Journal
JOURNAL OF VETERINARY MEDICAL SCIENCE
Volume 71, Issue 10, Pages 1381-1386Publisher
JAPAN SOC VET SCI
DOI: 10.1292/jvms.001381
Keywords
dentate gyrus; gerbil; ischemia/reperfusion; microglia; neuronal degeneration
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Funding
- Korean Governnient (MOEHRD) [KRF-2007-412-J00502]
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In the present study, we investigated the time-course changes of neuronal degeneration and microglial activation in the gerbil dentate gyrus after transient cerebral ischemia using Fluoro-Jade B histofluorescence staining and immunohistochemistry for Iba-1. Fluoro-Jade B positive cells were observed from 6 hr and markedly increased 1 day after ischemia/reperfusion. Iba-1-immunoreactive microglia were increased and hypertrophied at early time, and Iba-1-immunoreactivity was highest at 2 days after ischemia/reperfusion. These results may be direct evidence on neuronal degeneration and microglial activation in the gerbil dentate gyrus after ischemia/reperfusion.
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