Silencing of microRNA-135b inhibits invasion, migration, and stemness of CD24+CD44+ pancreatic cancer stem cells through JADE-1-dependent AKT/mTOR pathway

The MiR-135b–BMAL1–YY1 loop disturbs pancreatic clockwork to promote tumourigenesis and chemoresistance

(2018) Weiliang Jiang et al.   Cell Death & Disease

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2018) Freddie Bray et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Metabolism and Epigenetics of Pancreatic Cancer Stem Cells

(2018) M. Perusina Lanfranca et al.   SEMINARS IN CANCER BIOLOGY

MiR-1 inhibits prostate cancer PC3 cells proliferation through the Akt/mTOR signaling pathway by binding to c-Met

(2018) Song Gao et al.   BIOMEDICINE & PHARMACOTHERAPY

TGF-β1 promoted chondrocyte proliferation by regulating Sp1 through MSC-exosomes derived miR-135b

(2018) Rui Wang et al.   CELL CYCLE

Poor expression of microRNA-135b results in the inhibition of cisplatin resistance and proliferation and induces the apoptosis of gastric cancer cells through MST1-mediated MAPK signaling pathway

(2018) Jie Zhou et al.   FASEB JOURNAL

Interleukin 1 Upregulates MicroRNA 135b to Promote Inflammation-associated Gastric Carcinogenesis in Mice

(2018) Tae-Su Han et al.   GASTROENTEROLOGY

Hypoxia potentiates gemcitabine-induced stemness in pancreatic cancer cells through AKT/Notch1 signaling

(2018) Zhengle Zhang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

The Orexin-A-Regulated Akt/mTOR Pathway Promotes Cell Proliferation Through Inhibiting Apoptosis in Pancreatic Cancer Cells

(2018) Linna Suo et al.   Frontiers in Endocrinology

Ligustrazine promoted hypoxia-treated cell growth by upregulation of miR-135b in human umbilical vein endothelial cells

(2018) Shujing Wei et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Delivery of miR-212 by chimeric peptide-condensed supramolecular nanoparticles enhances the sensitivity of pancreatic ductal adenocarcinoma to doxorubicin

(2018) Wei Chen et al.   BIOMATERIALS

The epithelial to mesenchymal transition (EMT) and cancer stem cells: implication for treatment resistance in pancreatic cancer

(2017) Pingting Zhou et al.   Molecular Cancer

Upregulation of microRNA-135b and microRNA-182 promotes chemoresistance of colorectal cancer by targeting ST6GALNAC2 via PI3K/AKT pathway

(2017) Bing Liu et al.   MOLECULAR CARCINOGENESIS

Expression of SOX2, NANOG and OCT4 in a mouse model of lipopolysaccharide-induced acute uterine injury and intrauterine adhesions

(2017) Li Xiao et al.   Reproductive Biology and Endocrinology

Correlation analysis of VHL and Jade-1 gene expression in human renal cell carcinoma

(2016) Wu Xiao-fen et al.   Open Medicine

MTUS1 and its targeting miRNAs in colorectal carcinoma: significant associations

(2015) Onder Ozcan et al.   TUMOR BIOLOGY

A new role for the PI3K/Akt signaling pathway in the epithelial-mesenchymal transition

(2015) Wenting Xu et al.   Cell Adhesion & Migration

PI3K/AKT/mTOR and sonic hedgehog pathways cooperate together to inhibit human pancreatic cancer stem cell characteristics and tumor growth

(2015) Narinder Sharma et al.   Oncotarget

Pancreatic Adenocarcinoma

(2015) David P. Ryan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Role of aberrant PI3K pathway activation in gallbladder tumorigenesis

(2015) Andrea Lunardi et al.   Oncotarget

Regulation of Colorectal Carcinoma Stemness, Growth, and Metastasis by an miR-200c-Sox2-Negative Feedback Loop Mechanism

(2014) Y.-X. Lu et al.   CLINICAL CANCER RESEARCH

DNMT-dependent suppression of microRNA regulates the induction of GBM tumor-propagating phenotype by Oct4 and Sox2

(2014) H Lopez-Bertoni et al.   ONCOGENE

Embelin Suppresses Growth of Human Pancreatic Cancer Xenografts, and Pancreatic Cancer Cells Isolated from KrasG12D Mice by Inhibiting Akt and Sonic Hedgehog Pathways

(2014) Minzhao Huang et al.   PLoS One

Increased expression of the pluripotency markers sex-determining region Y-box 2 and Nanog homeobox in ovarian endometriosis

(2014) Yong Song et al.   Reproductive Biology and Endocrinology

Embryonic stem cell factors and pancreatic cancer

(2014) Marta Herreros-Villanueva   WORLD JOURNAL OF GASTROENTEROLOGY

Mechanistic target of rapamycin (mTOR): a point of convergence in the action of insulin/IGF-1 and G protein-coupled receptor agonists in pancreatic cancer cells

(2014) Enrique Rozengurt   Frontiers in Physiology

miR-135b Coordinates Progression of ErbB2-Driven Mammary Carcinomas through Suppression of MID1 and MTCH2

(2013) Maddalena Arigoni et al.   AMERICAN JOURNAL OF PATHOLOGY

Functional characterisation of osteosarcoma cell lines and identification of mRNAs and miRNAs associated with aggressive cancer phenotypes

(2013) S U Lauvrak et al.   BRITISH JOURNAL OF CANCER

Candidate Tumor Suppressor and pVHL Partner Jade-1 Binds and Inhibits AKT in Renal Cell Carcinoma

(2013) L. Zeng et al.   CANCER RESEARCH

Expression of the pluripotent transcription factor OCT4 promotes cell migration in endometriosis

(2013) Jui-Hung Chang et al.   FERTILITY AND STERILITY

MicroRNA-135b promotes lung cancer metastasis by regulating multiple targets in the Hippo pathway and LZTS1

(2013) Ching-Wen Lin et al.   Nature Communications

MicroRNA-135b and Its Circuitry Networks as Potential Therapeutic Targets in Colon Cancer

(2013) Rohini Khatri et al.   Frontiers in Oncology

GANT-61 inhibits pancreatic cancer stem cell growth in vitro and in NOD/SCID/IL2R gamma null mice xenograft

(2012) Junsheng Fu et al.   CANCER LETTERS

Polycystin-1 regulates the stability and ubiquitination of transcription factor Jade-1

(2012) R. L. Foy et al.   HUMAN MOLECULAR GENETICS

The Ciliary Protein Nephrocystin-4 Translocates the Canonical Wnt Regulator Jade-1 to the Nucleus to Negatively Regulate β-Catenin Signaling

(2012) Lori Borgal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Stem cell transcription factor NANOG controls cell migration and invasion via dysregulation of E-cadherin and FoxJ1 and contributes to adverse clinical outcome in ovarian cancers

(2012) M K Y Siu et al.   ONCOGENE

The evolution of the TOR pathway and its role in cancer

(2012) E M Beauchamp et al.   ONCOGENE

Global microRNA expression profiling of microdissected tissues identifies miR-135b as a novel biomarker for pancreatic ductal adenocarcinoma

(2011) Johanna B. Munding et al.   INTERNATIONAL JOURNAL OF CANCER

Resveratrol Inhibits Pancreatic Cancer Stem Cell Characteristics in Human and KrasG12D Transgenic Mice by Inhibiting Pluripotency Maintaining Factors and Epithelial-Mesenchymal Transition

(2011) Sharmila Shankar et al.   PLoS One

Epidermal growth factor induces HCCR expression via PI3K/Akt/mTOR signaling in PANC-1 pancreatic cancer cells

(2010) Zekuan Xu et al.   BMC CANCER

With TOR, Less Is More: A Key Role for the Conserved Nutrient-Sensing TOR Pathway in Aging

(2010) Pankaj Kapahi et al.   Cell Metabolism