Article
Medicine, General & Internal
Yu Meng, Quan Quan, Fenfen Zhang, Yao Liu, Siling Ren, Xiaoling Mu
Summary: This study investigated the prognostic value of the Ki-67 index in endometrial stromal sarcoma and identified a cut-off value of 35% for predicting recurrence. High Ki-67 index and ovarian preservation were significantly associated with shorter progress free survival. The Ki-67 index could serve as a useful prognostic marker in endometrial stromal sarcoma.
FRONTIERS IN MEDICINE
(2022)
Article
Neurosciences
Shahad Iqneibi, Jamil Nazzal, Basma Owda, Hala Sultan, Runa Amoudi, Justin Z. Amarin, Sura Al-Ghnimat, Mamoun Ahram, Maysa Al-Hussaini
Summary: p27 and p57 are dysregulated in many cancers, including ependymoma. This study investigated the expression of p27, p57, cyclin D1, nestin, and Ki-67 in ependymoma and found significant associations between low p27 expression and tumors with foci of necrosis. Furthermore, cyclin D1, nestin, and Ki-67 were found to be associated with certain tumor features.
Article
Genetics & Heredity
Runyi Jiang, Jinbo Hu, Hongfei Zhou, Haifeng Wei, Shaohui He, Jianru Xiao
Summary: This study developed a prognostic gene signature based on hypoxia-related genes (HRGs) for predicting survival in Ewing sarcoma (EWS) patients. The study also identified potential therapeutic targets and found that targeting specific genes may improve the prognosis of EWS patients.
FRONTIERS IN GENETICS
(2022)
Article
Oncology
Giada Del Baldo, Rachid Abbas, Maria Antonietta De Ioris, Valentina Di Ruscio, Iside Alessi, Evelina Miele, Angela Mastronuzzi, Giuseppe Maria Milano
Summary: This study demonstrates the potential prognostic role of serum lactate dehydrogenase (LDH) in Ewing sarcoma diagnosis and the low cost of LDH evaluation makes it suitable as a prognostic biomarker in pediatric oncology with limited resources.
Article
Biochemistry & Molecular Biology
Elisa De Tomi, Rachele Campagnari, Elisa Orlandi, Alessia Cardile, Valentina Zanre, Marta Menegazzi, Macarena Gomez-Lira, Giovanni Gotte
Summary: ONC exhibits cytostatic and cytotoxic activities against melanoma by upregulating onco-suppressor microRNAs such as miR-20a-3p, miR-29a-3p, and miR-34a-5p. It also inhibits the expression of proteins involved in cell survival pathways and metastasis. These findings suggest that the anti-tumor effects of ONC in melanoma cells may be mediated by the regulation of miRNAs expression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Medicine, Research & Experimental
Afsane Bahrami, Gordon A. Ferns
Summary: miR-148b is a tumor suppressor gene that may be responsible for the tumorigenesis of various types of cancer. This review discusses the potential clinical importance of miR-148b in tumor diagnosis, prognosis, and therapeutics.
CURRENT MOLECULAR MEDICINE
(2022)
Article
Oncology
Pingping Wang, Hai Li, Yu Hu, Xiaojing Peng, Xinhua Ye, Di Xu, Ao Li
Summary: This study found a moderate correlation between vascular density grade and Ki-67 LI in soft tissue sarcoma, with other ultrasound features showing no correlation. The optimal cut-off point for distinguishing low and high proliferation groups was determined to be grade II. The area under the ROC curve was 0.74, with a sensitivity of 60.6% and specificity of 78.6%.
FRONTIERS IN ONCOLOGY
(2021)
Article
Environmental Sciences
Ghulam Qadir Chanihoon, Zunera Khalid, Hassan Imran Afridi, Tassadaq Hussain Jafar, Abdelmohsen A. Nassani, Ahsanullah Unar, Mohamed Haffar
Summary: The study compares the content of key mineral resources (magnesium, sodium, calcium, and potassium) in biological materials between ES hypertensive patients and healthy controls, finding that ES hypertensive patients have higher sodium levels but lower magnesium, potassium, and calcium levels.
ENVIRONMENTAL RESEARCH
(2022)
Article
Medicine, Research & Experimental
Jia-Xing Sun, Guo-Rui Dou, Zi-Yan Yang, Liang Liang, Juan-Li Duan, Bai Ruan, Man-Hong Li, Tian-Fang Chang, Xin-Yuan Xu, Juan-Juan Chen, Yu-Sheng Wang, Xian-Chun Yan, Hua Han
Summary: The study demonstrates that miR-218 acts as a downstream effector of Notch signaling in quiescent endothelial cells, inhibiting cell proliferation and sprouting, and could be a potential treatment for angiogenesis-related diseases.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Review
Oncology
Matthew G. Davey, Sean O. Hynes, Michael J. Kerin, Nicola Miller, Aoife J. Lowery
Summary: In breast cancer development, the expression of Ki-67 is a valuable indicator for prognosis and treatment decision making. The advent of molecular medicine has transformed breast cancer management by recognizing the heterogeneity of the disease and using a combination of factors for substratification and personalization of treatment modalities. Routine evaluation of Ki-67 as a proliferation marker in breast cancer patients has limitations, but promising strategies are being explored to enhance its utility in future oncology.
Review
Oncology
Qixin Liu, Ziheng Peng, Liangfang Shen, Lin Shen
Summary: Ki-67 overexpression is associated with poor overall survival rates in melanoma patients, but not correlated with PFS and RFS rates. Ki-67 expression levels are associated with tumor thickness.
FRONTIERS IN ONCOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Kai Zhang, Yue Dai, Yajie Liu, Juan Tao, Ziang Pan, Lizhi Xie, Shaowu Wang
Summary: The correlation between parameters derived from IVIM and DKI and Ki-67 LI in soft tissue sarcoma was explored in this study. MK was found to be the optimal imaging biomarker for assessing the Ki-67 expression of STS.
EUROPEAN RADIOLOGY
(2022)
Article
Oncology
Sun-Young Jun, Seung-Mo Hong, Kee-Taek Jang
Summary: The expression of Cyclin D1 in small intestinal adenocarcinomas (SIACs) has not been comprehensively studied. This study found that Cyclin D1 is commonly overexpressed in SIACs, and high expression of Cyclin D1 is associated with favorable prognostic indicators.
Article
Medicine, General & Internal
Jing Peng, Xing Min Han
Summary: This study investigated the characteristics and factors affecting the prognosis of ES/pPNET patients. It was found that the treatment method and metastasis at diagnosis were associated with the survival time of ES/pPNET patients.
Article
Medicine, General & Internal
D. Ayerden, M. Tayfur, M. G. Balci
Summary: The study found that Cyclin D1 and Ki-67 staining rates were increased in colon adenocarcinomas compared to colon adenomas, suggesting that immunohistochemical markers such as Cyclin D1 and Ki-67 could be helpful in differential diagnosis between adenocarcinomas and adenomas.
NIGERIAN JOURNAL OF CLINICAL PRACTICE
(2021)
Article
Oncology
Vito Amodio, Simona Lamba, Rosaria Chila, Chiara M. Cattaneo, Benedetta Mussolin, Giorgio Corti, Giuseppe Rospo, Enrico Berrino, Claudio Tripodo, Federica Pisati, Alice Bartolini, Maria Costanza Aquilano, Silvia Marsoni, Gianluca Mauri, Caterina Marchio, Sergio Abrignani, Federica Di Nicolantonio, Giovanni Germano, Alberto Bardelli
Summary: Patients with DNA mismatch repair deficiency (MMRd) in colorectal cancer (CRC) often respond to immune checkpoint blockade therapies, while those with mismatch repair-proficient (MMRp) tumors generally do not. MMRp CRCs with variable fractions of MMRd cells may impact immune surveillance. Modulation of the MMRd fraction in MMR heterogeneous tumors can enhance their immunogenicity.
Article
Oncology
Emanuela Palmerini, Marco Gambarotti, Antoine Italiano, Michael J. Nathenson, Ravin Ratan, Palma Dileo, Salvatore Provenzano, Robin L. Jones, Steven G. DuBois, Javier Martin-Broto, Enrique de Alava, Giacomo G. Baldi, Giovanni Grignani, Virginia Ferraresi, Antonella Brunello, Luca Paoluzzi, Rossella Bertulli, Nadia Hindi, Michael Montemurro, Christian Rothermundt, Stefania Cocchi, Carmen Salguero-Aranda, Davide Donati, Juan D. Martin, Amr H. Abdelhamid Ahmed, Alessandro Mazzocca, Elisa Carretta, Marilena Cesari, Michela Pierini, Alberto Righi, Marta Sbaraglia, Maria A. Laginestra, Katia Scotlandi, Angelo P. Dei Tos, Toni Ibrahim, Silvia Stacchiotti, Bruno Vincenzi
Summary: This study aimed to define the clinical characteristics, treatment, and outcome of undifferentiated small round cell sarcomas (URCSs) patients. The results showed significant differences in prognosis between URCS subtypes, and a full molecular assessment is needed to confirm the diagnosis. Prospective studies are needed to determine the optimal treatment strategy for each URCS subtype.
EUROPEAN JOURNAL OF CANCER
(2023)
Article
Immunology
Laura Quotti Tubi, Elisa Mandato, Sara Canovas Nunes, Arash Arjomand, Fortunato Zaffino, Sabrina Manni, Alessandro Casellato, Paolo Macaccaro, Nicola Vitulo, Sara Zumerle, Odile Filhol, Brigitte Boldyreff, Christian W. Siebel, Antonella Viola, Giorgio Valle, Federica Mainoldi, Stefano Casola, Valeria Cancila, Alessandro Gulino, Claudio Tripodo, Marco Pizzi, Angelo Paolo Dei Tos, Livio Trentin, Gianpietro Semenzato, Francesco Piazza
Summary: The role of CK2 in B-cell development and activation is not well understood. Using a CK2 beta(KO) mouse model, we found that CK2 beta(KO) mice exhibit increased marginal zone (MZ) B cells and reduced follicular B cells, suggesting a role for CK2 in the regulation of BCR and NOTCH2 signaling pathways. Further analysis revealed enhanced activation of the NOTCH2 pathway in CK2 beta(KO) mice, supporting MZ B-cell development. Additionally, CK2 beta(KO) mice showed alterations in immune response and B-cell activation processes. In vitro assays demonstrated impaired signaling downstream of BCR, Toll-like receptor, CD40, and IL-4R in B cells lacking CK2 beta.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Gastroenterology & Hepatology
Rosaria M. Pipitone, Francesco Malvestiti, Grazia Pennisi, Oveis Jamialahmadi, Paola Dongiovanni, Giorgio Bertolazzi, Jussi Pihlajamaeki, Hannele Yki-Jaervinen, Umberto Vespasiani-Gentilucci, Federica Tavaglione, Samantha Maurotti, Cristiana Bianco, Gabriele Di Maria, Marco Enea, Anna L. Fracanzani, Vesa Kaerjae, Giulia Lupo, Ville Maennistoe, Marica Meroni, Roberto Piciotti, Sami Qadri, Rossella Zito, Antonio Craxi, Vito Di Marco, Calogero Camma, Claudio Tripodo, Luca Valenti, Stefano Romeo, Salvatore Petta, Stefania Grimaudo
Summary: The study found that the variation in the PDCD1 gene is associated with liver inflammation and progression to hepatocellular carcinoma (HCC) in patients with nonalcoholic fatty liver disease (NAFLD). The rs13023138 G>C variation was found to be associated with severe steatosis, NASH, and advanced fibrosis in individuals who underwent liver biopsy.
LIVER INTERNATIONAL
(2023)
Article
Cell Biology
Ubaldo Gioia, Sara Tavella, Pamela Martinez-Orellana, Giada Cicio, Andrea Colliva, Marta Ceccon, Matteo Cabrini, Ana C. Henriques, Valeria Fumagalli, Alessia Paldino, Ettore Presot, Sreejith Rajasekharan, Nicola Iacomino, Federica Pisati, Valentina Matti, Sara Sepe, Matilde I. Conte, Sara Barozzi, Zeno Lavagnino, Tea Carletti, Maria Concetta Volpe, Paola Cavalcante, Matteo Iannacone, Chiara Rampazzo, Rossana Bussani, Claudio Tripodo, Serena Zacchigna, Alessandro Marcello, Fabrizio d'Adda di Fagagna
Summary: SARS-CoV-2 causes DNA damage and alters the DNA damage response, leading to inflammation and cellular senescence.
NATURE CELL BIOLOGY
(2023)
Article
Biology
Francesco Paolo Cammarata, Filippo Torrisi, Nunzio Vicario, Valentina Bravata, Alessandro Stefano, Lucia Salvatorelli, Simona D'Aprile, Pierangela Giustetto, Giusi Irma Forte, Luigi Minafra, Marco Calvaruso, Selene Richiusa, Giuseppe Antonio Pablo Cirrone, Giada Petringa, Giuseppe Broggi, Sebastiano Cosentino, Fabrizio Scopelliti, Gaetano Magro, Danilo Porro, Massimo Libra, Massimo Ippolito, Giorgio Russo, Rosalba Parenti, Giacomo Cuttone
Summary: Despite aggressive therapeutic regimens, glioblastoma (GBM) remains a deadly brain tumor with significant resistance to radiotherapy and chemotherapy. Proton boron capture therapy (PBCT) shows promise in increasing therapeutic effectiveness and improving the quality of life of GBM patients, by utilizing radiosensitizing agents to enhance the effects of proton beam. A preclinical evaluation of PBCT in a GBM model demonstrated increased cell death and mitophagy, validating PBCT as a scalable strategy to treat GBM.
COMMUNICATIONS BIOLOGY
(2023)
Article
Oncology
Elisabetta Setola, S. Benini, A. Righi, G. Gamberi, E. Carretta, C. Ferrari, S. Avnet, E. Palmerini, G. Magagnoli, M. Gambarotti, P. L. Lollini, M. Cesari, S. Cocchi, A. Paioli, A. Longhi, K. Scotlandi, M. A. Laginestra, D. M. Donati, N. Baldini, T. Ibrahim
Summary: This study found a higher frequency of IDH mutations in G3 CCBC compared to G2. No significant differences in overall survival, relapse-free survival, and progression-free survival were observed based on the mutational status. After relapse, a higher rate of G3 was observed in IDH mutated CCBC.
Article
Oncology
Caterina Cascini, Chiara Ratti, Laura Botti, Beatrice Parma, Valeria Cancila, Adriana Salvaggio, Cristina Meazza, Claudio Tripodo, Mario P. Colombo, Claudia Chiodoni
Summary: Osteosarcoma (OS) is the most common primary bone tumor in children and adolescent. In this study, it was found that intralesional administration of a TLR9 agonist can effectively inhibit tumor growth and also have therapeutic effects on untreated contralateral lesions. The findings suggest that TLR9 agonist can act as an in situ anti-tumor vaccine, activating innate and adaptive immune responses to suppress tumor growth.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2023)
Article
Multidisciplinary Sciences
S. Cortellino, V. Quagliariello, G. Delfanti, O. Blazevits, C. Chiodoni, N. Maurea, A. Di Mauro, F. Tatangelo, F. Pisati, A. Shmahala, S. Lazzeri, V. Spagnolo, E. Visco, C. Tripodo, G. Casorati, P. Dellabona, V. D. Longo
Summary: This study explores the use of periodic cycles of a fasting-mimicking diet (FMD) to reduce the side effects caused by immunotherapy in cancer treatment. The combination of FMD cycles with immunotherapy shows promising results in delaying cancer growth and reducing cardiotoxicity.
NATURE COMMUNICATIONS
(2023)
Meeting Abstract
Oncology
Michal M. Hoppe, Patrick Jaynes, Shuangyi Fan, Yanfen Peng, Shruti Sridhar, Phuong Mai Hoang, Xin Liu, Sanjay de Mel, Limei Poon, Esther Chan, Joanne Lee, Choon Kiat Ong, Tiffany Tang, Soon Thye Lim, Chandramouli Nagarajan, Nicholas F. Grigoropoulos, Soo-Yong Tan, Susan Swee-Shan Hue, Sheng-Tsung Chang, Shih-Sung Chuang, Shaoying Li, Joseph D. Khoury, Hyungwon Choi, Pedro Farinha, Anja Mottok, David W. Scott, Carl Harris, Alessia Bottos, Gayatri Kumar, Kasthuri Kannan, Laura J. Gay, Hendrik F. Runge, Ilias Moutsopoulos, Irina Mohorianu, Daniel J. Hodson, Yen-Chee Lin, Wee-Joo Chng, Siok-Bian Ng, Claudio Tripodo, Anand D. Jeyasekharan
Meeting Abstract
Oncology
Caterina Cascini, Daniele Lecis, Laura Botti, Chiara Ratti, Valeria Cancila, Katia Scotlandi, Claudio Tripodo, Mario Paolo Colombo, Claudia Chiodoni
Article
Cell Biology
Annamaria Aprile, Laura Raggi, Simona Bolamperti, Isabella Villa, Mariangela Storto, Gaia Morello, Sarah Marktel, Claudio Tripodo, Maria Domenica Cappellini, Irene Motta, Alessandro Rubinacci, Giuliana Ferrari
Summary: Clinical evidence suggests a relationship between blood and bone, but the underlying mechanism is not fully understood. A study using beta-thalassemia as a model found that increased fibroblast growth factor 23 (FGF23) levels in patients and mice with beta-thalassemia were induced by erythropoietin via ERK1/2 and STAT5 pathways. Inhibiting FGF23 signaling with carboxyl-terminal FGF23 peptide rescued bone defects and restored hematopoietic stem cell function in mice with beta-thalassemia. FGF23 may serve as a molecular link connecting anemia, bone, and the hematopoietic stem cell niche.
SCIENCE TRANSLATIONAL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Caterina Mancarella, Andrea Morrione, Katia Scotlandi
Summary: Sarcomas are a common type of bone and soft tissue cancers in children and adolescents. Limited therapeutic options exist for these cancers, but targeted protein degradation (TPD) shows promise in overcoming some of the challenges in sarcoma treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Jose Luis Cortes-Sanchez, Daniela Melnik, Viviann Sandt, Stefan Kahlert, Shannon Marchal, Ian R. D. Johnson, Marco Calvaruso, Christian Liemersdorf, Simon L. Wuest, Daniela Grimm, Marcus Krueger
Summary: In the preparation of space and microgravity experiments, the use of ground-based facilities for initial experiments and feasibility studies is common. One approach to simulate microgravity conditions on Earth is to use a random positioning machine (RPM) as a rotary bioreactor. Combined with a suitable low-mass model system, such as cell cultures, these devices have been shown to produce results similar to those obtained in actual space experiments under real microgravity conditions. The RPM serves as a simulator of microgravity by randomizing the impact of Earth's gravity vector especially for suspended cells, and it also simulates physiological shear forces on the adherent cell layer.
Meeting Abstract
Gastroenterology & Hepatology
Grazia Pennisi, Rosaria Maria Pipitone, Francesco Malvestiti, Oveis Jamialahmadi, Paola Dongiovanni, Giorgio Bertolazzi, Jussi Pihlajamaki, Hannele Yki-Jarvinen, Umberto Vespasiani Gentilucci, Federica Tavaglione, Samantha Maurotti, Cristiana Bianco, Gabriele Di Maria, Marco Enea, Anna Ludovica Fracanzani, Vesa Karja, Giulia Lupo, Ville Mannisto, Marica Meroni, Roberto Piciotti, Sami Qadri, Rossella Zito, Antonio Craxi, Vito Di Marco, Calogero Camma, Claudio Tripodo, Luca Valenti, Stefano Romeo, Salvatore Petta, Stefania Grimaudo
JOURNAL OF HEPATOLOGY
(2023)