Sustained Action of Ceramide on the Insulin Signaling Pathway in Muscle Cells

Free fatty acid induced impairment of insulin signaling is prevented by the diastereomeric mixture of calophyllic acid and isocalophyllic acid in skeletal muscle cells

(2015) Natasha Jaiswal et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Targeting sphingolipid metabolism in the treatment of obesity/type 2 diabetes

(2015) Lara Bellini et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Characterising the Inhibitory Actions of Ceramide upon Insulin Signaling in Different Skeletal Muscle Cell Models: A Mechanistic Insight

(2014) Rana Mahfouz et al.   PLoS One

Are cultured human myotubes far from home?

(2013) Vigdis Aas et al.   CELL AND TISSUE RESEARCH

Small-Molecule Inhibitors of PKR Improve Glucose Homeostasis in Obese Diabetic Mice

(2013) T. Nakamura et al.   DIABETES

Protein tyrosine phosphatase 1B inhibition ameliorates palmitate-induced mitochondrial dysfunction and apoptosis in skeletal muscle cells

(2013) Gholamreza Taheripak et al.   FREE RADICAL BIOLOGY AND MEDICINE

Modulation of Double-Stranded RNA-Activated Protein Kinase in Insulin Sensitive Tissues of Obese Humans

(2013) Bruno M. Carvalho et al.   Obesity

Double-Stranded RNA-Activated Protein Kinase Is a Key Modulator of Insulin Sensitivity in Physiological Conditions and in Obesity in Mice

(2012) M. A. Carvalho-Filho et al.   ENDOCRINOLOGY

A liquid chromatography/tandem mass spectrometry method for measuring the in vivo incorporation of plasma free fatty acids into intramyocellular ceramides in humans

(2012) Agnieszka U. Blachnio-Zabielska et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

Eukaryotic Initiation Factor 2 Phosphorylation and Translational Control in Metabolism

(2012) Thomas D. Baird et al.   Advances in Nutrition

Endoplasmic reticulum stress does not mediate palmitate-induced insulin resistance in mouse and human muscle cells

(2011) R. Hage Hassan et al.   DIABETOLOGIA

Protection from Palmitate-Induced Mitochondrial DNA Damage Prevents from Mitochondrial Oxidative Stress, Mitochondrial Dysfunction, Apoptosis, and Impaired Insulin Signaling in Rat L6 Skeletal Muscle Cells

(2011) Larysa V. Yuzefovych et al.   ENDOCRINOLOGY

Double-Stranded RNA-Dependent Protein Kinase Links Pathogen Sensing with Stress and Metabolic Homeostasis

(2010) Takahisa Nakamura et al.   CELL

A role for protein kinase PKR in the mediation of Epstein–Barr virus latent membrane protein-1-induced IL-6 and IL-10 expression

(2010) San San Lin et al.   CYTOKINE

Inhibition of De Novo Ceramide Synthesis Reverses Diet-Induced Insulin Resistance and Enhances Whole-Body Oxygen Consumption

(2010) J. R. Ussher et al.   DIABETES

Saturated- and n-6 Polyunsaturated-Fat Diets Each Induce Ceramide Accumulation in Mouse Skeletal Muscle: Reversal and Improvement of Glucose Tolerance by Lipid Metabolism Inhibitors

(2010) G. Frangioudakis et al.   ENDOCRINOLOGY

Protein kinase C isoforms: Mediators of reactive lipid metabolites in the development of insulin resistance

(2010) Sophie Turban et al.   FEBS LETTERS

The Double-stranded RNA–dependent Protein Kinase Differentially Regulates Insulin Receptor Substrates 1 and 2 in HepG2 Cells

(2010) Xuerui Yang et al.   MOLECULAR BIOLOGY OF THE CELL

Different impacts of saturated and unsaturated free fatty acids on COX-2 expression in C2C12 myotubes

(2009) Akito Kadotani et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Repression of PKR mediates palmitate-induced apoptosis in HepG2 cells through regulation of Bcl-2

(2009) Xuerui Yang et al.   CELL RESEARCH

Plasma Membrane Subdomain Compartmentalization Contributes to Distinct Mechanisms of Ceramide Action on Insulin Signaling

(2009) C. M. Blouin et al.   DIABETES

Bax signaling regulates palmitate-mediated apoptosis in C2C12 myotubes

(2008) Jonathan M. Peterson et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Targeting of PKCζ and PKB to caveolin-enriched microdomains represents a crucial step underpinning the disruption in PKB-directed signalling by ceramide

(2008) Eric Hajduch et al.   BIOCHEMICAL JOURNAL

Updating the effects of fatty acids on skeletal muscle

(2008) Leonardo R. Silveira et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Bioactive sphingolipids: metabolism and function

(2008) Nana Bartke et al.   JOURNAL OF LIPID RESEARCH

Principles of bioactive lipid signalling: lessons from sphingolipids

(2008) Yusuf A. Hannun et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY