The Double-Edged Sword: Conserved Functions of Extracellular Hsp90 in Wound Healing and Cancer

ERKs in Cancer: Friends or Foes?

(2014) Xavier Deschênes-Simard et al.   CANCER RESEARCH

Hsp90 Binds Directly to Fibronectin (FN) and Inhibition Reduces the Extracellular Fibronectin Matrix in Breast Cancer Cells

(2014) Morgan C. Hunter et al.   PLoS One

LDL Receptor–Related Protein-1

(2013) Steven L. Gonias et al.   AMERICAN JOURNAL OF PATHOLOGY

A Switch in the Expression of Embryonic EMT-Inducers Drives the Development of Malignant Melanoma

(2013) Julie Caramel et al.   CANCER CELL

Myeloid Cell Receptor LRP1/CD91 Regulates Monocyte Recruitment and Angiogenesis in Tumors

(2013) Nicole D. Staudt et al.   CANCER RESEARCH

Immune Chaperone gp96 Drives the Contributions of Macrophages to Inflammatory Colon Tumorigenesis

(2013) Crystal Morales et al.   CANCER RESEARCH

ERK1/2 Blockade Prevents Epithelial-Mesenchymal Transition in Lung Cancer Cells and Promotes Their Sensitivity to EGFR Inhibition

(2013) J. M. Buonato et al.   CANCER RESEARCH

Molecular Chaperone gp96 Is a Novel Therapeutic Target of Multiple Myeloma

(2013) Y. Hua et al.   CLINICAL CANCER RESEARCH

The hemopexin domain of MMP3 is responsible for mammary epithelial invasion and morphogenesis through extracellular interaction with HSP90 

(2013) A. L. Correia et al.   GENES & DEVELOPMENT

Secreted Heat Shock Protein 90α (HSP90α) Induces Nuclear Factor-κB-mediated TCF12 Protein Expression to Down-regulate E-cadherin and to Enhance Colorectal Cancer Cell Migration and Invasion

(2013) Wei-Shone Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Extracellular Heat Shock Protein 90 Signals through Subdomain II and the NPVY Motif of LRP-1 Receptor to Akt1 and Akt2: a Circuit Essential for Promoting Skin Cell Migration In Vitro and Wound Healing In Vivo

(2013) F. Tsen et al.   MOLECULAR AND CELLULAR BIOLOGY

Exosomes secreted under hypoxia enhance invasiveness and stemness of prostate cancer cells by targeting adherens junction molecules

(2013) Anand Ramteke et al.   MOLECULAR CARCINOGENESIS

Paralog-selective Hsp90 inhibitors define tumor-specific regulation of HER2

(2013) Pallav D Patel et al.   Nature Chemical Biology

Mapping differential interactomes by affinity purification coupled with data-independent mass spectrometry acquisition

(2013) Jean-Philippe Lambert et al.   NATURE METHODS

EphA2 promotes epithelial–mesenchymal transition through the Wnt/β-catenin pathway in gastric cancer cells

(2013) J Huang et al.   ONCOGENE

Multilayer control of the EMT master regulators

(2013) H Zheng et al.   ONCOGENE

Extracellular Hsp90 mediates an NF-κB dependent inflammatory stromal program: Implications for the prostate tumor microenvironment

(2013) JE Bohonowych et al.   PROSTATE

Epithelial Plasticity: A Common Theme in Embryonic and Cancer Cells

(2013) M. A. Nieto   SCIENCE

The Complex Function of Hsp70 in Metastatic Cancer

(2013) Kata Juhasz et al.   Cancers

Recent Developments in Myofibroblast Biology

(2012) Boris Hinz et al.   AMERICAN JOURNAL OF PATHOLOGY

Eph/Ephrin Signaling in Injury and Inflammation

(2012) Mark G. Coulthard et al.   AMERICAN JOURNAL OF PATHOLOGY

Toll-like receptor 4 signaling promotes epithelial-mesenchymal transition in human hepatocellular carcinoma induced by lipopolysaccharide

(2012) Ying-Ying Jing et al.   BMC Medicine

Control of Tumor Bioenergetics and Survival Stress Signaling by Mitochondrial HSP90s

(2012) Young Chan Chae et al.   CANCER CELL

Accessories to the Crime: Functions of Cells Recruited to the Tumor Microenvironment

(2012) Douglas Hanahan et al.   CANCER CELL

TWIST1 Is an ERK1/2 Effector That Promotes Invasion and Regulates MMP-1 Expression in Human Melanoma Cells

(2012) M. B. Weiss et al.   CANCER RESEARCH

Quantitative Analysis of Hsp90-Client Interactions Reveals Principles of Substrate Recognition

(2012) Mikko Taipale et al.   CELL

Matrix metalloproteinases and epidermal wound repair

(2012) Vera L. Martins et al.   CELL AND TISSUE RESEARCH

Hsp90 Molecular Chaperone Inhibitors: Are We There Yet?

(2012) L. Neckers et al.   CLINICAL CANCER RESEARCH

Epithelial-mesenchymal transitions: insights from development

(2012) J. Lim et al.   DEVELOPMENT

The reactive stroma microenvironment and prostate cancer progression

(2012) David A Barron et al.   ENDOCRINE-RELATED CANCER

Hypoxia-inducible factors as key regulators of tumor inflammation

(2012) Soulafa Mamlouk et al.   INTERNATIONAL JOURNAL OF CANCER

Secreted Hsp90 Is a Novel Regulator of the Epithelial to Mesenchymal Transition (EMT) in Prostate Cancer

(2012) Michael W. Hance et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chaperone gp96-independent Inhibition of Endotoxin Response by Chaperone-based Peptide Inhibitors

(2012) Shuang Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Anticancer Drugs Cause Release of Exosomes with Heat Shock Proteins from Human Hepatocellular Carcinoma Cells That Elicit Effective Natural Killer Cell Antitumor Responsesin Vitro

(2012) Li-Hong Lv et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hectd1 regulates intracellular localization and secretion of Hsp90 to control cellular behavior of the cranial mesenchyme

(2012) Anjali A. Sarkar et al.   JOURNAL OF CELL BIOLOGY

The critical roles of endoplasmic reticulum chaperones and unfolded protein response in tumorigenesis and anticancer therapies

(2012) B Luo et al.   ONCOGENE

Cell Surface Cdc37 Participates in Extracellular HSP90 Mediated Cancer Cell Invasion

(2012) Avraam El Hamidieh et al.   PLoS One

A comparison of epithelial-to-mesenchymal transition and re-epithelialization

(2012) Philip L. Leopold et al.   SEMINARS IN CANCER BIOLOGY

Molecular mechanisms mediating metastasis of hypoxic breast cancer cells

(2012) Gregg L. Semenza   TRENDS IN MOLECULAR MEDICINE

Epithelial-Mesenchymal Transition: General Principles and Pathological Relevance with Special Emphasis on the Role of Matrix Metalloproteinases

(2012) P. Nistico et al.   Cold Spring Harbor Perspectives in Biology

Akt/PKB-Mediated Phosphorylation of Twist1 Promotes Tumor Metastasis via Mediating Cross-Talk between PI3K/Akt and TGF-β Signaling Axes

(2012) Gongda Xue et al.   Cancer Discovery

TLR9 is important for protection against intestinal damage and for intestinal repair

(2012) William Alfred Rose II et al.   Scientific Reports

Matrix Metalloproteinase 3 Is a Mediator of Pulmonary Fibrosis

(2011) Cory M. Yamashita et al.   AMERICAN JOURNAL OF PATHOLOGY

Hypoxia Stimulates Low-Density Lipoprotein Receptor–Related Protein-1 Expression Through Hypoxia-Inducible Factor-1α in Human Vascular Smooth Muscle Cells

(2011) Jose Castellano et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Beyond the endoplasmic reticulum: atypical GRP78 in cell viability, signalling and therapeutic targeting

(2011) Min Ni et al.   BIOCHEMICAL JOURNAL

Secreted heat shock protein-90 (Hsp90) in wound healing and cancer

(2011) Wei Li et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Cancer-associated-fibroblasts and tumour cells: a diabolic liaison driving cancer progression

(2011) Paolo Cirri et al.   CANCER AND METASTASIS REVIEWS

Twist1-Induced Invadopodia Formation Promotes Tumor Metastasis

(2011) Mark A. Eckert et al.   CANCER CELL

The Unholy Trinity: Inflammation, Cytokines, and STAT3 Shape The Cancer Microenvironment

(2011) Ning Li et al.   CANCER CELL

An EGFR-ERK-SOX9 Signaling Cascade Links Urothelial Development and Regeneration to Cancer

(2011) S. Ling et al.   CANCER RESEARCH

Tumor Metastasis: Molecular Insights and Evolving Paradigms

(2011) Scott Valastyan et al.   CELL

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Extracellular HSP90: Conquering the cell surface

(2011) Katerina Sidera et al.   CELL CYCLE

Heat Shock Protein 90-Sheltered Overexpression of Insulin-Like Growth Factor 1 Receptor Contributes to Malignancy of Thymic Epithelial Tumors

(2011) M. Breinig et al.   CLINICAL CANCER RESEARCH

The functional role of reactive stroma in benign prostatic hyperplasia

(2011) Isaiah G. Schauer et al.   DIFFERENTIATION

Inhibition of RPE cell sterile inflammatory responses and endotoxin-induced uveitis by a cell-impermeable HSP90 inhibitor

(2011) Suofu Qin et al.   EXPERIMENTAL EYE RESEARCH

Tumor Promotion via Injury- and Death-Induced Inflammation

(2011) Ali Kuraishy et al.   IMMUNITY

Extracellular heat shock protein 90 plays a role in translocating chaperoned antigen from endosome to proteasome for generating antigenic peptide to be cross-presented by dendritic cells

(2011) J. Oura et al.   INTERNATIONAL IMMUNOLOGY

A fragment of secreted Hsp90α carries properties that enable it to accelerate effectively both acute and diabetic wound healing in mice

(2011) Chieh-Fang Cheng et al.   JOURNAL OF CLINICAL INVESTIGATION

The Unfolded Protein Response Is a Major Mechanism by Which LRP1 Regulates Schwann Cell Survival after Injury

(2011) E. Mantuano et al.   JOURNAL OF NEUROSCIENCE

A potentially common peptide target in secreted heat shock protein-90α for hypoxia-inducible factor-1α–positive tumors

(2011) Divya Sahu et al.   MOLECULAR BIOLOGY OF THE CELL

Affinity-based proteomics reveal cancer-specific networks coordinated by Hsp90

(2011) Kamalika Moulick et al.   Nature Chemical Biology

Inflammation meets cancer, with NF-κB as the matchmaker

(2011) Yinon Ben-Neriah et al.   NATURE IMMUNOLOGY

Focal adhesion kinase links mechanical force to skin fibrosis via inflammatory signaling

(2011) Victor W Wong et al.   NATURE MEDICINE

Why don't we get more cancer? A proposed role of the microenvironment in restraining cancer progression

(2011) Mina J Bissell et al.   NATURE MEDICINE

Hypoxia and Inflammation

(2011) Holger K. Eltzschig et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Novel Extracellular Hsp90 Mediated Co-Receptor Function for LRP1 Regulates EphA2 Dependent Glioblastoma Cell Invasion

(2011) Udhayakumar Gopal et al.   PLoS One

Extracellular Heat Shock Protein (Hsp)70 and Hsp90α Assist in Matrix Metalloproteinase-2 Activation and Breast Cancer Cell Migration and Invasion

(2011) Jessica D. Sims et al.   PLoS One

LIV-1 Promotes Prostate Cancer Epithelial-to-Mesenchymal Transition and Metastasis through HB-EGF Shedding and EGFR-Mediated ERK Signaling

(2011) Hui-Wen Lue et al.   PLoS One

A Perspective on Cancer Cell Metastasis

(2011) C. L. Chaffer et al.   SCIENCE

Actin cytoskeleton in myofibroblast differentiation: Ultrastructure defining form and driving function

(2011) Nathan Sandbo et al.   Translational Research

Extracellular Matrix Degradation and Remodeling in Development and Disease

(2011) P. Lu et al.   Cold Spring Harbor Perspectives in Biology

The regulatory mechanism of Hsp90α secretion from endothelial cells and its role in angiogenesis during wound healing

(2010) Xiaomin Song et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Secretion of extracellular hsp90α via exosomes increases cancer cell motility: a role for plasminogen activation

(2010) Jessica McCready et al.   BMC CANCER

Monoclonal antibody 4C5 prevents activation of MMP2 and MMP9 by disrupting their interaction with extracellular HSP90 and inhibits formation of metastatic breast cancer cell deposits

(2010) Dimitris Stellas et al.   BMC CELL BIOLOGY

Hypoxia, inflammation, and the tumor microenvironment in metastatic disease

(2010) Elizabeth C. Finger et al.   CANCER AND METASTASIS REVIEWS

Tobacco Smoke Promotes Lung Tumorigenesis by Triggering IKKβ- and JNK1-Dependent Inflammation

(2010) Hiroyuki Takahashi et al.   CANCER CELL

Cancer-Associated Fibroblasts Are Activated in Incipient Neoplasia to Orchestrate Tumor-Promoting Inflammation in an NF-κB-Dependent Manner

(2010) Neta Erez et al.   CANCER CELL

Matrix Metalloproteinase-9 Is Upregulated in Nucleophosmin-Anaplastic Lymphoma Kinase-Positive Anaplastic Lymphomas and Activated at the Cell Surface by the Chaperone Heat Shock Protein 90 to Promote Cell Invasion

(2010) F. Lagarrigue et al.   CANCER RESEARCH

Functional Roles of Multiple Feedback Loops in Extracellular Signal-Regulated Kinase and Wnt Signaling Pathways That Regulate Epithelial-Mesenchymal Transition

(2010) S.-Y. Shin et al.   CANCER RESEARCH

EphB Signaling Directs Peripheral Nerve Regeneration through Sox2-Dependent Schwann Cell Sorting

(2010) Simona Parrinello et al.   CELL

Immunity, Inflammation, and Cancer

(2010) Sergei I. Grivennikov et al.   CELL

Differential Proteomics Identification of HSP90 as Potential Serum Biomarker in Hepatocellular Carcinoma by Two-dimensional Electrophoresis and Mass Spectrometry

(2010) Yiyi Sun et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Low Density Lipoprotein Receptor-related Protein (LRP1) Regulates Rac1 and RhoA Reciprocally to Control Schwann Cell Adhesion and Migration

(2010) Elisabetta Mantuano et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transactivation of the Epidermal Growth Factor Receptor by Heat Shock Protein 90 via Toll-like Receptor 4 Contributes to the Migration of Glioblastoma Cells

(2010) Dominique Thuringer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Secreted Heat Shock Protein 90α Induces Colorectal Cancer Cell Invasion through CD91/LRP-1 and NF-κB-mediated Integrin αVExpression

(2010) Jinn-Shiun Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Regulatory Mechanism of Extracellular Hsp90α on Matrix Metalloproteinase-2 Processing and Tumor Angiogenesis

(2010) Xiaomin Song et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cell Surface Relocalization of the Endoplasmic Reticulum Chaperone and Unfolded Protein Response Regulator GRP78/BiP

(2010) Yi Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Heat Shock Protein 90 Mediates Efficient Antigen Cross Presentation through the Scavenger Receptor Expressed by Endothelial Cells-I

(2010) A. Murshid et al.   JOURNAL OF IMMUNOLOGY

ErbB/EGF Signaling and EMT in Mammary Development and Breast Cancer

(2010) Katharine M. Hardy et al.   JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA

Effect of the Secretory Small GTPase Rab27B on Breast Cancer Growth, Invasion, and Metastasis

(2010) An Hendrix et al.   JNCI-Journal of the National Cancer Institute

Activation of GRP78 on Endothelial Cell Membranes by an ADAM15-Derived Peptide Induces Angiogenesis

(2010) Annat Raiter et al.   JOURNAL OF VASCULAR RESEARCH

ERK2 but Not ERK1 Induces Epithelial-to-Mesenchymal Transformation via DEF Motif-Dependent Signaling Events

(2010) Sejeong Shin et al.   MOLECULAR CELL

HSP90 at the hub of protein homeostasis: emerging mechanistic insights

(2010) Mikko Taipale et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Stromal genes discriminate preinvasive from invasive disease, predict outcome, and highlight inflammatory pathways in digestive cancers

(2010) A. Saadi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hsp90 as a Gatekeeper of Tumor Angiogenesis: Clinical Promise and Potential Pitfalls

(2010) J. E. Bohonowych et al.   Journal of Oncology

GRP78: A Multifunctional Receptor on the Cell Surface

(2009) Mario Gonzalez–Gronow et al.   ANTIOXIDANTS & REDOX SIGNALING

GRP-78 secreted by tumor cells blocks the antiangiogenic activity of bortezomib

(2009) J. Kern et al.   BLOOD

Heat shock protein 90: translation from cancer to Alzheimer's disease treatment?

(2009) Wenjie Luo et al.   BMC NEUROSCIENCE

Inflammation and oncogenesis: a vicious connection

(2009) Sergei I Grivennikov et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Wound repair at a glance

(2009) T. J. Shaw et al.   JOURNAL OF CELL SCIENCE

Participation of the lipoprotein receptor LRP1 in hypoxia-HSP90  autocrine signaling to promote keratinocyte migration

(2009) D. T. Woodley et al.   JOURNAL OF CELL SCIENCE

Single proteins might have dual but related functions in intracellular and extracellular microenvironments

(2009) Derek C. Radisky et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The regulatory mechanism of Hsp90α secretion and its function in tumor malignancy

(2009) Xiaofeng Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Induction of a MT1-MMP and MT2-MMP-dependent basement membrane transmigration program in cancer cells by Snail1

(2009) I. Ota et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Expression of Toll-like receptor 4 in the prostate gland and its association with the severity of prostate cancer

(2009) Gerardo Gatti et al.   PROSTATE

Proteomics reveals lowering oxygen alters cytoskeletal and endoplasmatic stress proteins in human endothelial cells

(2009) Louise Østergaard et al.   PROTEOMICS

The Extracellular Matrix: Not Just Pretty Fibrils

(2009) R. O. Hynes   SCIENCE

Cancer associated fibroblasts in cancer pathogenesis

(2009) Omar E. Franco et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Extracellular heat shock protein 90 induces interleukin-8 in vascular smooth muscle cells

(2008) Sung-Woon Chung et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Dual Targeting of HSC70 and HSP72 Inhibits HSP90 Function and Induces Tumor-Specific Apoptosis

(2008) Marissa V. Powers et al.   CANCER CELL

Role of Acetylation and Extracellular Location of Heat Shock Protein 90  in Tumor Cell Invasion

(2008) Y. Yang et al.   CANCER RESEARCH

Expression of heat shock protein 90 at the cell surface in human neuroblastoma cells

(2008) Cristina Cid et al.   CELL STRESS & CHAPERONES

Bypassing cellular EGF receptor dependence through epithelial-to-mesenchymal-like transitions

(2008) Sharon Barr et al.   CLINICAL & EXPERIMENTAL METASTASIS

NF-κB and epithelial to mesenchymal transition of cancer

(2008) Chengyin Min et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Toll-like receptors, wound healing, and carcinogenesis

(2008) Johannes Kluwe et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Transforming Growth Factor   (TGF )-Stimulated Secretion of HSP90 : Using the Receptor LRP-1/CD91 To Promote Human Skin Cell Migration against a TGF -Rich Environment during Wound Healing

(2008) C.-F. Cheng et al.   MOLECULAR AND CELLULAR BIOLOGY

Identification of Proteins Associating with Glycosylphosphatidylinositol- Anchored T-Cadherin on the Surface of Vascular Endothelial Cells: Role for Grp78/BiP in T-Cadherin-Dependent Cell Survival

(2008) M. Philippova et al.   MOLECULAR AND CELLULAR BIOLOGY

Erk5 Controls Slug Expression and Keratinocyte Activation during Wound Healing

(2008) Valerie Arnoux et al.   MOLECULAR BIOLOGY OF THE CELL

The EphA2 Receptor and EphrinA1 Ligand in Solid Tumors: Function and Therapeutic Targeting

(2008) J. Wykosky et al.   MOLECULAR CANCER RESEARCH

Wound repair and regeneration

(2008) Geoffrey C. Gurtner et al.   NATURE

Cancer-related inflammation

(2008) Alberto Mantovani et al.   NATURE

The S100A8–serum amyloid A3–TLR4 paracrine cascade establishes a pre-metastatic phase

(2008) Sachie Hiratsuka et al.   NATURE CELL BIOLOGY

Direct regulation of TWIST by HIF-1α promotes metastasis

(2008) Muh-Hwa Yang et al.   NATURE CELL BIOLOGY

Cancer as an overhealing wound: an old hypothesis revisited

(2008) Matthias Schäfer et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

LDL Receptor-Related Protein 1: Unique Tissue-Specific Functions Revealed by Selective Gene Knockout Studies

(2008) Anna P. Lillis et al.   PHYSIOLOGICAL REVIEWS

Prostate cancer serum biomarker discovery through proteomic analysis of alpha-2 macroglobulin protein complexes

(2008) Earle F. Burgess et al.   Proteomics Clinical Applications

PERSPECTIVE ARTICLE: Growth factors and cytokines in wound healing

(2008) Stephan Barrientos et al.   WOUND REPAIR AND REGENERATION