A central role for calcineurin in protein misfolding neurodegenerative diseases

The plasma membrane protein Rch1 is a negative regulator of cytosolic calcium homeostasis and positively regulated by the calcium/calcineurin signaling pathway in budding yeast

(2016) Yunying Zhao et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Calpastatin overexpression reduces oxidative stress-induced mitochondrial impairment and cell death in human neuroblastoma SH-SY5Y cells by decreasing calpain and calcineurin activation, induction of mitochondrial fission and destruction of mitochondrial fusion

(2016) Kulvadee Tangmansakulchai et al.   MITOCHONDRION

Mitochondria and endoplasmic reticulum crosstalk in amyotrophic lateral sclerosis

(2016) Giovanni Manfredi et al.   NEUROBIOLOGY OF DISEASE

Calcineurin β protects brain after injury by activating the unfolded protein response

(2016) Yanan Chen et al.   NEUROBIOLOGY OF DISEASE

Protein phosphatase role in adenosine A1 receptor-induced AMPA receptor trafficking and rat hippocampal neuronal damage in hypoxia/reperfusion injury

(2016) Jocelyn Stockwell et al.   NEUROPHARMACOLOGY

RCAN1 overexpression promotes age-dependent mitochondrial dysregulation related to neurodegeneration in Alzheimer’s disease

(2015) Helen Wong et al.   ACTA NEUROPATHOLOGICA

Intracellular calcium signaling regulates autophagy via calcineurin-mediated TFEB dephosphorylation

(2015) Yanju Tong et al.   Autophagy

Isoflurane induced cognitive impairment in aged rats through hippocampal calcineurin/NFAT signaling

(2015) Cheng Ni et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Regulatory Mechanisms of Endoplasmic Reticulum Resident IP3 Receptors

(2015) Syed Zahid Ali Shah et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Death Receptor 6 and Caspase-6 Regulate Prion Peptide-Induced Axonal Degeneration in Rat Spinal Neurons

(2015) Yunsheng Wang et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Unfolded Protein Response Pathways in Neurodegenerative Diseases

(2015) Syed Zahid Ali Shah et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Dendritic and axonal mechanisms of Ca2+ elevation impair BDNF transport in Aβ oligomer–treated hippocampal neurons

(2015) Kathlyn J. Gan et al.   MOLECULAR BIOLOGY OF THE CELL

Lysosomal calcium signalling regulates autophagy through calcineurin and TFEB

(2015) Diego L. Medina et al.   NATURE CELL BIOLOGY

Reduction of increased calcineurin activity rescues impaired homeostatic synaptic plasticity in presenilin 1 M146V mutant

(2015) Seonil Kim et al.   NEUROBIOLOGY OF AGING

α-Synuclein-mediated inhibition of ATF6 processing into COPII vesicles disrupts UPR signaling in Parkinson's disease

(2015) Joel J. Credle et al.   NEUROBIOLOGY OF DISEASE

RCAN1 links impaired neurotrophin trafficking to aberrant development of the sympathetic nervous system in Down syndrome

(2015) Ami Patel et al.   Nature Communications

Transcriptional Profiling of Hypoxic Neural Stem Cells Identifies Calcineurin-NFATc4 Signaling as a Major Regulator of Neural Stem Cell Biology

(2015) Marta Moreno et al.   Stem Cell Reports

Calcineurin Downregulation in the Amygdala Is Sufficient to Induce Anxiety-like and Depression-like Behaviors in C57BL/6J Male Mice

(2014) Yann S. Mineur et al.   BIOLOGICAL PSYCHIATRY

Calcineurin is part of a negative feedback loop in the InsP3/Ca2+ signalling pathway in blowfly salivary glands

(2014) Kristoffer Heindorff et al.   CELL CALCIUM

Tau hyperphosphorylation and deregulation of calcineurin in mouse models of Huntington's disease

(2014) Maud Gratuze et al.   HUMAN MOLECULAR GENETICS

A calcineurin- and NFAT-dependent pathway is involved in  -synuclein-induced degeneration of midbrain dopaminergic neurons

(2014) J. Luo et al.   HUMAN MOLECULAR GENETICS

RCAN1 Overexpression Exacerbates Calcium Overloading-Induced Neuronal Apoptosis

(2014) Xiulian Sun et al.   PLoS One

Calcineurin determines toxic versus beneficial responses to  -synuclein

(2014) G. Caraveo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

FK506 reduces abnormal prion protein through the activation of autolysosomal degradation and prolongs survival in prion-infected mice

(2013) Takehiro Nakagaki et al.   Autophagy

Calcineurin Inhibition Rescues Early Synaptic Plasticity Deficits in a Mouse Model of Alzheimer’s Disease

(2013) Virve Cavallucci et al.   NEUROMOLECULAR MEDICINE

Tau protein phosphatases in Alzheimer's disease: The leading role of PP2A

(2012) Ludovic Martin et al.   AGEING RESEARCH REVIEWS

Over-expression of RCAN1 causes Down syndrome-like hippocampal deficits that alter learning and memory

(2012) Katherine R. Martin et al.   HUMAN MOLECULAR GENETICS

Inhibition of the NFAT Pathway Alleviates Amyloid Beta Neurotoxicity in a Mouse Model of Alzheimer's Disease

(2012) E. Hudry et al.   JOURNAL OF NEUROSCIENCE

Neural functions of calcineurin in synaptic plasticity and memory

(2012) K. Baumgartel et al.   LEARNING & MEMORY

Calcium phosphatase calcineurin influences tau metabolism

(2012) Celeste M. Karch et al.   NEUROBIOLOGY OF AGING

Role of calcineurin in neurodegeneration produced by misfolded proteins and endoplasmic reticulum stress

(2011) Abhisek Mukherjee et al.   CURRENT OPINION IN CELL BIOLOGY

Amyloid   Induces the Morphological Neurodegenerative Triad of Spine Loss, Dendritic Simplification, and Neuritic Dystrophies through Calcineurin Activation

(2010) H.-Y. Wu et al.   JOURNAL OF NEUROSCIENCE

Calcineurin inhibition with systemic FK506 treatment increases dendritic branching and dendritic spine density in healthy adult mouse brain

(2010) Tara L. Spires-Jones et al.   NEUROSCIENCE LETTERS

Prion neurodegeneration

(2010) Giovanna R. Mallucci   Prion

CREB's control of intrinsic and synaptic plasticity: implications for CREB-dependent memory models

(2010) Eva Benito et al.   TRENDS IN NEUROSCIENCES

Calcineurin Inhibition at the Clinical Phase of Prion Disease Reduces Neurodegeneration, Improves Behavioral Alterations and Increases Animal Survival

(2010) Abhisek Mukherjee et al.   PLoS Pathogens

Genetic inhibition of calcineurin induces diastolic dysfunction in mice with chronic pressure overload

(2009) Ricardo J. Gelpi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Intermediate- and long-term recognition memory deficits in Tg2576 mice are reversed with acute calcineurin inhibition

(2009) Giulio Taglialatela et al.   BEHAVIOURAL BRAIN RESEARCH

Regulator of Calcineurin (RCAN1-1L) Is Deficient in Huntington Disease and Protective against Mutant Huntingtin Toxicityin Vitro

(2009) Gennady Ermak et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inverse Regulation of Plasticity-related Immediate Early Genes by Calcineurin in Hippocampal Neurons

(2009) Brian Yee Hong Lam et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of Calcineurin-mediated Endocytosis and α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors Prevents Amyloid β Oligomer-induced Synaptic Disruption

(2009) Wei-Qin Zhao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genetic and pharmacological inhibition of calcineurin corrects the BDNF transport defect in Huntington's disease

(2009) Jose R Pineda et al.   Molecular Brain

Selective induction of calcineurin activity and signaling by oligomeric amyloid beta

(2008) Lindsay C. Reese et al.   AGING CELL

Tau binds both subunits of calcineurin, and binding is impaired by calmodulin

(2008) Da-yu Yu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Infusion of FK506, a specific inhibitor of calcineurin, induces potent tau hyperphosphorylation in mouse brain

(2008) Jing Luo et al.   BRAIN RESEARCH BULLETIN

Overactivation of calcineurin induced by amyloid-beta and prion proteins

(2008) Paula Agostinho et al.   NEUROCHEMISTRY INTERNATIONAL

Aβ Plaques Lead to Aberrant Regulation of Calcium Homeostasis In Vivo Resulting in Structural and Functional Disruption of Neuronal Networks

(2008) Kishore V. Kuchibhotla et al.   NEURON

Calcium and apoptosis: ER-mitochondria Ca2+ transfer in the control of apoptosis

(2008) P Pinton et al.   ONCOGENE

NFAT signaling in neural development and axon growth

(2007) Tuan Nguyen et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE