Structural characterization of the interaction of α-synuclein nascent chains with the ribosomal surface and trigger factor

Structural disorder of monomeric α-synuclein persists in mammalian cells

(2016) Francois-Xavier Theillet et al.   NATURE

A structural ensemble of a ribosome–nascent chain complex during cotranslational protein folding

(2016) Lisa D Cabrita et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A structural ensemble of a ribosome–nascent chain complex during cotranslational protein folding

(2016) Lisa D Cabrita et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Folding of an intrinsically disordered protein by phosphorylation as a regulatory switch

(2014) Alaji Bah et al.   NATURE

Structural Basis for Protein Antiaggregation Activity of the Trigger Factor Chaperone

(2014) T. Saio et al.   SCIENCE

Electrostatic Effect of the Ribosomal Surface on Nascent Polypeptide Dynamics

(2013) Anders M. Knight et al.   ACS Chemical Biology

GROMACS 4.5: a high-throughput and highly parallel open source molecular simulation toolkit

(2013) Sander Pronk et al.   BIOINFORMATICS

A Relationship between the Aggregation Rates of α-Synuclein Variants and the β-Sheet Populations in Their Monomeric Forms

(2013) Carlo Camilloni et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Reshaping of the conformational search of a protein by the chaperone trigger factor

(2013) Alireza Mashaghi et al.   NATURE

Dynamic enzyme docking to the ribosome coordinates N-terminal processing with polypeptide folding

(2013) Arzu Sandikci et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

In-Cell NMR Characterization of the Secondary Structure Populations of a Disordered Conformation of α-Synuclein within E. coli Cells

(2013) Christopher A. Waudby et al.   PLoS One

The remarkable conformational plasticity of alpha-synuclein: blessing or curse?

(2013) Angélique Deleersnijder et al.   TRENDS IN MOLECULAR MEDICINE

Mechanisms of SecM-Mediated Stalling in the Ribosome

(2012) James Gumbart et al.   BIOPHYSICAL JOURNAL

Residue-Specific α-Helix Propensities from Molecular Simulation

(2012) Robert B. Best et al.   BIOPHYSICAL JOURNAL

An analysis of NMR sensitivity enhancements obtained using non-uniform weighted sampling, and the application to protein NMR

(2012) Christopher A. Waudby et al.   JOURNAL OF MAGNETIC RESONANCE

Trigger Factor Slows Co-translational Folding through Kinetic Trapping while Sterically Protecting the Nascent Chain from Aberrant Cytosolic Interactions

(2012) Edward P. O’Brien et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Concerted Action of the Ribosome and the Associated Chaperone Trigger Factor Confines Nascent Polypeptide Folding

(2012) Anja Hoffmann et al.   MOLECULAR CELL

In vivo translation rates can substantially delay the cotranslational folding of the Escherichia coli cytosolic proteome

(2012) P. Ciryam et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ribosome-associated chaperones as key players in proteostasis

(2012) Steffen Preissler et al.   TRENDS IN BIOCHEMICAL SCIENCES

The Ribosome Modulates Nascent Protein Folding

(2011) C. M. Kaiser et al.   SCIENCE

SecM-Stalled Ribosomes Adopt an Altered Geometry at the Peptidyl Transferase Center

(2011) Shashi Bhushan et al.   PLOS BIOLOGY

Protein folding in the cell: challenges and progress

(2010) Anne Gershenson et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Folding at the birth of the nascent chain: coordinating translation with co-translational folding

(2010) Gong Zhang et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Versatility of Trigger Factor Interactions with Ribosome-Nascent Chain Complexes

(2010) Sathish Kumar Lakshmipathy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

α-Helical nascent polypeptide chains visualized within distinct regions of the ribosomal exit tunnel

(2010) Shashi Bhushan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Cotranslational structure acquisition of nascent polypeptides monitored by NMR spectroscopy

(2010) C. Eichmann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pair potentials for protein folding: Choice of reference states and sensitivity of predicted native states to variations in the interaction schemes

(2010) Marcos R. Betancourt et al.   PROTEIN SCIENCE

The Native 3D Organization of Bacterial Polysomes

(2009) Florian Brandt et al.   CELL

Large-scale purification of ribosome-nascent chain complexes for biochemical and structural studies

(2009) Anna Rutkowska et al.   FEBS LETTERS

Probing ribosome-nascent chain complexes produced in vivo by NMR spectroscopy

(2009) Lisa D. Cabrita et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Confined dynamics of a ribosome-bound nascent globin: Cone angle analysis of fluorescence depolarization decays in the presence of two local motions

(2009) Jamie P. Ellis et al.   PROTEIN SCIENCE

Practical protocols for production of very high yields of recombinant proteins usingEscherichia coli

(2009) Arun Sivashanmugam et al.   PROTEIN SCIENCE

Molecular mechanism and structure of Trigger Factor bound to the translating ribosome

(2008) Frieder Merz et al.   EMBO JOURNAL

A Multifaceted Approach to the Interpretation of NMR Order Parameters:  A Case Study of a Dynamic α-Helix†

(2008) Eric Johnson et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Differential Dynamical Effects of Macromolecular Crowding on an Intrinsically Disordered Protein and a Globular Protein: Implications for In-Cell NMR Spectroscopy

(2008) Conggang Li et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Proteins with weakly funneled energy landscapes challenge the classical structure-function paradigm

(2008) G. A. Papoian   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA