The charged linker of the molecular chaperone Hsp90 modulates domain contacts and biological function

Designed Hsp90 Heterodimers Reveal an Asymmetric ATPase-Driven Mechanism In Vivo

(2014) Parul Mishra et al.   MOLECULAR CELL

Integration of the accelerator Aha1 in the Hsp90 co-chaperone cycle

(2013) Jing Li et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Limitations of Constant-Force-Feedback Experiments

(2012) Phillip J. Elms et al.   BIOPHYSICAL JOURNAL

Quantitative Analysis of Hsp90-Client Interactions Reveals Principles of Substrate Recognition

(2012) Mikko Taipale et al.   CELL

Hidden Markov Analysis of Trajectories in Single-Molecule Experiments and the Effects of Missed Events

(2012) Johannes Stigler et al.   CHEMPHYSCHEM

Chaperoning the Chaperone: A Role for the Co-chaperone Cpr7 in Modulating Hsp90 Function in Saccharomyces cerevisiae

(2012) Abbey D. Zuehlke et al.   GENETICS

Charged linker sequence modulates eukaryotic heat shock protein 90 (Hsp90) chaperone activity

(2012) S. Tsutsumi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Hsp90 chaperone machinery: Conformational dynamics and regulation by co-chaperones

(2011) Jing Li et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Cross-Monomer Substrate Contacts Reposition the Hsp90 N-Terminal Domain and Prime the Chaperone Activity

(2011) Timothy O. Street et al.   JOURNAL OF MOLECULAR BIOLOGY

Substrate Binding Drives Large-Scale Conformational Changes in the Hsp90 Molecular Chaperone

(2011) Timothy O. Street et al.   MOLECULAR CELL

The Complex Folding Network of Single Calmodulin Molecules

(2011) J. Stigler et al.   SCIENCE

Asymmetric Activation of the Hsp90 Dimer by Its Cochaperone Aha1

(2010) Marco Retzlaff et al.   MOLECULAR CELL

Mixed Hsp90–cochaperone complexes are important for the progression of the reaction cycle

(2010) Jing Li et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Charged Linker Region Is an Important Regulator of Hsp90 Function

(2009) Otmar Hainzl et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hsp90 charged-linker truncation reverses the functional consequences of weakened hydrophobic contacts in the N domain

(2009) Shinji Tsutsumi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The large conformational changes of Hsp90 are only weakly coupled to ATP hydrolysis

(2009) Moritz Mickler et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Dissection of the ATP-induced conformational cycle of the molecular chaperone Hsp90

(2009) Martin Hessling et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Direct Observation of Hierarchical Folding in Single Riboswitch Aptamers

(2008) W. J. Greenleaf et al.   SCIENCE