.   CANCER LETTERS

Loss of 5-Hydroxymethylcytosine Is an Epigenetic Hallmark of Melanoma

(2012) Christine Guo Lian et al.   CELL

Convergent Multi-miRNA Targeting of ApoE Drives LRP1/LRP8-Dependent Melanoma Metastasis and Angiogenesis

(2012) Nora Pencheva et al.   CELL

Small-Molecule Inhibition of BRDT for Male Contraception

(2012) Martin M. Matzuk et al.   CELL

microRNA-21 is upregulated in malignant melanoma and influences apoptosis of melanocytic cells

(2012) Imke Satzger et al.   EXPERIMENTAL DERMATOLOGY

miR-137 Inhibits the Invasion of Melanoma Cells through Downregulation of Multiple Oncogenic Target Genes

(2012) Chonglin Luo et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

MicroRNA-26a Is Strongly Downregulated in Melanoma and Induces Cell Death through Repression of Silencer of Death Domains (SODD)

(2012) Steven N. Reuland et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Serum microRNAs as biomarkers for recurrence in melanoma

(2012) Erica B Friedman et al.   Journal of Translational Medicine

Loss of microRNA-205 expression is associated with melanoma progression

(2012) Shujing Liu et al.   LABORATORY INVESTIGATION

In situ measurement of miR-205 in malignant melanoma tissue supports its role as a tumor suppressor microRNA

(2012) Jason A Hanna et al.   LABORATORY INVESTIGATION

The role of HOX genes in normal hematopoiesis and acute leukemia

(2012) R A Alharbi et al.   LEUKEMIA

The long non-coding RNAs, a new cancer diagnostic and therapeutic gold mine

(2012) Peng Qi et al.   MODERN PATHOLOGY

MicroRNA miR-125b controls melanoma progression by direct regulation of c-Jun protein expression

(2012) M Kappelmann et al.   ONCOGENE

Regulation of cell cycle checkpoint kinase WEE1 by miR-195 in malignant melanoma

(2012) A Bhattacharya et al.   ONCOGENE

Structure-Based Mechanistic Insights into DNMT1-Mediated Maintenance DNA Methylation

(2012) J. Song et al.   SCIENCE

Loss of microRNA-200a and c, and microRNA-203 expression at the invasive front of primary cutaneous melanoma is associated with increased thickness and disease progression

(2012) Léon C. van Kempen et al.   VIRCHOWS ARCHIV

miR-193b Regulates Mcl-1 in Melanoma

(2011) Jiamin Chen et al.   AMERICAN JOURNAL OF PATHOLOGY

Mutant IDH1 Confers an in Vivo Growth in a Melanoma Cell Line with BRAF Mutation

(2011) Tatsuhiro Shibata et al.   AMERICAN JOURNAL OF PATHOLOGY

Oncometabolite 2-Hydroxyglutarate Is a Competitive Inhibitor of α-Ketoglutarate-Dependent Dioxygenases

(2011) Wei Xu et al.   CANCER CELL

Tet2 Loss Leads to Increased Hematopoietic Stem Cell Self-Renewal and Myeloid Transformation

(2011) Kelly Moran-Crusio et al.   CANCER CELL

5-Hydroxymethylcytosine Is Strongly Depleted in Human Cancers but Its Levels Do Not Correlate with IDH1 Mutations

(2011) S.-G. Jin et al.   CANCER RESEARCH

The Melanoma-Upregulated Long Noncoding RNA SPRY4-IT1 Modulates Apoptosis and Invasion

(2011) D. Khaitan et al.   CANCER RESEARCH

Thymine DNA Glycosylase Is Essential for Active DNA Demethylation by Linked Deamination-Base Excision Repair

(2011) Salvatore Cortellino et al.   CELL

Identification of 67 Histone Marks and Histone Lysine Crotonylation as a New Type of Histone Modification

(2011) Minjia Tan et al.   CELL

MicroRNAs as regulators of epithelial-mesenchymal transition

(2011) Philip A. Gregory et al.   CELL CYCLE

Tet1 and Tet2 Regulate 5-Hydroxymethylcytosine Production and Cell Lineage Specification in Mouse Embryonic Stem Cells

(2011) Kian Peng Koh et al.   Cell Stem Cell

microRNA-214 contributes to melanoma tumour progression through suppression of TFAP2C

(2011) Elisa Penna et al.   EMBO JOURNAL

DNA methylation: TET proteins—guardians of CpG islands?

(2011) Kristine Williams et al.   EMBO REPORTS

Downregulation of microRNA-29c is associated with hypermethylation of tumor-related genes and disease outcome in cutaneous melanoma

(2011) Tung Nguyen et al.   Epigenetics

miRNA-205 Suppresses Melanoma Cell Proliferation and Induces Senescence via Regulation of E2F1 Protein

(2011) Altaf A. Dar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The circulating microRNA-221 level in patients with malignant melanoma as a new tumor marker

(2011) Hisashi Kanemaru et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

MicroRNA-9 up-regulates E-cadherin through inhibition of NF-κB1-Snail1 pathway in melanoma

(2011) Shujing Liu et al.   JOURNAL OF PATHOLOGY

Methylation levels of the "long interspersed nucleotide element-1" repetitive sequences predict survival of melanoma patients

(2011) Luca Sigalotti et al.   Journal of Translational Medicine

Melanoma stem cells: not rare, but well done

(2011) Sasha D Girouard et al.   LABORATORY INVESTIGATION

TET1 and hydroxymethylcytosine in transcription and DNA methylation fidelity

(2011) Kristine Williams et al.   NATURE

The histone methyltransferase SETDB1 is recurrently amplified in melanoma and accelerates its onset

(2011) Craig J. Ceol et al.   NATURE

A novel oncogenic role for the miRNA-506-514 cluster in initiating melanocyte transformation and promoting melanoma growth

(2011) K L Streicher et al.   ONCOGENE

MicroRNA-149*, a p53-responsive microRNA, functions as an oncogenic regulator in human melanoma

(2011) L. Jin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tet-Mediated Formation of 5-Carboxylcytosine and Its Excision by TDG in Mammalian DNA

(2011) Y.-F. He et al.   SCIENCE

A Perspective on Cancer Cell Metastasis

(2011) C. L. Chaffer et al.   SCIENCE

Long noncoding RNAs and human disease

(2011) Orly Wapinski et al.   TRENDS IN CELL BIOLOGY

A Temporarily Distinct Subpopulation of Slow-Cycling Melanoma Cells Is Required for Continuous Tumor Growth

(2010) Alexander Roesch et al.   CELL

Inactivation of miR-34a by aberrant CpG methylation in multiple types of cancer

(2010) Dmitri Lodygin et al.   CELL CYCLE

GLI2-Mediated Melanoma Invasion and Metastasis

(2010) Vasileia-Ismini Alexaki et al.   JNCI-Journal of the National Cancer Institute

Epigenetics of human cutaneous melanoma: setting the stage for new therapeutic strategies

(2010) Luca Sigalotti et al.   Journal of Translational Medicine

DNMT1 maintains progenitor function in self-renewing somatic tissue

(2010) George L. Sen et al.   NATURE

Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification

(2010) Shinsuke Ito et al.   NATURE

Conserved role of intragenic DNA methylation in regulating alternative promoters

(2010) Alika K. Maunakea et al.   NATURE

Cancer-associated IDH mutations: biomarker and therapeutic opportunities

(2010) K E Yen et al.   ONCOGENE

DNA replication fidelity and cancer

(2010) Bradley D. Preston et al.   SEMINARS IN CANCER BIOLOGY

MicroRNA-dependent regulation of cKit in cutaneous melanoma

(2009) O. Igoucheva et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Genetic characterization of TET1, TET2, and TET3 alterations in myeloid malignancies

(2009) O. Abdel-Wahab et al.   BLOOD

Enhanced Antitumor Activity Induced by Adoptive T-Cell Transfer and Adjunctive Use of the Histone Deacetylase Inhibitor LAQ824

(2009) D. D. Vo et al.   CANCER RESEARCH

MicroRNAs: Target Recognition and Regulatory Functions

(2009) David P. Bartel   CELL

Downregulation of miRNA-200c Links Breast Cancer Stem Cells with Normal Stem Cells

(2009) Yohei Shimono et al.   CELL

Potentiation of a Topoisomerase I Inhibitor, Karenitecin, by the Histone Deacetylase Inhibitor Valproic Acid in Melanoma: Translational and Phase I/II Clinical Trial

(2009) A. I. Daud et al.   CLINICAL CANCER RESEARCH

CpG Island Methylator Phenotype Predicts Progression of Malignant Melanoma

(2009) A. Tanemura et al.   CLINICAL CANCER RESEARCH

A novel signaling network as a critical rheostat for the biology and maintenance of the normal stem cell and the cancer-initiating cell

(2009) Keisuke Ito et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Finding the fifth base: Genome-wide sequencing of cytosine methylation

(2009) R. Lister et al.   GENOME RESEARCH

Human DNA methylomes at base resolution show widespread epigenomic differences

(2009) Ryan Lister et al.   NATURE

IDH1andIDH2Mutations in Gliomas

(2009) Hai Yan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1

(2009) M. Tahiliani et al.   SCIENCE

O6-Methylguanine-DNA methyltransferase inactivation and chemotherapy

(2008) B. Verbeek et al.   BRITISH MEDICAL BULLETIN

The Promyelocytic Leukemia Zinc Finger-MicroRNA-221/-222 Pathway Controls Melanoma Progression through Multiple Oncogenic Mechanisms

(2008) F. Felicetti et al.   CANCER RESEARCH

The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells

(2008) Sendurai A. Mani et al.   CELL

Aging stem cells, latexin, and longevity

(2008) Ying Liang et al.   EXPERIMENTAL CELL RESEARCH

The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2

(2008) S.-M. Park et al.   GENES & DEVELOPMENT

Identification of cells initiating human melanomas

(2008) Tobias Schatton et al.   NATURE

Integrin β3 expression is regulated by let-7a miRNA in malignant melanoma

(2008) D W Müller et al.   ONCOGENE