Article
Immunology
Pei Zhou, Hongbo Guan, Yanyan Guo, Liangliang Zhu, Xiaomei Liu
Summary: Maternal obesity leads to a reduction in peroxisome number in fetal kidneys, activating oxidative stress and inflammasomes, ultimately leading to inflammation and apoptosis. The antioxidant PQQ plays a protective role by reducing ROS levels and inhibiting ER stress and inflammasome activation.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Cell Biology
Qianqian Di, Xibao Zhao, Haimei Tang, Xunwei Li, Yue Xiao, Han Wu, Zherui Wu, Jiazheng Quan, Weilin Chen
Summary: The research shows that USP22 inhibits the activation of NLRP3 inflammasome by promoting autophagy, and has the potential to be a therapeutic target for NLRP3 inflammasome-related diseases.
Article
Cell Biology
Baoshan Cai, Jian Zhao, Yuling Zhang, Yaxing Liu, Chunhong Ma, Fan Yi, Yi Zheng, Lei Zhang, Tian Chen, Huiqing Liu, Bingyu Liu, Chengjiang Gao
Summary: USP5 acts as a key scaffold protein in recruiting the E3 ligase MARCHF7 for autophagic degradation of NLRP3 independently of its deubiquitinating enzyme activity. Knockdown of USP5 promotes inflammatory signaling release, while overexpression has inhibitory effects.
Article
Immunology
Jiong Cui, Pianpian Hong, Zhenzhou Li, Jiaqun Lin, Xiaoting Wu, Kun Nie, Xiaohong Zhang, Jianxin Wan
Summary: Numerous epidemiological studies have shown that hyperuricemia (HUA) increases the risk of renal diseases and renal fibrosis. This study investigated the effects of chloroquine (CQ) on a high-fat diet (HFD) exacerbated mouse model of hyperuricemic nephropathy (HN). The results demonstrated that CQ improved renal dysfunction and inhibited the activation of NLRP3 inflammasomes in HN mice, suggesting its potential as a therapeutic strategy for HN treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Medicine, Research & Experimental
Saeed Daneshyar, Gholamreza Tavoosidana, Mahdi Bahmani, Saeed Shokati Basir, Maryam Delfan, Ismail Laher, Ayoub Saeidi, Urs Granacher, Hassane Zouhal
Summary: This study aims to investigate the combined effects of high-fat diets and exercise training on autophagy in mouse white adipose tissue. The results show that both the high-fat diet and exercise training groups had increased levels of autophagy-related genes and proteins. The combination of high-fat diet and exercise enhances autophagosome formation and modulates lysosomal degradation in white adipose tissue.
Review
Biochemistry & Molecular Biology
Xuelian Li, Xianjie Zhu, Yumiao Wei
Summary: Atherosclerosis is a lipid-driven disease characterized by the imbalance between inflammatory and regressive processes. Recent studies have suggested a link between autophagy and vascular inflammation. This review summarizes the underlying mechanisms associated with different autophagic pathways and NLRP3 inflammasomes in vascular inflammation, aiming to provide additional evidence for atherosclerosis research.
Article
Neurosciences
Yong Li, Yujie Cheng, Yuan Zhou, Hongmei Du, Cui Zhang, Zhentao Zhao, Yuenan Chen, Zhongnan Zhou, Jinyu Mei, Wenning Wu, Ming Chen
Summary: The study revealed that high-fat diet induced metabolic disorders, depression, and anxiety-like behaviors in mice. The high-fat diet inhibited AMPK phosphorylation and promoted mTOR phosphorylation, with rapamycin treatment showing improvement in these effects.
EXPERIMENTAL NEUROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Chetan Ram, Shobhit Gairola, Shobhit Verma, Madhav Nilakanth Mugale, Srinivasa Reddy Bonam, Upadhyayula Suryanarayana Murty, Bidya Dhar Sahu
Summary: Nephropathy, the most common microvascular disorder in diabetes, is aggravated by oxidative stress and inflammatory response caused by persistent hyperglycemia. This study investigated the effects of biochanin A on inflammation, NLRP3 inflammasome activation, oxidative stress, and fibrosis in diabetic kidneys. The results showed that biochanin A improved renal function, reduced histological changes, and suppressed NF-kappa B/NLRP3 axis in diabetic rats. In vitro studies also demonstrated that biochanin A reduced oxidative stress and apoptosis in high-glucose-induced renal tubular epithelial cells. Additionally, it inhibited the upregulation of NLRP3 and its associated proteins and blunted TGF-beta/Smad signaling and collagen production. These findings suggest the potential role of biochanin A in attenuating diabetic nephropathy.
Article
Environmental Sciences
Jinjin Jiang, Shibin Ding, Guofu Zhang, Yaqi Dong
Summary: The combined exposure to ambient particulate matter and a high-fat diet can exacerbate renal injury by inducing inflammation and fibrosis in the kidney, possibly through activation of the NLRP3 inflammasome and the TGF-beta 1/Smad2 signaling pathway.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Biochemistry & Molecular Biology
Yuxin Lin, Zibo Li, Yicheng Wang, Tian Tian, Penghui Jia, Yu Ye, Miao He, Zixiao Yang, Chunmei Li, Deyin Guo, Panpan Hou
Summary: This study identifies a novel autophagy cargo receptor, CCDC50, which negatively regulates NLRP3 inflammasome assembly and the release of related inflammatory factors by degrading NLRP3. CCDC50 deficiency results in upregulation of signaling pathways associated with autoinflammatory diseases and enhances gut inflammation response.
Article
Biochemistry & Molecular Biology
Yuxin Lin, Zibo Li, Yicheng Wang, Tian Tian, Penghui Jia, Yu Ye, Miao He, Zixiao Yang, Chunmei Li, Deyin Guo, Panpan Hou
Summary: The NLRP3-directed inflammasome complex plays a crucial role in host defense against microbial infection and monitoring cellular damage. However, its hyperactivation is implicated in the pathogenesis of inflammatory diseases, such as inflammatory bowel disease (IBD). Autophagy and autophagy-related genes are closely linked to NLRP3-mediated inflammation in these diseases. This study reveals that CCDC50, a novel autophagy cargo receptor, negatively regulates NLRP3 inflammasome assembly and suppresses the release of pro-caspase-1 and interleukin 1 beta (IL-1 beta) by promoting autophagic degradation of NLRP3. Knockdown of CCDC50 leads to upregulation of signaling pathways associated with autoinflammatory diseases, and CCDC50 deficiency enhances proinflammatory cytokine response triggered by various NLRP3 stimuli. Furthermore, mice lacking CCDC50 are more susceptible to DSS-induced colitis and exhibit more severe gut inflammation with elevated NLRP3 inflammasome activity, emphasizing the protective role of CCDC50 in controlling gut inflammation.
Article
Immunology
Do-Wan Shim, Hyo-Joung Cho, Inhwa Hwang, Taek-Yeol Jung, Hyun-Seok Kim, Ju Hee Ryu, Je-Wook Yu
Summary: The depletion of NAD(+) affects the innate immune potential of macrophages and has an impact on NLRP3 activation. FK866 facilitates NLRP3 activation by promoting perinuclear clustering of mitochondria, while supplementation with NAD(+) can counteract the FK866-induced caspase-1 cleavage.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Xiao Sun, Yingzhi Liu, Ziheng Huang, Wenye Xu, Wei Hu, Lina Yi, Zhe Liu, Hung Chan, Judeng Zeng, Xiaodong Liu, Huarong Chen, Jun Yu, Francis Ka Leung Chan, Siew Chien Ng, Sunny Hei Wong, Maggie Haitian Wang, Tony Gin, Gavin Matthew Joynt, David Shu Cheong Hui, Xuan Zou, Yuelong Shu, Christopher Hon Ki Cheng, Shisong Fang, Huanle Luo, Jing Lu, Matthew Tak Vai Chan, Lin Zhang, William Ka Kei Wu
Summary: A recent study found that Non-Structural Protein 6 (NSP6) of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) can activate the inflammasome and induce pyroptosis in lung epithelial cells, leading to severe COVID-19. NSP6 impairs lysosome acidification to inhibit autophagic flux and interacts with ATP6AP1 to inhibit its cleavage-mediated activation. A variant of NSP6 associated with asymptomatic COVID-19 exhibits reduced binding to ATP6AP1 and weakened ability to induce pyroptosis. This study suggests that pharmacological rectification of autophagic flux could be a potential therapeutic strategy for SARS-CoV-2 infection.
CELL DEATH AND DIFFERENTIATION
(2022)
Article
Pharmacology & Pharmacy
Zhengzhu Sun, Chongfeng Fang, Shasha Xu, Bin Wang, Danlei Li, Xiaoman Liu, Yafei Mi, Hangyuan Guo, Jianjun Jiang
Summary: SIRT3 effectively attenuates DOX-induced cardiotoxicity by inhibiting NLRP3 inflammasome activation and regulating autophagy. This finding provides a theoretical foundation for further exploration of cardiac toxicity.
BIOCHEMICAL PHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Laura Urwanisch, Michela Luciano, Jutta Horejs-Hoeck
Summary: Chronic inflammation plays a crucial role in the development and progression of tumors, with the NLRP3 inflammasome being a key player in inflammation mediated by cells of the innate immune system. Research on the role of NLRP3 in leukemia has increased in recent years, highlighting the connection between NLRP3, autophagy, and leukemia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Food Science & Technology
Suhuan Mei, Manivel Perumal, Maurizio Battino, David D. Kitts, Jianbo Xiao, Haile Ma, Xiumin Chen
Summary: Mangiferin has potential applications in nutraceutical and functional food products due to its bioactivities, but its low bioavailability limits its efficacy. This review provides information on food sources, absorption, and metabolism of mangiferin, as well as recent progress in enhancing its bioavailability. The safety and improved bioavailability are key factors for successful use of mangiferin as a dietary supplement or nutraceutical.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Rossana Passannante, Vanessa Gomez-Vallejo, Unai Cossio, Jesus Ruiz-Cabello, Aitor Lekuona, Victor Salinas, Laura Amado-Rodriguez, Guillermo M. Albaiceta, Abraham Martin, Luka Rejc, Jordi Llop
Summary: The study investigates the use of radiofluorinated gas [F-18]SF6 as a PET ventilation marker in an animal model of impaired lung ventilation. The results show that [F-18]SF6 can accurately locate hypoventilated areas and may have implications in the early diagnosis of acute lung disease.
MOLECULAR IMAGING AND BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Andrea Pirkovic, Aleksandra Vilotic, Suncica Borozan, Mirjana Nacka-Aleksic, Zanka Bojic-Trbojevic, Milica Jovanovic Krivokuca, Maurizio Battino, Francesca Giampieri, Dragana Dekanski
Summary: The bioactive compound oleuropein derived from olives was evaluated for its effects on damage induced by hydrogen peroxide in human trophoblast cells in vitro. The study found that oleuropein had cytoprotective effects by improving antioxidant status, preventing protein and lipid damage, and reducing iNOS levels.
Article
Dentistry, Oral Surgery & Medicine
Juliana Portes, Beatriz Bullon, Isabel Gallardo, Patricia Fernandez-Riejos, Jose Luis Quiles, Francesca Giampieri, Pedro Bullon
Summary: The prevalence of undiagnosed diabetes and prediabetes in elderly patients attending a dental clinic was high and underestimated. Risk factors such as periodontitis, overweight, high blood pressure, and low adherence to the Mediterranean diet were observed in these patients.
JOURNAL OF DENTISTRY
(2023)
Article
Biochemistry & Molecular Biology
Jose M. Romero-Marquez, Maria D. Navarro-Hortal, Francisco J. Orantes, Adelaida Esteban-Munoz, Cristina M. Perez-Oleaga, Maurizio Battino, Cristina Sanchez-Gonzalez, Lorenzo Rivas-Garcia, Francesca Giampieri, Jose L. Quiles, Tamara Y. Forbes-Hernandez
Summary: This study aims to characterize monofloral avocado honey (AH) and evaluate its phenolic profile and antioxidant capacity. The results show that AH exhibits high antioxidant capacity in vitro and in vivo, which is relevant for the prevention of Alzheimer's disease.
Review
Food Science & Technology
Marco Brusati, Luciana Baroni, Gianluca Rizzo, Francesca Giampieri, Maurizio Battino
Summary: Plant-based milk alternatives can be divided into two main categories: plant-based formulas and plant-based drinks, which differ in production processes and regulation. These products have gained wide acceptance in the international market. The nutritional characteristics of various plant-based milk alternatives differ due to their origin and manufacturing. Plant-based drinks, unlike formulas from plant and cow origin, are nutritionally different from cow's milk and can be consumed by children after using formula. Scientific organizations have expressed conflicting opinions on the use of these products in children's diets, especially in terms of timing, quantities, and type of product. Considering the child's overall diet and health, it is recommended to see these foods not as simple substitutes for cow's milk, but as part of a varied diet, with individual advice for use.
Review
Chemistry, Multidisciplinary
Andrea Beltran-Noboa, Alejandro Jordan-Alvarez, Mabel Guevara-Teran, Blanca Gallo, Luis A. . Berrueta, Francesca Giampieri, Maurizio Battino, Jose M. Alvarez-Suarez, Eduardo Tejera
Summary: Ocimum is the largest genus in the Lamiacea family and includes aromatic plants like basil, which have culinary and medicinal potential. This systematic review examines the chemical composition of nonessential oils in different species of Ocimum. The study reveals a wide variety of compounds, suggesting that this genus could be a valuable source of bioactive compounds. However, there is a significant gap between the number of Ocimum species discovered and the studies that have determined their chemical characterization.
Article
Chemistry, Multidisciplinary
Lydia Martinez-Parra, Marina Pinol-Cancer, Carlos Sanchez-Cano, Ana B. Miguel-Coello, Desire Di Silvio, Ana M. Gomez, Clara Uriel, Sandra Plaza-Garcia, Marta Gallego, Raquel Pazos, Hugo Groult, Marc Jeannin, Kalotina Geraki, Laura Fernandez-Mendez, Ainhize Urkola-Arsuaga, Maria Jesus Sanchez-Guisado, Juliana Carrillo-Romero, Wolfgang J. Parak, Maurizio Prato, Fernando Herranz, Jesus Ruiz-Cabello, Susana Carregal-Romero
Summary: Atherosclerosis is a complex disease with severe consequences. Existing diagnostic protocols lack specificity and fail to predict plaque vulnerability. However, emerging technologies, such as customized nanotechnological solutions, show promise in noninvasive imaging of atherosclerotic plaques. Our study demonstrates the effectiveness of Gd (III)-doped amorphous calcium carbonate nanoparticles in comparative studies of nanoparticle targeting for atherosclerosis.
Review
Food Science & Technology
Yu Sun, Arshad Mehmood, Francesca Giampieri, Maurizio Antonio Battino, Xiumin Chen
Summary: Diabetes is a serious chronic disease worldwide, and GABA has good potential for anti-diabetic effects. This review summarizes the dietary sources of GABA, along with animal and human studies, while also discussing the mechanisms behind its anti-diabetic properties.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Food Science & Technology
Elsa Martinez-Ferri, Lucia Cervantes, Carmen Soria, Tamara Forbes-Hernandez, Patricia Reboredo-Rodriguez, Maurizio Battino, Maria Teresa Ariza
Summary: Strawberry phenolic compounds play a crucial role in providing health benefits and contribute significantly to antioxidant capacity. This study investigated the phenolic compounds and antioxidant capacity of different genotypes of strawberries, as well as their bioaccessibility and bioavailability after in vitro digestion. The results showed variations in phenolic compounds and antioxidant capacity among different cultivars. Additionally, the study found that the health-promoting properties of strawberries are altered after digestion, and the bioavailability of antioxidant capacity can serve as an indicator for selecting strawberries with health-promoting properties in breeding programs.
Article
Biochemistry & Molecular Biology
Jose M. Romero-Marquez, Maria D. Navarro-Hortal, Tamara Y. Forbes-Hernandez, Alfonso Varela-Lopez, Juan G. Puentes, Raquel Del Pino-Garcia, Cristina Sanchez-Gonzalez, Inaki Elio, Maurizio Battino, Roberto Garcia, Sebastian Sanchez, Jose L. Quiles
Summary: In this study, olive leaves from different geographical origins were analyzed for their phytochemical profile, antioxidant capacity, neuroprotective activity, and anti-inflammatory effects. The results showed that olive leaves from Spain and Italy had the highest antioxidant and neuroprotective activities, while those from Greece had the lowest. The content of oleoside methyl ester and p-hydroxybenzoic acid in the Spanish and Italian samples, respectively, were strongly associated with these biological activities.
Article
Cultural Studies
Yijun Sun
Article
Food Science & Technology
Guanhua Lv, Hengpeng Wang, Xiaoou Wei, Minmin Lu, Wenhao Yang, Halah Aalim, Esra Capanoglu, Xiaobo Zou, Maurizio Battino, Di Zhang
Summary: This study investigated the effects of different cooking methods on chicken protein oxidation, structural and digestion characteristics, and the impact of undigested protein on intestinal flora fermentation. The results showed that roasting and deep-frying led to higher protein oxidation, while boiling resulted in the lowest oxidation. Stir-frying and deep-frying reduced protein digestibility and changed its structure. Roasting had the greatest impact on intestinal flora, generating the highest number of new species and exhibiting a lower production of short-chain fatty acids. The adverse effects on intestinal flora of stir-frying and deep-frying were not as significant as that of roasting.
Review
Nanoscience & Nanotechnology
Juan Pellico, Jesus Ruiz-Cabello, Fernando Herranz
Summary: Iron oxide nanoparticles (IONP) have great potential in biomedical imaging, particularly in magnetic resonance imaging (MRI). However, the negative contrast produced by superparamagnetic nanomaterials in MRI can make it difficult to identify accumulated probes. Researchers are exploring alternative options that can incorporate the advantages of IONP and possess valuable properties for molecular imaging, such as combining IONP with nuclear imaging techniques. Factors such as radiolabeling strategy and nanoprobe complexity need to be considered for the creation of multimodal probes.
ACS APPLIED NANO MATERIALS
(2023)
Article
Food Science & Technology
Gabriela Pilco-Romero, Aida M. Chisaguano-Tonato, Maria E. Herrera-Fontana, Luis F. Chimbo-Gandarac, Majid Sharifi-Rad, Francesca Giampieri, Maurizio Battinof, Maria Gabriela Vernaza, Jose M. Alvarez-Suarez
Summary: The house cricket is a potential food resource with high digestibility protein and various nutrients. Research suggests that it could be used in the food industry, and its protein solubility and water retention capacity can be beneficial for creating nutritious products.
TRENDS IN FOOD SCIENCE & TECHNOLOGY
(2023)
