Ceramide Content in Liver Increases Along with Insulin Resistance in Obese Patients

CerS1-Derived C18:0 Ceramide in Skeletal Muscle Promotes Obesity-Induced Insulin Resistance

(2019) Sarah M. Turpin-Nolan et al.   Cell Reports

Triglyceride deposit cardiomyovasculopathy: a rare cardiovascular disorder

(2019) Ming Li et al.   Orphanet Journal of Rare Diseases

Clusters of Glycemic Response to Oral Glucose Tolerance Tests Explain Multivariate Metabolic and Anthropometric Outcomes of Bariatric Surgery in Obese Patients

(2019) Lukasz Szczerbinski et al.   Journal of Clinical Medicine

Non-Alcoholic Fatty Liver Disease in Children and Adolescents: Lifestyle Change - a Systematic Review and Meta-Analysis

(2018) Melina Utz-Melere et al.   Annals of Hepatology

Molecular mechanisms of hepatic lipid accumulation in non-alcoholic fatty liver disease

(2018) David Højland Ipsen et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Increased Hepatic PDGF-AA Signaling Mediates Liver Insulin Resistance in Obesity-Associated Type 2 Diabetes

(2018) Amar Abderrahmani et al.   DIABETES

Specific Hepatic Sphingolipids Relate to Insulin Resistance, Oxidative Stress, and Inflammation in Nonalcoholic Steatohepatitis

(2018) Maria Apostolopoulou et al.   DIABETES CARE

The effect of high fat diet and metformin treatment on liver lipids accumulation and their impact on insulin action

(2018) Piotr Zabielski et al.   Scientific Reports

The effect of high-fat diet and inhibition of ceramide production on insulin action in liver

(2018) Piotr Zabielski et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Obesity-induced changes in lipid mediators persist after weight loss

(2017) A Hernandez-Carretero et al.   INTERNATIONAL JOURNAL OF OBESITY

Effect of metformin on bioactive lipid metabolism in insulin-resistant muscle

(2017) Piotr Zabielski et al.   JOURNAL OF ENDOCRINOLOGY

The Crucial Role of C18-Cer in Fat-Induced Skeletal Muscle Insulin Resistance

(2016) Agnieszka U. Blachnio-Zabielska et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Hepatic ceramides dissociate steatosis and insulin resistance in patients with non-alcoholic fatty liver disease

(2016) Panu K. Luukkonen et al.   JOURNAL OF HEPATOLOGY

Targeted Induction of Ceramide Degradation Leads to Improved Systemic Metabolism and Reduced Hepatic Steatosis

(2015) Jonathan Y. Xia et al.   Cell Metabolism

Sustained Action of Ceramide on the Insulin Signaling Pathway in Muscle Cells

(2015) Rima Hage Hassan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

BMI-related progression of atypical PKC-dependent aberrations in insulin signaling through IRS-1, Akt, FoxO1 and PGC-1α in livers of obese and type 2 diabetic humans

(2015) Mini P. Sajan et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Obesity-Induced CerS6-Dependent C16:0 Ceramide Production Promotes Weight Gain and Glucose Intolerance

(2014) Sarah M. Turpin et al.   Cell Metabolism

C16:0-Ceramide Signals Insulin Resistance

(2014) Timothy Hla et al.   Cell Metabolism

Influence of fish oil on skeletal muscle mitochondrial energetics and lipid metabolites during high-fat diet

(2013) Ian R. Lanza et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Distinct patterns of tissue-specific lipid accumulation during the induction of insulin resistance in mice by high-fat feeding

(2013) N. Turner et al.   DIABETOLOGIA

Mechanisms of hepatic triglyceride accumulation in non-alcoholic fatty liver disease

(2013) Yuki Kawano et al.   JOURNAL OF GASTROENTEROLOGY

Inhibition of ceramidede novosynthesis reduces liver lipid accumulation in rats with nonalcoholic fatty liver disease

(2013) Krzysztof Kurek et al.   LIVER INTERNATIONAL

Saturated and unsaturated fat induce hepatic insulin resistance independently of TLR-4 signaling and ceramide synthesis in vivo

(2013) T. Galbo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fenretinide Prevents Lipid-induced Insulin Resistance by Blocking Ceramide Biosynthesis

(2012) Benjamin T. Bikman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A liquid chromatography/tandem mass spectrometry method for measuring the in vivo incorporation of plasma free fatty acids into intramyocellular ceramides in humans

(2012) Agnieszka U. Blachnio-Zabielska et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

Ceramide metabolism is affected by obesity and diabetes in human adipose tissue

(2011) A.U. Błachnio-Zabielska et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Cellular mechanism of insulin resistance in nonalcoholic fatty liver disease

(2011) N. Kumashiro et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of De Novo Ceramide Synthesis Reverses Diet-Induced Insulin Resistance and Enhances Whole-Body Oxygen Consumption

(2010) J. R. Ussher et al.   DIABETES

Effect of high fat diet enriched with unsaturated and diet rich in saturated fatty acids on sphingolipid metabolism in rat skeletal muscle

(2010) Agnieszka Blachnio-Zabielska et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Receptor-mediated activation of ceramidase activity initiates the pleiotropic actions of adiponectin

(2010) William L Holland et al.   NATURE MEDICINE

Central role of ceramide biosynthesis in body weight regulation, energy metabolism, and the metabolic syndrome

(2009) Guang Yang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Free fatty acid-induced muscle insulin resistance and glucose uptake dysfunction: Evidence for PKC activation and oxidative stress-activated signaling pathways

(2009) Rafik Ragheb et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS