Article
Chemistry, Applied
Qinxin Huang, Xidong Jiao, Bowen Yan, Nana Zhang, Jianlian Huang, Jianxin Zhao, Hao Zhang, Wei Chen, Daming Fan
Summary: This study investigated the changes in microbiota and gel properties during chilled surimi storage, and found that Pseudomonas gessardii had the greatest influence on surimi quality.
Article
Chemistry, Multidisciplinary
Qingxin Liu, Yinglan Wu, Min Feng, Wanmin Chen, Zhiping Zheng
Summary: Silver complexes with proteinogenic amino acid ligands have potential applications in biomedical and antimicrobial fields. This study synthesized silver complexes with cluster-type core motif and proteinogenic amino acid ligands, and investigated the reaction conditions and properties.
Article
Engineering, Environmental
Sara Peixoto, Susana Loureiro, Isabel Henriques
Summary: The study highlights the significant effects of Ag2S NPs on the soil microbiome composition, while AgNO3 exerts a stronger influence on both composition and functional parameters over time. Distinct variants of ammoniaoxidizing and nitrite-oxidizing bacteria genes emerged in silver-treated soils, suggesting a potential succession of bacteria with different degrees of silver-tolerance.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Multidisciplinary Sciences
Hazuki Akazawa, Itsuko Fukuda, Haruna Kaneda, Shoichi Yoda, Mamoru Kimura, Ryohei Nomoto, Shuji Ueda, Yasuhito Shirai, Ro Osawa
Summary: Hyaluronan (HA) is a high-molecular-weight glycosaminoglycan widely distributed in connective tissues. Bacteria capable of degrading HA to lower molecular weight oligosaccharides were isolated from human feces. The study revealed that dietary HA is degraded by human gut microbiota to more absorbable oligo-HAs, which exert beneficial effects.
Article
Agriculture, Multidisciplinary
Qixing Jiang, Lishi Wang, Pei Gao, Peipei Yu, Fang Yang, Dawei Yu, Han Chen, Wenshui Xia
Summary: The study found that adding chicken breast significantly improved the mechanical properties and crystalline structure of mixed minced meat products, increasing the strength and water holding capacity of the gel. The addition of chicken breast also enhanced the thermal stability of the mixed sol and improved its rheological properties.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2023)
Review
Biochemistry & Molecular Biology
Pawel Serek, Monika Oleksy-Wawrzyniak
Summary: The intestinal barrier, composed of cells, mucus, and microbiota, plays a crucial role in maintaining immune homeostasis. Disturbances in its tightness can lead to a range of issues, including systemic infections and autoimmune diseases. Zonulin, a protein found in epithelial cells, plays a key regulatory role.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Hind Mubaraki, Navin Anand Ingle, Mohammad Abdul Baseer, Osamah M. AlMugeiren, Sarah Mubaraki, Marco Cicciu, Giuseppe Minervini
Summary: The use of silver diamine fluoride (SDF) has been shown to significantly reduce the growth of bacterial biofilms, indicating its potential as an effective treatment for dental caries. Further research is advised to explore the potential of SDF as a standard therapy choice for dental caries and to further investigate its relationship with bacterial biofilms.
Article
Chemistry, Physical
Ya-Qi Zhu, Wei-Qiang Huang, Guang Chen, Lei Xia, Ye-Zi You, Yue Yu
Summary: Researchers have developed a novel gel that can capture and trap bacteria, preventing their invasion, and the gel has the ability to generate reactive oxygen species (ROS) that can effectively kill bacteria. Experimental results have shown that this gel can accelerate the healing of infected wounds.
Article
Biochemistry & Molecular Biology
Agnieszka Gibala, Paulina Zeliszewska, Tomasz Gosiewski, Agnieszka Krawczyk, Dorota Duraczynska, Joanna Szaleniec, Maciej Szaleniec, Magdalena Ocwieja
Summary: The research showed that larger AgNPs possess stronger biocidal properties, with positively charged arginine-stabilized AgNPs and negatively charged EGCGAgNPs demonstrating the most significant antibacterial and fungicidal effects among the studied nanoparticles.
Article
Food Science & Technology
Linglu Meng, Xidong Jiao, Bowen Yan, Jianlian Huang, Jianxin Zhao, Hao Zhang, Wei Chen, Daming Fan
Summary: The study found that increasing fish mince size led to higher protein and fat contents in the gel, but decreased moisture content. While gels made from larger mince had lower strength and water holding capacity, microwave heating greatly reduced the detrimental effects of the larger size.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Borbala Tegze, Emoke Albert, Boglarka Diko, Norbert Nagy, Adel Racz, Gyorgy Safran, Attila Sulyok, Zoltan Horvolgyi
Summary: In this study, mesoporous TiO2 sol-gel coatings were modified with silver using two methods, and the effects of silver modification on the functional properties were investigated. The samples made with the impregnation method showed better functional properties despite having significantly lower silver content. The pore structure influenced the Ag content achieved by the impregnation method, and subsequently affected their photoactivity.
Article
Chemistry, Physical
Mantvydas Merkis, Egidijus Griskonis, Jurgita Laurikaitiene, Judita Puiso, Ignas Pikas, Satimboy Palvanov, Diana Adliene
Summary: This study investigates the dose sensitivity enhancing effect of silver nanoparticles on dosimetric gels. The nanoparticles are added to nMAG and NIPAM dose gel formulations, and their synthesis and characterization are conducted. The results show that Ag nanoparticles allow for higher sensitivity in both NIPAM and nMAG dose gels, and further analysis indicates signs of radiation-enhancing effect. Improved gel dosimeters could be valuable for dose verification procedures, although the application of nanoparticle-enriched dose gels for simulating dose enhancement effect in human tissue is not straightforward due to variations in different gel dosimeters.
RADIATION PHYSICS AND CHEMISTRY
(2023)
Article
Polymer Science
Jinling Hong, Jiaying Wu, Yanhong Chen, Zedong Jiang, Yanbing Zhu, Zhipeng Li, Xianmu Chen, Hui Ni, Mingjing Zheng
Summary: The study examined the effect of different concentrations (0.1%, 0.2%, and 0.3% w/w) of black tea powder on the antioxidant activity and gel characteristics of frozen fish balls. The results demonstrated that black tea powder significantly increased the antioxidant activity of the fish balls, with the highest effect observed at a concentration of 0.3%. Moreover, the addition of 0.3% black tea powder enhanced the gel strength, hardness, and chewiness of the fish balls while reducing their whiteness. Electron scanning microscopy revealed that black tea powder promoted protein crosslinking and decreased pore size in the gel network structure. These findings suggest that black tea powder can be used as a natural antioxidant and texture enhancer in fish balls, primarily due to its phenolic compounds.
Article
Engineering, Electrical & Electronic
Sayani Palit, Jim-Long Her, See-Tong Pang, Tung-Ming Pan
Summary: This study investigates the effect of silver doping on the structural and electrical properties of RuAgxOy films for an EGFET sensor. Different concentrations of silver doping were used to fabricate the RuAgxOy sensing film, and the resulting films were analyzed using various techniques. The film with 3% silver doping showed excellent pH sensitivity, linearity, and stability.
SENSORS AND ACTUATORS A-PHYSICAL
(2023)
Article
Chemistry, Medicinal
Yue Li, Shuangling Luo, Haobing Wang, Yidan Lai, Dan Li, Qianling Zhang, Huaiyi Huang, Pingyu Zhang
Summary: Photoactive antibacterial therapy has great application potential, and a photoactivated iridium complex (Ir-Cl) is synthesized for antibacterial research. Ir-Cl exhibits photoacidolysis and generates H+ and Ir-OH under blue light irradiation. It selectively permeates S. aureus and has excellent photoactive antibacterial activity. Mechanism studies show that Ir-Cl can ablate bacterial membranes and biofilms under light irradiation. Metabolomics analysis reveals that Ir-Cl with light exposure mainly disturbs amino acid degradation and pyrimidine metabolism, causing irreversible damage to S. aureus. This work guides the application of metal complexes in antibacterial research.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Review
Biochemistry & Molecular Biology
Pasquale Sacco, Seidy Pedroso-Santana, Yogesh Kumar, Nicolas Joly, Patrick Martin, Patrizia Bocchetta
Summary: The ionotropic gelation of chitosan is commonly used for biomedical applications, with recent extensions to the fabrication of flat structures. This method, along with novel procedures, has been explored for synthesizing chitosan-based flat membranes and films.
Review
Biochemistry & Molecular Biology
Francesca Cuomo, Silvio Iacovino, Pasquale Sacco, Antonella De Leonardis, Andrea Ceglie, Francesco Lopez
Summary: This review presents recent advances in the delivery of bioactive phenolic compounds mediated by colloid systems. The focus is on the progress made in this field in recent years. The structural and dynamic aspects of different colloid delivery systems, as well as the interactions with two bioactive constituents, are discussed. Two case studies are presented, one representing hydrophobic phenolic compounds and the other representing hydrophilic compounds.
Article
Chemistry, Multidisciplinary
Pasquale Sacco, Francesco Piazza, Chiara Pizzolitto, Gabriele Baj, Francesco Brun, Eleonora Marsich, Ivan Donati
Summary: This study presents a strategy to control the dissipation rate of viscoplastic substrates while precisely regulating linear elasticity, and reveals the crucial link between this material property and cellular responses in 2D cultures.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Correction
Biochemical Research Methods
Qiqian Liu, Pasquale Sacco, Eleonora Marsich, Franco Furlani, Celia Arib, Nadia Djaker, Marc Lamy de la Chapelle, Ivan Donati, Jolanda Spadavecchia
BIOCONJUGATE CHEMISTRY
(2022)
Article
Chemistry, Applied
Chiara Pizzolitto, Fabiana Esposito, Pasquale Sacco, Eleonora Marsich, Valentina Gargiulo, Emiliano Bedini, Ivan Donati
Summary: In this study, lactose-modified chitosan was sulfated using SO3.py or SO3.DMF as sulfating agents. The extent and selectivity of chemical sulfation were determined using various experimental methods. The sulfated samples were found to induce aggregation of human bone marrow mesenchymal stem cells, resulting in smaller nodules.
CARBOHYDRATE POLYMERS
(2022)
Article
Chemistry, Applied
Giovanni Ferraro, Emiliano Fratini, Pasquale Sacco, Fioretta Asaro, Francesca Cuomo, Ivan Donati, Francesco Lopez
Summary: This study investigated the effect of biomacromolecule concentration and ageing on the structural integrity of chia mucilage-based hydrogel networks. The results showed that ageing destabilizes the hydrogel architecture, leading to a decrease in strength and viscosity, as well as an increase in mesh size.
FOOD HYDROCOLLOIDS
(2022)
Article
Nanoscience & Nanotechnology
Memona Khan, Hui Liu, Pasquale Sacco, Eleonora Marsich, Xiaowu Li, Nadia Djaker, Jolanda Spadavecchia
Summary: In this study, a novel hybrid gold nanoparticle system was developed and formulated. The nanoparticles showed high stability, non-toxicity, and efficient performance as a PTT agent. The study also demonstrated the biological efficacy on three different cell lines.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Silvina Guidugli, Myriam Villegas, Julio Benegas, Ivan Donati, Sergio Paoletti
Summary: Experimental and theoretical data were used to study the hydration and chain expansion of pectic acid upon charging. The theoretical predictions were confirmed by experimental measurements, showing a high level of accuracy. The relevance of hydration to the bonding mechanism of calcium ions by sodium pectate was discussed. The results also indicated that charged chains are more expanded than neutral chains under typical conditions of ionic strength.
BIOPHYSICAL CHEMISTRY
(2023)
Article
Chemistry, Applied
Chiara Pizzolitto, Francesca Scognamiglio, Pasquale Sacco, Sara Lipari, Maurizio Romano, Ivan Donati, Eleonora Marsich
Summary: This study investigated the effect of different viscoplastic ECM mimics on the osteogenic engagement of MSCs. By developing a soft hydrogel, it was found that the presence of temporary cross-links led to early osteogenic commitment of MSCs, while purely elastic hydrogels required a longer time for differentiation to occur.
CARBOHYDRATE POLYMERS
(2023)
Article
Engineering, Biomedical
Francesco Piazza, Pietro Parisse, Julia Passerino, Eleonora Marsich, Luca Bersanini, Davide Porrelli, Gabriele Baj, Ivan Donati, Pasquale Sacco
Summary: The rate of cooling after heating is crucial for the structure and performance of agarose hydrogel networks. This study presents a material strategy for the fine modulation of quenching during the temperature-curing steps of agarose, revealing insights into the accumulation and recovery of agarose on the surface. The temperature curing of agarose allows for the production of networks with tunable mechanics and is suitable for mechanobiology studies.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Engineering, Multidisciplinary
Francesco Piazza, Matilde Colella, Giuseppe Cinelli, Francesco Lopez, Ivan Donati, Pasquale Sacco
Summary: This study investigates the structural changes of chia seed mucilage when treated with alpha-amylase, the most abundant enzyme in human saliva. The results reveal that the material thickens and the elastic modulus increases after enzyme treatment, indicating a restructuring of the chia mucilage network mediated by alpha-amylase. This finding has implications for the commercial processing of chia seed mucilage.
Article
Polymer Science
Sergio Paoletti, Ivan Donati
Summary: Pectate and alginate are important biopolymers that can form ionotropic gels when di- or multivalent counterions are added. Both polysaccharides exhibit similar gelation mechanisms with calcium ions, the most relevant counterion type. Specific Ca2+/polyion interactions play a crucial role in the formation of ion-mediated chain/chain cross-links. The affinity of Ca2+ for pectate is higher than for alginate. Calcium ions selectively accumulate near the polyanion(s), promoting the formation of chemical bonds and charge neutralization. Dilatometric and microcalorimetric changes are larger for pectate than for alginate. Light-scattering experiments confirm the intermolecular bonding of calcium ions from the early stages of linker addition.
Correction
Chemistry, Multidisciplinary
Qiqian Liu, Hui Liu, Pasquale Sacco, Nadia Djaker, Marc Lamy de la Chapelle, Eleonora Marsich, Xiaowu Li, Jolanda Spadavecchia
NANOSCALE ADVANCES
(2022)
Meeting Abstract
Cell & Tissue Engineering
Pasquale Sacco, Chiara Pizzolitto
TISSUE ENGINEERING PART A
(2022)
Article
Polymer Science
Lorenzo Mio, Pasquale Sacco, Ivan Donati
Summary: This study examines the effect of temperature and polymer concentration on the strain hardening of chitosan hydrogels. The results show that the extent of hardening can be modulated by varying the gel temperature, but is independent of other experimental conditions. The study suggests that this effect is due to a delicate balance between physical entanglements and covalent crosslinks in highly acetylated chitosan hydrogels under large deformations.
Review
Chemistry, Applied
Xingran Kou, Dongdong Su, Fei Pan, Xiwei Xu, Qingran Meng, Qinfei Ke
Summary: This review provides a systematic discussion of the application of molecular dynamics (MD) simulations in aroma compounds (ACs)/cyclodextrins (CDs) inclusion complexes (ICs). It covers the establishment of the simulation process, parameter selection, model evaluation, and various application cases, summarizing the major achievements and challenges of this method.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Haoyu Yu, Quanbin Zhang, Ammad Ahmad Farooqi, Jing Wang, Yang Yue, Lihua Geng, Ning Wu
Summary: Brown algae are rich in fucoidan, which has been found to have anti-cancer and anti-metastasis effects. Fucoidan inhibits tumor cell growth, proliferation, and metastasis, and also promotes immune responses in the tumor microenvironment.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Liang Dong, Yanan Li, Hailin Cong, Bing Yu, Youqing Shen
Summary: Gene therapy is a revolutionary treatment that requires suitable vectors for protecting and releasing exogenous nucleic acids in target cells. Chitosan, as a non-viral vector, has gained attention due to its good biocompatibility and ability to load large amounts of nucleic acids. This paper summarizes the potential of chitosan and its derivatives as gene delivery vector materials, discusses factors influencing transfection efficiency, performance evaluation, ways to optimize infectious efficiency, and current research development directions. It also provides an outlook on the future prospects of chitosan.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ana Iglesias-Mejuto, Beatriz Magarinos, Tania Ferreira-Goncalves, Ricardo Starbird-Perez, Carmen Alvarez-Lorenzo, Catarina Pinto Reis, Ines Ardao, Carlos A. Garcia-Gonzalez
Summary: This study developed a novel processing strategy to manufacture drug-loaded and personalized aerogels with nanostructures. The aerogels demonstrated bioactivity and antimicrobial effects, promoting bone regeneration and preventing infections in bone tissue engineering.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Zhenxu Shi, Dimei Yang, Yan Zhou, Xinyu Chen, Lin Gan, Jin Huang
Summary: This study proposes a micro-assembly method to improve the photoluminescent properties of crystalline cellulose nanocrystals (CNCs) by organizing them within a sub-micrometer-sized metal-organic framework and coating with TiO2. The TiO2 coating prevents CNC assembly breakdown and allows information to be revealed using screenprinted labels for anti-counterfeiting purposes.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Xuejiao Liu, Bin Fu, Jierong Chen, Zhenyu Sun, Dongdong Zheng, Zhonghua Li, Bing Gu, Ying Zhang, Haojie Lu
Summary: Liver disease is a major cause of global mortality, and identifying biomarkers for diagnosing its progression is crucial for improving outcomes. Targeted mass spectrometry is a powerful tool for verifying biomarker candidates and clinical applications, particularly for glycoproteins translation. However, the limitation of analyzing only one sample per run has become apparent. In this study, a high-throughput intact N-glycopeptides quantification strategy was developed, allowing the validation of 20 samples per run with an average analysis time of 3 minutes per sample. The strategy was applied in a cohort of 461 serum samples and identified a panel of 10 IgG N-glycopeptides that have strong clinical utility in evaluating the severity of liver disease.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Qian Wang, Hao Jiang, Hongli Zhang, Weiqiao Lu, Xiao Wang, Wenfeng Xu, Jia Li, Youjing Lv, Guoyun Li, Chao Cai, Guangli Yu
Summary: This study proposes a novel strategy of antibody-beta-glucan conjugates (AGC) to enhance the antitumor immune response to immune checkpoint blockade (ICB) therapy. AGC demonstrated powerful tumor suppression and promoted interaction between tumor cells and dendritic cells (DCs), thereby enhancing immunotherapeutic benefits.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Chaeyeon Lee, Sojeong Lee, Sang Wook Kang
Summary: The study aims to enhance the properties of porous membranes by addressing the limitations associated with phase separation. By using cellulose acetate and citric acid, the researchers were able to fabricate membranes with improved mechanical strength and thermal stability. The cross-linking effect of citric acid resulted in a more uniform pore structure and higher porosity.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Tejaswini Kolipaka, Giriraj Pandey, Noella Abraham, Dadi A. Srinivasarao, Rajeev Singh Raghuvanshi, P. S. Rajinikanth, Vidya Tickoo, Saurabh Srivastava
Summary: This review focuses on the design and application of polysaccharide-based hydrogel wound dressings, highlighting aspects such as biocompatibility, biodegradability, drug entrapment, moisturizing ability, swelling, and mechanical properties. Additionally, various crosslinking methods and recent developments in stimuli-responsive hydrogels are discussed.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Anqi Xu, Nan Zhang, Shixing Su, Hongyu Shi, Daoqiang Lu, Xifeng Li, Xin Zhang, Xin Feng, Zhuohua Wen, Gengwu Ma, Mengshi Huang, Chi Huang, Yuqi Hu, Hao Yuan, Qinwen Liu, Daogang Guan, Jun Wang, Chuanzhi Duan
Summary: The study presents a one-pot radical polymerization method to fabricate a hydrogel with adhesive properties, which can effectively treat bacterial-infected diabetic wounds and accelerate wound healing.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Montarop Yamabhai, Munthipha Khamphio, Thae Thae Min, Chai Noy Soem, Nguyen Cao Cuong, Waheni Rizki Aprilia, Krisanai Luesukprasert, Karsidete Teeranitayatarn, Atthaphon Maneedaeng, Tina R. Tuveng, Silje B. Lorentzen, Simen Antonsen, Paiboon Jitprasertwong, Vincent G. H. Eijsink
Summary: The study investigates the bioconversion of chitosan into soluble anti-inflammatory chitosan oligosaccharides (CHOS) using an enzyme. The results show that the generated CHOS have anti-inflammatory activity, but the magnitude of the activity depends on the substrate and production process. Different methods of dissolving chitosan also affect the properties of CHOS. The study highlights the importance of quality assurance in CHOS preparations.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Wen Cao, Jiangping Wu, Xinya Zhao, Zixu Li, Jie Yu, Taili Shao, Xuefeng Hou, Lutan Zhou, Chunfei Wang, Guodong Wang, Jun Han
Summary: In this study, a water-soluble polysaccharide (PLP1) was successfully isolated and purified from Pueraria lobata. It was found that PLP1 was composed of specific glycosidic units and exhibited a better free radical-scavenging ability. Moreover, PLP1 effectively protected the liver against acute alcoholic liver disease (ALD) in mice.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ya Su, Yaqian Liu, Xueyan Hu, Yueqi Lu, Jinyuan Zhang, Wenbo Jin, Wang Liu, Yan Shu, Yuen Yee Cheng, Wenfang Li, Yi Nie, Bo Pan, Kedong Song
Summary: A 3D printed scaffold based on carbon dots-curcumin nano-drug release has been developed for drug delivery after breast cancer surgery. The scaffold showed effective inhibition of tumor growth, antibacterial activity, and promotion of wound healing, making it a promising approach for preventing tumor recurrence.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ekaterina Sokolova, Diane Jouanneau, Antonin Chevenier, Murielle Jam, Nathalie Desban, Pierre Colas, Elizabeth Ficko-Blean, Gurvan Michel
Summary: Carrageenans, a compound synthesized in red algae, have various biological properties and are valuable in the pharmaceutical and cosmetic industries. Their fine structure affects wound healing, oxidative processes, hemostasis, and inflammation. Enzymatic modification of carrageenans produces oligosaccharides that bind to natural human serum antibodies and specific antibodies, showing potential for therapeutic applications.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Yan Shi, Miao Yu, Kaijin Qiu, Tiantian Kong, Chunjing Guo, Wenxue Zhang, Daquan Chen, Ming Kong
Summary: In this study, functionalized transfersomes were developed to co-deliver doxorubicin and 1MT towards primary tumors and tumor draining lymph nodes via transdermal administration using microneedles. The results showed that the nano-complexed microneedles exhibited a stronger suppression in tumor growth compared to the intravenous group.
CARBOHYDRATE POLYMERS
(2024)
