Cooperative antiproliferative signaling by aspirin and indole-3-carbinol targets microphthalmia-associated transcription factor gene expression and promoter activity in human melanoma cells

Inhibition of oncogenic BRAF activity by indole-3-carbinol disrupts microphthalmia-associated transcription factor expression and arrests melanoma cell proliferation

(2016) Aishwarya Kundu et al.   MOLECULAR CARCINOGENESIS

Targeting drivers of melanoma with synthetic small molecules and phytochemicals

(2015) Leah Ray Strickland et al.   CANCER LETTERS

Melanoma-intrinsic β-catenin signalling prevents anti-tumour immunity

(2015) Stefani Spranger et al.   NATURE

Multiple drug resistance-associated protein 4 (MRP4), prostaglandin transporter (PGT), and 15-hydroxyprostaglandin dehydrogenase (15-PGDH) as determinants of PGE2 levels in cancer

(2015) Tyler J. Kochel et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

Molecular stratification of metastatic melanoma using gene expression profiling : Prediction of survival outcome and benefit from molecular targeted therapy

(2015) Helena Cirenajwis et al.   Oncotarget

Aspirin might reduce the incidence of pancreatic cancer: A meta-analysis of observational studies

(2015) Yan-Peng Zhang et al.   Scientific Reports

Molecular Pathways: Aspirin and Wnt Signaling--A Molecularly Targeted Approach to Cancer Prevention and Treatment

(2014) M. K. Gala et al.   CLINICAL CANCER RESEARCH

The Antiproliferative Response of Indole-3-Carbinol in Human Melanoma Cells Is Triggered by an Interaction with NEDD4-1 and Disruption of Wild-Type PTEN Degradation

(2014) Ida Aronchik et al.   MOLECULAR CANCER RESEARCH

Melanoma: Clinical Features and Genomic Insights

(2014) E. B. Hawryluk et al.   Cold Spring Harbor Perspectives in Medicine

Aspirin is associated with lower melanoma risk among postmenopausal Caucasian women

(2013) Christina A. Gamba et al.   CANCER

Molecular and cellular pathogenesis of melanoma initiation and progression

(2013) Tarik Regad   CELLULAR AND MOLECULAR LIFE SCIENCES

Wnt/β-Catenin Signaling and Disease

(2012) Hans Clevers et al.   CELL

Expression of Microphthalmia-associated Transcription Factor (MITF), Which Is Critical for Melanoma Progression, Is Inhibited by Both Transcription Factor GLI2 and Transforming Growth Factor-β

(2012) Marie-Jeanne Pierrat et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phase II Study of the MEK1/MEK2 Inhibitor Trametinib in Patients With MetastaticBRAF-Mutant Cutaneous Melanoma Previously Treated With or Without a BRAF Inhibitor

(2012) Kevin B. Kim et al.   JOURNAL OF CLINICAL ONCOLOGY

Short-term effects of daily aspirin on cancer incidence, mortality, and non-vascular death: analysis of the time course of risks and benefits in 51 randomised controlled trials

(2012) Peter M Rothwell et al.   LANCET

Survival in BRAF V600–Mutant Advanced Melanoma Treated with Vemurafenib

(2012) Jeffrey A. Sosman et al.   NEW ENGLAND JOURNAL OF MEDICINE

Effects of nitric oxide-releasing nonsteroidal anti-inflammatory drugs (NONO-NSAIDs) on melanoma cell adhesion

(2012) Huiwen Cheng et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Indole-3-carbinol downregulation of telomerase gene expression requires the inhibition of estrogen receptor-alpha and Sp1 transcription factor interactions within the hTERT promoter and mediates the G1 cell cycle arrest of human breast cancer cells

(2011) C. N. Marconett et al.   CARCINOGENESIS

Biology and Clinical Relevance of the Micropthalmia Family of Transcription Factors in Human Cancer

(2011) Rizwan Haq et al.   JOURNAL OF CLINICAL ONCOLOGY

Target protein interactions of indole-3-carbinol and the highly potent derivative 1-benzyl-I3C with the C-terminal domain of human elastase uncouples cell cycle arrest from apoptotic signaling

(2011) Ida Aronchik et al.   MOLECULAR CARCINOGENESIS

β-Catenin Signaling Increases during Melanoma Progression and Promotes Tumor Cell Survival and Chemoresistance

(2011) Tobias Sinnberg et al.   PLoS One

Direct Inhibition of Elastase Activity by Indole-3-Carbinol Triggers a CD40-TRAF Regulatory Cascade That Disrupts NF-κB Transcriptional Activity in Human Breast Cancer Cells

(2010) Ida Aronchik et al.   CANCER RESEARCH

Effect of daily aspirin on long-term risk of death due to cancer: analysis of individual patient data from randomised trials

(2010) Peter M Rothwell et al.   LANCET

Indole-3-carbinol (I3C)-induced apoptosis in nasopharyngeal cancer cells through Fas/FasL and MAPK pathway

(2010) Yu Xu et al.   MEDICAL ONCOLOGY

Indole-3-Carbinol Triggers Aryl Hydrocarbon Receptor-dependent Estrogen Receptor (ER)α Protein Degradation in Breast Cancer Cells Disrupting an ERα-GATA3 Transcriptional Cross-Regulatory Loop

(2010) Crystal N. Marconett et al.   MOLECULAR BIOLOGY OF THE CELL

Asymmetric Acetylation of the Cyclooxygenase-2 Homodimer by Aspirin and Its Effects on the Oxygenation of Arachidonic, Eicosapentaenoic, and Docosahexaenoic Acids

(2010) N. P. Sharma et al.   MOLECULAR PHARMACOLOGY

Cellular signaling perturbation by natural products

(2009) Fazlul H. Sarkar et al.   CELLULAR SIGNALLING

Wnt/β-Catenin Signaling: Components, Mechanisms, and Diseases

(2009) Bryan T. MacDonald et al.   DEVELOPMENTAL CELL

Minireview: Modulation of Hormone Receptor Signaling by Dietary Anticancer Indoles

(2009) Gary L. Firestone et al.   MOLECULAR ENDOCRINOLOGY

β-Catenin hits chromatin: regulation of Wnt target gene activation

(2009) Christian Mosimann et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Biochemical mechanism of acetylsalicylic acid (Aspirin) selective toxicity toward melanoma cell lines

(2008) Nikhil M. Vad et al.   MELANOMA RESEARCH

Oncogenic BRAF Regulates Melanoma Proliferation through the Lineage Specific Factor MITF

(2008) Claudia Wellbrock et al.   PLoS One

The dietary phytochemical indole-3-carbinol is a natural elastase enzymatic inhibitor that disrupts cyclin E protein processing

(2008) H. H. Nguyen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA