Gremlin activates the Notch pathway linked to renal inflammation

The binding of the bone morphogenetic protein antagonist gremlin to kidney heparan sulfate: Such binding is not essential for BMP antagonism

(2017) Arnold Junior Tatsinkam et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Gremlin and renal diseases: ready to jump the fence to clinical utility?

(2017) Sergio Mezzano et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Endothelial Jag1-RBPJ signalling promotes inflammatory leucocyte recruitment and atherosclerosis

(2016) Meritxell Nus et al.   CARDIOVASCULAR RESEARCH

Inhibition of Notch Signaling Ameliorates Acute Kidney Failure and Downregulates Platelet-Derived Growth Factor Receptor β in the Mouse Model

(2016) Jan Kramer et al.   CELLS TISSUES ORGANS

Monomeric gremlin is a novel vascular endothelial growth factor receptor-2 antagonist

(2016) Elisabetta Grillo et al.   Oncotarget

Gremlin inhibits UV-induced skin cell damages via activating VEGFR2-Nrf2 signaling

(2016) Chao Ji et al.   Oncotarget

Targeting the Gremlin-VEGFR2 axis - a promising strategy for multiple diseases?

(2015) Robert Erdmann et al.   JOURNAL OF PATHOLOGY

Gremlin regulates renal inflammation via the vascular endothelial growth factor receptor 2 pathway

(2015) Carolina Lavoz et al.   JOURNAL OF PATHOLOGY

BMP signalling: agony and antagony in the family

(2015) Derek P. Brazil et al.   TRENDS IN CELL BIOLOGY

NOTCH inhibits osteoblast formation in inflammatory arthritis via noncanonical NF-κB

(2014) Hengwei Zhang et al.   JOURNAL OF CLINICAL INVESTIGATION

Tubular Overexpression of Gremlin Induces Renal Damage Susceptibility in Mice

(2014) Alejandra Droguett et al.   PLoS One

Notch and NF-κB Signaling Pathways in the Biology of Classical Hodgkin Lymphoma

(2011) R. Schwarzer et al.   CURRENT MOLECULAR MEDICINE

Crosstalk between the canonical NF-κB and Notch signaling pathways inhibits Pparγ expression and promotes pancreatic cancer progression in mice

(2011) Eleni Maniati et al.   JOURNAL OF CLINICAL INVESTIGATION

Notch2/Hes-1 Pathway Plays an Important Role in Renal Ischemia and Reperfusion Injury-Associated Inflammation and Apoptosis and the γ-Secretase Inhibitor DAPT has a Nephroprotective Effect

(2011) RenFa Huang et al.   RENAL FAILURE

Gremlin is a novel agonist of the major proangiogenic receptor VEGFR2

(2010) S. Mitola et al.   BLOOD

The story of Notch and chronic kidney disease

(2010) Shuchita Sharma et al.   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

Epithelial Notch signaling regulates interstitial fibrosis development in the kidneys of mice and humans

(2010) Bernhard Bielesz et al.   JOURNAL OF CLINICAL INVESTIGATION

NF- B in Renal Inflammation

(2010) A. B. Sanz et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Expression of Notch pathway proteins correlates with albuminuria, glomerulosclerosis, and renal function

(2010) Mariana Murea et al.   KIDNEY INTERNATIONAL

TWEAK Activates the Non-Canonical NFκB Pathway in Murine Renal Tubular Cells: Modulation of CCL21

(2010) Ana B. Sanz et al.   PLoS One

In Vivo Delivery of Gremlin siRNA Plasmid Reveals Therapeutic Potential against Diabetic Nephropathy by Recovering Bone Morphogenetic Protein-7

(2010) Qingxian Zhang et al.   PLoS One

Notch Activation Differentially Regulates Renal Progenitors Proliferation and Differentiation Toward the Podocyte Lineage in Glomerular Disorders

(2010) Laura Lasagni et al.   STEM CELLS

Allelic Depletion of grem1 Attenuates Diabetic Kidney Disease

(2009) S. A. Roxburgh et al.   DIABETES

The Pathogenic Role of Notch Activation in Podocytes

(2009) Thiruvur Niranjan et al.   NEPHRON EXPERIMENTAL NEPHROLOGY

Notch inhibition reverses kidney failure

(2008) Matthias Kretzler et al.   NATURE MEDICINE

The Notch pathway in podocytes plays a role in the development of glomerular disease

(2008) Thiruvur Niranjan et al.   NATURE MEDICINE

Co-regulation of Gremlin and Notch signalling in diabetic nephropathy

(2007) David W. Walsh et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE