HSP90 Interacts with the Fibronectin N-terminal Domains and Increases Matrix Formation

Hsp90 middle domain phosphorylation initiates a complex conformational program to recruit the ATPase-stimulating cochaperone Aha1

(2019) Wanping Xu et al.   Nature Communications

Co-chaperones TIMP2 and AHA1 Competitively Regulate Extracellular HSP90:Client MMP2 Activity and Matrix Proteolysis

(2019) Alexander J. Baker-Williams et al.   Cell Reports

Targeted cancer therapy through 17-DMAG as an Hsp90 inhibitor: Overview and current state of the art

(2018) Hassan Mellatyar et al.   BIOMEDICINE & PHARMACOTHERAPY

Synergistic role of HSP90α and HSP90β to promote myofibroblast persistence in lung fibrosis

(2018) Pierre-Simon Bellaye et al.   EUROPEAN RESPIRATORY JOURNAL

Dancing with the Diva: Hsp90–Client Interactions

(2018) Martina Radli et al.   JOURNAL OF MOLECULAR BIOLOGY

Dysregulated fibronectin trafficking by Hsp90 inhibition restricts prostate cancer cell invasion

(2018) Heather K. Armstrong et al.   Scientific Reports

HSP90 inhibitors disrupt a transient HSP90-HSF1 interaction and identify a noncanonical model of HSP90-mediated HSF1 regulation

(2018) Toshiki Kijima et al.   Scientific Reports

LRP1 is required for novobiocin-mediated fibronectin turnover

(2018) Natasha Marie-Eraine Boel et al.   Scientific Reports

The HSP90 chaperone machinery

(2017) Florian H. Schopf et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mechanistic basis for the recognition of a misfolded protein by the molecular chaperone Hsp90

(2017) Javier Oroz et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mechanistic basis for the recognition of a misfolded protein by the molecular chaperone Hsp90

(2017) Javier Oroz et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

HSP90 inhibitor 17-DMAG exerts anticancer effects against gastric cancer cells principally by altering oxidant-antioxidant balance

(2017) Jeong Goo Kim et al.   Oncotarget

Hsp90 dependence of a kinase is determined by its conformational landscape

(2017) Qi Luo et al.   Scientific Reports

The Hsp70/Hsp90 Chaperone Machinery in Neurodegenerative Diseases

(2017) Rachel E. Lackie et al.   Frontiers in Neuroscience

Fibronectin is a stress responsive gene regulated by HSF1 in response to geldanamycin

(2017) Karim Colin Hassan Dhanani et al.   Scientific Reports

Fibronectin-targeted drug delivery in cancer

(2016) Heena Kumra et al.   ADVANCED DRUG DELIVERY REVIEWS

Extracellular matrix component signaling in cancer

(2016) Hinke A.B. Multhaupt et al.   ADVANCED DRUG DELIVERY REVIEWS

Extracellular matrix structure

(2016) Achilleas D. Theocharis et al.   ADVANCED DRUG DELIVERY REVIEWS

Dynamic structure of plasma fibronectin

(2016) Lisa M. Maurer et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Molecular Mechanism of Protein Kinase Recognition and Sorting by the Hsp90 Kinome-Specific Cochaperone Cdc37

(2016) Dimitra Keramisanou et al.   MOLECULAR CELL

Atomic structure of Hsp90-Cdc37-Cdk4 reveals that Hsp90 traps and stabilizes an unfolded kinase

(2016) K. A. Verba et al.   SCIENCE

Hsp90: Breaking the Symmetry

(2015) Matthias P. Mayer et al.   MOLECULAR CELL

Cell surface heparan sulfate proteoglycans are involved in the binding of Hsp90α and Hsp90β to the cell plasma membrane

(2015) Anastasiya V Snigireva et al.   Cell Adhesion & Migration

Client Proteins and Small Molecule Inhibitors Display Distinct Binding Preferences for Constitutive and Stress-Induced HSP90 Isoforms and Their Conformationally Restricted Mutants

(2015) Thomas L. Prince et al.   PLoS One

Glucocorticoid Receptor Function Regulated by Coordinated Action of the Hsp90 and Hsp70 Chaperone Cycles

(2014) Elaine Kirschke et al.   CELL

Hsp90-Tau Complex Reveals Molecular Basis for Specificity in Chaperone Action

(2014) G. Elif Karagöz et al.   CELL

The extracellular matrix modulates the hallmarks of cancer

(2014) M. W. Pickup et al.   EMBO REPORTS

Insidious Changes in Stromal Matrix Fuel Cancer Progression

(2014) Fayth L. Miles et al.   MOLECULAR CANCER RESEARCH

Modulation of the Hsp90 Chaperone Cycle by a Stringent Client Protein

(2014) Oliver Robin Lorenz et al.   MOLECULAR CELL

Hsp90 Binds Directly to Fibronectin (FN) and Inhibition Reduces the Extracellular Fibronectin Matrix in Breast Cancer Cells

(2014) Morgan C. Hunter et al.   PLoS One

The charged linker of the molecular chaperone Hsp90 modulates domain contacts and biological function

(2014) Markus Jahn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Double-Edged Sword: Conserved Functions of Extracellular Hsp90 in Wound Healing and Cancer

(2014) Michael Hance et al.   Cancers

Orthogonal High-Throughput Thermal Scanning Method for Rank Ordering Protein Formulations

(2013) Vishal C. Nashine et al.   AAPS PHARMSCITECH

ATP-driven molecular chaperone machines

(2013) Daniel K. Clare et al.   BIOPOLYMERS

Expression and prognostic significance of fibronectin and matrix metalloproteases in breast cancer metastasis

(2013) Belen Fernandez-Garcia et al.   HISTOPATHOLOGY

Fibronectin expression in carcinoma cells correlates with tumor aggressiveness and poor clinical outcome in patients with invasive breast cancer

(2013) Young Kyung Bae et al.   HUMAN PATHOLOGY

Chaperone machines for protein folding, unfolding and disaggregation

(2013) Helen Saibil   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The chaperone Hsp90: changing partners for demanding clients

(2013) Alina Röhl et al.   TRENDS IN BIOCHEMICAL SCIENCES

Structure, Function and Regulation of the Hsp90 Machinery

(2013) Johannes Buchner et al.   Biomedical Journal

Characterization of the interaction of Aha1 with components of the Hsp90 chaperone machine and client proteins

(2012) Liang Sun et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Quantitative Analysis of Hsp90-Client Interactions Reveals Principles of Substrate Recognition

(2012) Mikko Taipale et al.   CELL

Solubility-Promoting Function of Hsp90 Contributes to Client Maturation and Robust Cell Growth

(2012) Natalie W. Pursell et al.   EUKARYOTIC CELL

The extracellular matrix: A dynamic niche in cancer progression

(2012) Pengfei Lu et al.   JOURNAL OF CELL BIOLOGY

Charged linker sequence modulates eukaryotic heat shock protein 90 (Hsp90) chaperone activity

(2012) S. Tsutsumi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hsp90 structure and function studied by NMR spectroscopy

(2011) Tatiana Didenko et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The ‘active life’ of Hsp90 complexes

(2011) Chrisostomos Prodromou   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Fibronectin Aggregation and Assembly

(2011) Tomoo Ohashi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MT1-MMP regulates the turnover and endocytosis of extracellular matrix fibronectin

(2011) F. Shi et al.   JOURNAL OF CELL SCIENCE

Intrinsic disorder of the extracellular matrix

(2011) Franck Peysselon et al.   Molecular BioSystems

Fibronectins, Their Fibrillogenesis, and In Vivo Functions

(2011) J. E. Schwarzbauer et al.   Cold Spring Harbor Perspectives in Biology

Assembly of Fibronectin Extracellular Matrix

(2010) Purva Singh et al.   Annual Review of Cell and Developmental Biology

Secretion of extracellular hsp90α via exosomes increases cancer cell motility: a role for plasminogen activation

(2010) Jessica McCready et al.   BMC CANCER

Monoclonal antibody 4C5 prevents activation of MMP2 and MMP9 by disrupting their interaction with extracellular HSP90 and inhibits formation of metastatic breast cancer cell deposits

(2010) Dimitris Stellas et al.   BMC CELL BIOLOGY

BoneJ: Free and extensible bone image analysis in ImageJ

(2010) Michael Doube et al.   BONE

Targeting heat shock proteins in cancer

(2010) Gaëtan Jego et al.   CANCER LETTERS

The Regulatory Mechanism of Extracellular Hsp90α on Matrix Metalloproteinase-2 Processing and Tumor Angiogenesis

(2010) Xiaomin Song et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Charge-Rich Regions Modulate the Anti-Aggregation Activity of Hsp90

(2010) Natalie Wayne et al.   JOURNAL OF MOLECULAR BIOLOGY

HSP90 at the hub of protein homeostasis: emerging mechanistic insights

(2010) Mikko Taipale et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Staged stromal extracellular 3D matrices differentially regulate breast cancer cell responses through PI3K and beta1-integrins

(2009) Remedios Castelló-Cros et al.   BMC CANCER

Bimolecular fluorescence complementation: lighting up seven transmembrane domain receptor signalling networks

(2009) Rachel H Rose et al.   BRITISH JOURNAL OF PHARMACOLOGY

Inhibiting the transcription factor HSF1 as an anticancer strategy

(2009) Luke Whitesell et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

The Charged Linker Region Is an Important Regulator of Hsp90 Function

(2009) Otmar Hainzl et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Revisiting the mystery of fibronectin multimers: The fibronectin matrix is composed of fibronectin dimers cross-linked by non-covalent bonds

(2009) Tomoo Ohashi et al.   MATRIX BIOLOGY