Development and scale-up of the recovery and purification of a domain antibody Fc fusion protein-comparison of a two and three-step approach

A tandem laboratory scale protein purification process using Protein A affinity and anion exchange chromatography operated in a weak partitioning mode

(2013) Michael Shamashkin et al.   BIOTECHNOLOGY AND BIOENGINEERING

Using high throughput screening to define virus clearance by chromatography resins

(2013) Lisa Connell-Crowley et al.   BIOTECHNOLOGY AND BIOENGINEERING

Viral clearance by flow-through mode ion exchange columns and membrane adsorbers

(2013) G. R. Miesegaes et al.   BIOTECHNOLOGY PROGRESS

A model mechanism for protein precipitation by caprylic acid: Application to plasma purification

(2012) Victor Morais et al.   BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY

Caprylic acid precipitation method for impurity reduction: An alternative to conventional chromatography for monoclonal antibody purification

(2012) Yan Brodsky et al.   BIOTECHNOLOGY AND BIOENGINEERING

Applying high-throughput methods to develop a purification process for a highly glycosylated protein

(2012) Nooshafarin Sanaie et al.   Biotechnology Journal

Designing new monoclonal antibody purification processes using mixed-mode chromatography sorbents

(2011) Magali Toueille et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Developability Index: A Rapid In Silico Tool for the Screening of Antibody Aggregation Propensity

(2011) Timothy M. Lauer et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Comparison of the chromatographic properties of IgG1 and IgG2 antibody subclasses

(2010) Sanchayita Ghose et al.   BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY

Strategies for developing design spaces for viral clearance by anion exchange chromatography during monoclonal antibody production

(2010) Daniel M. Strauss et al.   BIOTECHNOLOGY PROGRESS

Performance of hexamer peptide ligands for affinity purification of immunoglobulin G from commercial cell culture media

(2010) Amith D. Naik et al.   JOURNAL OF CHROMATOGRAPHY A

Low-Level Expression of a Folding-Incompetent Protein in Escherichia coli: Search for the Molecular Determinants of Protein Aggregation In Vivo

(2010) Julia Winkelmann et al.   JOURNAL OF MOLECULAR BIOLOGY

Prediction of Aggregation Prone Regions of Therapeutic Proteins

(2010) Naresh Chennamsetty et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Recovery and purification process development for monoclonal antibody production

(2010) Hui F. Liu et al.   mAbs

Development and validation of a reverse phase HPLC method for the determination of caprylic acid in formulations of therapeutic immunoglobulins and its application to antivenom production

(2009) María Herrera et al.   BIOLOGICALS

Understanding the mechanism of virus removal by Q sepharose fast flow chromatography during the purification of CHO-cell derived biotherapeutics

(2009) Daniel M. Strauss et al.   BIOTECHNOLOGY AND BIOENGINEERING

Recent Advancement in Application of Hydrophobic Interaction Chromatography for Aggregate Removal in Industrial Purification Process

(2009) Yuefeng Lu et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Bacteriophage and impurity carryover and total organic carbon release during extended protein A chromatography

(2009) Scott Lute et al.   JOURNAL OF CHROMATOGRAPHY A

A mechanistic study of Protein A chromatography resin lifetime

(2009) Canping Jiang et al.   JOURNAL OF CHROMATOGRAPHY A

Aggregation-Prone Motifs in Human Immunoglobulin G

(2009) Naresh Chennamsetty et al.   JOURNAL OF MOLECULAR BIOLOGY

The Role of Biomacromolecular Crowding, Ionic Strength, and Physicochemical Gradients in the Complexities of Life's Emergence

(2009) J. Spitzer et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

CD40 and autoimmunity: The dark side of a great activator

(2009) Anna L. Peters et al.   SEMINARS IN IMMUNOLOGY

Viral clearance using disposable systems in monoclonal antibody commercial downstream processing

(2008) Joe X. Zhou et al.   BIOTECHNOLOGY AND BIOENGINEERING

High-throughput screening of chromatographic separations: II. Hydrophobic interaction

(2008) Jack F. Kramarczyk et al.   BIOTECHNOLOGY AND BIOENGINEERING

Host cell protein clearance during protein a chromatography: Development of an improved column wash step

(2008) Abhinav A. Shukla et al.   BIOTECHNOLOGY PROGRESS

Comparison of standard and new generation hydrophobic interaction chromatography resins in the monoclonal antibody purification process

(2007) Jie Chen et al.   JOURNAL OF CHROMATOGRAPHY A