CD38: A Potential Therapeutic Target in Cardiovascular Disease

The beneficial health effects of flavonoids on the cardiovascular system: Focus on K+ channels

(2020) F Fusi et al.   PHARMACOLOGICAL RESEARCH

Targeting NLRP3 (Nucleotide-Binding Domain, Leucine-Rich–Containing Family, Pyrin Domain–Containing-3) Inflammasome in Cardiovascular Disorders

(2019) Zheng Wang et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Inhibition of CD38 with the thiazoloquin(az)olin(on)e 78c protects the heart against post-ischemic injury

(2019) James Boslett et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

DNA damage-induced PARP1 activation confers cardiomyocyte dysfunction through NAD+ depletion in experimental atrial fibrillation

(2019) Deli Zhang et al.   Nature Communications

MR (Mineralocorticoid Receptor) Induces Adipose Tissue Senescence and Mitochondrial Dysfunction Leading to Vascular Dysfunction in Obesity

(2019) Clara Lefranc et al.   HYPERTENSION

Rational Design and Identification of Small‐Molecule Allosteric Inhibitors of CD38.

(2019) Liangren Zhang et al.   CHEMBIOCHEM

Targeting CD38 Enhances the Antileukemic Activity of Ibrutinib in Chronic Lymphocytic Leukemia

(2019) Alak Manna et al.   CLINICAL CANCER RESEARCH

Rationale and tutorial for analysing and reporting sex differences in cardiovascular associations

(2019) Mark Woodward   HEART

The endothelial mineralocorticoid receptor: Contributions to sex differences in cardiovascular disease

(2019) M. Elizabeth Moss et al.   PHARMACOLOGY & THERAPEUTICS

NAADP Receptors

(2019) Antony Galione   Cold Spring Harbor Perspectives in Biology

Direct Gating of the TRPM2 Channel by cADPR via Specific Interactions with the ADPR Binding Pocket

(2019) Peilin Yu et al.   Cell Reports

The Multi-faceted Ecto-enzyme CD38: Roles in Immunomodulation, Cancer, Aging, and Metabolic Diseases

(2019) Kelly A. Hogan et al.   Frontiers in Immunology

Increased Vascular Contractility in Hypertension Results From Impaired Endothelial Calcium Signaling

(2019) Calum Wilson et al.   HYPERTENSION

Resolving the topological enigma in Ca2+-signaling by cyclic ADP-ribose and NAADP

(2019) Hon Cheung Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Characterization of CD38 in the major cell types of the heart: endothelial cells highly express CD38 with activation by hypoxia-reoxygenation triggering NAD(P)H depletion

(2018) James Boslett et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Emerging potential benefits of modulating NAD+ metabolism in cardiovascular disease

(2018) Daniel S. Matasic et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Nanobody-based dual epitopes protein identification (DepID) assay for measuring soluble CD38 in plasma of multiple myeloma patients

(2018) Ting Li et al.   ANALYTICA CHIMICA ACTA

SIRT1 and SIRT6 Signaling Pathways in Cardiovascular Disease Protection

(2018) Nunzia D'Onofrio et al.   ANTIOXIDANTS & REDOX SIGNALING

A Potent and Specific CD38 Inhibitor Ameliorates Age-Related Metabolic Dysfunction by Reversing Tissue NAD + Decline

(2018) Mariana G. Tarragó et al.   Cell Metabolism

Blockade of CD38 diminishes lipopolysaccharide-induced macrophage classical activation and acute kidney injury involving NF-κB signaling suppression

(2018) Bingyan Shu et al.   CELLULAR SIGNALLING

Calcium Signaling and Reactive Oxygen Species in Mitochondria

(2018) Edoardo Bertero et al.   CIRCULATION RESEARCH

Novel Role for the Immunoproteasome Subunit PSMB10 in Angiotensin II–Induced Atrial Fibrillation in MiceNovelty and Significance

(2018) Jing Li et al.   HYPERTENSION

Hypoxia-Induced Mitogenic Factor Promotes Cardiac Hypertrophy via Calcium-Dependent and Hypoxia-Inducible Factor-1α MechanismsNovelty and Significance

(2018) Santosh Kumar et al.   HYPERTENSION

CD38 produces nicotinic acid adenosine dinucleotide phosphate in the lysosome

(2018) Cheng Fang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genetic deletion of CD38 confers post-ischemic myocardial protection through preserved pyridine nucleotides

(2018) James Boslett et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

N 6-Methyladenosine modification of lincRNA 1281 is critically required for mESC differentiation potential

(2018) Dandan Yang et al.   NUCLEIC ACIDS RESEARCH

Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults

(2018) Christopher R. Martens et al.   Nature Communications

Pure dietary flavonoids quercetin and (−)-epicatechin augment nitric oxide products and reduce endothelin-1 acutely in healthy men

(2018) Wai Mun Loke et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Role of inflammation in the pathogenesis of atherosclerosis and therapeutic interventions

(2018) Paolo Raggi et al.   ATHEROSCLEROSIS

CD38 Deficiency Protects Heart from High Fat Diet-Induced Oxidative Stress Via Activating Sirt3/FOXO3 Pathway

(2018) Ling-Fang Wang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Pulmonary arterial hypertension induced by a novel method: Twice-intraperitoneal injection of monocrotaline

(2018) Wei Zhuang et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Cardiovascular effects of flavonoids

(2018) Manuel Sanchez et al.   CURRENT MEDICINAL CHEMISTRY

Oxidative activation of type III CD38 by NADPH oxidase–derived hydrogen peroxide in Ca2+ signaling

(2018) Dae-Ryoung Park et al.   FASEB JOURNAL

Emerging role of SIRT3 in mitochondrial dysfunction and cardiovascular diseases

(2018) Jie Wu et al.   FREE RADICAL RESEARCH

Forecasting life expectancy, years of life lost, and all-cause and cause-specific mortality for 250 causes of death: reference and alternative scenarios for 2016–40 for 195 countries and territories

(2018) Kyle J Foreman et al.   LANCET

17β-Estradiol Promotes Apoptosis in Airway Smooth Muscle Cells Through CD38/SIRT1/p53 Pathway

(2018) Yu Liu et al.   Frontiers in Endocrinology

Modulation of signaling mechanisms in the heart by thioredoxin 1

(2017) Narayani Nagarajan et al.   FREE RADICAL BIOLOGY AND MEDICINE

Implication of CD38 gene in autophagic degradation of collagen I in mouse coronary arterial myocytes

(2017) Pin-Lan  Li   Frontiers in Bioscience-Landmark

CD38 positively regulates postnatal development of astrocytes cell-autonomously and oligodendrocytes non-cell-autonomously

(2017) Tsuyoshi Hattori et al.   GLIA

CD38 modulates respiratory syncytial virus-driven proinflammatory processes in human monocyte-derived dendritic cells

(2017) Ilaria Schiavoni et al.   IMMUNOLOGY

Synthesis of the Ca 2+ -mobilizing messengers NAADP and cADPR by intracellular CD38 enzyme in the mouse heart: Role in β-adrenoceptor signaling

(2017) Wee K. Lin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CD38 promotes angiotensin II-induced cardiac hypertrophy

(2017) Xiao-Hui Guan et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Luteolinidin Protects the Postischemic Heart through CD38 Inhibition with Preservation of NAD(P)(H)

(2017) James Boslett et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Role of autophagy in advanced atherosclerosis

(2017) Yu-Ning Zhu et al.   Molecular Medicine Reports

CD38 in the pathogenesis of allergic airway disease: Potential therapeutic targets

(2017) Deepak A. Deshpande et al.   PHARMACOLOGY & THERAPEUTICS

Cytosolic interaction of type III human CD38 with CIB1 modulates cellular cyclic ADP-ribose levels

(2017) Jun Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Nuclear Receptor LXR Limits Bacterial Infection of Host Macrophages through a Mechanism that Impacts Cellular NAD Metabolism

(2017) Jonathan Matalonga et al.   Cell Reports

Inflammation in atherosclerosis

(2016) Soraya Taleb   Archives of Cardiovascular Diseases

Daratumumab depletes CD38+ immune regulatory cells, promotes T-cell expansion, and skews T-cell repertoire in multiple myeloma

(2016) J. Krejcik et al.   BLOOD

Why NAD + Declines during Aging: It’s Destroyed

(2016) Michael B. Schultz et al.   Cell Metabolism

CD38 Dictates Age-Related NAD Decline and Mitochondrial Dysfunction through an SIRT3-Dependent Mechanism

(2016) Juliana Camacho-Pereira et al.   Cell Metabolism

Lysosomal cholesterol accumulation in macrophages leading to coronary atherosclerosis in CD38−/−mice

(2016) Xiaoyang Xu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) and Cyclic ADP-Ribose (cADPR) Mediate Ca2+ Signaling in Cardiac Hypertrophy Induced by β-Adrenergic Stimulation

(2016) Rukhsana Gul et al.   PLoS One

CD38 Mediates Angiotensin II–Induced Intracellular Ca2+Release in Rat Pulmonary Arterial Smooth Muscle Cells

(2015) Suengwon Lee et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Contribution of Nrf2 to Atherogenic Phenotype Switching of Coronary Arterial Smooth Muscle Cells Lacking CD38 Gene

(2015) Ming Xu et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Comparative Analysis of Pharmacophore Features and Quantitative Structure-Activity Relationships for CD38 Covalent and Non-covalent Inhibitors

(2015) Shuang Zhang et al.   Chemical Biology & Drug Design

Discovery of 4-Amino-8-quinoline Carboxamides as Novel, Submicromolar Inhibitors of NAD-Hydrolyzing Enzyme CD38

(2015) J. David Becherer et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery, Synthesis, and Biological Evaluation of Thiazoloquin(az)olin(on)es as Potent CD38 Inhibitors

(2015) Curt D. Haffner et al.   JOURNAL OF MEDICINAL CHEMISTRY

Targeting CD38 with Daratumumab Monotherapy in Multiple Myeloma

(2015) Henk M. Lokhorst et al.   NEW ENGLAND JOURNAL OF MEDICINE

Depletion of NADP(H) due to CD38 activation triggers endothelial dysfunction in the postischemic heart

(2015) Levy A. Reyes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Defective autophagosome trafficking contributes to impaired autophagic flux in coronary arterial myocytes lacking CD38 gene

(2014) Yang Zhang et al.   CARDIOVASCULAR RESEARCH

Regulation of Akt Signaling by Sirtuins

(2014) Vinodkumar B. Pillai et al.   CIRCULATION RESEARCH

Cellular and Molecular Electrophysiology of Atrial Fibrillation Initiation, Maintenance, and Progression

(2014) Jordi Heijman et al.   CIRCULATION RESEARCH

The Clinical Profile and Pathophysiology of Atrial Fibrillation

(2014) Jason Andrade et al.   CIRCULATION RESEARCH

Inhibition of glioma progression by a newly discovered CD38 inhibitor

(2014) Eran Blacher et al.   INTERNATIONAL JOURNAL OF CANCER

Revealing CD38 Cellular Localization Using a Cell Permeable, Mechanism-Based Fluorescent Small-Molecule Probe

(2014) Jonathan H. Shrimp et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Self-eating in the plaque: what macrophage autophagy reveals about atherosclerosis

(2014) Ismail Sergin et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Declining NAD+ Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging

(2013) Ana P. Gomes et al.   CELL

CD73 Protein as a Source of Extracellular Precursors for Sustained NAD+Biosynthesis in FK866-treated Tumor Cells

(2013) Alessia Grozio et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Overexpression of SIRT1 in vascular smooth muscle cells attenuates angiotensin II-induced vascular remodeling and hypertension in mice

(2013) Peng Gao et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

CD38 Ligation in Peripheral Blood Mononuclear Cells of Myeloma Patients Induces Release of Protumorigenic IL-6 and Impaired Secretion of IFNγCytokines and Proliferation

(2013) Giorgio Fedele et al.   MEDIATORS OF INFLAMMATION

B lymphocytes trigger monocyte mobilization and impair heart function after acute myocardial infarction

(2013) Yasmine Zouggari et al.   NATURE MEDICINE

Type 2 ryanodine receptor: A novel therapeutic target in myocardial ischemia/reperfusion

(2013) Jérémy Fauconnier et al.   PHARMACOLOGY & THERAPEUTICS

The role of Na+/H+ exchanger in Ca2+ overload and ischemic myocardial damage in hearts from type 2 diabetic db/db mice

(2012) Ryuko Anzawa et al.   Cardiovascular Diabetology

Sirtuins and Pyridine Nucleotides

(2012) Maha Abdellatif   CIRCULATION RESEARCH

Flavonoid Apigenin Is an Inhibitor of the NAD+ase CD38: Implications for Cellular NAD+ Metabolism, Protein Acetylation, and Treatment of Metabolic Syndrome

(2012) C. Escande et al.   DIABETES

NAADP Mediates Insulin-Stimulated Glucose Uptake and Insulin Sensitization by PPARγ in Adipocytes

(2012) Eun-Kyung Song et al.   Cell Reports

Flavonoids as inhibitors of human CD38

(2011) Esther Kellenberger et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

CD38 and chronic lymphocytic leukemia: a decade later

(2011) F. Malavasi et al.   BLOOD

Disruption of CD38 gene enhances cardiac functions by elevating serum testosterone in the male null mice

(2011) Lu Gan et al.   LIFE SCIENCES

Expression of CD38 with intracellular enzymatic activity: a possible explanation for the insulin release induced by intracellular cADPR

(2011) Yasuhiko Ohta et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

CD38 Exacerbates Focal Cytokine Production, Postischemic Inflammation and Brain Injury after Focal Cerebral Ischemia

(2011) Chi-un Choe et al.   PLoS One

CD38 as a Regulator of Cellular NAD: A Novel Potential Pharmacological Target for Metabolic Conditions

(2009) Eduardo Chini   CURRENT PHARMACEUTICAL DESIGN

Ablation of triadin causes loss of cardiac Ca2+ release units, impaired excitation-contraction coupling, and cardiac arrhythmias

(2009) N. Chopra et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A novel signaling pathway of ADP-ribosyl cyclase activation by angiotensin II in adult rat cardiomyocytes

(2008) Rukhsana Gul et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Regulation of store-operated Ca2+ entry by CD38 in human airway smooth muscle

(2008) Gary C. Sieck et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Unsaturated lipid peroxidation-derived aldehydes activate autophagy in vascular smooth-muscle cells

(2008) Bradford G. Hill et al.   BIOCHEMICAL JOURNAL

Evolution and Function of the ADP Ribosyl Cyclase/CD38 Gene Family in Physiology and Pathology

(2008) Fabio Malavasi et al.   PHYSIOLOGICAL REVIEWS