Functions of phospholipid flippases

Dissecting Ent3p: the ENTH domain binds different SNAREs via distinct amino acid residues while the C-terminus is sufficient for retrograde transport from endosomes

(2010) Jana Zimmermann et al.   BIOCHEMICAL JOURNAL

A flippase-independent function of ATP8B1, the protein affected in familial intrahepatic cholestasis type 1, is required for apical protein expression and microvillus formation in polarized epithelial cells

(2010) Patricia M. Verhulst et al.   HEPATOLOGY

Intracellular Targeting Signals and Lipid Specificity Determinants of the ALA/ALIS P4-ATPase Complex Reside in the Catalytic ALA α-Subunit

(2010) Rosa L. López-Marqués et al.   MOLECULAR BIOLOGY OF THE CELL

Disruption of the Lipid-Transporting LdMT-LdRos3 Complex in Leishmania donovani Affects Membrane Lipid Asymmetry but Not Host Cell Invasion

(2010) Adrien Weingärtner et al.   PLoS One

Oligomeric Dop1p is Part of the Endosomal Neo1p-Ysl2p-Arl1p Membrane Remodeling Complex

(2010) Sónia Barbosa et al.   TRAFFIC

Differential effects of progressive familial intrahepatic cholestasis type 1 and benign recurrent intrahepatic cholestasis type 1 mutations on canalicular localization of ATP8B1

(2009) Dineke E. Folmer et al.   HEPATOLOGY

Activity of the Bile Salt Export Pump (ABCB11) Is Critically Dependent on Canalicular Membrane Cholesterol Content

(2009) Coen C. Paulusma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Localization, Purification, and Functional Reconstitution of the P4-ATPase Atp8a2, a Phosphatidylserine Flippase in Photoreceptor Disc Membranes

(2009) Jonathan A. Coleman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cdc50p Plays a Vital Role in the ATPase Reaction Cycle of the Putative Aminophospholipid Transporter Drs2p

(2009) Guillaume Lenoir et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of a novel mouse P4-ATPase family member highly expressed during spermatogenesis

(2009) P. Xu et al.   JOURNAL OF CELL SCIENCE

A P4-ATPase Protein Interaction Network Reveals a Link between Aminophospholipid Transport and Phosphoinositide Metabolism

(2009) Catheleyne F. Puts et al.   JOURNAL OF PROTEOME RESEARCH

Control of Protein and Sterol Trafficking by Antagonistic Activities of a Type IV P-type ATPase and Oxysterol Binding Protein Homologue

(2009) Baby-Periyanayaki Muthusamy et al.   MOLECULAR BIOLOGY OF THE CELL

Regulation of a Golgi flippase by phosphoinositides and an ArfGEF

(2009) Paramasivam Natarajan et al.   NATURE CELL BIOLOGY

ATP8B1 is essential for maintaining normal hearing

(2009) J. M. Stapelbroek et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reconstitution of phospholipid translocase activity with purified Drs2p, a type-IV P-type ATPase from budding yeast

(2009) X. Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A protein kinase network regulates the function of aminophospholipid flippases

(2009) F. M. Roelants et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

P-Type ATPase TAT-2 Negatively Regulates Monomethyl Branched-Chain Fatty Acid Mediated Function in Post-Embryonic Growth and Development in C. elegans

(2009) Emylie Seamen et al.   PLoS Genetics

An unexpectedly high degree of specialization and a widespread involvement in sterol metabolism among the C. elegans putative aminophospholipid translocases

(2008) Nicholas N Lyssenko et al.   BMC DEVELOPMENTAL BIOLOGY

Abcg5/8 Independent Biliary Cholesterol Excretion in Atp8b1-Deficient Mice

(2008) Annemiek Groen et al.   GASTROENTEROLOGY

ATP8B1 Deficiency Disrupts the Bile Canalicular Membrane Bilayer Structure in Hepatocytes, But FXR Expression and Activity Are Maintained

(2008) Shi–Ying Cai et al.   GASTROENTEROLOGY

Arf1-GTP-induced Tubule Formation Suggests a Function of Arf Family Proteins in Curvature Acquisition at Sites of Vesicle Budding

(2008) Michael Krauss et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein Kinases Fpk1p and Fpk2p are Novel Regulators of Phospholipid Asymmetry

(2008) Kenzi Nakano et al.   MOLECULAR BIOLOGY OF THE CELL

P4-ATPase Requirement for AP-1/Clathrin Function in Protein Transport from the trans-Golgi Network and Early Endosomes

(2008) Ke Liu et al.   MOLECULAR BIOLOGY OF THE CELL

The Arabidopsis P4-ATPase ALA3 Localizes to the Golgi and Requires a  -Subunit to Function in Lipid Translocation and Secretory Vesicle Formation

(2008) L. R. Poulsen et al.   PLANT CELL

Membrane curvature induced by Arf1-GTP is essential for vesicle formation

(2008) R. Beck et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Expression of Atp8b3 in murine testis and its characterization as a testis specific P-type ATPase

(2008) Eun-Yeung Gong et al.   REPRODUCTION

Role of C. elegans TAT-1 Protein in Maintaining Plasma Membrane Phosphatidylserine Asymmetry

(2008) M. Darland-Ransom et al.   SCIENCE

Membrane Phosphatidylserine Regulates Surface Charge and Protein Localization

(2008) T. Yeung et al.   SCIENCE

The C. elegans P4-ATPase TAT-1 Regulates Lysosome Biogenesis and Endocytosis

(2008) Anne-Françoise Ruaud et al.   TRAFFIC