IL-6/JAK1 pathway drives PD-L1 Y112 phosphorylation to promote cancer immune evasion

Eradication of Triple-Negative Breast Cancer Cells by Targeting Glycosylated PD-L1

(2018) Chia-Wei Li et al.   CANCER CELL

Combined blockade of IL-6 and PD-1/PD-L1 signaling abrogates mutual regulation of their immunosuppressive effects in the tumor microenvironment

(2018) Hirotake Tsukamoto et al.   CANCER RESEARCH

PD-L1 on host cells is essential for PD-L1 blockade–mediated tumor regression

(2018) Haidong Tang et al.   JOURNAL OF CLINICAL INVESTIGATION

Host expression of PD-L1 determines efficacy of PD-L1 pathway blockade–mediated tumor regression

(2018) Heng Lin et al.   JOURNAL OF CLINICAL INVESTIGATION

Targeting the IL-6/JAK/STAT3 signalling axis in cancer

(2018) Daniel E. Johnson et al.   Nature Reviews Clinical Oncology

Mouse models of hepatocellular carcinoma: an overview and highlights for immunotherapy research

(2018) Zachary J. Brown et al.   Nature Reviews Gastroenterology & Hepatology

A major chromatin regulator determines resistance of tumor cells to T cell–mediated killing

(2018) Deng Pan et al.   SCIENCE

Genomic correlates of response to immune checkpoint therapies in clear cell renal cell carcinoma

(2018) Diana Miao et al.   SCIENCE

Oncogenic JAK2 V617F causes PD-L1 expression, mediating immune escape in myeloproliferative neoplasms

(2018) Alessandro Prestipino et al.   Science Translational Medicine

STT3-dependent PD-L1 accumulation on cancer stem cells promotes immune evasion

(2018) Jung-Mao Hsu et al.   Nature Communications

Metformin Promotes Antitumor Immunity via Endoplasmic-Reticulum-Associated Degradation of PD-L1

(2018) Jong-Ho Cha et al.   MOLECULAR CELL

AXER is an ATP/ADP exchanger in the membrane of the endoplasmic reticulum

(2018) Marie-Christine Klein et al.   Nature Communications

Palmitoylation stabilizes PD-L1 to promote breast tumor growth

(2018) Yi Yang et al.   CELL RESEARCH

High plasma interleukin-6 levels associated with poor prognosis of patients with advanced hepatocellular carcinoma

(2017) Yu-Yun Shao et al.   JAPANESE JOURNAL OF CLINICAL ONCOLOGY

Regorafenib for patients with hepatocellular carcinoma who progressed on sorafenib treatment (RESORCE): a randomised, double-blind, placebo-controlled, phase 3 trial

(2017) Jordi Bruix et al.   LANCET

Nivolumab in patients with advanced hepatocellular carcinoma (CheckMate 040): an open-label, non-comparative, phase 1/2 dose escalation and expansion trial

(2017) Anthony B El-Khoueiry et al.   LANCET

Identification of CMTM6 and CMTM4 as PD-L1 protein regulators

(2017) Riccardo Mezzadra et al.   NATURE

Cyclin D–CDK4 kinase destabilizes PD-L1 via cullin 3–SPOP to control cancer immune surveillance

(2017) Jinfang Zhang et al.   NATURE

CMTM6 maintains the expression of PD-L1 and regulates anti-tumour immunity

(2017) Marian L. Burr et al.   NATURE

Overall Survival with Combined Nivolumab and Ipilimumab in Advanced Melanoma

(2017) Jedd D. Wolchok et al.   NEW ENGLAND JOURNAL OF MEDICINE

Deubiquitination and Stabilization of PD-L1 by CSN5

(2016) Seung-Oe Lim et al.   CANCER CELL

Loss of IFN-γ Pathway Genes in Tumor Cells as a Mechanism of Resistance to Anti-CTLA-4 Therapy

(2016) Jianjun Gao et al.   CELL

Tumor Interferon Signaling Regulates a Multigenic Resistance Program to Immune Checkpoint Blockade

(2016) Joseph L. Benci et al.   CELL

Mutations Associated with Acquired Resistance to PD-1 Blockade in Melanoma

(2016) Jesse M. Zaretsky et al.   NEW ENGLAND JOURNAL OF MEDICINE

Epigenetic gene regulation by Janus kinase 1 in diffuse large B-cell lymphoma

(2016) Lixin Rui et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PD-L1 (B7-H1) and PD-1 pathway blockade for cancer therapy: Mechanisms, response biomarkers, and combinations

(2016) Weiping Zou et al.   Science Translational Medicine

Hepatocellular carcinoma

(2016) Josep M. Llovet et al.   Nature Reviews Disease Primers

Severe Hepatitis Promotes Hepatocellular Carcinoma Recurrence via NF- B Pathway-Mediated Epithelial-Mesenchymal Transition after Resection

(2015) T.-J. Wu et al.   CLINICAL CANCER RESEARCH

Proteolytic cleavage, trafficking, and functions of nuclear receptor tyrosine kinases

(2015) Mei-Kuang Chen et al.   FEBS Journal

Tim-3 expression in tumour-associated macrophages: a new player in HCC progression

(2015) Tobias Flecken et al.   GUT

Anti–PD-1/PD-L1 therapy of human cancer: past, present, and future

(2015) Lieping Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

IL-6 as a keystone cytokine in health and disease

(2015) Christopher A Hunter et al.   NATURE IMMUNOLOGY

Combination cancer immunotherapy and new immunomodulatory targets

(2015) Kathleen M. Mahoney et al.   NATURE REVIEWS DRUG DISCOVERY

Nivolumab and Ipilimumab versus Ipilimumab in Untreated Melanoma

(2015) Michael A. Postow et al.   NEW ENGLAND JOURNAL OF MEDICINE

Targeting JAK kinase in solid tumors: emerging opportunities and challenges

(2015) M Buchert et al.   ONCOGENE

Identification of Liver Cancer Progenitors Whose Malignant Progression Depends on Autocrine IL-6 Signaling

(2013) Guobin He et al.   CELL

Whole-genome sequencing identifies recurrent mutations in hepatocellular carcinoma

(2013) Z. Kan et al.   GENOME RESEARCH

MicroRNA-26a suppresses tumor growth and metastasis of human hepatocellular carcinoma by targeting interleukin-6-Stat3 pathway

(2013) Xin Yang et al.   HEPATOLOGY

N-Linked Protein Glycosylation in the Endoplasmic Reticulum

(2013) J. Breitling et al.   Cold Spring Harbor Perspectives in Biology

Serum interleukin-6 and C-reactive protein as a prognostic indicator in hepatocellular carcinoma

(2012) Jeong Won Jang et al.   CYTOKINE

Tim-3/galectin-9 signaling pathway mediates T-cell dysfunction and predicts poor prognosis in patients with hepatitis B virus-associated hepatocellular carcinoma

(2012) Hang Li et al.   HEPATOLOGY

JAKs go nuclear: Emerging role of nuclear JAK1 and JAK2 in gene expression and cell growth

(2011) Fouad A. Zouein et al.   GROWTH FACTORS

Dietary and Genetic Obesity Promote Liver Inflammation and Tumorigenesis by Enhancing IL-6 and TNF Expression

(2010) Eek Joong Park et al.   CELL

Nuclear trafficking of the epidermal growth factor receptor family membrane proteins

(2010) Y-N Wang et al.   ONCOGENE