The melanocortin-4 receptor as target for obesity treatment: a systematic review of emerging pharmacological therapeutic options

Chronic Treatment With a Melanocortin-4 Receptor Agonist Causes Weight Loss, Reduces Insulin Resistance, and Improves Cardiovascular Function in Diet-Induced Obese Rhesus Macaques

(2012) P. Kievit et al.   DIABETES

The FDA's Assessment of Two Drugs for Chronic Weight Management

(2012) Eric Colman et al.   NEW ENGLAND JOURNAL OF MEDICINE

Social Position, Psychological Stress, and Obesity: A Systematic Review

(2012) Carla J. Moore et al.   Journal of the Academy of Nutrition and Dietetics

Serendipitous discovery of a new class of agonists for the melanocortin 1 and 4 receptors and a new class of cyclophanes

(2011) Kilian Conde-Frieboes et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Discovery of a piperazine urea based compound as a potent, selective, orally bioavailable melanocortin subtype-4 receptor partial agonist

(2011) Qingmei Hong et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Sympathetic Response to Insulin Is Mediated by Melanocortin 3/4 Receptors in the Hypothalamic Paraventricular Nucleus

(2011) Kathryn R. Ward et al.   HYPERTENSION

Spiroindane based amides as potent and selective MC4R agonists for the treatment of obesity

(2010) Shuwen He et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Discovery of highly potent and efficacious MC4R agonists with spiroindane N-Me-1,2,4-triazole privileged structures for the treatment of obesity

(2010) Shuwen He et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Novel pharmacological MC4R agonists can efficiently activate mutated MC4R from obese patient with impaired endogenous agonist response

(2010) Pierre Roubert et al.   JOURNAL OF ENDOCRINOLOGY

Pharmacological Chaperones Restore Function to MC4R Mutants Responsible for Severe Early-Onset Obesity

(2010) P. Rene et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Obesity-Linked Variants of Melanocortin-4 Receptor Are Misfolded in the Endoplasmic Reticulum and Can Be Rescued to the Cell Surface by a Chemical Chaperone

(2010) Susana Granell et al.   MOLECULAR ENDOCRINOLOGY

Multicenter, Placebo-Controlled Trial of Lorcaserin for Weight Management

(2010) Steven R. Smith et al.   NEW ENGLAND JOURNAL OF MEDICINE

Pericardial Fat and Atrial Conduction Abnormalities in the Multiethnic Study of Atherosclerosis (MESA)

(2010) Michael J. Babcock et al.   Obesity

The economic burden of obesity worldwide: a systematic review of the direct costs of obesity

(2010) D. Withrow et al.   Obesity Reviews

Potent and Selective Agonism of the Melanocortin Receptor 4 With MK-0493 Does Not Induce Weight Loss in Obese Human Subjects: Energy Intake Predicts Lack of Weight Loss Efficacy

(2009) R Krishna et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Analysis of the therapeutic functions of novel melanocortin receptor agonists in MC3R- and MC4R-deficient C57BL/6J mice

(2009) K. Ganesh Kumar et al.   PEPTIDES

Structure-activity relationship and metabolic stability studies of backbone cyclization and N-methylation of melanocortin peptides

(2008) Yaniv Linde et al.   BIOPOLYMERS

Backbone Cyclic Peptidomimetic Melanocortin-4 Receptor Agonist as a Novel Orally Administrated Drug Lead for Treating Obesity

(2008) Shmuel Hess et al.   JOURNAL OF MEDICINAL CHEMISTRY

Gene-environment interaction and obesity

(2008) Lu Qi et al.   NUTRITION REVIEWS

Identification and characterization of pyrrolidine diastereoisomers as potent functional agonists and antagonists of the human melanocortin-4 receptor

(2007) Chen Chen et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS