Mechanical Properties of the Tumor Stromal Microenvironment Probed In Vitro and Ex Vivo by In Situ-Calibrated Optical Trap-Based Active Microrheology

In vivo tissue has non-linear rheological behavior distinct from 3D biomimetic hydrogels, as determined by AMOTIV microscopy

(2016) Benjamin H. Blehm et al.   BIOMATERIALS

Correlating confocal microscopy and atomic force indentation reveals metastatic cancer cells stiffen during invasion into collagen I matrices

(2016) Jack R. Staunton et al.   Scientific Reports

Independent Control of Topography for 3D Patterning of the ECM Microenvironment

(2015) Jiyun Kim et al.   ADVANCED MATERIALS

Editorial Board

(2015)   AMERICAN JOURNAL OF PATHOLOGY

The Role of Stroma in Tumor Development

(2015) Zena Werb et al.   CANCER JOURNAL

Human breast cancer invasion and aggression correlates with ECM stiffening and immune cell infiltration

(2015) I. Acerbi et al.   Integrative Biology

Beyond 3D culture models of cancer

(2015) Kandice Tanner et al.   Science Translational Medicine

Local 3D matrix microenvironment regulates cell migration through spatiotemporal dynamics of contractility-dependent adhesions

(2015) Andrew D. Doyle et al.   Nature Communications

Three-dimensional matrix fiber alignment modulates cell migration and MT1-MMP utility by spatially and temporally directing protrusions

(2015) Stephanie I. Fraley et al.   Scientific Reports

Calibration of Optical Tweezers for In Vivo Force Measurements: How do Different Approaches Compare?

(2014) Yonggun Jun et al.   BIOPHYSICAL JOURNAL

Water Permeation Drives Tumor Cell Migration in Confined Microenvironments

(2014) Kimberly M. Stroka et al.   CELL

The extracellular matrix modulates the hallmarks of cancer

(2014) M. W. Pickup et al.   EMBO REPORTS

Computational segmentation of collagen fibers from second-harmonic generation images of breast cancer

(2014) Jeremy S. Bredfeldt et al.   JOURNAL OF BIOMEDICAL OPTICS

Extracellular matrix assembly: a multiscale deconstruction

(2014) Janna K. Mouw et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Generation of compartmentalized pressure by a nuclear piston governs cell motility in a 3D matrix

(2014) R. J. Petrie et al.   SCIENCE

Impact of Dimensionality and Network Disruption on Microrheology of Cancer Cells in 3D Environments

(2014) Michael Mak et al.   PLoS Computational Biology

Collagen Prolyl Hydroxylases Are Essential for Breast Cancer Metastasis

(2013) D. M. Gilkes et al.   CANCER RESEARCH

Preclinical intravital microscopy of the tumour-stroma interface: invasion, metastasis, and therapy response

(2013) Stephanie Alexander et al.   CURRENT OPINION IN CELL BIOLOGY

Stiff Collagen Matrices Increase Tumorigenic Prolactin Signaling in Breast Cancer Cells

(2013) Craig E. Barcus et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Physical limits of cell migration: Control by ECM space and nuclear deformation and tuning by proteolysis and traction force

(2013) Katarina Wolf et al.   JOURNAL OF CELL BIOLOGY

Correction for Blehm et al., In vivo optical trapping indicates kinesin’s stall force is reduced by dynein during intracellular transport

(2013)   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Strain history dependence of the nonlinear stress response of fibrin and collagen networks

(2013) S. Munster et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Strain stiffening in collagen I networks

(2012) Stéphanie Motte et al.   BIOPOLYMERS

The extracellular matrix: A dynamic niche in cancer progression

(2012) Pengfei Lu et al.   JOURNAL OF CELL BIOLOGY

Matrix rigidity regulates a switch between TGF-β1–induced apoptosis and epithelial–mesenchymal transition

(2012) Jennifer L. Leight et al.   MOLECULAR BIOLOGY OF THE CELL

The nanomechanical signature of breast cancer

(2012) Marija Plodinec et al.   Nature Nanotechnology

Aligned Collagen Is a Prognostic Signature for Survival in Human Breast Carcinoma

(2011) Matthew W. Conklin et al.   AMERICAN JOURNAL OF PATHOLOGY

Cancer Invasion and the Microenvironment: Plasticity and Reciprocity

(2011) Peter Friedl et al.   CELL

Biophysical regulation of tumor cell invasion: moving beyond matrix stiffness

(2011) Amit Pathak et al.   Integrative Biology

Mechanisms by Which the Extracellular Matrix and Integrin Signaling Act to Regulate the Switch Between Tumor Suppression and Tumor Promotion

(2011) Patricia J. Keely   JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA

Concentration Independent Modulation of Local Micromechanics in a Fibrin Gel

(2011) Maxwell A. Kotlarchyk et al.   PLoS One

The mechanical stress–strain properties of single electrospun collagen type I nanofibers

(2010) C.R. Carlisle et al.   Acta Biomaterialia

Fluid Mechanics of Microrheology

(2010) Todd M. Squires et al.   Annual Review of Fluid Mechanics

A Blind Spot in Confocal Reflection Microscopy: The Dependence of Fiber Brightness on Fiber Orientation in Imaging Biopolymer Networks

(2010) Louise M. Jawerth et al.   BIOPHYSICAL JOURNAL

Size-Dependent Rheology of Type-I Collagen Networks

(2010) Richard C. Arevalo et al.   BIOPHYSICAL JOURNAL

The role of the tissue microenvironment in the regulation of cancer cell motility and invasion

(2010) Jan Brábek et al.   Cell Communication and Signaling

Dynamic interplay between the collagen scaffold and tumor evolution

(2010) Mikala Egeblad et al.   CURRENT OPINION IN CELL BIOLOGY

Characterization of hydrogel microstructure using laser tweezers particle tracking and confocal reflection imaging

(2010) M A Kotlarchyk et al.   JOURNAL OF PHYSICS-CONDENSED MATTER

A force detection technique for single-beam optical traps based on direct measurement of light momentum changes

(2010) Arnau Farré et al.   OPTICS EXPRESS

Mammary Gland ECM Remodeling, Stiffness, and Mechanosignaling in Normal Development and Tumor Progression

(2010) P. Schedin et al.   Cold Spring Harbor Perspectives in Biology

Mechanotransduction: a major regulator of homeostasis and development

(2010) Kevin S. Kolahi et al.   Wiley Interdisciplinary Reviews-Systems Biology and Medicine

Collagen Structure and Stability

(2009) Matthew D. Shoulders et al.   Annual Review of Biochemistry

Particle-Tracking Microrheology of Living Cells: Principles and Applications

(2009) Denis Wirtz   Annual Review of Biophysics

Tissue architecture and function: dynamic reciprocity via extra- and intra-cellular matrices

(2009) Ren Xu et al.   CANCER AND METASTASIS REVIEWS

Proteolytic interstitial cell migration: a five-step process

(2009) Peter Friedl et al.   CANCER AND METASTASIS REVIEWS

A Stiff Blow from the Stroma: Collagen Crosslinking Drives Tumor Progression

(2009) Mei Rosa Ng et al.   CANCER CELL

Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling

(2009) Kandice R. Levental et al.   CELL

Shear Wave Spectroscopy for In Vivo Quantification of Human Soft Tissues Visco-Elasticity

(2009) T. Deffieux et al.   IEEE TRANSACTIONS ON MEDICAL IMAGING

One-dimensional topography underlies three-dimensional fibrillar cell migration

(2009) Andrew D. Doyle et al.   JOURNAL OF CELL BIOLOGY

Large amplitude oscillatory shear of pseudoplastic and elastoviscoplastic materials

(2009) Randy H. Ewoldt et al.   RHEOLOGICA ACTA

Robust Pore Size Analysis of Filamentous Networks from Three-Dimensional Confocal Microscopy

(2008) Walter Mickel et al.   BIOPHYSICAL JOURNAL

Stress-Strain Experiments on Individual Collagen Fibrils

(2008) Zhilei L. Shen et al.   BIOPHYSICAL JOURNAL

New measures for characterizing nonlinear viscoelasticity in large amplitude oscillatory shear

(2008) Randy H. Ewoldt et al.   JOURNAL OF RHEOLOGY

Image Correlation Spectroscopy of Multiphoton Images Correlates with Collagen Mechanical Properties

(2007) Christopher B. Raub et al.   BIOPHYSICAL JOURNAL

An efficient implementation of the gliding box lacunarity algorithm

(2007) Charles R. Tolle et al.   PHYSICA D-NONLINEAR PHENOMENA