WNK signalling pathways in blood pressure regulation

Extracellular K+rapidly controls NaCl cotransporter phosphorylation in the native distal convoluted tubule by Cl−-dependent and independent mechanisms

(2016) David Penton et al.   JOURNAL OF PHYSIOLOGY-LONDON

SPAK and OSR1 play essential roles in potassium homeostasis through actions on the distal convoluted tubule

(2016) Mohammed Z. Ferdaus et al.   JOURNAL OF PHYSIOLOGY-LONDON

Unique chloride-sensing properties of WNK4 permit the distal nephron to modulate potassium homeostasis

(2016) Andrew S. Terker et al.   KIDNEY INTERNATIONAL

Small-molecule WNK inhibition regulates cardiovascular and renal function

(2016) Ken Yamada et al.   Nature Chemical Biology

Characterisation of the Cullin-3 mutation that causes a severe form of familial hypertension and hyperkalaemia

(2015) F.-R. Schumacher et al.   EMBO Molecular Medicine

Critical role of the SPAK protein kinase CCT domain in controlling blood pressure

(2015) Jinwei Zhang et al.   HUMAN MOLECULAR GENETICS

Hypertension-causing Mutations in Cullin3 Protein Impair RhoA Protein Ubiquitination and Augment the Association with Substrate Adaptors

(2015) Stella-Rita C. Ibeawuchi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Integrated compensatory network is activated in the absence of NCC phosphorylation

(2015) P. Richard Grimm et al.   JOURNAL OF CLINICAL INVESTIGATION

Generation and analysis of knock-in mice carrying pseudohypoaldosteronism type II-causing mutations in the cullin 3 gene

(2015) Y. Araki et al.   Biology Open

Gene-centric Meta-analysis in 87,736 Individuals of European Ancestry Identifies Multiple Blood-Pressure-Related Loci

(2014) Vinicius Tragante et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Hypertension Due to Antiangiogenic Cancer Therapy With Vascular Endothelial Growth Factor Inhibitors: Understanding and Managing a New Syndrome

(2014) Heather Yvonne Small et al.   CANADIAN JOURNAL OF CARDIOLOGY

Impaired degradation of WNK1 and WNK4 kinases causes PHAII in mutant KLHL3 knock-in mice

(2014) Koichiro Susa et al.   HUMAN MOLECULAR GENETICS

Hyperkalemic hypertension–associated cullin 3 promotes WNK signaling by degrading KLHL3

(2014) James A. McCormick et al.   JOURNAL OF CLINICAL INVESTIGATION

Discovery of Novel SPAK Inhibitors That Block WNK Kinase Signaling to Cation Chloride Transporters

(2014) E. Kikuchi et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The Effect of WNK4 on the Na+-Cl- Cotransporter Is Modulated by Intracellular Chloride

(2014) S. Bazua-Valenti et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Reduced Blood Pressure of CFTR-F508del Carriers Correlates with Diminished Arterial Reactivity Rather than Circulating Blood Volume in Mice

(2014) Veronica A. Peotta et al.   PLoS One

Zebrafish WNK Lysine Deficient Protein Kinase 1 (wnk1) Affects Angiogenesis Associated with VEGF Signaling

(2014) Ju-Geng Lai et al.   PLoS One

Chloride Sensing by WNK1 Involves Inhibition of Autophosphorylation

(2014) A. T. Piala et al.   Science Signaling

Interactive contribution of serine/threonine kinase 39 gene multiple polymorphisms to hypertension among northeastern Han Chinese

(2014) Hongye Zhao et al.   Scientific Reports

Influence of Obesity on Association Between Genetic Variants Identified by Genome-Wide Association Studies and Hypertension Risk in Chinese Children

(2013) B. Xi et al.   AMERICAN JOURNAL OF HYPERTENSION

Chemical library screening for WNK signalling inhibitors using fluorescence correlation spectroscopy

(2013) Takayasu Mori et al.   BIOCHEMICAL JOURNAL

The CUL3–KLHL3 E3 ligase complex mutated in Gordon's hypertension syndrome interacts with and ubiquitylates WNK isoforms: disease-causing mutations in KLHL3 and WNK4 disrupt interaction

(2013) Akihito Ohta et al.   BIOCHEMICAL JOURNAL

Incidence and risk of hypertension with a novel multi-targeted kinase inhibitor axitinib in cancer patients: a systematic review and meta-analysis

(2013) Wei-Xiang Qi et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Advances in Blood Pressure Genomics

(2013) Patricia B. Munroe et al.   CIRCULATION RESEARCH

An inducible transgenic mouse model for familial hypertension with hyperkalaemia (Gordon's syndrome or pseudohypoaldosteronism type II)

(2013) Jabed A. Chowdhury et al.   CLINICAL SCIENCE

The emerging family of CULLIN3-RING ubiquitin ligases (CRL3s): cellular functions and disease implications

(2013) Pascal Genschik et al.   EMBO JOURNAL

Dietary Salt Intake Regulates WNK3–SPAK–NKCC1 Phosphorylation Cascade in Mouse Aorta Through Angiotensin II

(2013) Moko Zeniya et al.   HYPERTENSION

WNK1 Protein Kinase Regulates Embryonic Cardiovascular Development through the OSR1 Signaling Cascade

(2013) Jian Xie et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphorylation Regulates NCC Stability and Transporter Activity In Vivo

(2013) S.-S. Yang et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

SPAK Differentially Mediates Vasopressin Effects on Sodium Cotransporters

(2013) T. Saritas et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The SLC12 family of electroneutral cation-coupled chloride cotransporters

(2013) Juan Pablo Arroyo et al.   MOLECULAR ASPECTS OF MEDICINE

CUL3 gene analysis enables early intervention for pediatric pseudohypoaldosteronism type II in infancy

(2013) Madori Osawa et al.   PEDIATRIC NEPHROLOGY

STK39 Polymorphism Is Associated with Essential Hypertension: A Systematic Review and Meta-Analysis

(2013) Bo Xi et al.   PLoS One

WNK1-related Familial Hyperkalemic Hypertension results from an increased expression of L-WNK1 specifically in the distal nephron

(2013) E. Vidal-Petiot et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Kelch-like 3 and Cullin 3 regulate electrolyte homeostasis via ubiquitination and degradation of WNK4

(2013) S. Shibata et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A young child with pseudohypoaldosteronism type II by a mutation of Cullin 3

(2013) Shoji Tsuji et al.   BMC Nephrology

Impaired KLHL3-Mediated Ubiquitination of WNK4 Causes Human Hypertension

(2013) Mai Wakabayashi et al.   Cell Reports

High-Frequency Variant p.T60M in NaCl Cotransporter and Blood Pressure Variability in Han Chinese

(2012) Leping Shao et al.   AMERICAN JOURNAL OF NEPHROLOGY

Non-replication study of a genome-wide association study for hypertension and blood pressure in African Americans

(2012) Srividya Kidambi et al.   BMC Medical Genetics

Cullin-3 Regulates Vascular Smooth Muscle Function and Arterial Blood Pressure via PPARγ and RhoA/Rho-Kinase

(2012) Christopher J. Pelham et al.   Cell Metabolism

WNK3-SPAK Interaction is Required for the Modulation of NCC and other Members of the SLC12 Family

(2012) Diana Pacheco-Alvarez et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Phosphatidylinositol 3-Kinase/Akt Signaling Pathway Activates the WNK-OSR1/SPAK-NCC Phosphorylation Cascade in Hyperinsulinemic db/db Mice

(2012) Hidenori Nishida et al.   HYPERTENSION

Mutations in kelch-like 3 and cullin 3 cause hypertension and electrolyte abnormalities

(2012) Lynn M. Boyden et al.   NATURE

KLHL3 mutations cause familial hyperkalemic hypertension by impairing ion transport in the distal nephron

(2012) Hélène Louis-Dit-Picard et al.   NATURE GENETICS

Molecular Physiology of SPAK and OSR1: Two Ste20-Related Protein Kinases Regulating Ion Transport

(2012) Kenneth B. Gagnon et al.   PHYSIOLOGICAL REVIEWS

Activation of the renal Na+:Cl- cotransporter by angiotensin II is a WNK4-dependent process

(2012) M. Castaneda-Bueno et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A SPAK Isoform Switch Modulates Renal Salt Transport and Blood Pressure

(2011) James A. McCormick et al.   Cell Metabolism

MO25 is a master regulator of SPAK/OSR1 and MST3/MST4/YSK1 protein kinases

(2011) Beatrice M Filippi et al.   EMBO JOURNAL

WNK1 Regulates Vasoconstriction and Blood Pressure Response to α 1 -Adrenergic Stimulation in Mice

(2011) Sonia Bergaya et al.   HYPERTENSION

WNK2 Kinase Is a Novel Regulator of Essential Neuronal Cation-Chloride Cotransporters

(2011) Jesse Rinehart et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Antagonistic Regulation of Cystic Fibrosis Transmembrane Conductance Regulator Cell Surface Expression by Protein Kinases WNK4 and Spleen Tyrosine Kinase

(2011) A. I. Mendes et al.   MOLECULAR AND CELLULAR BIOLOGY

Contribution of Casein Kinase 2 and Spleen Tyrosine Kinase to CFTR Trafficking and Protein Kinase A-Induced Activity

(2011) S. Luz et al.   MOLECULAR AND CELLULAR BIOLOGY

Impaired phosphorylation of Na+-K+-2Cl- cotransporter by oxidative stress-responsive kinase-1 deficiency manifests hypotension and Bartter-like syndrome

(2011) S.-H. Lin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A minor role of WNK3 in regulating phosphorylation of renal NKCC2 and NCC co-transporters in vivo

(2011) K. Oi et al.   Biology Open

Phosphoregulation of the Na–K–2Cl and K–Cl cotransporters by the WNK kinases

(2010) Kristopher T. Kahle et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Role of the WNK-activated SPAK kinase in regulating blood pressure

(2010) Fatema H. Rafiqi et al.   EMBO Molecular Medicine

Serum and Glucocorticoid-induced Kinase (SGK) 1 and the Epithelial Sodium Channel Are Regulated by Multiple with No Lysine (WNK) Family Members

(2010) Charles J. Heise et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SPAK-Knockout Mice Manifest Gitelman Syndrome and Impaired Vasoconstriction

(2010) S.-S. Yang et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Global Noncommunicable Diseases — Where Worlds Meet

(2010) K.M. Venkat Narayan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Endothelial-Specific Expression of WNK1 Kinase Is Essential for Angiogenesis and Heart Development in Mice

(2009) Jian Xie et al.   AMERICAN JOURNAL OF PATHOLOGY

WNK4 Diverts the Thiazide-sensitive NaCl Cotransporter to the Lysosome and Stimulates AP-3 Interaction

(2009) Arohan R. Subramanya et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Renal and Brain Isoforms of WNK3 Have Opposite Effects on NCCT Expression

(2009) M. Glover et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The regulation of salt transport and blood pressure by the WNK-SPAK/OSR1 signalling pathway

(2008) C. Richardson et al.   JOURNAL OF CELL SCIENCE

Activation of the thiazide-sensitive Na+-Cl- cotransporter by the WNK-regulated kinases SPAK and OSR1

(2008) C. Richardson et al.   JOURNAL OF CELL SCIENCE

Whole-genome association study identifies STK39 as a hypertension susceptibility gene

(2008) Y. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA