Is Lactate an Oncometabolite? Evidence Supporting a Role for Lactate in the Regulation of Transcriptional Activity of Cancer-Related Genes in MCF7 Breast Cancer Cells

How do mutations affecting the breast cancer genes BRCA1 and BRCA2 cause cancer susceptibility?

(2019) Ashok R. Venkitaraman   DNA REPAIR

Metabolic regulation of gene expression by histone lactylation

(2019) Di Zhang et al.   NATURE

Glutamine blockade induces divergent metabolic programs to overcome tumor immune evasion

(2019) Robert D. Leone et al.   SCIENCE

Lactate-mediated epigenetic reprogramming regulates formation of human pancreatic cancer-associated fibroblasts

(2019) Tushar D Bhagat et al.   eLife

Do the associations of sedentary behaviour with cardiovascular disease mortality and cancer mortality differ by physical activity level? A systematic review and harmonised meta-analysis of data from 850 060 participants

(2018) Ulf Ekelund et al.   BRITISH JOURNAL OF SPORTS MEDICINE

The Science and Translation of Lactate Shuttle Theory

(2018) George A. Brooks   Cell Metabolism

Expression and mutations of BRCA in breast cancer and ovarian cancer: Evidence from bioinformatics analyses

(2018) Zhu Wang et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Somatic mutant clones colonize the human esophagus with age

(2018) Iñigo Martincorena et al.   SCIENCE

A metabolic core model elucidates how enhanced utilization of glucose and glutamine, with enhanced glutamine-dependent lactate production, promotes cancer cell growth: The WarburQ effect

(2017) Chiara Damiani et al.   PLoS Computational Biology

Limits of aerobic metabolism in cancer cells

(2017) Jorge Fernandez-de-Cossio-Diaz et al.   Scientific Reports

Reexamining cancer metabolism: lactate production for carcinogenesis could be the purpose and explanation of the Warburg Effect

(2016) Iñigo San-Millán et al.   CARCINOGENESIS

KRAS, BRAF, and PIK3CA mutations, and patient prognosis in 126 pancreatic cancers: pyrosequencing technology and literature review

(2016) Lei Zhou et al.   MEDICAL ONCOLOGY

Effects of BRCA1- and BRCA2-Related Mutations on Ovarian and Breast Cancer Survival: A Meta-analysis

(2014) Q. Zhong et al.   CLINICAL CANCER RESEARCH

Antitumor Activity of 7-Aminocarboxycoumarin Derivatives, a New Class of Potent Inhibitors of Lactate Influx but Not Efflux

(2014) N. Draoui et al.   MOLECULAR CANCER THERAPEUTICS

The PI3K/AKT/mTOR pathway in breast cancer: targets, trials and biomarkers

(2014) Elisavet Paplomata et al.   Therapeutic Advances in Medical Oncology

Synthesis and pharmacological evaluation of carboxycoumarins as a new antitumor treatment targeting lactate transport in cancer cells

(2013) Nihed Draoui et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Blocking Lactate Export by Inhibiting the Myc Target MCT1 Disables Glycolysis and Glutathione Synthesis

(2013) J. R. Doherty et al.   CANCER RESEARCH

Role of hypoxia-inducible factors in breast cancer metastasis

(2013) Daniele M Gilkes et al.   Future Oncology

Lactate kinetics at the lactate threshold in trained and untrained men

(2013) Laurent A. Messonnier et al.   JOURNAL OF APPLIED PHYSIOLOGY

Cancer Genome Landscapes

(2013) B. Vogelstein et al.   SCIENCE

Exercise tames the wild side of the Myc network: a hypothesis

(2012) Kishorchandra Gohil et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

The scaffold protein MEK Partner 1 is required for the survival of estrogen receptor positive breast cancer cells

(2012) Mihaela Marina et al.   Cell Communication and Signaling

Targeting the Lactate Transporter MCT1 in Endothelial Cells Inhibits Lactate-Induced HIF-1 Activation and Tumor Angiogenesis

(2012) Pierre Sonveaux et al.   PLoS One

Lactate Activates HIF-1 in Oxidative but Not in Warburg-Phenotype Human Tumor Cells

(2012) Christophe J. De Saedeleer et al.   PLoS One

Ketones and lactate increase cancer cell “stemness,” driving recurrence, metastasis and poor clinical outcome in breast cancer

(2011) Ubaldo E. Martinez-Outschoorn et al.   CELL CYCLE

Global quantification of mammalian gene expression control

(2011) Björn Schwanhäusser et al.   NATURE

An Autocrine Lactate Loop Mediates Insulin-Dependent Inhibition of Lipolysis through GPR81

(2010) Kashan Ahmed et al.   Cell Metabolism

Deciphering the Role of PI3K/Akt/mTOR Pathway in Breast Cancer Biology and Pathogenesis

(2010) Priscilla F. McAuliffe et al.   Clinical Breast Cancer

Mitochondrial and plasma membrane lactate transporter and lactate dehydrogenase isoform expression in breast cancer cell lines

(2010) Rajaa Hussien et al.   PHYSIOLOGICAL GENOMICS

Accumulation of driver and passenger mutations during tumor progression

(2010) I. Bozic et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MYC-Induced Cancer Cell Energy Metabolism and Therapeutic Opportunities

(2009) C. V. Dang et al.   CLINICAL CANCER RESEARCH

HIF-1: upstream and downstream of cancer metabolism

(2009) Gregg L Semenza   CURRENT OPINION IN GENETICS & DEVELOPMENT

Cell-cell and intracellular lactate shuttles

(2009) George A. Brooks   JOURNAL OF PHYSIOLOGY-LONDON

How is mRNA expression predictive for protein expression? A correlation study on human circulating monocytes

(2008) Yanfang Guo et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Roles of p53, Myc and HIF-1 in Regulating Glycolysis — the Seventh Hallmark of Cancer

(2008) S. J. Yeung et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Expression of BRCA1 protein in breast cancer and its prognostic significance

(2008) Emad A. Rakha et al.   HUMAN PATHOLOGY

Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice

(2008) Pierre Sonveaux et al.   JOURNAL OF CLINICAL INVESTIGATION

Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction

(2008) D. R. Wise et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA