Exendin-4 Attenuates Remodeling in the Remote Myocardium of Rats After an Acute Myocardial Infarction by Activating β-Arrestin-2, Protein Phosphatase 2A, and Glycogen Synthase Kinase-3 and Inhibiting β-Catenin

Cardiac Cyclic Nucleotide Phosphodiesterases: Roles and Therapeutic Potential in Heart Failure

(2020) Michael E. J. Preedy   CARDIOVASCULAR DRUGS AND THERAPY

Exendin-4 Ameliorates Cardiac Remodeling in Experimentally Induced Myocardial Infarction in Rats by Inhibiting PARP1/NF-κB Axis in A SIRT1-Dependent Mechanism

(2020) Refaat A. Eid et al.   Cardiovascular Toxicology

Exendin‐4 protects the hearts of rats from ischemia/reperfusion injury by boosting antioxidant levels and inhibition of JNK/p 66 Shc/NADPH axis

(2020) Refaat A. Eid et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Exendin-4 Protects Against Myocardial Ischemia-Reperfusion Injury by Upregulation of SIRT1 and SIRT3 and Activation of AMPK

(2020) Refaat A. Eid et al.   Journal of Cardiovascular Translational Research

Protective effects of glucagon‐like peptide‐1 on cardiac remodeling by inhibiting oxidative stress through mammalian target of rapamycin complex 1/p70 ribosomal protein S6 kinase pathway in diabetes mellitus

(2019) Dongjuan Wang et al.   Journal of Diabetes Investigation

Cardioprotective effect of ghrelin against myocardial infarction-induced left ventricular injury via inhibition of SOCS3 and activation of JAK2/STAT3 signaling

(2018) Refaat A. Eid et al.   BASIC RESEARCH IN CARDIOLOGY

Subacute ghrelin administration inhibits apoptosis and improves ultrastructural abnormalities in remote myocardium post-myocardial infarction

(2018) Refaat A. Eid et al.   BIOMEDICINE & PHARMACOTHERAPY

Two distinct domains of the glucagon-like peptide-1 receptor control peptide-mediated biased agonism

(2018) Saifei Lei et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crosstalk between the TGF-β and WNT signalling pathways during cardiac fibrogenesis

(2018) Edyta Działo et al.   ACTA BIOCHIMICA POLONICA

β-Arrestin2 Improves Post–Myocardial Infarction Heart Failure via Sarco(endo)plasmic Reticulum Ca 2+ -ATPase–Dependent Positive Inotropy in CardiomyocytesNovelty and Significance

(2017) Katie A. McCrink et al.   HYPERTENSION

Enhanced-autophagy by exenatide mitigates doxorubicin-induced cardiotoxicity

(2017) Kyung Hye Lee et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Exendin-4 inhibits structural remodeling and improves Ca 2+ homeostasis in rats with heart failure via the GLP-1 receptor through the eNOS/cGMP/PKG pathway

(2017) Jingjing Chen et al.   PEPTIDES

A Practical Guide to Approaching Biased Agonism at G Protein Coupled Receptors

(2017) Jaimee Gundry et al.   Frontiers in Neuroscience

Exendin-4 induces myocardial protection through MKK3 and Akt-1 in infarcted hearts

(2016) Jianfeng Du et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Myofibroblasts and inflammatory cells as players of cardiac fibrosis

(2016) Hitoshi Kurose et al.   ARCHIVES OF PHARMACAL RESEARCH

Enhanced protection against renal ischemia–reperfusion injury with combined melatonin and exendin-4 in a rodent model

(2016) Yi-Chih Chang et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Evidence for biased agonists and antagonists at the endothelin receptors

(2016) Janet J. Maguire   LIFE SCIENCES

Exendin-4 attenuates adverse cardiac remodelling in streptozocin-induced diabetes via specific actions on infiltrating macrophages

(2015) Mitchel Tate et al.   BASIC RESEARCH IN CARDIOLOGY

Exendin-4 protects against post-myocardial infarction remodelling via specific actions on inflammation and the extracellular matrix

(2015) Emma Robinson et al.   BASIC RESEARCH IN CARDIOLOGY

Loss of Secreted Frizzled-Related Protein-1 Leads to Deterioration of Cardiac Function in Mice and Plays a Role in Human Cardiomyopathy

(2015) P. Sklepkiewicz et al.   Circulation-Heart Failure

Fluoride-Induced Neuron Apoptosis and Expressions of Inflammatory Factors by Activating Microglia in Rat Brain

(2015) Nan Yan et al.   MOLECULAR NEUROBIOLOGY

Cross talk between PI3K-AKT-GSK-3β and PP2A pathways determines tau hyperphosphorylation

(2015) Yixuan Wang et al.   NEUROBIOLOGY OF AGING

Rutin Increases Muscle Mitochondrial Biogenesis with AMPK Activation in High-Fat Diet-Induced Obese Rats

(2015) Sangjin Seo et al.   Nutrients

Increased Stiffness Is the Major Early Abnormality in a Pig Model of Severe Aortic Stenosis and Predisposes to Congestive Heart Failure in the Absence of Systolic Dysfunction

(2015) K. Ishikawa et al.   Journal of the American Heart Association

Aldehyde dehydrogenase-2 protects against myocardial infarction-related cardiac fibrosis through modulation of the Wnt/β-catenin signaling pathway

(2015) Yingchun Zhou et al.   Therapeutics and Clinical Risk Management

Cardiovascular Actions of Incretin-Based Therapies

(2014) John R. Ussher et al.   CIRCULATION RESEARCH

Toll-Like Receptor-4 Modulates Survival by Induction of Left Ventricular Remodeling after Myocardial Infarction in Mice

(2014) A. Riad et al.   JOURNAL OF IMMUNOLOGY

Identification and Characterization of GLP-1 Receptor-Expressing Cells Using a New Transgenic Mouse Model

(2013) P. Richards et al.   DIABETES

Negative Impact of β-Arrestin-1 on Post-Myocardial Infarction Heart Failure via Cardiac and Adrenal-Dependent Neurohormonal Mechanisms

(2013) Ashley Bathgate-Siryk et al.   HYPERTENSION

GLP-1 receptor activation and Epac2 link atrial natriuretic peptide secretion to control of blood pressure

(2013) Minsuk Kim et al.   NATURE MEDICINE

Ambient fine particulate matter and ozone exposures induce inflammation in epicardial and perirenal adipose tissues in rats fed a high fructose diet

(2013) Lixian Sun et al.   Particle and Fibre Toxicology

Metformin Inhibits Angiotensin II-Induced Differentiation of Cardiac Fibroblasts into Myofibroblasts

(2013) Jian Bai et al.   PLoS One

Assessing left ventricular systolic dysfunction after myocardial infarction: are ejection fraction and dP/dtmax complementary or redundant?

(2012) Kiyotake Ishikawa et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Cardiovascular Biology of the Incretin System

(2012) John R. Ussher et al.   ENDOCRINE REVIEWS

The Glucagon-Like Peptide-1 Receptor—or Not?

(2012) Charles Pyke et al.   ENDOCRINOLOGY

Molecular Mechanisms Underlying Cardiac Protein Phosphatase 2A Regulation in Heart

(2012) Sean T. DeGrande et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Exenatide reduces reperfusion injury in patients with ST-segment elevation myocardial infarction

(2011) Jacob Lønborg et al.   EUROPEAN HEART JOURNAL

Glycogen synthase kinase-3 is essential for β-arrestin-2 complex formation and lithium-sensitive behaviors in mice

(2011) W. Timothy O’Brien et al.   JOURNAL OF CLINICAL INVESTIGATION

Active Wnt signaling in response to cardiac injury

(2010) Martinus I. F. J. Oerlemans et al.   BASIC RESEARCH IN CARDIOLOGY

Pyrvinium, a Potent Small Molecule Wnt Inhibitor, Promotes Wound Repair and Post-MI Cardiac Remodeling

(2010) Sarika Saraswati et al.   PLoS One

Secreted Frizzled Related Protein 4 Reduces Fibrosis Scar Size and Ameliorates Cardiac Function After Ischemic Injury

(2010) Kentaro Matsushima et al.   TISSUE ENGINEERING PART A

Infarto do miocárdio experimental em ratos: análise do modelo

(2009) Leonardo A. M. Zornoff et al.   Arquivos Brasileiros de Cardiologia

Hypoxia-activated Smad3-specific Dephosphorylation by PP2A

(2009) Pekka T. Heikkinen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Exenatide Reduces Infarct Size and Improves Cardiac Function in a Porcine Model of Ischemia and Reperfusion Injury

(2009) Leo Timmers et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Identification of Potential Pharmacological Targets by Analysis of the Comprehensive G Protein-Coupled Receptor Repertoire in the Four Cardiac Chambers

(2009) T. Moore-Morris et al.   MOLECULAR PHARMACOLOGY

Regulation of the ankyrin-B-based targeting pathway following myocardial infarction

(2008) Thomas J. Hund et al.   CARDIOVASCULAR RESEARCH

Secreted Frizzled-related protein 2 is a procollagen C proteinase enhancer with a role in fibrosis associated with myocardial infarction

(2008) Koichi Kobayashi et al.   NATURE CELL BIOLOGY

Protective effects of GLP-1 analogues exendin-4 and GLP-1(9–36) amide against ischemia–reperfusion injury in rat heart

(2007) David P. Sonne et al.   REGULATORY PEPTIDES