AP ‐2 reduces amyloidogenesis by promoting BACE 1 trafficking and degradation in neurons
Published 2020 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
AP
‐2 reduces amyloidogenesis by promoting
BACE
1 trafficking and degradation in neurons
Authors
Keywords
-
Journal
EMBO REPORTS
Volume -, Issue -, Pages -
Publisher
EMBO
Online
2020-04-23
DOI
10.15252/embr.201947954
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- LC3-Associated Endocytosis Facilitates β-Amyloid Clearance and Mitigates Neurodegeneration in Murine Alzheimer’s Disease
- (2019) Bradlee L. Heckmann et al. CELL
- Aβ34 is a BACE1-derived degradation intermediate associated with amyloid clearance and Alzheimer’s disease progression
- (2019) Filip Liebsch et al. Nature Communications
- Presynaptic endocytic factors in autophagy and neurodegeneration
- (2018) Domenico Azarnia Tehran et al. CURRENT OPINION IN NEUROBIOLOGY
- Randomized Trial of Verubecestat for Mild-to-Moderate Alzheimer’s Disease
- (2018) Michael F. Egan et al. NEW ENGLAND JOURNAL OF MEDICINE
- Intracellular Ca2+stores control in vivo neuronal hyperactivity in a mouse model of Alzheimer’s disease
- (2018) Chommanad Lerdkrai et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Lymphoblast-derived integration-free ISRM-CON9 iPS cell line from a 75 year old female
- (2018) Soraia Martins et al. Stem Cell Research
- Integrative transcriptome analyses of the aging brain implicate altered splicing in Alzheimer’s disease susceptibility
- (2018) Towfique Raj et al. NATURE GENETICS
- Axonal organization defects in the hippocampus of adult conditional BACE1 knockout mice
- (2018) Ming-Hsuan Ou-Yang et al. Science Translational Medicine
- Synaptic Vesicle Endocytosis Occurs on Multiple Timescales and Is Mediated by Formin-Dependent Actin Assembly
- (2017) Tolga Soykan et al. NEURON
- Retrograde transport of TrkB-containing autophagosomes via the adaptor AP-2 mediates neuronal complexity and prevents neurodegeneration
- (2017) Natalia L. Kononenko et al. Nature Communications
- Direct imaging of APP proteolysis in living cells
- (2017) Niccoló Parenti et al. PeerJ
- A Multi-network Approach Identifies Protein-Specific Co-expression in Asymptomatic and Symptomatic Alzheimer’s Disease
- (2017) Nicholas T. Seyfried et al. Cell Systems
- The Cellular Phase of Alzheimer’s Disease
- (2016) Bart De Strooper et al. CELL
- Bin1 and CD2AP polarise the endocytic generation of beta‐amyloid
- (2016) Florent Ubelmann et al. EMBO REPORTS
- Autophagy-mediated Regulation of BACE1 Protein Trafficking and Degradation
- (2016) Tuancheng Feng et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- A LRRK2-Dependent EndophilinA Phosphoswitch Is Critical for Macroautophagy at Presynaptic Terminals
- (2016) Sandra-Fausia Soukup et al. NEURON
- Lymphoblast-derived integration-free iPS cell line from a 69-year-old male
- (2016) Friederike Schröter et al. Stem Cell Research
- Lymphoblast-derived integration-free iPS cell line from a 65-year-old Alzheimer's disease patient expressing the TREM2 p.R47H variant
- (2016) Friederike Schröter et al. Stem Cell Research
- Lymphoblast-derived integration-free iPS cell line from a female 67-year-old Alzheimer's disease patient with TREM2 (R47H) missense mutation
- (2016) Friederike Schröter et al. Stem Cell Research
- Endophilin-A Deficiency Induces the Foxo3a-Fbxo32 Network in the Brain and Causes Dysregulation of Autophagy and the Ubiquitin-Proteasome System
- (2016) John D. Murdoch et al. Cell Reports
- Elevated Neuronal Excitability Due to Modulation of the Voltage-Gated Sodium Channel Nav1.6 by Aβ1−42
- (2016) Xi Wang et al. Frontiers in Neuroscience
- Alzheimer’s Disease Risk Genes and Mechanisms of Disease Pathogenesis
- (2015) Celeste M. Karch et al. BIOLOGICAL PSYCHIATRY
- ADAM10 and BACE1 are localized to synaptic vesicles
- (2015) Jolanta L. Lundgren et al. JOURNAL OF NEUROCHEMISTRY
- The AP2 clathrin adaptor protein complex regulates the abundance of GLR-1 glutamate receptors in the ventral nerve cord of Caenorhabditis elegans
- (2015) Steven D. Garafalo et al. MOLECULAR BIOLOGY OF THE CELL
- η-Secretase processing of APP inhibits neuronal activity in the hippocampus
- (2015) Michael Willem et al. NATURE
- Central role for PICALM in amyloid-β blood-brain barrier transcytosis and clearance
- (2015) Zhen Zhao et al. NATURE NEUROSCIENCE
- R47H Variant ofTREM2Associated With Alzheimer Disease in a Large Late-Onset Family
- (2015) Olena Korvatska et al. JAMA Neurology
- Targeting the β secretase BACE1 for Alzheimer's disease therapy
- (2014) Riqiang Yan et al. LANCET NEUROLOGY
- Axonal BACE1 dynamics and targeting in hippocampal neurons: a role for Rab11 GTPase
- (2014) Virginie Buggia-Prévot et al. Molecular Neurodegeneration
- Clathrin/AP-2 Mediate Synaptic Vesicle Reformation from Endosome-like Vacuoles but Are Not Essential for Membrane Retrieval at Central Synapses
- (2014) Natalia L. Kononenko et al. NEURON
- Lysosomal Sorting of Amyloid- by the SORLA Receptor Is Impaired by a Familial Alzheimer's Disease Mutation
- (2014) S. Caglayan et al. Science Translational Medicine
- Lost after translation: missorting of Tau protein and consequences for Alzheimer disease
- (2014) Hans Zempel et al. TRENDS IN NEUROSCIENCES
- Decreased CALM expression reduces Aβ42 to total Aβ ratio through clathrin-mediated endocytosis of γ-secretase
- (2014) Kunihiko Kanatsu et al. Nature Communications
- Directed differentiation of forebrain GABA interneurons from human pluripotent stem cells
- (2013) Yan Liu et al. Nature Protocols
- Activity-Induced Convergence of APP and BACE-1 in Acidic Microdomains via an Endocytosis-Dependent Pathway
- (2013) Utpal Das et al. NEURON
- Microglia as Dynamic and Essential Components of the Amyloid Hypothesis
- (2013) Sam Gandy et al. NEURON
- Compromised fidelity of endocytic synaptic vesicle protein sorting in the absence of stonin 2
- (2013) N. L. Kononenko et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Adaptor complex AP2/PICALM, through interaction with LC3, targets Alzheimer's APP-CTF for terminal degradation via autophagy
- (2013) Y. Tian et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Intracellular Itinerary of Internalised β-Secretase, BACE1, and Its Potential Impact on β-Amyloid Peptide Biogenesis
- (2013) Pei Zhi Cheryl Chia et al. TRAFFIC
- Simple and Direct Assembly of Kymographs from Movies Using KYMOMAKER
- (2013) Kyoko Chiba et al. TRAFFIC
- Aβ Secretion and Plaque Formation Depend on Autophagy
- (2013) Per Nilsson et al. Cell Reports
- Secretome protein enrichment identifies physiological BACE1 protease substrates in neurons
- (2012) Peer-Hendrik Kuhn et al. EMBO JOURNAL
- Role of Phosphatidylinositol Clathrin Assembly Lymphoid-Myeloid Leukemia (PICALM) in Intracellular Amyloid Precursor Protein (APP) Processing and Amyloid Plaque Pathogenesis
- (2012) Qingli Xiao et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The Neural Cell Adhesion Molecules L1 and CHL1 Are Cleaved by BACE1 Proteasein Vivo
- (2012) Lujia Zhou et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- BACE1 Protein Endocytosis and Trafficking Are Differentially Regulated by Ubiquitination at Lysine 501 and the Di-leucine Motif in the Carboxyl Terminus
- (2012) Eugene L. Kang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Autophagosomes initiate distally and mature during transport toward the cell soma in primary neurons
- (2012) Sandra Maday et al. JOURNAL OF CELL BIOLOGY
- Stabilization of GABAA Receptors at Endocytic Zones Is Mediated by an AP2 Binding Motif within the GABAA Receptor 3 Subunit
- (2012) K. R. Smith et al. JOURNAL OF NEUROSCIENCE
- Adaptor protein 2–mediated endocytosis of the β-secretase BACE1 is dispensable for amyloid precursor protein processing
- (2012) Yogikala Prabhu et al. MOLECULAR BIOLOGY OF THE CELL
- A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline
- (2012) Thorlakur Jonsson et al. NATURE
- Probing sporadic and familial Alzheimer’s disease using induced pluripotent stem cells
- (2012) Mason A. Israel et al. NATURE
- Levetiracetam suppresses neuronal network dysfunction and reverses synaptic and cognitive deficits in an Alzheimer's disease model
- (2012) P. E. Sanchez et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Rapidly Progressive Alzheimer Disease
- (2011) Christian Schmidt ARCHIVES OF NEUROLOGY
- A Sensitive and Quantitative Technique for Detecting Autophagic Events Based on Lysosomal Delivery
- (2011) Hiroyuki Katayama et al. CHEMISTRY & BIOLOGY
- Molecular mechanism and physiological functions of clathrin-mediated endocytosis
- (2011) Harvey T. McMahon et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Autophagy failure in Alzheimer's disease—locating the primary defect
- (2011) Ralph A. Nixon et al. NEUROBIOLOGY OF DISEASE
- NMDA Mediated Contextual Conditioning Changes miRNA Expression
- (2011) Min Jeong Kye et al. PLoS One
- ADP ribosylation factor 6 (ARF6) controls amyloid precursor protein (APP) processing by mediating the endosomal sorting of BACE1
- (2011) R. Sannerud et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A High Precision Survey of the Molecular Dynamics of Mammalian Clathrin-Mediated Endocytosis
- (2011) Marcus J. Taylor et al. PLOS BIOLOGY
- Plasma membrane contributes to the formation of pre-autophagosomal structures
- (2010) Brinda Ravikumar et al. NATURE CELL BIOLOGY
- Amyloid-β–induced neuronal dysfunction in Alzheimer's disease: from synapses toward neural networks
- (2010) Jorge J Palop et al. NATURE NEUROSCIENCE
- Molecular Circuitry of Endocytosis at Nerve Terminals
- (2009) Jeremy Dittman et al. Annual Review of Cell and Developmental Biology
- Intermediate- and long-term recognition memory deficits in Tg2576 mice are reversed with acute calcineurin inhibition
- (2009) Giulio Taglialatela et al. BEHAVIOURAL BRAIN RESEARCH
- Lysosomal localization of GLUT8 in the testis - the EXXXLL motif of GLUT8 is sufficient for its intracellular sorting via AP1- and AP2-mediated interaction
- (2009) Muhammed Kasim Diril et al. FEBS Journal
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExplorePublish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn More