Block one, unleash a hundred. Mechanisms of DAB2IP inactivation in cancer

DAB2IP regulates EMT and metastasis of prostate cancer through targeting PROX1 transcription and destabilizing HIF1α protein

(2016) Bin Wang et al.   CELLULAR SIGNALLING

Targeting EZH2 in cancer

(2016) Kimberly H Kim et al.   NATURE MEDICINE

Tumor suppressor protein DAB2IP participates in chromosomal stability maintenance through activating spindle assembly checkpoint and stabilizing kinetochore-microtubule attachments

(2016) Lan Yu et al.   NUCLEIC ACIDS RESEARCH

Loss of DAB2IP in RCC cells enhances their growth and resistance to mTOR-targeted therapies

(2016) J Zhou et al.   ONCOGENE

AIP1 Expression in Tumor Niche Suppresses Tumor Progression and Metastasis

(2015) W. Ji et al.   CANCER RESEARCH

Integrative Clinical Genomics of Advanced Prostate Cancer

(2015) Dan Robinson et al.   CELL

DAB2IP regulates the chemoresistance to pirarubicin and tumor recurrence of non-muscle invasive bladder cancer through STAT3/Twist1/P-glycoprotein signaling

(2015) Kaijie Wu et al.   CELLULAR SIGNALLING

High glucose and/or high insulin affects HIF-1 signaling by regulating AIP1 in human umbilical vein endothelial cells

(2015) Shuang Li et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

miR-889 promotes proliferation of esophageal squamous cell carcinomas through DAB2IP

(2015) Yanting Xu et al.   FEBS LETTERS

TNF biology, pathogenic mechanisms and emerging therapeutic strategies

(2015) George D. Kalliolias et al.   Nature Reviews Rheumatology

DAB2IP loss confers the resistance of prostate cancer to androgen deprivation therapy through activating STAT3 and inhibiting apoptosis

(2015) J Zhou et al.   Cell Death & Disease

The positive feedback between Snail and DAB2IP regulates EMT, invasion and metastasis in colorectal cancer

(2015) Jianmei Wang et al.   Oncotarget

Absence of DAB2IP promotes cancer stem cell like signatures and indicates poor survival outcome in colorectal cancer

(2015) Jiang Min et al.   Scientific Reports

Pretreatment biopsy analysis of DAB2IP identifies subpopulation of high-risk prostate cancer patients with worse survival following radiation therapy

(2015) Corbin Jacobs et al.   Cancer Medicine

Negative regulation of DAB2IP by Akt and SCFFbw7 pathways

(2015) Xiangpeng Dai et al.   Oncotarget

The role of homeostatic regulation between tumor suppressor DAB2IP and oncogenic Skp2 in prostate cancer growth

(2015) Yuh-Shyan Tsai et al.   Oncotarget

DAB2IP Regulates Autophagy in Prostate Cancer in Response to Combined Treatment of Radiation and a DNA-PKcs Inhibitor

(2015) Lan Yu et al.   NEOPLASIA

AIP1 Mediates Vascular Endothelial Cell Growth Factor Receptor-3–Dependent Angiogenic and Lymphangiogenic Responses

(2014) Huanjiao Jenny Zhou et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Associations of Single Nucleotide Polymorphisms in miR-146a, miR-196a, miR-149 and miR-499 with Colorectal Cancer Susceptibility

(2014) Wei Du et al.   Asian Pacific Journal of Cancer Prevention

Endoplasmic Reticulum Stress in Malignancy

(2014) Hanna J. Clarke et al.   CANCER CELL

Downregulation of DAB2IP results in cell proliferation and invasion and contributes to unfavorable outcomes in bladder cancer

(2014) Yi-Jun Shen et al.   CANCER SCIENCE

Aberrant Regulation and Function of MicroRNAs in Cancer

(2014) Brian D. Adams et al.   CURRENT BIOLOGY

Mutant p53 Reprograms TNF Signaling in Cancer Cells through Interaction with the Tumor Suppressor DAB2IP

(2014) Giulio Di Minin et al.   MOLECULAR CELL

PI3K and cancer: lessons, challenges and opportunities

(2014) David A. Fruman et al.   NATURE REVIEWS DRUG DISCOVERY

DAB2IP regulates cancer stem cell phenotypes through modulating stem cell factor receptor and ZEB1

(2014) E-J Yun et al.   ONCOGENE

AIP1 Suppresses Atherosclerosis by Limiting Hyperlipidemia-Induced Inflammation and Vascular Endothelial Dysfunction

(2013) Qunhua Huang et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Predicting PDZ domain mediated protein interactions from structure

(2013) Shirley Hui et al.   BMC BIOINFORMATICS

The Mechanism of DAB2IP in Chemoresistance of Prostate Cancer Cells

(2013) K. Wu et al.   CLINICAL CANCER RESEARCH

Cancer stem cells: The challenges ahead

(2013) Jan Paul Medema   NATURE CELL BIOLOGY

The role of DAB2IP in androgen receptor activation during prostate cancer progression

(2013) K Wu et al.   ONCOGENE

Both Internalization and AIP1 Association Are Required for Tumor Necrosis Factor Receptor 2-Mediated JNK Signaling

(2012) Weidong Ji et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The unfolded protein response at the crossroads of cellular life and death during endoplasmic reticulum stress

(2012) Richard Jäger et al.   BIOLOGY OF THE CELL

Expression patterns of human DAB2IP protein in fetal tissues

(2012) S Liu et al.   BIOTECHNIC & HISTOCHEMISTRY

EZH2-Regulated DAB2IP Is a Medulloblastoma Tumor Suppressor and a Positive Marker for Survival

(2012) M. Smits et al.   CLINICAL CANCER RESEARCH

AIP1 in Graft Arteriosclerosis

(2012) Wang Min et al.   TRENDS IN CARDIOVASCULAR MEDICINE

AIP1 Prevents Graft Arteriosclerosis by Inhibiting Interferon-γ–Dependent Smooth Muscle Cell Proliferation and Intimal Expansion

(2011) Luyang Yu et al.   CIRCULATION RESEARCH

Low expression of DAB2IP contributes to malignant development and poor prognosis in hepatocellular carcinoma

(2011) Xiaojing Zhang et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

The Ras-ERK and PI3K-mTOR pathways: cross-talk and compensation

(2011) Michelle C. Mendoza et al.   TRENDS IN BIOCHEMICAL SCIENCES

Immunity, Inflammation, and Cancer

(2010) Sergei I. Grivennikov et al.   CELL

Epothilone B Confers Radiation Dose Enhancement in DAB2IP Gene Knock-Down Radioresistant Prostate Cancer Cells

(2010) Zhaolu Kong et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Inactivation of Ras GTPase-activating proteins promotes unrestrained activity of wild-type Ras in human liver cancer

(2010) Diego F. Calvisi et al.   JOURNAL OF HEPATOLOGY

An oncogene–tumor suppressor cascade drives metastatic prostate cancer by coordinately activating Ras and nuclear factor-κB

(2010) Junxia Min et al.   NATURE MEDICINE

Role of DAB2IP in modulating epithelial-to-mesenchymal transition and prostate cancer metastasis

(2010) D. Xie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evidence of epithelial to mesenchymal transition associated with increased tumorigenic potential in an immortalized normal prostate epithelial cell line

(2010) Calin O. Marian et al.   PROSTATE

Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability

(2009) F. Colotta et al.   CARCINOGENESIS

AIP1 Functions as Arf6-GAP to Negatively Regulate TLR4 Signaling

(2009) Ting Wan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DAB2IP coordinates both PI3K-Akt and ASK1 pathways for cell survival and apoptosis

(2009) D. Xie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

AIP1 Recruits Phosphatase PP2A to ASK1 in Tumor Necrosis Factor–Induced ASK1-JNK Activation

(2008) Wang Min et al.   CIRCULATION RESEARCH

AIP1 Is Critical in Transducing IRE1-mediated Endoplasmic Reticulum Stress Response

(2008) Dianhong Luo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of Ras Signaling in the Induction of Snail by Transforming Growth Factor-β

(2008) Kana Horiguchi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

AIP1 functions as an endogenous inhibitor of VEGFR2-mediated signaling and inflammatory angiogenesis in mice

(2008) Haifeng Zhang et al.   JOURNAL OF CLINICAL INVESTIGATION

An intronic microRNA silences genes that are functionally antagonistic to its host gene

(2008) S. Barik   NUCLEIC ACIDS RESEARCH