Cancer stemness in hepatocellular carcinoma: mechanisms and translational potential
Published 2020 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Cancer stemness in hepatocellular carcinoma: mechanisms and translational potential
Authors
Keywords
-
Journal
BRITISH JOURNAL OF CANCER
Volume 122, Issue 10, Pages 1428-1440
Publisher
Springer Science and Business Media LLC
Online
2020-03-31
DOI
10.1038/s41416-020-0823-9
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- SIRT 1/ MRPS 5 axis enhances the metabolic flexibility of liver cancer stem cells
- (2019) Zhihao Wei et al. HEPATOLOGY
- Genome-wide RNAi Screen identifies PMPCB as a therapeutic vulnerability in EpCAM+ hepatocellular carcinoma
- (2019) Atsushi Takai et al. CANCER RESEARCH
- Insulin receptor isoform A favors tumor progression in human hepatocellular carcinoma by increasing stem/progenitor cell features
- (2019) Eva Benabou et al. CANCER LETTERS
- CXCL11 promotes self-renewal and tumorigenicity of α2δ1+ liver tumor-initiating cells through CXCR3/ERK1/2 signaling
- (2019) Yuan Zhang et al. CANCER LETTERS
- TNF-α derived from M2 tumor-associated macrophages promotes epithelial-mesenchymal transition and cancer stemness through the Wnt/β-catenin pathway in SMMC-7721 hepatocellular carcinoma cells
- (2019) Yongxu Chen et al. EXPERIMENTAL CELL RESEARCH
- c-Met signaling is essential for mouse adult liver progenitor cells expansion after TGF-β-induced EMT and regulates cell phenotypic switch
- (2019) Laura Almalé et al. STEM CELLS
- TLR 4 increases the stemness and is highly expressed in relapsed human hepatocellular carcinoma
- (2019) Shuang Zhou et al. Cancer Medicine
- IL-6/JAK1 pathway drives PD-L1 Y112 phosphorylation to promote cancer immune evasion
- (2019) Li-Chuan Chan et al. JOURNAL OF CLINICAL INVESTIGATION
- Cancer-associated fibroblasts endow stem-like qualities to liver cancer cells by modulating autophagy
- (2019) Zhenxiong Zhao et al. Cancer Management and Research
- Collagen 1A1 (COL1A1) Is a Reliable Biomarker and Putative Therapeutic Target for Hepatocellular Carcinogenesis and Metastasis
- (2019) Hon-Ping Ma et al. Cancers
- IRAK1 Augments Cancer Stemness and Drug Resistance via the AP-1/AKR1B10 Signaling Cascade in Hepatocellular Carcinoma
- (2018) Bowie Y. Cheng et al. CANCER RESEARCH
- Metabolic reprogramming enables hepatocarcinoma cells to efficiently adapt and survive to a nutrient-restricted microenvironment
- (2018) Shamir Cassim et al. CELL CYCLE
- Cripto-1 contributes to stemness in hepatocellular carcinoma by stabilizing Dishevelled-3 and activating Wnt/β-catenin pathway
- (2018) Regina Cheuk-Lam Lo et al. CELL DEATH AND DIFFERENTIATION
- Baicalein targets GTPase-mediated autophagy to eliminate liver tumor initiating stem cell-like cells resistant to mTORC1 inhibition
- (2018) Raymond Wu et al. HEPATOLOGY
- Efficacy of annexin A3 blockade in sensitizing hepatocellular carcinoma to sorafenib and regorafenib
- (2018) Man Tong et al. JOURNAL OF HEPATOLOGY
- Prevention of hepatocellular carcinoma by targeting MYCN-positive liver cancer stem cells with acyclic retinoid
- (2018) Xian-Yang Qin et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- CD133-directed CAR T cells for advanced metastasis malignancies: A phase I trial
- (2018) Yao Wang et al. OncoImmunology
- Enrichment of cancer stem cells via β-catenin contributing to the tumorigenesis of hepatocellular carcinoma
- (2018) Harshul Pandit et al. BMC CANCER
- Small molecule-mediated reprogramming of human hepatocytes into bipotent progenitor cells
- (2018) Yohan Kim et al. JOURNAL OF HEPATOLOGY
- Oncogenic STRAP Supports Hepatocellular Carcinoma Growth by Enhancing Wnt/β-catenin Signaling
- (2018) Wenhui Wang et al. MOLECULAR CANCER RESEARCH
- Transforming Growth Factor-β-Induced Cell Plasticity in Liver Fibrosis and Hepatocarcinogenesis
- (2018) Isabel Fabregat et al. Frontiers in Oncology
- The long noncoding RNA LncHDAC2 drives the self-renewal of liver cancer stem cells via activation of Hedgehog Signaling
- (2018) Jiayi Wu et al. JOURNAL OF HEPATOLOGY
- Cancer-associated fibroblasts promote the stemness of CD24+ liver cells via paracrine signaling
- (2018) Yawen Li et al. JOURNAL OF MOLECULAR MEDICINE-JMM
- iNOS promotes CD24+CD133+ liver cancer stem cell phenotype through a TACE/ADAM17-dependent Notch signaling pathway
- (2018) Ronghua Wang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Targeting glutaminase 1 attenuates stemness properties in hepatocellular carcinoma by increasing reactive oxygen species and suppressing Wnt/beta-catenin pathway
- (2018) Binghua Li et al. EBioMedicine
- Stearoyl-CoA Desaturase Promotes Liver Fibrosis and Tumor Development in Mice via a Wnt Positive-Signaling Loop by Stabilization of Low-Density Lipoprotein-Receptor-Related Proteins 5 and 6
- (2017) Keane K.Y. Lai et al. GASTROENTEROLOGY
- SENP1 promotes hypoxia-induced cancer stemness by HIF-1α deSUMOylation and SENP1/HIF-1α positive feedback loop
- (2017) Chun-Ping Cui et al. GUT
- Stearoyl-CoA desaturase regulates sorafenib resistance via modulation of ER stress-induced differentiation
- (2017) Mark Kin Fai Ma et al. JOURNAL OF HEPATOLOGY
- Mitophagy Controls the Activities of Tumor Suppressor p53 to Regulate Hepatic Cancer Stem Cells
- (2017) Kai Liu et al. MOLECULAR CELL
- Transcriptional activation of PD-L1 by Sox2 contributes to the proliferation of hepatocellular carcinoma cells
- (2017) Feng Zhong et al. ONCOLOGY REPORTS
- Dishevelled-3 phosphorylation is governed by HIPK2/PP1Cα/ITCH axis and the non-phosphorylated form promotes cancer stemness via LGR5 in hepatocellular carcinoma
- (2017) Yu-Man Tsui et al. Oncotarget
- C-terminal truncated hepatitis B virus X protein regulates tumorigenicity, self-renewal and drug resistance via STAT3/Nanog signaling pathway
- (2017) Rachel Hiu Ha Ching et al. Oncotarget
- Hepatocellular Carcinomas Originate Predominantly from Hepatocytes and Benign Lesions from Hepatic Progenitor Cells
- (2017) Krishna S. Tummala et al. Cell Reports
- Lipopolysaccharide supports maintaining the stemness of CD133+ hepatoma cells through activation of the NF-κB/HIF-1α pathway
- (2016) Fo-Bao Lai et al. CANCER LETTERS
- MELK is an oncogenic kinase essential for early hepatocellular carcinoma recurrence
- (2016) Hongping Xia et al. CANCER LETTERS
- NRBP2 Overexpression Increases the Chemosensitivity of Hepatocellular Carcinoma Cells via Akt Signaling
- (2016) Lixing Zhang et al. CANCER RESEARCH
- TSC1/2 mutations define a molecular subset of HCC with aggressive behaviour and treatment implication
- (2016) Daniel W H Ho et al. GUT
- The plastic cellular states of liver cells: Are EpCAM and Lgr5 fit for purpose?
- (2016) Meritxell Huch et al. HEPATOLOGY
- Octamer 4/microRNA-1246 signaling axis drives Wnt/β-catenin activation in liver cancer stem cells
- (2016) Stella Chai et al. HEPATOLOGY
- EpCAM-regulated intramembrane proteolysis induces a cancer stem cell-like gene signature in hepatitis B virus-infected hepatocytes
- (2016) Saravana Kumar Kailasam Mani et al. JOURNAL OF HEPATOLOGY
- Long non-coding RNA DILC regulates liver cancer stem cells via IL-6/STAT3 axis
- (2016) Xue Wang et al. JOURNAL OF HEPATOLOGY
- Laminin-332 sustains chemoresistance and quiescence as part of the human hepatic cancer stem cell niche
- (2016) Olivier Govaere et al. JOURNAL OF HEPATOLOGY
- lnc-β-Catm elicits EZH2-dependent β-catenin stabilization and sustains liver CSC self-renewal
- (2016) Pingping Zhu et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Regulation of a TGF-β1-CD147 self-sustaining network in the differentiation plasticity of hepatocellular carcinoma cells
- (2016) J Wu et al. ONCOGENE
- ASPP2 suppresses stem cell-like characteristics and chemoresistance by inhibiting the Src/FAK/Snail axis in hepatocellular carcinoma
- (2016) Lu Xu et al. TUMOR BIOLOGY
- lnc-β-Catm elicits EZH2-dependent β-catenin stabilization and sustains liver CSC self-renewal
- (2016) Pingping Zhu et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- C-terminal truncated hepatitis B virus X protein promotes hepatocellular carcinogenesis through induction of cancer and stem cell-like properties
- (2016) Kai-Yu Ng et al. Oncotarget
- Matrix stiffness-mediated effects on stemness characteristics occurring in HCC cells
- (2016) Yang You et al. Oncotarget
- Cancer-Associated Fibroblasts Regulate Tumor-Initiating Cell Plasticity in Hepatocellular Carcinoma through c-Met/FRA1/HEY1 Signaling
- (2016) Eunice Yuen Ting Lau et al. Cell Reports
- Identification of a unique hepatocellular carcinoma line, Li-7, with CD13(+) cancer stem cells hierarchy and population change upon its differentiation during culture and effects of sorafenib
- (2015) Takeshi Yamada et al. BMC CANCER
- Induction of tumor initiation is dependent on CD44s in c-Met+ hepatocellular carcinoma
- (2015) Hien Dang et al. BMC CANCER
- An Imbalance in TAZ and YAP Expression in Hepatocellular Carcinoma Confers Cancer Stem Cell-like Behaviors Contributing to Disease Progression
- (2015) H. Hayashi et al. CANCER RESEARCH
- The Long Noncoding RNA lncTCF7 Promotes Self-Renewal of Human Liver Cancer Stem Cells through Activation of Wnt Signaling
- (2015) Yanying Wang et al. Cell Stem Cell
- Nuclear factor kappa B-mediated CD47 up-regulation promotes sorafenib resistance and its blockade synergizes the effect of sorafenib in hepatocellular carcinoma in mice
- (2015) Jessica Lo et al. HEPATOLOGY
- RBMY, a novel inhibitor of glycogen synthase kinase 3β, increases tumor stemness and predicts poor prognosis of hepatocellular carcinoma
- (2015) Huey-Huey Chua et al. HEPATOLOGY
- Hypoxia promotes vasculogenic mimicry formation by the Twist1-Bmi1 connection in hepatocellular carcinoma
- (2015) KUN LIU et al. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
- Defeating EpCAM+ liver cancer stem cells by targeting chromatin remodeling enzyme CHD4 in human hepatocellular carcinoma
- (2015) Kouki Nio et al. JOURNAL OF HEPATOLOGY
- Lysine-specific demethylase 1 promotes the stemness and chemoresistance of Lgr5+ liver cancer initiating cells by suppressing negative regulators of β-catenin signaling
- (2015) Z-J Lei et al. ONCOGENE
- Annexin A3 as a Potential Target for Immunotherapy of Liver Cancer Stem-Like Cells
- (2015) Qiu-Zhong Pan et al. STEM CELLS
- CD24 promotes HCC progression via triggering Notch-related EMT and modulation of tumor microenvironment
- (2015) Xin Wan et al. TUMOR BIOLOGY
- ANXA3/JNK Signaling Promotes Self-Renewal and Tumor Growth, and Its Blockade Provides a Therapeutic Target for Hepatocellular Carcinoma
- (2015) Man Tong et al. Stem Cell Reports
- Recognition and killing of cancer stem-like cell population in hepatocellular carcinoma cells by cytokine-induced killer cells via NKG2d-ligands recognition
- (2015) Xiao-Xiang Rong et al. OncoImmunology
- ER Stress Cooperates with Hypernutrition to Trigger TNF-Dependent Spontaneous HCC Development
- (2014) Hayato Nakagawa et al. CANCER CELL
- MYC Activates Stem-like Cell Potential in Hepatocarcinoma by a p53-Dependent Mechanism
- (2014) H. Akita et al. CANCER RESEARCH
- Evolution of the Cancer Stem Cell Model
- (2014) Antonija Kreso et al. Cell Stem Cell
- Epigenetic modification of MiR-429 promotes liver tumour-initiating cell properties by targeting Rb binding protein 4
- (2014) Liang Li et al. GUT
- Blockade of CD47-mediated cathepsin S/protease-activated receptor 2 signaling provides a therapeutic target for hepatocellular carcinoma
- (2014) Terence Kin-Wah Lee et al. HEPATOLOGY
- A mesenchymal-like phenotype and expression of CD44 predict lack of apoptotic response to sorafenib in liver tumor cells
- (2014) Joan Fernando et al. INTERNATIONAL JOURNAL OF CANCER
- Knockdown of NANOG enhances chemosensitivity of liver cancer cells to doxorubicin by reducing MDR1 expression
- (2014) JIA-JIA ZHOU et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- Histone deacetylase 3 participates in self-renewal of liver cancer stem cells through histone modification
- (2013) Chungang Liu et al. CANCER LETTERS
- Cancer stem cells: A contentious hypothesis now moving forward
- (2013) Michael L. O’Connor et al. CANCER LETTERS
- Interleukin-8 is related to poor chemotherapeutic response and tumourigenicity in hepatocellular carcinoma
- (2013) Seo Young Park et al. EUROPEAN JOURNAL OF CANCER
- Expression of Intercellular Adhesion Molecule 1 by Hepatocellular Carcinoma Stem Cells and Circulating Tumor Cells
- (2013) Shupeng Liu et al. GASTROENTEROLOGY
- Whole-genome sequencing identifies recurrent mutations in hepatocellular carcinoma
- (2013) Z. Kan et al. GENOME RESEARCH
- Visualization of stem cell features in human hepatocellular carcinoma revealsin vivosignificance of tumor-host interaction and clinical course
- (2013) Shunsuke Muramatsu et al. HEPATOLOGY
- Maelstrom promotes hepatocellular carcinoma metastasis by inducing epithelial-mesenchymal transition by way of Akt/GSK-3β/Snail signaling
- (2013) Lulu Liu et al. HEPATOLOGY
- Reciprocal regulation by TLR4 and TGF-β in tumor-initiating stem-like cells
- (2013) Chia-Lin Chen et al. JOURNAL OF CLINICAL INVESTIGATION
- Telomere length, TERT and shelterin complex proteins in hepatocellular carcinomas expressing “stemness”-related markers
- (2013) Haeryoung Kim et al. JOURNAL OF HEPATOLOGY
- The transcription factor SALL4 regulates stemness of EpCAM-positive hepatocellular carcinoma
- (2013) Sha Sha Zeng et al. JOURNAL OF HEPATOLOGY
- In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration
- (2013) Meritxell Huch et al. NATURE
- Cancer stem cells: The challenges ahead
- (2013) Jan Paul Medema NATURE CELL BIOLOGY
- Hepatic Stellate Cells Secreted Hepatocyte Growth Factor Contributes to the Chemoresistance of Hepatocellular Carcinoma
- (2013) Guofeng Yu et al. PLoS One
- Concise Review: The Sox2-Oct4 Connection: Critical Players in a Much Larger Interdependent Network Integrated at Multiple Levels
- (2013) Angie Rizzino STEM CELLS
- BMP4 Administration Induces Differentiation of CD133+Hepatic Cancer Stem Cells, Blocking Their Contributions to Hepatocellular Carcinoma
- (2012) Lixing Zhang et al. CANCER RESEARCH
- Leucine-rich repeat-containing G protein-coupled receptor 5 regulates epithelial cell phenotype and survival of hepatocellular carcinoma cells
- (2012) Mariko Fukuma et al. EXPERIMENTAL CELL RESEARCH
- Cancer stem cells in solid tumors: an overview and new approaches for their isolation and characterization
- (2012) Virginia Tirino et al. FASEB JOURNAL
- Oncogene-specific formation of chemoresistant murine hepatic cancer stem cells
- (2012) Edward Kai-Hua Chow et al. HEPATOLOGY
- Circulating stem cell-like epithelial cell adhesion molecule-positive tumor cells indicate poor prognosis of hepatocellular carcinoma after curative resection
- (2012) Yun-Fan Sun et al. HEPATOLOGY
- Discrete nature of EpCAM+and CD90+cancer stem cells in human hepatocellular carcinoma
- (2012) Taro Yamashita et al. HEPATOLOGY
- Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma
- (2012) Wing-Kin Sung et al. NATURE GENETICS
- Integrated analysis of somatic mutations and focal copy-number changes identifies key genes and pathways in hepatocellular carcinoma
- (2012) Cécile Guichard et al. NATURE GENETICS
- CD24+ Liver Tumor-Initiating Cells Drive Self-Renewal and Tumor Initiation through STAT3-Mediated NANOG Regulation
- (2011) Terence Kin Wah Lee et al. Cell Stem Cell
- Human hepatic cancer stem cells are characterized by common stemness traits and diverse oncogenic pathways
- (2011) Jens U. Marquardt et al. HEPATOLOGY
- CD133+ liver tumor-initiating cells promote tumor angiogenesis, growth, and self-renewal through neurotensin/interleukin-8/CXCL1 signaling
- (2011) Kwan Ho Tang et al. HEPATOLOGY
- Hepatitis C Virus-Induced Cancer Stem Cell-Like Signatures in Cell Culture and Murine Tumor Xenografts
- (2011) N. Ali et al. JOURNAL OF VIROLOGY
- miR-130b Promotes CD133+ Liver Tumor-Initiating Cell Growth and Self-Renewal via Tumor Protein 53-Induced Nuclear Protein 1
- (2010) Stephanie Ma et al. Cell Stem Cell
- Granulin-Epithelin Precursor and ATP-Dependent Binding Cassette (ABC)B5 Regulate Liver Cancer Cell Chemoresistance
- (2010) Siu Tim Cheung et al. GASTROENTEROLOGY
- Lupeol targets liver tumor-initiating cells through phosphatase and tensin homolog modulation
- (2010) Terence Kin Wah Lee et al. HEPATOLOGY
- Octamer 4 (Oct4) mediates chemotherapeutic drug resistance in liver cancer cells through a potential Oct4-AKT-ATP-binding cassette G2 pathway
- (2010) Xiao Qi Wang et al. HEPATOLOGY
- CD13 is a therapeutic target in human liver cancer stem cells
- (2010) Naotsugu Haraguchi et al. JOURNAL OF CLINICAL INVESTIGATION
- Recurrent hepatocellular carcinoma cells with stem cell-like properties: possible targets for immunotherapy
- (2009) Xiaolan Xu et al. CYTOTHERAPY
- EpCAM, a new marker for cancer stem cells in hepatocellular carcinoma
- (2009) Benoit Terris et al. JOURNAL OF HEPATOLOGY
- EpCAM and -Fetoprotein Expression Defines Novel Prognostic Subtypes of Hepatocellular Carcinoma
- (2008) T. Yamashita et al. CANCER RESEARCH
- EpCAM-Positive Hepatocellular Carcinoma Cells Are Tumor-Initiating Cells With Stem/Progenitor Cell Features
- (2008) Taro Yamashita et al. GASTROENTEROLOGY
- Transforming growth factor-β and hepatocyte transdifferentiation in liver fibrogenesis
- (2008) Nadja M Meindl-Beinker et al. JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started