Argonaute Proteins: From Structure to Function in Development and Pathological Cell Fate Determination

Integrative single-cell analysis

(2019) Tim Stuart et al.   NATURE REVIEWS GENETICS

Regulation of MicroRNA Machinery and Development by Interspecies S-Nitrosylation

(2019) Puneet Seth et al.   CELL

Let‐7a‐regulated translational readthrough of mammalian AGO 1 generates a micro RNA pathway inhibitor

(2019) Anumeha Singh et al.   EMBO JOURNAL

Multidomain Convergence of Argonaute during RISC Assembly Correlates with the Formation of Internal Water Clusters

(2019) Mi Seul Park et al.   MOLECULAR CELL

Metazoan MicroRNAs

(2018) David P. Bartel   CELL

Capturing Totipotent Stem Cells

(2018) Christopher L. Baker et al.   Cell Stem Cell

Expression of Alternative Ago2 Isoform Associated with Loss of microRNA-Driven Translational Repression in Mouse Oocytes

(2018) Jacob W. Freimer et al.   CURRENT BIOLOGY

Dual Strategies for Argonaute2-Mediated Biogenesis of Erythroid miRNAs Underlie Conserved Requirements for Slicing in Mammals

(2018) David Jee et al.   MOLECULAR CELL

tRNA fragments (tRFs) guide Ago to regulate gene expression post-transcriptionally in a Dicer-independent manner

(2018) Canan Kuscu et al.   RNA

Argonaute 2 Is Required for Extra-embryonic Endoderm Differentiation of Mouse Embryonic Stem Cells

(2018) Richard Patryk Ngondo et al.   Stem Cell Reports

Argonaute-miRNA Complexes Silence Target mRNAs in the Nucleus of Mammalian Stem Cells

(2018) Aishe A. Sarshad et al.   MOLECULAR CELL

Placentation defects are highly prevalent in embryonic lethal mouse mutants

(2018) Vicente Perez-Garcia et al.   NATURE

Regulation of microRNA function in animals

(2018) Luca F. R. Gebert et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Regulation of microRNA biogenesis and its crosstalk with other cellular pathways

(2018) Thomas Treiber et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Single cell transcriptome analysis of human, marmoset and mouse embryos reveals common and divergent features of preimplantation development

(2018) Thorsten Boroviak et al.   DEVELOPMENT

Acetylation of AGO2 promotes cancer progression by increasing oncogenic miR-19b biogenesis

(2018) Hailong Zhang et al.   ONCOGENE

The Role of RNA Interference in Stem Cell Biology: Beyond the Mutant Phenotypes

(2017) Maxime Bodak et al.   JOURNAL OF MOLECULAR BIOLOGY

An Argonaute phosphorylation cycle promotes microRNA-mediated silencing

(2017) Ryan J. Golden et al.   NATURE

Human Argonaute3 has slicer activity

(2017) Mi Seul Park et al.   NUCLEIC ACIDS RESEARCH

Argonaute Utilization for miRNA Silencing Is Determined by Phosphorylation-Dependent Recruitment of LIM-Domain-Containing Proteins

(2017) Katherine S. Bridge et al.   Cell Reports

Protein Expression Landscape of Mouse Embryos during Pre-implantation Development

(2017) Yawei Gao et al.   Cell Reports

Dicer, a new regulator of pluripotency exit and LINE-1 elements in mouse embryonic stem cells

(2017) Maxime Bodak et al.   FEBS Open Bio

KRAS-MEK Signaling Controls Ago2 Sorting into Exosomes

(2016) Andrew J. McKenzie et al.   Cell Reports

SUMOylation of Argonaute-2 regulates RNA interference activity

(2015) Fernando Josa-Prado et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Early embryonic-like cells are induced by downregulating replication-dependent chromatin assembly

(2015) Takashi Ishiuchi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Functional analyses of phosphorylation events in human Argonaute 2

(2015) Joaquin Lopez-Orozco et al.   RNA

Early embryonic-like cells are induced by downregulating replication-dependent chromatin assembly

(2015) Takashi Ishiuchi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Programmed Translational Readthrough Generates Antiangiogenic VEGF-Ax

(2014) Sandeepa M. Eswarappa et al.   CELL

Dephosphorylation of Tyrosine 393 in Argonaute 2 by Protein Tyrosine Phosphatase 1B Regulates Gene Silencing in Oncogenic RAS-Induced Senescence

(2014) Ming Yang et al.   MOLECULAR CELL

The evolutionary journey of Argonaute proteins

(2014) Daan C Swarts et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Sumoylation of Human Argonaute 2 at Lysine-402 Regulates Its Stability

(2014) Umut Sahin et al.   PLoS One

Demystifying the nuclear function of Argonaute proteins

(2014) Vera Huang et al.   RNA Biology

Generation of catalytic human Ago4 identifies structural elements important for RNA cleavage

(2014) Judith Hauptmann et al.   RNA

Alteration of miRNA activity via context-specific modifications of Argonaute proteins

(2014) David Jee et al.   TRENDS IN CELL BIOLOGY

Beyond microRNA – Novel RNAs derived from small non-coding RNA and their implication in cancer

(2013) Elena S. Martens-Uzunova et al.   CANCER LETTERS

Reciprocal Inhibition between Intracellular Antiviral Signaling and the RNAi Machinery in Mammalian Cells

(2013) Gil Ju Seo et al.   Cell Host & Microbe

A transient reversal of miRNA-mediated repression controls macrophage activation

(2013) Anup Mazumder et al.   EMBO REPORTS

Chromatin remodeling by the small RNA machinery in mammalian cells

(2013) Long-Cheng Li   Epigenetics

T cell activation induces proteasomal degradation of Argonaute and rapid remodeling of the microRNA repertoire

(2013) Yelena Bronevetsky et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Akt-Mediated Phosphorylation of Argonaute 2 Downregulates Cleavage and Upregulates Translational Repression of MicroRNA Targets

(2013) Shane R. Horman et al.   MOLECULAR CELL

EGFR modulates microRNA maturation in response to hypoxia through phosphorylation of AGO2

(2013) Jia Shen et al.   NATURE

Argonaute proteins: functional insights and emerging roles

(2013) Gunter Meister   NATURE REVIEWS GENETICS

Homeostatic control of Argonaute stability by microRNA availability

(2013) Peter Smibert et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Turning catalytically inactive human Argonaute proteins into active slicer enzymes

(2013) Judith Hauptmann et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Molecular dissection of human Argonaute proteins by DNA shuffling

(2013) Nina Schürmann et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Antiviral RNA Interference in Mammalian Cells

(2013) P. V. Maillard et al.   SCIENCE

Eukaryote-Specific Insertion Elements Control Human ARGONAUTE Slicer Activity

(2013) Kotaro Nakanishi et al.   Cell Reports

The Making of a Slicer: Activation of Human Argonaute-1

(2013) Christopher R. Faehnle et al.   Cell Reports

Totipotent Embryonic Stem Cells Arise in Ground-State Culture Conditions

(2013) Sophie M. Morgani et al.   Cell Reports

The Structure of Human Argonaute-2 in Complex with miR-20a

(2012) Elad Elkayam et al.   CELL

Analysis of human embryos from zygote to blastocyst reveals distinct gene expression patterns relative to the mouse

(2012) Kathy K. Niakan et al.   DEVELOPMENTAL BIOLOGY

AGO4 Regulates Entry into Meiosis and Influences Silencing of Sex Chromosomes in the Male Mouse Germline

(2012) Andrew J. Modzelewski et al.   DEVELOPMENTAL CELL

Enhanced Susceptibility of Ago1/3 Double-Null Mice to Influenza A Virus Infection

(2012) Melanie Van Stry et al.   JOURNAL OF VIROLOGY

Structure of yeast Argonaute with guide RNA

(2012) Kotaro Nakanishi et al.   NATURE

Embryonic stem cell potency fluctuates with endogenous retrovirus activity

(2012) Todd S. Macfarlan et al.   NATURE

The Crystal Structure of Human Argonaute2

(2012) N. T. Schirle et al.   SCIENCE

Hypoxia Potentiates MicroRNA-Mediated Gene Silencing through Posttranslational Modification of Argonaute2

(2011) C. Wu et al.   MOLECULAR AND CELLULAR BIOLOGY

Poly(ADP-Ribose) Regulates Stress Responses and MicroRNA Activity in the Cytoplasm

(2011) Anthony K.L. Leung et al.   MOLECULAR CELL

Crystal structure of the MID-PIWI lobe of a eukaryotic Argonaute protein

(2011) A. Boland et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MicroRNA Function Is Globally Suppressed in Mouse Oocytes and Early Embryos

(2010) Nayoung Suh et al.   CURRENT BIOLOGY

Crystal structure and ligand binding of the MID domain of a eukaryotic Argonaute protein

(2010) Andreas Boland et al.   EMBO REPORTS

Canonical and alternate functions of the microRNA biogenesis machinery

(2010) M. M. W. Chong et al.   GENES & DEVELOPMENT

Structural basis for 5′-nucleotide base-specific recognition of guide RNA by human AGO2

(2010) Filipp Frank et al.   NATURE

A dicer-independent miRNA biogenesis pathway that requires Ago catalysis

(2010) Sihem Cheloufi et al.   NATURE

Phosphorylation of human Argonaute proteins affects small RNA binding

(2010) Sabine Rüdel et al.   NUCLEIC ACIDS RESEARCH

The let-7 target gene mouse lin-41 is a stem cell specific E3 ubiquitin ligase for the miRNA pathway protein Ago2

(2009) Agnieszka Rybak et al.   NATURE CELL BIOLOGY

Control of alternative splicing through siRNA-mediated transcriptional gene silencing

(2009) Mariano Alló et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The GW182 protein family in animal cells: New insights into domains required for miRNA-mediated gene silencing

(2009) A. Eulalio et al.   RNA

A Genetic Strategy for Single and Combinatorial Analysis of miRNA Function in Mammalian Hematopoietic Stem Cells

(2009) Eirini P. Papapetrou et al.   STEM CELLS

Essential role for Argonaute2 protein in mouse oogenesis

(2009) Masahiro Kaneda et al.   Epigenetics & Chromatin

Phosphorylation of Argonaute 2 at serine-387 facilitates its localization to processing bodies

(2008) Yan Zeng et al.   BIOCHEMICAL JOURNAL

Argonaute-2 Expression Is Regulated by Epidermal Growth Factor Receptor and Mitogen-Activated Protein Kinase Signaling and Correlates with a Transformed Phenotype in Breast Cancer Cells

(2008) Brian D. Adams et al.   ENDOCRINOLOGY

Maternal Argonaute 2 Is Essential for Early Mouse Development at the Maternal-Zygotic Transition

(2008) Karin Lykke-Andersen et al.   MOLECULAR BIOLOGY OF THE CELL

Prolyl 4-hydroxylation regulates Argonaute 2 stability

(2008) Hank H. Qi et al.   NATURE

Endogenous siRNAs from naturally formed dsRNAs regulate transcripts in mouse oocytes

(2008) Toshiaki Watanabe et al.   NATURE

Pseudogene-derived small interfering RNAs regulate gene expression in mouse oocytes

(2008) Oliver H. Tam et al.   NATURE