Hypertension, the renin–angiotensin system, and the risk of lower respiratory tract infections and lung injury: implications for COVID-19

Q&A: The novel coronavirus outbreak causing COVID-19

(2020) Dale Fisher et al.   BMC Medicine

Prognostic value of blood pressure drops during the first 24 h after hospital admission for risk stratification of community-acquired pneumonia: a retrospective cohort study

(2020) Bernhard Schulte-Hubbert et al.   INFECTION

Angiotensin-converting enzyme 2 (ACE2) as a SARS-CoV-2 receptor: molecular mechanisms and potential therapeutic target

(2020) Haibo Zhang et al.   INTENSIVE CARE MEDICINE

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

(2020) Chaolin Huang et al.   LANCET

Viral load of SARS-CoV-2 in clinical samples

(2020) Yang Pan et al.   LANCET INFECTIOUS DISEASES

An interactive web-based dashboard to track COVID-19 in real time

(2020) Ensheng Dong et al.   LANCET INFECTIOUS DISEASES

A pneumonia outbreak associated with a new coronavirus of probable bat origin

(2020) Peng Zhou et al.   NATURE

Covid-19 — Navigating the Uncharted

(2020) Anthony S. Fauci et al.   NEW ENGLAND JOURNAL OF MEDICINE

Similarity in Case Fatality Rates (CFR) of COVID-19/SARS-COV-2 in Italy and China

(2020) Rossella Porcheddu et al.   Journal of Infection in Developing Countries

Comparative genetic analysis of the novel coronavirus (2019-nCoV/SARS-CoV-2) receptor ACE2 in different populations

(2020) Yanan Cao et al.   Cell Discovery

Enteric involvement of coronaviruses: is faecal–oral transmission of SARS-CoV-2 possible?

(2020) Charleen Yeo et al.   Lancet Gastroenterology & Hepatology

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

(2020) Markus Hoffmann et al.   CELL

White Blood Cells and Blood Pressure

(2020) Mateusz Siedlinski et al.   CIRCULATION

Characteristics and Outcomes of 21 Critically Ill Patients With COVID-19 in Washington State

(2020) Matt Arentz et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Detection of SARS-CoV-2 in Different Types of Clinical Specimens

(2020) Wenling Wang et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Case-Fatality Rate and Characteristics of Patients Dying in Relation to COVID-19 in Italy

(2020) Graziano Onder et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Critical Care Utilization for the COVID-19 Outbreak in Lombardy, Italy

(2020) Giacomo Grasselli et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Can angiotensin receptor-blocking drugs perhaps be harmful in the COVID-19 pandemic?

(2020) Murray Esler et al.   JOURNAL OF HYPERTENSION

COVID-19 and Italy: what next?

(2020) Andrea Remuzzi et al.   LANCET

Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study

(2020) Fei Zhou et al.   LANCET

Temporal profiles of viral load in posterior oropharyngeal saliva samples and serum antibody responses during infection by SARS-CoV-2: an observational cohort study

(2020) Kelvin Kai-Wang To et al.   LANCET INFECTIOUS DISEASES

Are patients with hypertension and diabetes mellitus at increased risk for COVID-19 infection?

(2020) Lei Fang et al.   Lancet Respiratory Medicine

Cardiovascular Implications of Fatal Outcomes of Patients With Coronavirus Disease 2019 (COVID-19)

(2020) Tao Guo et al.   JAMA Cardiology

Potential Effects of Coronaviruses on the Cardiovascular System

(2020) Mohammad Madjid et al.   JAMA Cardiology

Renin-Angiotensin System Blockers and the COVID-19 Pandemic

(2020) A.H. Jan Danser et al.   HYPERTENSION

Stopping RAS Inhibitors to Minimize Acute Kidney Injury

(2019) Charles Tomson et al.   Clinical Journal of the American Society of Nephrology

The immunometabolic role of indoleamine 2 3-dioxygenase in atherosclerotic cardiovascular disease: immune homeostatic mechanisms in the artery wall

(2019) Daniel F J Ketelhuth   CARDIOVASCULAR RESEARCH

Age-dependent differences in pulmonary host responses in ARDS: a prospective observational cohort study

(2019) Laura R. Schouten et al.   Annals of Intensive Care

Immunometabolism and atherosclerosis: perspectives and clinical significance: a position paper from the Working Group on Atherosclerosis and Vascular Biology of the European Society of Cardiology

(2019) Daniel F J Ketelhuth et al.   CARDIOVASCULAR RESEARCH

Causal association between periodontitis and hypertension: evidence from Mendelian randomization and a randomized controlled trial of non-surgical periodontal therapy

(2019) Marta Czesnikiewicz-Guzik et al.   EUROPEAN HEART JOURNAL

Novel Therapeutic Approaches Targeting the Renin-Angiotensin System and Associated Peptides in Hypertension and Heart Failure

(2019) Lauren B. Arendse et al.   PHARMACOLOGICAL REVIEWS

Biobanking and Cryopreservation of Human Lung Explants for Omic Analysis

(2019) Sarah G. Chu et al.   EUROPEAN RESPIRATORY JOURNAL

ACE2 exhibits protective effects against LPS-induced acute lung injury in mice by inhibiting the LPS-TLR4 pathway

(2019) Rensong Ye et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Attenuation of pulmonary ACE2 activity impairs inactivation of des-Arg9 bradykinin/BKB1R axis and facilitates LPS-induced neutrophil infiltration

(2018) Chhinder P. Sodhi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Hypertension and increased endothelial mechanical stretch promote monocyte differentiation and activation: roles of STAT3, interleukin 6 and hydrogen peroxide

(2018) Roxana Loperena et al.   CARDIOVASCULAR RESEARCH

IL-6 trans-signalling contributes to aldosterone-induced cardiac fibrosis

(2018) Chia-Hung Chou et al.   CARDIOVASCULAR RESEARCH

Deoxycorticosterone acetate-salt hypertension activates placental growth factor in the spleen to couple sympathetic drive and immune system activation

(2018) Marialuisa Perrotta et al.   CARDIOVASCULAR RESEARCH

Mechanical stretch on endothelial cells interconnects innate and adaptive immune response in hypertension

(2018) Daniela Carnevale et al.   CARDIOVASCULAR RESEARCH

Status of Hypertension in China

(2018) Zengwu Wang et al.   CIRCULATION

Targeting the renin–angiotensin system as novel therapeutic strategy for pulmonary diseases

(2018) Wan Shun Daniel Tan et al.   CURRENT OPINION IN PHARMACOLOGY

2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults

(2018) Paul K. Whelton et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

The ACE2/Angiotensin-(1–7)/MAS Axis of the Renin-Angiotensin System: Focus on Angiotensin-(1–7)

(2018) Robson Augusto Souza Santos et al.   PHYSIOLOGICAL REVIEWS

Do outpatient statins and ACEIs/ARBs have synergistic effects in reducing the risk of pneumonia? A population-based case-control study

(2018) Jiunn-Horng Kang et al.   PLoS One

Single-Cell Transcriptomic Analysis of Human Lung Provides Insights into the Pathobiology of Pulmonary Fibrosis

(2018) Paul A Reyfman et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Combined Antihypertensive Therapies That Increase Expression of Cardioprotective Biomarkers Associated With the Renin–Angiotensin and Kallikrein–Kinin Systems

(2018) Diego Lezama-Martinez et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

2018 Practice Guidelines for the management of arterial hypertension of the European Society of Cardiology and the European Society of Hypertension

(2018) Bryan Williams et al.   JOURNAL OF HYPERTENSION

2018 ESC/ESH Guidelines for the management of arterial hypertension

(2018) Bryan Williams et al.   JOURNAL OF HYPERTENSION

Immunomodulatory properties of captopril, an ACE inhibitor, on LPS-induced lung inflammation and fibrosis as well as oxidative stress

(2018) Javad Boskabadi et al.   INFLAMMOPHARMACOLOGY

Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016

(2017) Andrew Rhodes et al.   INTENSIVE CARE MEDICINE

Global Burden of Hypertension and Systolic Blood Pressure of at Least 110 to 115 mm Hg, 1990-2015

(2017) Mohammad H. Forouzanfar et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Renin angiotensin aldosterone inhibition in the treatment of cardiovascular disease

(2017) Carlos M. Ferrario et al.   PHARMACOLOGICAL RESEARCH

2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure

(2016) Piotr Ponikowski et al.   EUROPEAN HEART JOURNAL

Activation of Human T Cells in HypertensionNovelty and Significance

(2016) Hana A. Itani et al.   HYPERTENSION

Urinary angiotensin converting enzyme 2 is strongly related to urinary nephrin in type 2 diabetes patients

(2016) Ciorba Pop Mariana et al.   INTERNATIONAL UROLOGY AND NEPHROLOGY

Prevalence and control of hypertension in the general practice in Italy: updated analysis of a large database

(2016) G Tocci et al.   JOURNAL OF HUMAN HYPERTENSION

Gene Therapy With Angiotensin-(1-9) Preserves Left Ventricular Systolic Function After Myocardial Infarction

(2016) Caroline Fattah et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

New Approaches in the Treatment of Hypertension

(2015) S. Oparil et al.   CIRCULATION RESEARCH

Novel RAAS agonists and antagonists: clinical applications and controversies

(2015) Cesar A. Romero et al.   Nature Reviews Endocrinology

Angiotensin-Converting Enzyme Inhibition Attenuates Lipopolysaccharide-Induced Lung Injury by Regulating the Balance Between Angiotensin-Converting Enzyme and Angiotensin-Converting Enzyme 2 and Inhibiting Mitogen-Activated Protein Kinase Activation

(2015) Yingchuan Li et al.   SHOCK

Urinary Angiotensin-Converting Enzyme 2 in Hypertensive Patients May Be Increased by Olmesartan, an Angiotensin II Receptor Blocker

(2014) M. Furuhashi et al.   AMERICAN JOURNAL OF HYPERTENSION

Human intestine luminal ACE2 and amino acid transporter expression increased by ACE-inhibitors

(2014) Raphael N. Vuille-dit-Bille et al.   AMINO ACIDS

Urinary angiotensin-converting enzyme 2 increases in diabetic nephropathy by angiotensin II type 1 receptor blocker olmesartan

(2014) Masanori Abe et al.   JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM

The Association of Cardioprotective Medications with Pneumonia-Related Outcomes

(2014) Albert Wu et al.   PLoS One

Risk of Hospitalization for Community Acquired Pneumonia with Renin-Angiotensin Blockade in Elderly Patients: A Population-Based Study

(2014) Sachin Shah et al.   PLoS One

Angiotensin-converting enzyme 2 protects from lethal avian influenza A H5N1 infections

(2014) Zhen Zou et al.   Nature Communications

Angiotensin-converting enzyme 2 (ACE2) mediates influenza H7N9 virus-induced acute lung injury

(2014) Penghui Yang et al.   Scientific Reports

Immunosenescent CD8 + T Cells and C-X-C Chemokine Receptor Type 3 Chemokines Are Increased in Human Hypertension

(2013) Jong-Chan Youn et al.   HYPERTENSION

Community-acquired pneumonia in patients with chronic obstructive pulmonary disease requiring admission to the intensive care unit: Risk factors for mortality

(2013) Aykut Cilli et al.   JOURNAL OF CRITICAL CARE

TMPRSS2 and ADAM17 Cleave ACE2 Differentially and Only Proteolysis by TMPRSS2 Augments Entry Driven by the Severe Acute Respiratory Syndrome Coronavirus Spike Protein

(2013) A. Heurich et al.   JOURNAL OF VIROLOGY

Cardiac Complications in Patients With Community-Acquired Pneumonia

(2012) Vicente F. Corrales-Medina et al.   CIRCULATION

Olmesartan medoxomil treatment potently improves cardiac myosin-induced dilated cardiomyopathy via the modulation of ACE-2 and ANG 1–7 mas receptor

(2012) Vijayakumar Sukumaran et al.   FREE RADICAL RESEARCH

Cardioprotective Effects of Telmisartan against Heart Failure in Rats Induced By Experimental Autoimmune Myocarditis through the Modulation of Angiotensin-Converting Enzyme-2/Angiotensin 1-7/Mas Receptor Axis

(2012) Vijayakumar Sukumaran et al.   International Journal of Biological Sciences

Influenza and SARS-Coronavirus Activating Proteases TMPRSS2 and HAT Are Expressed at Multiple Sites in Human Respiratory and Gastrointestinal Tracts

(2012) Stephanie Bertram et al.   PLoS One

Risk of pneumonia associated with use of angiotensin converting enzyme inhibitors and angiotensin receptor blockers: systematic review and meta-analysis

(2012) D. Caldeira et al.   BMJ-British Medical Journal

Guidelines for the management of adult lower respiratory tract infections - Full version

(2011) M. Woodhead et al.   CLINICAL MICROBIOLOGY AND INFECTION

Evidence that TMPRSS2 Activates the Severe Acute Respiratory Syndrome Coronavirus Spike Protein for Membrane Fusion and Reduces Viral Control by the Humoral Immune Response

(2011) I. Glowacka et al.   JOURNAL OF VIROLOGY

Long-term systemic angiotensin II type 1 receptor blockade regulates mRNA expression of dorsomedial medulla renin-angiotensin system components

(2011) Shea Gilliam-Davis et al.   PHYSIOLOGICAL GENOMICS

A structural network associated with the kallikrein-kinin and renin-angiotensin systems

(2010) Veronika Stoka et al.   BIOLOGICAL CHEMISTRY

Efficient Activation of the Severe Acute Respiratory Syndrome Coronavirus Spike Protein by the Transmembrane Protease TMPRSS2

(2010) S. Matsuyama et al.   JOURNAL OF VIROLOGY

Blood-pressure reduction with LCZ696, a novel dual-acting inhibitor of the angiotensin II receptor and neprilysin: a randomised, double-blind, placebo-controlled, active comparator study

(2010) Luis Miguel Ruilope et al.   LANCET

Losartan, an antagonist of AT1 receptor for angiotensin II, attenuates lipopolysaccharide-induced acute lung injury in rat

(2008) Ling Liu et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Pharmacologic modulation of ACE2 expression

(2008) María José Soler et al.   CURRENT HYPERTENSION REPORTS

Angiotensin-converting enzyme 2: implications for blood pressure and kidney disease

(2008) Julie R Ingelfinger   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

Differential regulation of renal angiotensin-converting enzyme (ACE) and ACE2 during ACE inhibition and dietary sodium restriction in healthy rats

(2008) I. Hamming et al.   EXPERIMENTAL PHYSIOLOGY

The discovery of angiotensin-converting enzyme 2 and its role in acute lung injury in mice

(2008) Yumiko Imai et al.   EXPERIMENTAL PHYSIOLOGY