Emerging roles of linker histones in regulating chromatin structure and function

Regulatory functions and chromatin loading dynamics of linker histone H1 during endoreplication in Drosophila

(2017) Evgeniya N. Andreyeva et al.   GENES & DEVELOPMENT

Structure and Dynamics of a 197 bp Nucleosome in Complex with Linker Histone H1

(2017) Jan Bednar et al.   MOLECULAR CELL

Histone chaperone networks shaping chromatin function

(2017) Colin M. Hammond et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Chromatin potentiates transcription

(2017) Shigeki Nagai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The role of linker histone H1 modifications in the regulation of gene expression and chromatin dynamics

(2016) Annalisa Izzo et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Functional interplay between histone H1 and HMG proteins in chromatin

(2016) Yuri V. Postnikov et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Modulation of chromatin function through linker histone H1 variants

(2016) Andrzej Kowalski et al.   BIOLOGY OF THE CELL

Independent Biological and Biochemical Functions for Individual Structural Domains ofDrosophilaLinker Histone H1

(2016) Harsh Kavi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Small Number of Residues Can Determine if Linker Histones Are Bound On or Off Dyad in the Chromatosome

(2016) Bing-Rui Zhou et al.   JOURNAL OF MOLECULAR BIOLOGY

Modulations of DNA Contacts by Linker Histones and Post-translational Modifications Determine the Mobility and Modifiability of Nucleosomal H3 Tails

(2016) Alexandra Stützer et al.   MOLECULAR CELL

Piwi Modulates Chromatin Accessibility by Regulating Multiple Factors Including Histone H1 to Repress Transposons

(2016) Yuka W. Iwasaki et al.   MOLECULAR CELL

FACT Remodels the Tetranucleosomal Unit of Chromatin Fibers for Gene Transcription

(2016) Wei Li et al.   MOLECULAR CELL

The molecular hallmarks of epigenetic control

(2016) C. David Allis et al.   NATURE REVIEWS GENETICS

Hierarchical looping of zigzag nucleosome chains in metaphase chromosomes

(2016) Sergei A. Grigoryev et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The linker histone H1.0 generates epigenetic and functional intratumor heterogeneity

(2016) C. M. Torres et al.   SCIENCE

A quantitative investigation of linker histone interactions with nucleosomes and chromatin

(2016) Alison E. White et al.   Scientific Reports

Chromatin Fibers Are Formed by Heterogeneous Groups of Nucleosomes In Vivo

(2015) Maria Aurelia Ricci et al.   CELL

Functional coupling between writers, erasers and readers of histone and DNA methylation

(2015) Idelisse Ortiz Torres et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

The H1 linker histones: multifunctional proteins beyond the nucleosomal core particle

(2015) S. P. Hergeth et al.   EMBO REPORTS

Genome Distribution of Replication-independent Histone H1 Variants Shows H1.0 Associated with Nucleolar Domains and H1X Associated with RNA Polymerase II-enriched Regions

(2015) Regina Mayor et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Mechanisms of Nucleosome Recognition by Linker Histones

(2015) Bing-Rui Zhou et al.   MOLECULAR CELL

Histone H1 couples initiation and amplification of ubiquitin signalling after DNA damage

(2015) Tina Thorslund et al.   NATURE

DNA methylation pathways and their crosstalk with histone methylation

(2015) Jiamu Du et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Histone H1-mediated epigenetic regulation controls germline stem cell self-renewal by modulating H4K16 acetylation

(2015) Jin Sun et al.   Nature Communications

Linker histone H1.2 establishes chromatin compaction and gene silencing through recognition of H3K27me3

(2015) Jin-Man Kim et al.   Scientific Reports

A Genetic Screen and Transcript Profiling Reveal a Shared Regulatory Program for Drosophila Linker Histone H1 and Chromatin Remodeler CHD1

(2015) Harsh Kavi et al.   G3-Genes Genomes Genetics

Mutations in linker histone genes HIST1H1 B, C, D, and E; OCT2 (POU2F2); IRF8; and ARID1A underlying the pathogenesis of follicular lymphoma

(2014) H. Li et al.   BLOOD

The chromatin architectural proteins HMGD1 and H1 bind reciprocally and have opposite effects on chromatin structure and gene regulation

(2014) Narasimharao Nalabothula et al.   BMC GENOMICS

Chromatin as dynamic 10-nm fibers

(2014) Kazuhiro Maeshima et al.   CHROMOSOMA

Possible role of H1 histone in replication timing

(2014) Reed A. Flickinger   DEVELOPMENT GROWTH & DIFFERENTIATION

Citrullination regulates pluripotency and histone H1 binding to chromatin

(2014) Maria A. Christophorou et al.   NATURE

Mapping of six somatic linker histone H1 variants in human breast cancer cells uncovers specific features of H1.2

(2014) Lluís Millán-Ariño et al.   NUCLEIC ACIDS RESEARCH

Cryo-EM Study of the Chromatin Fiber Reveals a Double Helix Twisted by Tetranucleosomal Units

(2014) F. Song et al.   SCIENCE

Drosophila linker histone H1 coordinates STAT-dependent organization of heterochromatin and suppresses tumorigenesis caused by hyperactive JAK-STAT signaling

(2014) Na Xu et al.   Epigenetics & Chromatin

DNA Copy-Number Control through Inhibition of Replication Fork Progression

(2014) Jared T. Nordman et al.   Cell Reports

The Embryonic Linker Histone H1 Variant of Drosophila, dBigH1, Regulates Zygotic Genome Activation

(2013) Salvador Pérez-Montero et al.   DEVELOPMENTAL CELL

Linker histone H1.0 interacts with an extensive network of proteins found in the nucleolus

(2013) Anna A. Kalashnikova et al.   NUCLEIC ACIDS RESEARCH

Structural insights into the histone H1-nucleosome complex

(2013) B.-R. Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

H1 linker histone promotes epigenetic silencing by regulating both DNA methylation and histone H3 methylation

(2013) S.-M. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Drosophila H1 Regulates the Genetic Activity of Heterochromatin by Recruitment of Su(var)3-9

(2013) X. Lu et al.   SCIENCE

Linker Histone H1.2 Cooperates with Cul4A and PAF1 to Drive H4K31 Ubiquitylation-Mediated Transactivation

(2013) Kyunghwan Kim et al.   Cell Reports

The Genomic Landscape of the Somatic Linker Histone Subtypes H1.1 to H1.5 in Human Cells

(2013) Annalisa Izzo et al.   Cell Reports

High-Resolution Mapping of H1 Linker Histone Variants in Embryonic Stem Cells

(2013) Kaixiang Cao et al.   PLoS Genetics

Three-Dimensional Folding and Functional Organization Principles of the Drosophila Genome

(2012) Tom Sexton et al.   CELL

A dual role of linker histone H1.4 Lys 34 acetylation in transcriptional activation

(2012) K. Kamieniarz et al.   GENES & DEVELOPMENT

Combined bottom-up and top-down mass spectrometry analyses of the pattern of post-translational modifications of Drosophila melanogaster linker histone H1

(2012) Carles Bonet-Costa et al.   Journal of Proteomics

Gene Density, Transcription, and Insulators Contribute to the Partition of the Drosophila Genome into Physical Domains

(2012) Chunhui Hou et al.   MOLECULAR CELL

Topological domains in mammalian genomes identified by analysis of chromatin interactions

(2012) Jesse R. Dixon et al.   NATURE

Spatial partitioning of the regulatory landscape of the X-inactivation centre

(2012) Elphège P. Nora et al.   NATURE

Drosophila melanogaster linker histone dH1 is required for transposon silencing and to preserve genome integrity

(2012) Olivera Vujatovic et al.   NUCLEIC ACIDS RESEARCH

Functional interplay between p53 acetylation and H1.2 phosphorylation in p53-regulated transcription

(2012) K Kim et al.   ONCOGENE

Dense Chromatin Activates Polycomb Repressive Complex 2 to Regulate H3 Lysine 27 Methylation

(2012) W. Yuan et al.   SCIENCE

A unified phylogeny-based nomenclature for histone variants

(2012) Paul B Talbert et al.   Epigenetics & Chromatin

Dynamic Distribution of Linker Histone H1.5 in Cellular Differentiation

(2012) Jing-Yu Li et al.   PLoS Genetics

Histone H1 Depletion Impairs Embryonic Stem Cell Differentiation

(2012) Yunzhe Zhang et al.   PLoS Genetics

Global chromatin fibre compaction in response to DNA damage

(2011) Charlotte Hamilton et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Developmental control of gene copy number by repression of replication initiation and fork progression

(2011) N. Sher et al.   GENOME RESEARCH

Protein Kinase A-mediated Serine 35 Phosphorylation Dissociates Histone H1.4 from Mitotic Chromosome

(2011) Chi-Shuen Chu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Rhox Homeobox Gene Cluster Is Imprinted and Selectively Targeted for Regulation by Histone H1 and DNA Methylation

(2011) J. A. MacLean et al.   MOLECULAR AND CELLULAR BIOLOGY

On the structure and dynamics of the complex of the nucleosome and the linker histone

(2011) Georgi V. Pachov et al.   NUCLEIC ACIDS RESEARCH

Evidence for short-range helical order in the 30-nm chromatin fibers of erythrocyte nuclei

(2011) M. P. Scheffer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pioneer factors: directing transcriptional regulators within the chromatin environment

(2011) Luca Magnani et al.   TRENDS IN GENETICS

Multifunctionality of the linker histones: an emerging role for protein-protein interactions

(2010) Steven J McBryant et al.   CELL RESEARCH

Foxa1 Functions as a Pioneer Transcription Factor at Transposable Elements to ActivateAfpduring Differentiation of Embryonic Stem Cells

(2010) Joseph H. Taube et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Histone H1 phosphorylation is associated with transcription by RNA polymerases I and II

(2010) Yupeng Zheng et al.   JOURNAL OF CELL BIOLOGY

MeCP2 Binds Cooperatively to Its Substrate and Competes with Histone H1 for Chromatin Binding Sites

(2010) R. P. Ghosh et al.   MOLECULAR AND CELLULAR BIOLOGY

Linker histone H1 represses recombination at the ribosomal DNA locus in the budding yeast Saccharomyces cerevisiae

(2010) Chonghua Li et al.   MOLECULAR MICROBIOLOGY

Single-base resolution mapping of H1-nucleosome interactions and 3D organization of the nucleosome

(2010) S. H. Syed et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Site-specifically phosphorylated forms of H1.5 and H1.2 localized at distinct regions of the nucleus are related to different processes during the cell cycle

(2009) Heribert Talasz et al.   CHROMOSOMA

Histone H1 binding is inhibited by histone variant H3.3

(2009) Ulrich Braunschweig et al.   EMBO JOURNAL

Linker histone H1 is essential for Drosophila development, the establishment of pericentric heterochromatin, and a normal polytene chromosome structure

(2009) X. Lu et al.   GENES & DEVELOPMENT

Distinctive sequence patterns in metazoan and yeast nucleosomes: Implications for linker histone binding to AT-rich and methylated DNA

(2009) Feng Cui et al.   NUCLEIC ACIDS RESEARCH

Chromatin Condensing Functions of the Linker Histone C-Terminal Domain Are Mediated by Specific Amino Acid Composition and Intrinsic Protein Disorder†

(2008) Xu Lu et al.   BIOCHEMISTRY

Linker Histone Phosphorylation Regulates Global Timing of Replication Origin Firing

(2008) Christophe Thiriet et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Isolation and Characterization of a Novel H1.2 Complex That Acts as a Repressor of p53-mediated Transcription

(2008) Kyunghwan Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hydrodynamic Studies on Defined Heterochromatin Fragments Support a 30-nm Fiber Having Six Nucleosomes per Turn

(2008) Rodolfo Ghirlando et al.   JOURNAL OF MOLECULAR BIOLOGY

Nucleosome repeat length and linker histone stoichiometry determine chromatin fiber structure

(2008) Andrew Routh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reciprocal Binding of PARP-1 and Histone H1 at Promoters Specifies Transcriptional Outcomes

(2008) R. Krishnakumar et al.   SCIENCE