Lactate in Sarcoma Microenvironment: Much More than just a Waste Product

Correction to: Assessment of treatment responses in children and adolescents with Ewing sarcoma with metabolic tumor parameters derived from 18F-FDG-PET/CT and circulating tumor DNA

(2020) Christian Schmidkonz et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Lactate modulates CD4+ T-cell polarization and induces an immunosuppressive environment, which sustains prostate carcinoma progression via TLR8/miR21 axis

(2019) G. Comito et al.   ONCOGENE

Impact of Concomitant Administration of Gastric Acid–Suppressive Agents and Pazopanib on Outcomes in Soft-Tissue Sarcoma Patients Treated within the EORTC 62043/62072 Trials

(2019) Olivier Mir et al.   CLINICAL CANCER RESEARCH

Causes, consequences, and therapy of tumors acidosis

(2019) Smitha R. Pillai et al.   CANCER AND METASTASIS REVIEWS

Soft tissue sarcoma in Italy: From epidemiological data to clinical networking to improve patient care and outcomes

(2019) Annalisa Trama et al.   Cancer Epidemiology

Cancer-associated fibroblasts promote prostate cancer malignancy via metabolic rewiring and mitochondrial transfer

(2019) Luigi Ippolito et al.   ONCOGENE

The Tumor Metabolic Microenvironment: Lessons from Lactate

(2019) Juan C. García-Cañaveras et al.   CANCER RESEARCH

Long non‑coding RNA HAND2‑AS1 targets glucose metabolism and inhibits cancer cell proliferation in osteosarcoma

(2019) Shunguang Chen et al.   Oncology Letters

Targeting Glycolysis through Inhibition of Lactate Dehydrogenase Impairs Tumor Growth in Preclinical Models of Ewing Sarcoma

(2019) Choh Yeung et al.   CANCER RESEARCH

Treatment and outcome of the patients with rhabdomyosarcoma of the biliary tree: Experience of the Cooperative Weichteilsarkom Studiengruppe (CWS)

(2019) Cristian Urla et al.   BMC CANCER

Osteosarcoma‐initiating cells show high aerobic glycolysis and attenuation of oxidative phosphorylation mediated by LIN28B

(2019) Emi Mizushima et al.   CANCER SCIENCE

Fructose-1,6-Bisphosphatase 2 Inhibits Sarcoma Progression by Restraining Mitochondrial Biogenesis

(2019) Peiwei Huangyang et al.   Cell Metabolism

Metabolic regulation of gene expression by histone lactylation

(2019) Di Zhang et al.   NATURE

CAIX forms a transport metabolon with monocarboxylate transporters in human breast cancer cells

(2019) Samantha Ames et al.   ONCOGENE

Adipose-Derived Mesenchymal Stem Cells Promote M2 Macrophage Phenotype through Exosomes

(2019) June Seok Heo et al.   Stem Cells International

Therapeutic Application of Mesenchymal Stem Cells Derived Extracellular Vesicles for Immunomodulation

(2019) Marina O. Gomzikova et al.   Frontiers in Immunology

Is Serum Lactate Dehydrogenase Useful for Predicting Oncological Outcome in Patients With Soft Tissue Sarcoma?

(2019) TOMOKI NAKAMURA et al.   ANTICANCER RESEARCH

Carbonic anhydrase IX and acid transport in cancer

(2019) Holger M. Becker   BRITISH JOURNAL OF CANCER

Histone Lactylation: A New Role for Glucose Metabolism

(2019) Maria V. Liberti et al.   TRENDS IN BIOCHEMICAL SCIENCES

Lactate enhanced the effect of parathyroid hormone on osteoblast differentiation via GPR81-PKC-Akt signaling

(2018) Yu Wu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Computer-aided discovery and biological characterization of human lactate dehydrogenase 5 inhibitors with anti-osteosarcoma activity

(2018) Wei Cao et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Increased Tumor Glycolysis Characterizes Immune Resistance to Adoptive T Cell Therapy

(2018) Tina Cascone et al.   Cell Metabolism

Emerging Targeted and Immune-Based Therapies in Sarcoma

(2018) Seth M. Pollack et al.   JOURNAL OF CLINICAL ONCOLOGY

Role of metabolism in cancer cell radioresistance and radiosensitization methods

(2018) Le Tang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Expression and prognostic value of lactate dehydrogenase-A and -D subunits in human uterine myoma and uterine sarcoma

(2018) Ke-juan Song et al.   MEDICINE

Meta-analysis of serum lactate dehydrogenase and prognosis for osteosarcoma

(2018) Yucheng Fu et al.   MEDICINE

Bone marrow-derived mesenchymal stem cells promote invasiveness and transendothelial migration of osteosarcoma cells via a mesenchymal to amoeboid transition

(2018) Laura Pietrovito et al.   Molecular Oncology

miR‑186 functions as a tumor suppressor in osteosarcoma cells by suppressing the malignant phenotype and aerobic glycolysis

(2018) Qianren Xiao et al.   ONCOLOGY REPORTS

Exosomes derived from human adipose tissue-derived mesenchymal stem cells alleviate atopic dermatitis

(2018) Byong Seung Cho et al.   Stem Cell Research & Therapy

Increased Lactate Secretion by Cancer Cells Sustains Non-cell-autonomous Adaptive Resistance to MET and EGFR Targeted Therapies

(2018) Maria Apicella et al.   Cell Metabolism

MiR-323a-3p suppressed the glycolysis of osteosarcoma via targeting LDHA

(2018) Hanwen Chen et al.   Human Cell

Lactate: A Metabolic Driver in the Tumour Landscape

(2018) Luigi Ippolito et al.   TRENDS IN BIOCHEMICAL SCIENCES

Cancer-associated mesenchymal stroma fosters the stemness of osteosarcoma cells in response to intratumoral acidosis via NF-κB activation

(2017) Sofia Avnet et al.   INTERNATIONAL JOURNAL OF CANCER

Immune checkpoint inhibitors in sarcomas: in quest of predictive biomarkers

(2017) Robin Veenstra et al.   LABORATORY INVESTIGATION

Pembrolizumab in advanced soft-tissue sarcoma and bone sarcoma (SARC028): a multicentre, two-cohort, single-arm, open-label, phase 2 trial

(2017) Hussein A Tawbi et al.   LANCET ONCOLOGY

Metabolic origins of spatial organization in the tumor microenvironment

(2017) Carlos Carmona-Fontaine et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cancer acidity: An ultimate frontier of tumor immune escape and a novel target of immunomodulation

(2017) Veronica Huber et al.   SEMINARS IN CANCER BIOLOGY

Discovery of human lactate dehydrogenase A (LDHA) inhibitors as anticancer agents to inhibit the proliferation of MG-63 osteosarcoma cells

(2017) Aiping Fang et al.   MedChemComm

Pharmacological or genetic inhibition of LDHA reverses tumor progression of pediatric osteosarcoma

(2016) Shan Gao et al.   BIOMEDICINE & PHARMACOTHERAPY

Prognostic implications of PD-L1 expression in patients with soft tissue sarcoma

(2016) Chan Kim et al.   BMC CANCER

Upregulated Glucose Metabolism Correlates Inversely with CD8 + T-cell Infiltration and Survival in Squamous Cell Carcinoma

(2016) Christian H. Ottensmeier et al.   CANCER RESEARCH

Reexamining cancer metabolism: lactate production for carcinogenesis could be the purpose and explanation of the Warburg Effect

(2016) Iñigo San-Millán et al.   CARCINOGENESIS

LDHA-Associated Lactic Acid Production Blunts Tumor Immunosurveillance by T and NK Cells

(2016) Almut Brand et al.   Cell Metabolism

Overcoming cetuximab resistance in Ewing's sarcoma by inhibiting lactate dehydrogenase-A

(2016) JIAXIN FU et al.   Molecular Medicine Reports

Lactate metabolism is associated with mammalian mitochondria

(2016) Ying-Jr Chen et al.   Nature Chemical Biology

Increased Expression of the Glucose Transporter Type 1 Gene Is Associated With Worse Overall Survival in Resected Pancreatic Adenocarcinoma

(2016) Ashley H. Davis-Yadley et al.   PANCREAS

Tumor-Activated Mesenchymal Stromal Cells Promote Osteosarcoma Stemness and Migratory Potential via IL-6 Secretion

(2016) Margherita Cortini et al.   PLoS One

Epidemiology and Etiology of Sarcomas

(2016) Jane Y.C. Hui   SURGICAL CLINICS OF NORTH AMERICA

Current classification, treatment options, and new perspectives in the management of adipocytic sarcomas

(2016) Alessandro De Vita et al.   OncoTargets and Therapy

Mesenchymal stem cells and immunomodulation: current status and future prospects

(2016) F Gao et al.   Cell Death & Disease

NaHCO3 enhances the antitumor activities of cytokine-induced killer cells against hepatocellular carcinoma HepG2 cells

(2016) Ya Hong Yuan et al.   Oncology Letters

Advances in sarcoma diagnostics and treatment

(2016) Amanda R. Dancsok et al.   Oncotarget

The sweet trap in tumors: aerobic glycolysis and potential targets for therapy

(2016) Li Yu et al.   Oncotarget

Altered pH gradient at the plasma membrane of osteosarcoma cells is a key mechanism of drug resistance

(2016) Sofia Avnet et al.   Oncotarget

G-protein-coupled receptor 81 promotes a malignant phenotype in breast cancer through angiogenic factor secretion

(2016) Yu Jin Lee et al.   Oncotarget

Mesenchymal Stem Cell-Derived Exosomes Promote Fracture Healing in a Mouse Model

(2016) Taisuke Furuta et al.   Stem Cells Translational Medicine

Tumour-associated macrophages correlate with poor prognosis in myxoid liposarcoma and promote cell motility and invasion via the HB-EGF-EGFR-PI3K/Akt pathways

(2015) A Nabeshima et al.   BRITISH JOURNAL OF CANCER

Neutralization of Tumor Acidity Improves Antitumor Responses to Immunotherapy

(2015) Shari Pilon-Thomas et al.   CANCER RESEARCH

Phosphoenolpyruvate Is a Metabolic Checkpoint of Anti-tumor T Cell Responses

(2015) Ping-Chih Ho et al.   CELL

A Lactate-Induced Response to Hypoxia

(2015) Dong Chul Lee et al.   CELL

Lactate promotes glutamine uptake and metabolism in oxidative cancer cells

(2015) Jhudit Pérez-Escuredo et al.   CELL CYCLE

Modes of cancer cell invasion and the role of the microenvironment

(2015) Andrew G Clark et al.   CURRENT OPINION IN CELL BIOLOGY

Human Epidermal Growth Factor Receptor 2 (HER2) –Specific Chimeric Antigen Receptor–Modified T Cells for the Immunotherapy of HER2-Positive Sarcoma

(2015) Nabil Ahmed et al.   JOURNAL OF CLINICAL ONCOLOGY

T cell metabolic fitness in antitumor immunity

(2015) Peter J. Siska et al.   TRENDS IN IMMUNOLOGY

Hydroxycarboxylic acid receptors are essential for breast cancer cells to control their lipid/fatty acid metabolism

(2015) Claudia Stäubert et al.   Oncotarget

Lactate Regulates Metabolic and Pro-inflammatory Circuits in Control of T Cell Migration and Effector Functions

(2015) Robert Haas et al.   PLOS BIOLOGY

Immunoregulation by Mesenchymal Stem Cells: Biological Aspects and Clinical Applications

(2015) Marta E. Castro-Manrreza et al.   Journal of Immunology Research

Metabolic Characterization of Polarized M1 and M2 Bone Marrow-derived Macrophages Using Real-time Extracellular Flux Analysis

(2015) Jan Van den Bossche et al.   Jove-Journal of Visualized Experiments

Microenvironmental Targets in Sarcoma

(2015) Monika Ehnman et al.   Frontiers in Oncology

Disruption of BASIGIN decreases lactic acid export and sensitizes non-small cell lung cancer to biguanides independently of the LKB1 status

(2015) Sara Granja et al.   Oncotarget

The reverse Warburg effect in osteosarcoma

(2015) Federica Sotgia et al.   Oncotarget

Role of mesenchymal stem cells in osteosarcoma and metabolic reprogramming of tumor cells

(2015) Gloria Bonuccelli et al.   Oncotarget

Prognostic significance of miR-34a in Ewing sarcoma is associated with cyclin D1 and ki-67 expression

(2014) M. T. Marino et al.   ANNALS OF ONCOLOGY

Expression of programmed death 1 is correlated with progression of osteosarcoma

(2014) Wenjie Zheng et al.   APMIS

Lactate dehydrogenase 5 isoenzyme overexpression defines resistance of prostate cancer to radiotherapy

(2014) M I Koukourakis et al.   BRITISH JOURNAL OF CANCER

Cell Surface Lactate Receptor GPR81 Is Crucial for Cancer Cell Survival

(2014) C. L. Roland et al.   CANCER RESEARCH

The Glucose Transporter Glut1 Is Selectively Essential for CD4 T Cell Activation and Effector Function

(2014) Andrew N. Macintyre et al.   Cell Metabolism

A Pilot Trial Using Lymphocytes Genetically Engineered with an NY-ESO-1-Reactive T-cell Receptor: Long-term Follow-up and Correlates with Response

(2014) P. F. Robbins et al.   CLINICAL CANCER RESEARCH

Lactate Reduces Liver and Pancreatic Injury in Toll-Like Receptor– and Inflammasome-Mediated Inflammation via GPR81-Mediated Suppression of Innate Immunity

(2014) Rafaz Hoque et al.   GASTROENTEROLOGY

Hypoxia-inducible factors in regulation of immune responses in tumour microenvironment

(2014) Vinit Kumar et al.   IMMUNOLOGY

Interleukin-34 promotes tumor progression and metastatic process in osteosarcoma through induction of angiogenesis and macrophage recruitment

(2014) Aude I. Ségaliny et al.   INTERNATIONAL JOURNAL OF CANCER

Prognostic significance of serum lactate dehydrogenase level in osteosarcoma: a meta-analysis

(2014) Jian Chen et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

MSC-derived exosomes: a novel tool to treat therapy-refractory graft-versus-host disease

(2014) L Kordelas et al.   LEUKEMIA

Antitumor Activity of 7-Aminocarboxycoumarin Derivatives, a New Class of Potent Inhibitors of Lactate Influx but Not Efflux

(2014) N. Draoui et al.   MOLECULAR CANCER THERAPEUTICS

Functional polarization of tumour-associated macrophages by tumour-derived lactic acid

(2014) Oscar R. Colegio et al.   NATURE

Targeting glucose metabolism in chondrosarcoma cells enhances the sensitivity to doxorubicin through the inhibition of lactate dehydrogenase-A

(2014) GUOJUN HUA et al.   ONCOLOGY REPORTS

Inhibition of macrophage polarization prohibits growth of human osteosarcoma

(2014) Qiang Xiao et al.   TUMOR BIOLOGY

V-ATPase is a candidate therapeutic target for Ewing sarcoma

(2013) Sofia Avnet et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Blocking Lactate Export by Inhibiting the Myc Target MCT1 Disables Glycolysis and Glutathione Synthesis

(2013) J. R. Doherty et al.   CANCER RESEARCH

V-ATPase as an effective therapeutic target for sarcomas

(2013) Francesca Perut et al.   EXPERIMENTAL CELL RESEARCH

CD8+tumor-infiltrating lymphocytes at primary sites as a possible prognostic factor of cutaneous angiosarcoma

(2013) Hiroko Fujii et al.   INTERNATIONAL JOURNAL OF CANCER

Dichloroacetate improves immune dysfunction caused by tumor-secreted lactic acid and increases antitumor immunoreactivity

(2013) Toshimitsu Ohashi et al.   INTERNATIONAL JOURNAL OF CANCER

Proton pump inhibitor chemosensitization in human osteosarcoma: from the bench to the patients’ bed

(2013) Stefano Ferrari et al.   Journal of Translational Medicine

Glucose deprivation increases monocarboxylate transporter 1 (MCT1) expression and MCT1-dependent tumor cell migration

(2013) C J De Saedeleer et al.   ONCOGENE

The role of mesenchymal stem cells in cancer development

(2013) Hiroshi Yagi et al.   Frontiers in Genetics

Modulation of Microenvironment Acidity Reverses Anergy in Human and Murine Tumor-Infiltrating T Lymphocytes

(2012) A. Calcinotto et al.   CANCER RESEARCH

Multiple Biological Activities of Lactic Acid in Cancer: Influences on Tumor Growth,Angiogenesis and Metastasis

(2012) Suveera Dhup et al.   CURRENT PHARMACEUTICAL DESIGN

Lactate, a product of glycolytic metabolism, inhibits histone deacetylase activity and promotes changes in gene expression

(2012) Tom Latham et al.   NUCLEIC ACIDS RESEARCH

Targeting the Lactate Transporter MCT1 in Endothelial Cells Inhibits Lactate-Induced HIF-1 Activation and Tumor Angiogenesis

(2012) Pierre Sonveaux et al.   PLoS One

Indoleamine 2,3 dioxygenase and metabolic control of immune responses

(2012) David H. Munn et al.   TRENDS IN IMMUNOLOGY

Macrophage Infiltration Predicts a Poor Prognosis for Human Ewing Sarcoma

(2011) Toshifumi Fujiwara et al.   AMERICAN JOURNAL OF PATHOLOGY

Lactate Influx through the Endothelial Cell Monocarboxylate Transporter MCT1 Supports an NF- B/IL-8 Pathway that Drives Tumor Angiogenesis

(2011) F. Vegran et al.   CANCER RESEARCH

Cancer Invasion and the Microenvironment: Plasticity and Reciprocity

(2011) Peter Friedl et al.   CELL

The reverse Warburg effect: Aerobic glycolysis in cancer associated fibroblasts and the tumor stroma

(2011) Stephanos Pavlides et al.   CELL CYCLE

Understanding the metabolic basis of drug resistance

(2011) Ubaldo E. Martinez-Outschoorn et al.   CELL CYCLE

Prognostic and Predictive Role of Lactate Dehydrogenase 5 Expression in Colorectal Cancer Patients Treated with PTK787/ZK 222584 (Vatalanib) Antiangiogenic Therapy

(2011) M. I. Koukourakis et al.   CLINICAL CANCER RESEARCH

Lactate shuttles at a glance: from physiological paradigms to anti-cancer treatments

(2011) N. Draoui et al.   Disease Models & Mechanisms

Lactate enhances motility of tumor cells and inhibits monocyte migration and cytokine release

(2011) Kristina Goetze   INTERNATIONAL JOURNAL OF ONCOLOGY

Cutting Edge: Distinct Glycolytic and Lipid Oxidative Metabolic Programs Are Essential for Effector and Regulatory CD4+ T Cell Subsets

(2011) R. D. Michalek et al.   JOURNAL OF IMMUNOLOGY

Acetylation Targets the M2 Isoform of Pyruvate Kinase for Degradation through Chaperone-Mediated Autophagy and Promotes Tumor Growth

(2011) Lei Lv et al.   MOLECULAR CELL

Imatinib potentiates antitumor T cell responses in gastrointestinal stromal tumor through the inhibition of Ido

(2011) Vinod P Balachandran et al.   NATURE MEDICINE

Prognostic Impact of Lymphocytes in Soft Tissue Sarcomas

(2011) Sveinung W. Sorbye et al.   PLoS One

Tumour stromal cells derived from paediatric malignancies display MSC-like properties and impair NK cell cytotoxicity

(2010) Pascal-David Johann et al.   BMC CANCER

Ketones and lactate “fuel” tumor growth and metastasis

(2010) Gloria Bonuccelli et al.   CELL CYCLE

Macrophages, innate immunity and cancer: balance, tolerance, and diversity

(2010) Alberto Mantovani et al.   CURRENT OPINION IN IMMUNOLOGY

Inhibition of CD146 gene expression via RNA interference reduces in vitro perineural invasion on ACC-M cell

(2010) W. Chen et al.   JOURNAL OF ORAL PATHOLOGY & MEDICINE

Pro-inflammatory chemokine-chemokine receptor interactions within the Ewing sarcoma microenvironment determine CD8+ T-lymphocyte infiltration and affect tumour progression

(2010) Dagmar Berghuis et al.   JOURNAL OF PATHOLOGY

Safety Concern between Autologous Fat Graft, Mesenchymal Stem Cell and Osteosarcoma Recurrence

(2010) Pierre Perrot et al.   PLoS One

Anaphase-promoting complex/cyclosome-Cdh1 coordinates glycolysis and glutaminolysis with transition to S phase in human T lymphocytes

(2010) S. L. Colombo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evidence for an Alternative Glycolytic Pathway in Rapidly Proliferating Cells

(2010) M. G. Vander Heiden et al.   SCIENCE

Review of mifamurtide in the treatment of patients with osteosarcoma

(2010) Leo Kager et al.   Therapeutics and Clinical Risk Management

Coordinate Expression of Colony-Stimulating Factor-1 and Colony-Stimulating Factor-1-Related Proteins Is Associated with Poor Prognosis in Gynecological and Nongynecological Leiomyosarcoma

(2009) Inigo Espinosa et al.   AMERICAN JOURNAL OF PATHOLOGY

MSCs inhibit monocyte-derived DC maturation and function by selectively interfering with the generation of immature DCs: central role of MSC-derived prostaglandin E2

(2009) G. M. Spaggiari et al.   BLOOD

Cell contact, prostaglandin E2and transforming growth factor beta 1 play non-redundant roles in human mesenchymal stem cell induction of CD4+CD25Highforkhead box P3+regulatory T cells

(2009) K. English et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Therapeutic potential of mesenchymal stromal cells in a mouse breast cancer metastasis model

(2009) Bo Sun et al.   CYTOTHERAPY

CD147 silencing inhibits lactate transport and reduces malignant potential of pancreatic cancer cells in in vivo and in vitro models

(2009) W Schneiderhan et al.   GUT

pH-dependent antitumor activity of proton pump inhibitors against human melanoma is mediated by inhibition of tumor acidity

(2009) Angelo De Milito et al.   INTERNATIONAL JOURNAL OF CANCER

Anti-inflammatory M2 type macrophages characterize metastasized and tyrosine kinase inhibitor-treated gastrointestinal stromal tumors

(2009) Minka van Dongen et al.   INTERNATIONAL JOURNAL OF CANCER

Human mesenchymal stem cells inhibit cancer cell proliferation by secreting DKK-1

(2009) Y Zhu et al.   LEUKEMIA

Upregulation of lactate dehydrogenase A by ErbB2 through heat shock factor 1 promotes breast cancer cell glycolysis and growth

(2009) Y H Zhao et al.   ONCOGENE

Lactate Dehydrogenase 5 Expression in Squamous Cell Head and Neck Cancer Relates to Prognosis following Radical or Postoperative Radiotherapy

(2009) Michael I. Koukourakis et al.   ONCOLOGY

Glycolytic metabolism and tumour response to fractionated irradiation

(2009) Ulrike G.A. Sattler et al.   RADIOTHERAPY AND ONCOLOGY

Tyrosine Phosphorylation Inhibits PKM2 to Promote the Warburg Effect and Tumor Growth

(2009) T. Hitosugi et al.   Science Signaling

Prognostic Significance of Macrophage Infiltration in Leiomyosarcomas

(2008) C.-H. Lee et al.   CLINICAL CANCER RESEARCH

Lactate Inhibits Lipolysis in Fat Cells through Activation of an Orphan G-protein-coupled Receptor, GPR81

(2008) Changlu Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice

(2008) Pierre Sonveaux et al.   JOURNAL OF CLINICAL INVESTIGATION

Lactate promotes glioma migration by TGF-β2–dependent regulation of matrix metalloproteinase-2

(2008) Fusun Baumann et al.   NEURO-ONCOLOGY

The tumor microenvironment and its role in promoting tumor growth

(2008) T L Whiteside   ONCOGENE

Human Leukocyte Antigen-G5 Secretion by Human Mesenchymal Stem Cells Is Required to Suppress T Lymphocyte and Natural Killer Function and to Induce CD4+CD25highFOXP3+Regulatory T Cells

(2007) Zohair Selmani et al.   STEM CELLS