ΔNp63 regulates IL-33 and IL-31 signaling in atopic dermatitis

RNA-seq Studies Reveal New Insights into p63 and the Transcriptomic Landscape of the Mouse Skin

(2015) Jason M. Rizzo et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Tight junction protein claudin-4 is modulated via ΔNp63 in human keratinocytes

(2014) Terufumi Kubo et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A comparative encyclopedia of DNA elements in the mouse genome

(2014) Feng Yue et al.   NATURE

ΔNp63 Controls a TLR3-Mediated Mechanism That Abundantly Provides Thymic Stromal Lymphopoietin in Atopic Dermatitis

(2014) Terufumi Kubo et al.   PLoS One

Induced multipotency in adult keratinocytes through down-regulation ofΔNp63orDGCR8

(2014) Deepavali Chakravarti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human IL-31 is induced by IL-4 and promotes TH2-driven inflammation

(2013) Bryony Stott et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

A role for IL-25 and IL-33–driven type-2 innate lymphoid cells in atopic dermatitis

(2013) Maryam Salimi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Epidermal overexpression of transgenic ΔNp63 promotes type 2 immune and myeloid inflammatory responses and hyperplasia via NF-κB activation

(2013) Jihui Du et al.   JOURNAL OF PATHOLOGY

p63-expressing cells are the stem cells of developing prostate, bladder, and colorectal epithelia

(2013) J.-C. Pignon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Skin-specific expression of IL-33 activates group 2 innate lymphoid cells and elicits atopic dermatitis-like inflammation in mice

(2013) Yasutomo Imai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of Interleukin-33 in Innate-Type Immune Cells in Allergy

(2013) Susumu Nakae et al.   ALLERGOLOGY INTERNATIONAL

New Insights into Atopic Dermatitis: Role of Skin Barrier and Immune Dysregulation

(2013) Donald Y.M. Leung   ALLERGOLOGY INTERNATIONAL

 Np63 knockout mice reveal its indispensable role as a master regulator of epithelial development and differentiation

(2012) R.-A. Romano et al.   DEVELOPMENT

Increased frequencies of IL-31-producing T cells are found in chronic atopic dermatitis skin

(2012) Krisztina Szegedi et al.   EXPERIMENTAL DERMATOLOGY

IL-33 and ST2 in Atopic Dermatitis: Expression Profiles and Modulation by Triggering Factors

(2012) Terhi Savinko et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Activation of Epidermal Toll-Like Receptor 2 Enhances Tight Junction Function: Implications for Atopic Dermatitis and Skin Barrier Repair

(2012) I-Hsin Kuo et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

An integrated encyclopedia of DNA elements in the human genome

(2012)   NATURE

Differential analysis of gene regulation at transcript resolution with RNA-seq

(2012) Cole Trapnell et al.   NATURE BIOTECHNOLOGY

Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks

(2012) Cole Trapnell et al.   Nature Protocols

TNF-  Promotes c-REL/ Np63  Interaction and TAp73 Dissociation from Key Genes That Mediate Growth Arrest and Apoptosis in Head and Neck Cancer

(2011) H. Lu et al.   CANCER RESEARCH

 Np63 Versatilely Regulates a Broad NF- B Gene Program and Promotes Squamous Epithelial Proliferation, Migration, and Inflammation

(2011) X. Yang et al.   CANCER RESEARCH

Atopic dermatitis: a disease of altered skin barrier and immune dysregulation

(2011) Mark Boguniewicz et al.   IMMUNOLOGICAL REVIEWS

Nonlesional atopic dermatitis skin is characterized by broad terminal differentiation defects and variable immune abnormalities

(2011) Mayte Suárez-Fariñas et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

IL-31 regulates differentiation and filaggrin expression in human organotypic skin models

(2011) Christian Cornelissen et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Filaggrin Mutations Associated with Skin and Allergic Diseases

(2011) Alan D. Irvine et al.   NEW ENGLAND JOURNAL OF MEDICINE

Dysregulated ΔNp63α Inhibits Expression of Ink4a/arf, Blocks Senescence, and Promotes Malignant Conversion of Keratinocytes

(2011) Linan Ha et al.   PLoS One

The Role of TSLP in IL-13-Induced Atopic March

(2011) Zhou Zhu et al.   Scientific Reports

A User's Guide to the Encyclopedia of DNA Elements (ENCODE)

(2011)   PLOS BIOLOGY

ΔNp63 is an ectodermal gatekeeper of epidermal morphogenesis

(2010) R Shalom-Feuerstein et al.   CELL DEATH AND DIFFERENTIATION

Abnormal hair follicle development and altered cell fate of follicular keratinocytes in transgenic mice expressing  Np63 

(2010) R. A. Romano et al.   DEVELOPMENT

Extrinsic and intrinsic types of atopic dermatitis

(2010) Yoshiki Tokura   JOURNAL OF DERMATOLOGICAL SCIENCE

Genome-Wide Profiling of p63 DNA–Binding Sites Identifies an Element that Regulates Gene Expression during Limb Development in the 7q21 SHFM1 Locus

(2010) Evelyn N. Kouwenhoven et al.   PLoS Genetics

Broad defects in epidermal cornification in atopic dermatitis identified through genomic analysis

(2009) Emma Guttman-Yassky et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Differential expression of p63 isoforms in normal skin and hyperproliferative conditions

(2009) So-Young Kim et al.   JOURNAL OF CUTANEOUS PATHOLOGY

Histone modifications at human enhancers reflect global cell-type-specific gene expression

(2009) Nathaniel D. Heintzman et al.   NATURE

An Active Role of the ΔN Isoform of p63 in Regulating Basal Keratin Genes K5 and K14 and Directing Epidermal Cell Fate

(2009) Rose-Anne Romano et al.   PLoS One

Anti-interleukin-31-antibodies ameliorate scratching behaviour in NC/Nga mice: a model of atopic dermatitis

(2008) Øystein Grimstad et al.   EXPERIMENTAL DERMATOLOGY

Transgenic Expression of Interleukin-13 in the Skin Induces a Pruritic Dermatitis and Skin Remodeling

(2008) Tao Zheng et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Atopic Dermatitis

(2008) Thomas Bieber   NEW ENGLAND JOURNAL OF MEDICINE