Gremlin and renal diseases: ready to jump the fence to clinical utility?

The binding of the bone morphogenetic protein antagonist gremlin to kidney heparan sulfate: Such binding is not essential for BMP antagonism

(2017) Arnold Junior Tatsinkam et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Platelets as a novel source of Gremlin-1: Implications for thromboinflammation

(2017) Madhumita Chatterjee et al.   THROMBOSIS AND HAEMOSTASIS

High Plasma Levels of Gremlin-1 and Macrophage Migration Inhibitory Factor, but Not Their Ratio, Indicate an Increased Risk for Acute Coronary Syndrome in Patients With Type 2 Diabetes Mellitus

(2016) Karin A.L. Müller et al.   CLINICAL CARDIOLOGY

Monomeric gremlin is a novel vascular endothelial growth factor receptor-2 antagonist

(2016) Elisabetta Grillo et al.   Oncotarget

Gremlin inhibits UV-induced skin cell damages via activating VEGFR2-Nrf2 signaling

(2016) Chao Ji et al.   Oncotarget

miR-27a attenuates adipogenesis and promotes osteogenesis in steroid-induced rat BMSCs by targeting PPARγ and GREM1

(2016) Chenxi Gu et al.   Scientific Reports

Gremlin1 preferentially binds to bone morphogenetic protein-2 (BMP-2) and BMP-4 over BMP-7

(2015) Rachel H. Church et al.   BIOCHEMICAL JOURNAL

BMP4 and BMP Antagonists Regulate Human White and Beige Adipogenesis

(2015) Birgit Gustafson et al.   DIABETES

Gremlin1 and chronic pancreatitis: a new clinical target and biomarker?

(2015) Derek P. Brazil   JOURNAL OF MOLECULAR MEDICINE-JMM

Targeting the Gremlin-VEGFR2 axis - a promising strategy for multiple diseases?

(2015) Robert Erdmann et al.   JOURNAL OF PATHOLOGY

Gremlin regulates renal inflammation via the vascular endothelial growth factor receptor 2 pathway

(2015) Carolina Lavoz et al.   JOURNAL OF PATHOLOGY

Intrinsic BMP Antagonist Gremlin-1 as a Novel Circulating Marker in Pulmonary Arterial Hypertension

(2015) Jasmin Wellbrock et al.   LUNG

BMP signalling: agony and antagony in the family

(2015) Derek P. Brazil et al.   TRENDS IN CELL BIOLOGY

Tubular Overexpression of Gremlin Induces Renal Damage Susceptibility in Mice

(2014) Alejandra Droguett et al.   PLoS One

A Polymorphic Enhancer near GREM1 Influences Bowel Cancer Risk through Differential CDX2 and TCF7L2 Binding

(2014) Annabelle Lewis et al.   Cell Reports

Gremlin Activates the Smad Pathway Linked to Epithelial Mesenchymal Transdifferentiation in Cultured Tubular Epithelial Cells

(2014) Raquel Rodrigues-Diez et al.   Biomed Research International

Treatment with Anti–Gremlin 1 Antibody Ameliorates Chronic Hypoxia/SU5416–Induced Pulmonary Arterial Hypertension in Mice

(2013) Loredana Ciuclan et al.   AMERICAN JOURNAL OF PATHOLOGY

Cyclic Adenosine Monophosphate-Response Element–Binding Protein Mediates the Proangiogenic or Proinflammatory Activity of Gremlin

(2013) Michela Corsini et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Gremlin-1 Is an Inhibitor of Macrophage Migration Inhibitory Factor and Attenuates Atherosclerotic Plaque Growth in ApoE−/−Mice

(2013) Iris Müller et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Gremlin-1 Identifies Fibrosis and Predicts Adverse Outcome in Patients With Heart Failure Undergoing Endomyocardial Biopsy

(2013) Karin A.L. Mueller et al.   JOURNAL OF CARDIAC FAILURE

Gremlin aggravates hyperglycemia-induced podocyte injury by a TGFβ/smad dependent signaling pathway

(2013) Guiying Li et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Gremlin Is a Downstream Profibrotic Mediator of Transforming Growth Factor-Beta in Cultured Renal Cells

(2013) Raquel Rodrigues-Diez et al.   NEPHRON EXPERIMENTAL NEPHROLOGY

Gremlin Plays a Key Role in the Pathogenesis of Pulmonary Hypertension

(2012) Edwina Cahill et al.   CIRCULATION

Gremlin-1 Induces BMP-Independent Tumor Cell Proliferation, Migration, and Invasion

(2012) Minsoo Kim et al.   PLoS One

Gremlin is a novel agonist of the major proangiogenic receptor VEGFR2

(2010) S. Mitola et al.   BLOOD

Mechanisms of Tubulointerstitial Fibrosis

(2010) M. Zeisberg et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Overexpression of VEGF-A in podocytes of adult mice causes glomerular disease

(2010) Delma Veron et al.   KIDNEY INTERNATIONAL

Allelic Depletion of grem1 Attenuates Diabetic Kidney Disease

(2009) S. A. Roxburgh et al.   DIABETES

New Insights into Epithelial-Mesenchymal Transition in Kidney Fibrosis

(2009) Y. Liu   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Vascular endothelial growth factor and diabetic nephropathy

(2008) Sheldon Chen et al.   Current Diabetes Reports

Expression of gremlin, a bone morphogenetic protein antagonist,is associated with vascular calcification in uraemia

(2008) A. Jara et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Gremlin: A Novel Mediator of Epithelial Mesenchymal Transition and Fibrosis in Chronic Allograft Nephropathy

(2008) G. Carvajal et al.   TRANSPLANTATION PROCEEDINGS