Epigenetic Regulation of Multidrug Resistance Protein 1 and Breast Cancer Resistance Protein Transporters by Histone Deacetylase Inhibition

Brain region‐specific regulation of histone acetylation and efflux transporters in mice

(2019) Dahea You et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

Increased MDR1 Transporter Expression in Human Brain Endothelial Cells Through Enhanced Histone Acetylation and Activation of Aryl Hydrocarbon Receptor Signaling

(2019) Dahea You et al.   MOLECULAR NEUROBIOLOGY

Effect of Pregnenolone 16α-Carbonitrile on the Expression of P-Glycoprotein in the Intestine, Brain and Liver of Mice

(2018) Yuki Yamasaki et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Valproic acid inhibits the protective effects of stromal cells against chemotherapy in breast cancer: Insights from proteomics and systems biology

(2018) Farnaz Barneh et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Structural basis of small-molecule inhibition of human multidrug transporter ABCG2

(2018) Scott M. Jackson et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural basis of small-molecule inhibition of human multidrug transporter ABCG2

(2018) Scott M. Jackson et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A Phase I/II Study Targeting Angiogenesis Using Bevacizumab Combined with Chemotherapy and a Histone Deacetylase Inhibitor (Valproic Acid) in Advanced Sarcomas

(2018) Varun Monga et al.   Cancers

ABCG2- and ABCG4-Mediated Efflux of Amyloid-β Peptide 1-40 at the Mouse Blood-Brain Barrier

(2018) Tuan Minh Do et al.   JOURNAL OF ALZHEIMERS DISEASE

Targeted inhibition of HDAC8 increases the doxorubicin sensitivity of neuroblastoma cells via up regulation of miR-137

(2017) Gang Zhao et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Structure of the human multidrug transporter ABCG2

(2017) Nicholas M. I. Taylor et al.   NATURE

Down-regulation of the placental BCRP/ ABCG2 transporter in response to hypoxia signaling

(2017) Lissa N. Francois et al.   PLACENTA

The effect of histone deacetylase inhibition on the expression of P-glycoprotein in human placental trophoblast cell lines

(2017) Hongyu Duan et al.   PLACENTA

HDAC2 was involved in placental P-glycoprotein regulation both in vitro and vivo

(2017) Hongyu Duan et al.   PLACENTA

A subcellular map of the human proteome

(2017) Peter J. Thul et al.   SCIENCE

A pathology atlas of the human cancer transcriptome

(2017) Mathias Uhlen et al.   SCIENCE

The structure of the human ABC transporter ABCG2 reveals a novel mechanism for drug extrusion

(2017) Narakorn Khunweeraphong et al.   Scientific Reports

Silencing of histone deacetylase 2 suppresses malignancy for proliferation, migration, and invasion of glioblastoma cells and enhances temozolomide sensitivity

(2016) Zhiqiang Zhang et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

A phase I study to determine the pharmacokinetics and urinary excretion of belinostat and metabolites in patients with advanced solid tumors

(2016) Hanna Bailey et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Histone deacetylase 2 regulates doxorubicin (Dox) sensitivity of colorectal cancer cells by targeting ABCB1 transcription

(2016) Pingjiang Ye et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

A Role for P-Glycoprotein in Clearance of Alzheimer Amyloid ? -Peptide from the Brain

(2016) Wei Wang et al.   Current Alzheimer Research

The regulation of human hepatic drug transporter expression by activation of xenobiotic-sensing nuclear receptors

(2016) David E. Amacher   Expert Opinion on Drug Metabolism & Toxicology

Molecular and cellular effects of a novel hydroxamate-based HDAC inhibitor – belinostat – in glioblastoma cell lines: a preliminary report

(2016) Magdalena Kusaczuk et al.   INVESTIGATIONAL NEW DRUGS

Regulation of the placental BCRP transporter by PPAR gamma

(2016) Yixin Lin et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

Role of HDACs in optic nerve damage-induced nuclear atrophy of retinal ganglion cells

(2016) Heather M. Schmitt et al.   NEUROSCIENCE LETTERS

A novel histone deacetylase inhibitor, CKD5, has potent anti-cancer effects in glioblastoma

(2016) Seung Ah Choi et al.   Oncotarget

Differential effects of histone deacetylase inhibitors on cellular drug transporters and their implications for using epigenetic modifiers in combination chemotherapy

(2016) Benigno C. Valdez et al.   Oncotarget

Intercellular transfer of P-glycoprotein in human blood-brain barrier endothelial cells is increased by histone deacetylase inhibitors

(2016) Andreas Noack et al.   Scientific Reports

Histone deacetylase inhibitor entinostat in combination with a retinoid downregulates HER2 and reduces the tumor initiating cell population in aromatase inhibitor-resistant breast cancer

(2015) Amanda J. Schech et al.   BREAST CANCER RESEARCH AND TREATMENT

Neurorestoration induced by the HDAC inhibitor sodium valproate in the lactacystin model of Parkinson's is associated with histone acetylation and up-regulation of neurotrophic factors

(2015) Ian F Harrison et al.   BRITISH JOURNAL OF PHARMACOLOGY

FDA Approval: Belinostat for the Treatment of Patients with Relapsed or Refractory Peripheral T-cell Lymphoma

(2015) H.-Z. Lee et al.   CLINICAL CANCER RESEARCH

Panobinostat for the Treatment of Multiple Myeloma

(2015) J. P. Laubach et al.   CLINICAL CANCER RESEARCH

Antiepileptic drugs alter the expression of placental carriers: An in vitro study in a human placental cell line

(2015) Miriam Rubinchik-Stern et al.   EPILEPSIA

In vivoandex vivoregulation of breast cancer resistant protein (Bcrp) by peroxisome proliferator-activated receptor alpha (Pparα) at the blood-brain barrier

(2015) Md. Tozammel Hoque et al.   JOURNAL OF NEUROCHEMISTRY

Histone Deacetylase 10 Regulates the Cell Cycle G2/M Phase Transition via a Novel Let-7–HMGA2–Cyclin A2 Pathway

(2015) Yixuan Li et al.   MOLECULAR AND CELLULAR BIOLOGY

Tubulin Beta3 Serves as a Target of HDAC3 and Mediates Resistance to Microtubule-Targeting Drugs

(2015) Youngmi Kim et al.   MOLECULES AND CELLS

Tissue-based map of the human proteome

(2015) M. Uhlen et al.   SCIENCE

Quantification of Histone Deacetylase Isoforms in Human Frontal Cortex, Human Retina, and Mouse Brain

(2015) Kyle W. Anderson et al.   PLoS One

Role of the Breast Cancer Resistance Protein (BCRP/ABCG2) in Drug Transport—an Update

(2014) Qingcheng Mao et al.   AAPS Journal

Nuclear localization signal domain of HDAC3 is necessary and sufficient for the expression regulation of MDR1

(2014) Hyunmi Park et al.   BMB Reports

Effects of suberoylanilide hydroxamic acid (SAHA) combined with paclitaxel (PTX) on paclitaxel-resistant ovarian cancer cells and insights into the underlying mechanisms

(2014) Zhaohui Liu et al.   Cancer Cell International

Belinostat: First Global Approval

(2014) Raewyn M. Poole   DRUGS

A phase I and pharmacodynamic study of the histone deacetylase inhibitor belinostat plus azacitidine in advanced myeloid neoplasia

(2014) Olatoyosi Odenike et al.   INVESTIGATIONAL NEW DRUGS

Upregulation of Stat1-HDAC4 confers resistance to etoposide through enhanced multidrug resistance 1 expression in human A549 lung cancer cells

(2014) CHUTIMA KAEWPIBOON et al.   Molecular Medicine Reports

Valproic Acid Alleviates Memory Deficits and Attenuates Amyloid-β Deposition in Transgenic Mouse Model of Alzheimer’s Disease

(2014) Ai-Guo Xuan et al.   MOLECULAR NEUROBIOLOGY

Opioid-induced respiratory depression: ABCB1 transporter pharmacogenetics

(2014) S Sadhasivam et al.   PHARMACOGENOMICS JOURNAL

mRNA Levels of Related Abcb Genes Change Opposite to Each Other upon Histone Deacetylase Inhibition in Drug-Resistant Rat Hepatoma Cells

(2014) Ádám Sike et al.   PLoS One

Epigenetic regulation of MDR1 gene through post-translational histone modifications in prostate cancer

(2013) Rui Henrique et al.   BMC GENOMICS

Alteration of cancer stem cell-like phenotype by histone deacetylase inhibitors in squamous cell carcinoma of the head and neck

(2013) Kazuaki Chikamatsu et al.   CANCER SCIENCE

Translational Phase I Trial of Vorinostat (Suberoylanilide Hydroxamic Acid) Combined with Cytarabine and Etoposide in Patients with Relapsed, Refractory, or High-Risk Acute Myeloid Leukemia

(2013) I. Gojo et al.   CLINICAL CANCER RESEARCH

Nuclear receptors in regulation of biotransformation enzymes and drug transporters in the placental barrier

(2013) Petr Pavek et al.   DRUG METABOLISM REVIEWS

Intracellular distribution of human SIRT7 and mapping of the nuclear/nucleolar localization signal

(2013) Shashi Kiran et al.   FEBS Journal

Design, Synthesis, and Biological Evaluation of Potent and Selective Class IIa Histone Deacetylase (HDAC) Inhibitors as a Potential Therapy for Huntington’s Disease

(2013) Roland W. Bürli et al.   JOURNAL OF MEDICINAL CHEMISTRY

In vivoinduction of P-glycoprotein expression at the mouse blood-brain barrier: an intracerebral microdialysis study

(2013) Gary N. Y. Chan et al.   JOURNAL OF NEUROCHEMISTRY

Oral Administration of Histone Deacetylase Inhibitor MS-275 Ameliorates Neuroinflammation and Cerebral Amyloidosis and Improves Behavior in a Mouse Model

(2013) Zhi-Yuan Zhang et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

SAHA Enhances Synaptic Function and Plasticity In Vitro but Has Limited Brain Availability In Vivo and Does Not Impact Cognition

(2013) Jesse E. Hanson et al.   PLoS One

Epigenetic regulation of the ABCB1 gene in drug-sensitive and drug-resistant lymphoid tumour cell lines obtained from canine patients

(2013) Hirotaka Tomiyasu et al.   VETERINARY JOURNAL

High sodium butyrate levels induce MDR1 activation in colorectal cells: Impact of 15-deoxy-Δ12,14-prostaglandin J2 on the resistance to saquinavir

(2012) Stamatoula Pasvanis et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Dual regulation of P-glycoprotein expression by Trichostatin A in cancer cell lines

(2012) Trinidad Balaguer et al.   BMC MOLECULAR BIOLOGY

Histone Deacetylase Inhibitors Influence Chemotherapy Transport by Modulating Expression and Trafficking of a Common Polymorphic Variant of the ABCG2 Efflux Transporter

(2012) A. Basseville et al.   CANCER RESEARCH

Elevated level of lysine 9-acetylated histone H3 at the MDR1 promoter in multidrug-resistant cells

(2012) Monika Toth et al.   CANCER SCIENCE

Results From a Pivotal, Open-Label, Phase II Study of Romidepsin in Relapsed or Refractory Peripheral T-Cell Lymphoma After Prior Systemic Therapy

(2012) Bertrand Coiffier et al.   JOURNAL OF CLINICAL ONCOLOGY

Induction of differentiation and apoptosis in leukaemic cell lines by the novel benzamide family histone deacetylase 2 and 3 inhibitor MI-192

(2012) Marjorie Boissinot et al.   LEUKEMIA RESEARCH

SIRT3 Functions in the Nucleus in the Control of Stress-Related Gene Expression

(2012) T. Iwahara et al.   MOLECULAR AND CELLULAR BIOLOGY

The Effect of Vorinostat on the Development of Resistance to Doxorubicin in Neuroblastoma

(2012) Timothy B. Lautz et al.   PLoS One

Transcriptional Control of the Multi-Drug Transporter ABCB1 by Transcription Factor Sp3 in Different Human Tissues

(2012) Radka Gromnicova et al.   PLoS One

Transactivation of ABCG2 through a novel cis-element in the distal promoter by constitutive androstane receptor but not pregnane X receptor in human hepatocytes

(2011) Satoshi Benoki et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Identification and characterization of the major alternative promoter regulating Bcrp1/Abcg2 expression in the mouse intestine

(2011) Karthika Natarajan et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Romidepsin

(2011) Lily P.H. Yang   DRUGS

Role for Class I histone deacetylases in multidrug resistance

(2011) Yichun Xu et al.   EXPERIMENTAL CELL RESEARCH

Identification of a novel, tissue-specific ABCG2 promoter expressed in pediatric acute megakaryoblastic leukemia

(2011) Patrick K. Campbell et al.   LEUKEMIA RESEARCH

Upregulation of ABCG2 by Romidepsin via the Aryl Hydrocarbon Receptor Pathway

(2011) K. K. W. To et al.   MOLECULAR CANCER RESEARCH

Salinomycin overcomes ABC transporter-mediated multidrug and apoptosis resistance in human leukemia stem cell-like KG-1a cells

(2010) Dominik Fuchs et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Prediction of human pharmacokinetics and tissue distribution of apicidin, a potent histone deacetylase inhibitor, by physiologically based pharmacokinetic modeling

(2010) Beom Soo Shin et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Histone Methyltransferase MLL1 Regulates MDR1 Transcription and Chemoresistance

(2010) H. Huo et al.   CANCER RESEARCH

Histone Deacetylase Inhibitors Induce Cytochrome P450 2B by Activating Nuclear Receptor Constitutive Androstane Receptor

(2010) D. Takizawa et al.   DRUG METABOLISM AND DISPOSITION

Nucleocytoplasmic translocation of HDAC9 regulates gene expression and dendritic growth in developing cortical neurons

(2010) Noriyuki Sugo et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Protein kinase C-related kinase targets nuclear localization signals in a subset of class IIa histone deacetylases

(2010) Brooke C. Harrison et al.   FEBS LETTERS

Transcriptional suppression of breast cancer resistance protein (BCRP) by wild-type p53 through the NF-κB pathway in MCF-7 cells

(2010) Xuedong Wang et al.   FEBS LETTERS

HDAC inhibitors downregulate MRP2 expression in multidrug resistant cancer cells: Implication for chemosensitization

(2010) Kim   INTERNATIONAL JOURNAL OF ONCOLOGY

SIRT4 Regulates Fatty Acid Oxidation and Mitochondrial Gene Expression in Liver and Muscle Cells

(2010) Nargis Nasrin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Aryl Hydrocarbon Receptor Is a Transcriptional Activator of the Human Breast Cancer Resistance Protein (BCRP/ABCG2)

(2010) K. P. Tan et al.   MOLECULAR PHARMACOLOGY

Towards a knowledge-based Human Protein Atlas

(2010) Mathias Uhlen et al.   NATURE BIOTECHNOLOGY

Chemical phylogenetics of histone deacetylases

(2010) James E Bradner et al.   Nature Chemical Biology

Xenobiotic, Bile Acid, and Cholesterol Transporters: Function and Regulation

(2010) C. D. Klaassen et al.   PHARMACOLOGICAL REVIEWS

Regulation of P-glycoprotein and other ABC drug transporters at the blood–brain barrier

(2010) David S. Miller   TRENDS IN PHARMACOLOGICAL SCIENCES

Laboratory correlates for a phase II trial of romidepsin in cutaneous and peripheral T-cell lymphoma

(2009) Susan E. Bates et al.   BRITISH JOURNAL OF HAEMATOLOGY

SIRT5 Deacetylates Carbamoyl Phosphate Synthetase 1 and Regulates the Urea Cycle

(2009) Takashi Nakagawa et al.   CELL

Histone Deacetylase Inhibitors Induce a Very Broad, Pleiotropic Anticancer Drug Resistance Phenotype in Acute Myeloid Leukemia Cells by Modulation of Multiple ABC Transporter Genes

(2009) S. Hauswald et al.   CLINICAL CANCER RESEARCH

Novel Structural Insights into Class I and II Histone Deacetylases

(2009) Ralf Ficner   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Augmentation of atypical antipsychotics with valproic acid. An open-label study for most difficult patients with schizophrenia

(2009) Takefumi Suzuki et al.   HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL

Involvement of SIRT7 in resumption of rDNA transcription at the exit from mitosis

(2009) A. Grob et al.   JOURNAL OF CELL SCIENCE

Phase II Trial of Vorinostat in Recurrent Glioblastoma Multiforme: A North Central Cancer Treatment Group Study

(2009) Evanthia Galanis et al.   JOURNAL OF CLINICAL ONCOLOGY

Antidepressant Actions of Histone Deacetylase Inhibitors

(2009) H. E. Covington et al.   JOURNAL OF NEUROSCIENCE

P-glycoprotein and Breast Cancer Resistance Protein Influence Brain Distribution of Dasatinib

(2009) Y. Chen et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Histone Deacetylase Inhibitor Induction of P-Glycoprotein Transcription Requires Both Histone Deacetylase 1 Dissociation and Recruitment of CAAT/Enhancer Binding Protein   and pCAF to the Promoter Region

(2009) S.-N. Kim et al.   MOLECULAR CANCER RESEARCH

Inhibitors of Class 1 Histone Deacetylases Reverse Contextual Memory Deficits in a Mouse Model of Alzheimer's Disease

(2009) Mark Kilgore et al.   NEUROPSYCHOPHARMACOLOGY

Structure of P-Glycoprotein Reveals a Molecular Basis for Poly-Specific Drug Binding

(2009) S. G. Aller et al.   SCIENCE

Histone deacetylase inhibitor apicidin-mediated drug resistance: Involvement of P-glycoprotein

(2008) Yong Kee Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Determination of the class and isoform selectivity of small-molecule histone deacetylase inhibitors

(2008) Nagma Khan et al.   BIOCHEMICAL JOURNAL

Probing the elusive catalytic activity of vertebrate class IIa histone deacetylases

(2008) Philip Jones et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Differential expression of 12 histone deacetylase (HDAC) genes in astrocytomas and normal brain tissue: class II and IV are hypoexpressed in glioblastomas

(2008) Agda KB Lucio-Eterovic et al.   BMC CANCER

Epigenetic mechanisms involved in differential MDR1mRNA expression between gastric and colon cancer cell lines and rationales for clinical chemotherapy

(2008) Tae-Bum Lee et al.   BMC GASTROENTEROLOGY

Histone Deacetylase Inhibitor Romidepsin Has Differential Activity in Core Binding Factor Acute Myeloid Leukemia

(2008) O. M. Odenike et al.   CLINICAL CANCER RESEARCH

Quantitative Investigation of the Role of Breast Cancer Resistance Protein (Bcrp/Abcg2) in Limiting Brain and Testis Penetration of Xenobiotic Compounds

(2008) J. Enokizono et al.   DRUG METABOLISM AND DISPOSITION

Investigation of the Role of Breast Cancer Resistance Protein (Bcrp/Abcg2) on Pharmacokinetics and Central Nervous System Penetration of Abacavir and Zidovudine in the Mouse

(2008) N. Giri et al.   DRUG METABOLISM AND DISPOSITION

Histone deacetylase inhibitors up-regulate astrocyte GDNF and BDNF gene transcription and protect dopaminergic neurons

(2008) Xuefei Wu et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Pimelic Diphenylamide 106 Is a Slow, Tight-binding Inhibitor of Class I Histone Deacetylases

(2008) C. James Chou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Valproic acid inhibits Aβ production, neuritic plaque formation, and behavioral deficits in Alzheimer's disease mouse models

(2008) Hong Qing et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Human Protein Atlas-a tool for pathology

(2008) F Pontén et al.   JOURNAL OF PATHOLOGY

A Genecentric Human Protein Atlas for Expression Profiles Based on Antibodies

(2008) Lisa Berglund et al.   MOLECULAR & CELLULAR PROTEOMICS

Mice Lacking Histone Deacetylase 6 Have Hyperacetylated Tubulin but Are Viable and Develop Normally

(2008) Y. Zhang et al.   MOLECULAR AND CELLULAR BIOLOGY

Histone deacetylase inhibitors improve learning consolidation in young and in KA-induced-neurodegeneration and SAMP-8-mutant mice

(2008) Ángela Fontán-Lozano et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Histone Modifications at the ABCG2 Promoter following Treatment with Histone Deacetylase Inhibitor Mirror Those in Multidrug-Resistant Cells

(2008) K. K.W. To et al.   MOLECULAR CANCER RESEARCH

The many roles of histone deacetylases in development and physiology: implications for disease and therapy

(2008) Michael Haberland et al.   NATURE REVIEWS GENETICS

BCRP/ABCG2 in the Placenta: Expression, Function and Regulation

(2008) Qingcheng Mao   PHARMACEUTICAL RESEARCH

The Role of Placental Breast Cancer Resistance Protein in the Efflux of Glyburide across the Human Placenta

(2008) E. Pollex et al.   PLACENTA

Porphyrin Homeostasis Maintained by ABCG2 Regulates Self-Renewal of Embryonic Stem Cells

(2008) Jimmy Susanto et al.   PLoS One

Localization of mouse mitochondrial SIRT proteins: Shift of SIRT3 to nucleus by co-expression with SIRT5

(2007) Yasuhiko Nakamura et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

ABC multidrug transporters: structure, function and role in chemoresistance

(2007) Frances J Sharom   PHARMACOGENOMICS