VEGFR2 Blockade Improves Renal Damage in an Experimental Model of Type 2 Diabetic Nephropathy

Targeting the progression of chronic kidney disease

(2020) Marta Ruiz-Ortega et al.   Nature Reviews Nephrology

Therapeutic Inhibition of VEGF Signaling and Associated Nephrotoxicities

(2019) Chelsea C. Estrada et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Interleukin-17A blockade reduces albuminuria and kidney injury in an accelerated model of diabetic nephropathy

(2019) Carolina Lavoz et al.   KIDNEY INTERNATIONAL

AMPK signalling: Implications for podocyte biology in diabetic nephropathy

(2019) Maria Szrejder et al.   BIOLOGY OF THE CELL

Gremlin, A Potential Urinary Biomarker of Anca-Associated Crescentic Glomerulonephritis

(2019) Alejandra Droguett et al.   Scientific Reports

Gremlin-1 potentiates the dedifferentiation of VSMC in early stages of atherosclerosis

(2019) Renata Silvério de Barros et al.   DIFFERENTIATION

No evidence of Gremlin1-mediated activation of VEGFR2 signaling in endothelial cells

(2019) Louise R. Dutton et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of regulatory miRNAs of the PI3K/AKT/mTOR signaling in the pathogenesis of hepatocellular carcinoma

(2019) Farzad Rahmani et al.   JOURNAL OF CELLULAR PHYSIOLOGY

PI3K/AKT/mTOR signaling as a molecular target in head and neck cancer

(2019) Franziska E. Marquard et al.   BIOCHEMICAL PHARMACOLOGY

Gremlin activates the Notch pathway linked to renal inflammation

(2018) Carolina Lavoz et al.   CLINICAL SCIENCE

Gremlin Regulates Podocyte Apoptosis via Transforming Growth Factor-β (TGF-β) Pathway in Diabetic Nephropathy

(2018) Xiao-Bing Wang et al.   MEDICAL SCIENCE MONITOR

Targeting inflammation in diabetic nephropathy: a tale of hope

(2018) Juan Antonio Moreno et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Gremlin Regulates Tubular Epithelial to Mesenchymal Transition via VEGFR2: Potential Role in Renal Fibrosis

(2018) Laura Marquez-Exposito et al.   Frontiers in Pharmacology

VEGF and the diabetic kidney: More than too much of a good thing

(2017) Syamantak Majumder et al.   JOURNAL OF DIABETES AND ITS COMPLICATIONS

Therapeutic Considerations for Antihyperglycemic Agents in Diabetic Kidney Disease

(2017) Joshua J. Neumiller et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Gremlin and renal diseases: ready to jump the fence to clinical utility?

(2017) Sergio Mezzano et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Vascular endothelial growth factor (VEGF) and VEGF receptor inhibitors in the treatment of renal cell carcinomas

(2017) Robert Roskoski   PHARMACOLOGICAL RESEARCH

Gremlin-1 is a key regulator of the invasive cell phenotype in mesothelioma

(2017) Miao Yin et al.   Oncotarget

An Update on the Use of Animal Models in Diabetic Nephropathy Research

(2016) Boris Betz et al.   Current Diabetes Reports

Podocytes: the Weakest Link in Diabetic Kidney Disease?

(2016) Jamie S. Lin et al.   Current Diabetes Reports

Therapeutic angiogenesis by vascular endothelial growth factor supplementation for treatment of renal disease

(2016) Omar C. Logue et al.   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

Gremlin promotes retinal pigmentation epithelial (RPE) cell proliferation, migration and VEGF production via activating VEGFR2-Akt-mTORC2 signaling

(2016) Yuan Liu et al.   Oncotarget

Experimental validation of methods for differential gene expression analysis and sample pooling in RNA-seq

(2015) Anto P. Rajkumar et al.   BMC GENOMICS

Gremlin is a key pro-fibrogenic factor in chronic pancreatitis

(2015) Dustin Staloch et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Gremlin regulates renal inflammation via the vascular endothelial growth factor receptor 2 pathway

(2015) Carolina Lavoz et al.   JOURNAL OF PATHOLOGY

Gremlin Activates the Smad Pathway Linked to Epithelial Mesenchymal Transdifferentiation in Cultured Tubular Epithelial Cells

(2014) Raquel Rodrigues-Diez et al.   Biomed Research International

Gremlin aggravates hyperglycemia-induced podocyte injury by a TGFβ/smad dependent signaling pathway

(2013) Guiying Li et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Collapsing glomerulopathy superimposed on diabetic nephropathy: insights into etiology of an under-recognized, severe pattern of glomerular injury

(2013) Steven P. Salvatore et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Gremlin Is a Downstream Profibrotic Mediator of Transforming Growth Factor-Beta in Cultured Renal Cells

(2013) Raquel Rodrigues-Diez et al.   NEPHRON EXPERIMENTAL NEPHROLOGY

Bone morphogenetic proteins enhance an epithelial-mesenchymal transition in normal airway epithelial cells during restitution of a disrupted epithelium

(2013) Natasha McCormack et al.   RESPIRATORY RESEARCH

Gremlin induces cell proliferation and extra cellular matrix accumulation in mouse mesangial cells exposed to high glucose via the ERK1/2 pathway

(2013) Haixia Huang et al.   BMC Nephrology

KDOQI Clinical Practice Guideline for Diabetes and CKD: 2012 Update

(2012)   AMERICAN JOURNAL OF KIDNEY DISEASES

New targets for treatment of diabetic nephropathy

(2012) Frank C. Brosius et al.   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

Vegfa Protects the Glomerular Microvasculature in Diabetes

(2012) G. A. Sivaskandarajah et al.   DIABETES

Can We Target Tubular Damage to Prevent Renal Function Decline in Diabetes?

(2012) Joseph V. Bonventre   SEMINARS IN NEPHROLOGY

HSP27/HSPB1 as an adaptive podocyte antiapoptotic protein activated by high glucose and angiotensin II

(2011) Maria D Sanchez-Niño et al.   LABORATORY INVESTIGATION

Gremlin is a novel agonist of the major proangiogenic receptor VEGFR2

(2010) S. Mitola et al.   BLOOD

Modulation of Notch-1 Signaling Alleviates Vascular Endothelial Growth Factor–Mediated Diabetic Nephropathy

(2010) Chun-Liang Lin et al.   DIABETES

Glomerular Structure and Function Require Paracrine, Not Autocrine, VEGF-VEGFR-2 Signaling

(2010) K. Sison et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

BTBR Ob/Ob Mutant Mice Model Progressive Diabetic Nephropathy

(2010) K. L. Hudkins et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Overexpression of VEGF-A in podocytes of adult mice causes glomerular disease

(2010) Delma Veron et al.   KIDNEY INTERNATIONAL

In Vivo Delivery of Gremlin siRNA Plasmid Reveals Therapeutic Potential against Diabetic Nephropathy by Recovering Bone Morphogenetic Protein-7

(2010) Qingxian Zhang et al.   PLoS One

Allelic Depletion of grem1 Attenuates Diabetic Kidney Disease

(2009) S. A. Roxburgh et al.   DIABETES

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

(2009) Da Wei Huang et al.   Nature Protocols

The Pathogenic Role of Notch Activation in Podocytes

(2009) Thiruvur Niranjan et al.   NEPHRON EXPERIMENTAL NEPHROLOGY

The Notch pathway in podocytes plays a role in the development of glomerular disease

(2008) Thiruvur Niranjan et al.   NATURE MEDICINE

Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists

(2008) Da Wei Huang et al.   NUCLEIC ACIDS RESEARCH

Co-regulation of Gremlin and Notch signalling in diabetic nephropathy

(2007) David W. Walsh et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Nephrin mediates actin reorganization via phosphoinositide 3-kinase in podocytes

(2007) J. Zhu et al.   KIDNEY INTERNATIONAL