Article
Biochemistry & Molecular Biology
Buyun Kim, Ki Yong Lee, Byoungduck Park
Summary: Alzheimer's disease is a severe neurodegenerative disorder characterized by distinct pathological features. The nuclear factor-κB plays a crucial role in neuronal inflammation. Isoorientin (ISO) shows potential as a promising therapeutic drug candidate for the treatment and prevention of AD.
Review
Biochemistry & Molecular Biology
Bhagavathi Sundaram Sivamaruthi, Neha Raghani, Mehul Chorawala, Sankha Bhattacharya, Bhupendra G. Prajapati, Gehan M. Elossaily, Chaiyavat Chaiyasut
Summary: The NF-kappa B pathway plays a crucial role in various diseases, including Alzheimer's disease. It has the potential to mitigate neuroinflammation, modulate amyloid beta production, and promote neuronal survival in the progression of Alzheimer's disease. However, there are limitations and challenges associated with this approach, as balancing inflammation inhibition and preserving physiological immune responses is critical.
Article
Neurosciences
Rui Chen, Ziyu Wang, Zhongwen Zhi, Jisha Tian, Ying Zhao, Junshan Sun
Summary: Oxysophoridine suppresses A beta-induced oxidative stress and inflammation in BV-2 cells by inhibiting the TLR4/NF-kappa B pathway.
BRAIN RESEARCH BULLETIN
(2021)
Article
Plant Sciences
Yue Shen, Li Teng, Yuhan Qu, Jie Liu, Xudong Zhu, Shan Chen, Longfei Yang, Yuehui Huang, Qin Song, Qiang Fu
Summary: The dried aboveground part of Geranium Wilfordii Maxim., known as lao-guan-cao in Traditional Chinese Medicine, has been used for its anti-inflammatory and anti-proliferation activities. Specifically, the compound Corilagin (COR) found in this plant has shown various pharmacological effects, such as anti-inflammatory, anti-tumor, and anti-microbial properties. In a study focusing on rheumatoid arthritis (RA), COR demonstrated anti-proliferation and anti-inflammation effects by inhibiting synovial fibroblasts and suppressing inflammatory responses through NF-kappa B and MAPK signaling pathways.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Environmental Sciences
Xiaodong Yu, Tao Wu, Bo Liao, Zhongbo Du, Pingyu Zhu
Summary: Corilagin (CLG) possesses anti-tumor and anti-proliferative actions in bladder cancer cells by inhibiting cell viability, adhesion, movement, invasion, and inflammation, and inducing apoptosis. CLG also inhibits migration and invasion through the repression of NF-kappa B mediated P13K/Akt signaling pathways.
ENVIRONMENTAL TOXICOLOGY
(2022)
Article
Pharmacology & Pharmacy
Jing Liu, Ye Lin, Yang Yang, Yane Guo, Yanchang Shang, Bo Zhou, Tianlong Liu, Jiao Fan, Chao Wei
Summary: This study demonstrates that chronic Z-GS treatment can improve cognitive and neuropathological impairments in transgenic mouse models of Alzheimer's disease (AD). Z-GS treatment can improve learning and memory deficits, reduce amyloid-beta levels and plaque burden, alleviate neuroinflammation and synaptic defects. Furthermore, Z-GS treatment inhibits the TLR4/NF-kappa B signaling pathway and regulates amyloid precursor protein processing.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Plant Sciences
Jing Han, Haotian Zhang, Yu Zhang, Zan Zhang, Maomao Yu, Sijie Wang, Fei Han
Summary: This study evaluated the neuroprotective effects of Lingguizhugan decoction (LGZGD) on Aβ25-35-induced PC12 cells and elucidated its molecular mechanism. The results showed that LGZGD increased cell viability, reduced inflammatory factors, inhibited cell apoptosis, and modulated the NF-κB/MAPK signaling pathways. Therefore, LGZGD may be a valuable drug candidate for attenuating Aβ25-35-induced neurotoxicity.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Emily Sun, Aishat Motolani, Leonardo Campos, Tao Lu
Summary: This review provides an overview of the role of NF-kappa B in the pathogenesis of Alzheimer's Disease (AD), including its interaction with various molecular factors in AD models, neurons, and glial cells. With the multifactorial nature of AD development and the failure of many drugs, targeting the NF-kappa B signaling pathway may generate widespread interest in AD research and provide more therapeutic options for AD patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Yue Dong, Hanqiao Yu, Xueqi Li, Kelong Bian, Yayuan Zheng, Mingrui Dai, Xuejian Feng, Yao Sun, Yu He, Bin Yu, Haihong Zhang, Jiaxin Wu, Xianghui Yu, Hui Wu, Wei Kong
Summary: This study revealed, for the first time, that hyperphosphorylated tau (pTau) induces necroptosis and inflammation in Alzheimer's disease (AD) by activating the RIPK1/RIPK3/MLKL and NF-kappa B pathways, thereby contributing to neuronal death.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Cell Biology
Xuan Li, Wanlu Xie, Qiong Pan, Xiaoxun Zhang, Liangjun Zhang, Nan Zhao, Qiaoling Xie, Jingjing Ding, Jin Chai
Summary: This study found that both SEMA7A mutation and overexpression can activate the NF-κB p50/p65 pathway through integrin beta 1 and play a crucial role in inflammatory responses.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Biology
Fu-Chao Liu, Hung-Chen Lee, Chia-Chih Liao, An-Hsun Chou, Huang-Ping Yu
Summary: Corilagin post-treatment attenuates acetaminophen-induced liver injury through regulation of NOX-derived ROS and IL-6/STAT3 and MAPK/NF-kappa B signaling pathways.
Article
Engineering, Biomedical
Bibin Anand, Qi Wu, Maryam Nakhaei-Nejad, Govindarajan Karthivashan, Lyudmyla Dorosh, Sara Amidian, Abhishek Dahal, Xiuju Li, Maria Stepanova, Holger Wille, Fabrizio Giuliani, Satyabrata Kar
Summary: Native PLGA nanoparticles show therapeutic potential in the treatment of Alzheimer's disease by suppressing aggregation of beta-amyloid peptides, triggering their disassembly, reducing phosphorylation of tau protein, enhancing neuronal viability, and attenuating memory deficits and A beta levels in animal models of AD.
BIOACTIVE MATERIALS
(2022)
Article
Clinical Neurology
Kate E. Foley, Zachary Winder, Tiffany L. Sudduth, Barbara J. Martin, Peter T. Nelson, Gregory A. Jicha, Jordan P. Harp, Erica M. Weekman, Donna M. Wilcock
Summary: Protein-based plasma assays show promise in improving accessibility and specificity of molecular diagnostics for dementia. The study found significant associations between Alzheimer's disease and inflammatory biomarkers, suggesting peripheral inflammation plays a role in AD pathology. The strength of biomarker correlations varied across different clinical diagnoses, reflecting changes in cognitive continuum.
ALZHEIMERS & DEMENTIA
(2023)
Article
Neurosciences
Thomas J. LaRocca, Alyssa N. Cavalier, Christine M. Roberts, Maddie R. Lemieux, Pooja Ramesh, Micklaus A. Garcia, Christopher D. Link
Summary: The amyloid beta (A beta) peptide is believed to have a central role in Alzheimer's disease by synergistically promoting pro-inflammatory activation in primary human astrocytes with known cytokines. By directly substituting for the complement component C1q in a cytokine cocktail, A beta activates astrocytes similarly to neurotoxic astrocytes found in brain aging and AD. The biological action of A beta at low concentrations is distinct from that of high doses typically used in in vitro studies.
NEUROBIOLOGY OF DISEASE
(2021)
Article
Neurosciences
Zi-Xuan Tan, Fang Dong, Lin-Yu Wu, Ya-Shuo Feng, Feng Zhang
Summary: Alzheimer's disease is a major burden on global healthcare systems, and effective treatments are needed. Accumulation of neurotoxic beta-amyloid peptide (A beta) is a feature of AD, but medications targeting its reduction have yet to prove effective. Physical exercise has benefits for AD, including reducing A beta deposition to alleviate symptoms.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Chemistry, Medicinal
Van-Long Truong, Mira Jun, Woo-Sik Jeong
Summary: Consumption of plant-derived natural products and over-the-counter drugs is increasing globally, making studies on phytochemical-OTC drug interactions more significant. These interactions can impact the pharmacokinetics and pharmacodynamics of OTC drugs, with some interactions benefiting patients while others causing adverse effects.
JOURNAL OF MEDICINAL FOOD
(2021)
Article
Chemistry, Medicinal
Van-Long Truong, Benya Manochai, Thu-Trang Pham, Woo-Sik Jeong
Summary: The study revealed that Zingiber montanum oil (ZMO) has strong antioxidant and anti-inflammatory capabilities, making it a potential candidate for the prevention and treatment of inflammatory and oxidative conditions.
JOURNAL OF MEDICINAL FOOD
(2021)
Article
Food Science & Technology
Fang Dong, Hu-Zhe Zheng, Woo-Sik Jeong, Shin-Kyo Chung, Zhong-Yuan Qu, Xiang Zou, Chen Liu, Qiong Xiang, Feng Feng
Summary: The study optimized the synthesis process to obtain selenium-Euryale ferox Salisb. polysaccharide, which showed antioxidant activity, suggesting its potential use as an antioxidant or selenium nutritional supplement.
APPLIED BIOLOGICAL CHEMISTRY
(2021)
Review
Plant Sciences
Van-Long Truong, Woo-Sik Jeong
Summary: This review provides an overview of red ginseng oil (RGO), focusing on its extraction technologies, chemical composition, health benefits, and safety. The molecular mechanisms underlying the bioactivity of RGO are discussed, along with its potential applications in nutraceuticals, functional foods, and functional cosmetics. Further studies should aim to deepen our understanding of the underlying molecular mechanisms, explore the composition-functionality relationship, and verify the bioactivities of RGO in clinical models.
JOURNAL OF GINSENG RESEARCH
(2022)
Article
Food Science & Technology
Van-Long Truong, Woo-Sik Jeong
Summary: Polyphenols, including phenolic acids, flavonoids, and procyanidins, are abundant in food and beverage derived from plants. Tea polyphenols have established antioxidant and anti-inflammatory properties, and their supplementation can prevent inflammatory conditions and improve the outcome of patients with inflammatory bowel diseases (IBD).
FOOD SCIENCE AND HUMAN WELLNESS
(2022)
Article
Biochemistry & Molecular Biology
Van-Long Truong, Razanamanana H. G. Rarison, Woo-Sik Jeong
Summary: Sweet pepper juices can reduce UVB-induced skin damage and offer protective effects against photoaging by regulating genes involved in dermal matrix production, downregulating pro-inflammatory proteins, enhancing antioxidant defense, and preventing DNA damage.
Article
Plant Sciences
Tae-Hyu Kim, Van-Long Truong, Woo-Sik Jeong
Summary: The root extract of Ligularia fischeri Turcz has higher antioxidant capacity and total flavonoid levels, enhancing cellular antioxidant defense and exhibiting anti-inflammatory effects.
Article
Food Science & Technology
Minhye Shin, Van-Long Truong, Minjee Lee, Donggyu Kim, Myun Soo Kim, Hana Cho, Young Hoon Jung, Jungwoo Yang, Woo Sik Jeong, Younghoon Kim
Summary: In this study, the inhibitory effects of probiotic culture supernatants on tyrosinase were evaluated, and novel bacterial metabolites that can be used as potent tyrosinase inhibitors were discovered. These metabolites can reduce melanin synthesis and alter protein expression associated with melanogenesis. The findings suggest that probiotic culture supernatants containing high amounts of phenyllactic acid have potential use as anti-melanogenesis agents in food and medicines.
CURRENT RESEARCH IN FOOD SCIENCE
(2023)
Article
Microbiology
Hyeon Ji Jeon, Seung-Hwan You, Eoun Ho Nam, Van-Long Truong, Ji-Hong Bang, Yeon-Ji Bae, Razanamanana H. G. Rarison, Sang-Kyu Kim, Woo-Sik Jeong, Young Hoon Jung, Minhye Shin
Summary: This study evaluated the effects of red ginseng dietary fiber (RGDF) on the fermentation profiles and probiotic properties of strains belonging to the Lactobacillaceae family. The results showed that RGDF promoted the production of short-chain fatty acids, carbon source utilization, and gut epithelial adhesion of Lactiplantibacillus plantarum, while inhibiting the attachment of enteropathogens. Metabolomic analyses revealed that RGDF induced metabolic alterations associated with central carbon metabolism and produced RGDF-specific metabolites secreted by L. plantarum. These findings suggest the potential applications of RGDF as prebiotics and the bioactive compounds produced by RGDF-supplemented L. plantarum as novel postbiotic metabolites for human disease prevention and treatment.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Food Science & Technology
Azka Ainun Nisaa, Chern-Ein Oon, Sasidharan Sreenivasan, Venugopal Balakrishnan, Deepa Rajendran, Jun-Jie Tan, Fatin Fazrina Roslan, Svetoslav Dimitrov Todorov, Woo-Sik Jeong, Feiyan Zhao, Nur Syafiqah Mohamad Nasir, Zakuan Zainy Deris, Heping Zhang, Yong-Ha Park, Guoxia Liu, Min-Tze Liong
Summary: We compared the microbiota profiles of breast milk from women with and without vaginal yeast infection during pregnancy. Breast milk from women with vaginal yeast infection exhibited higher alpha diversity across different taxonomic levels. The composition of breast milk from the two groups showed marginal differences at certain taxonomic levels. Our findings suggest that vaginal infection during pregnancy may affect breast milk composition, but it may not pose a threat to infant growth and development.
PREVENTIVE NUTRITION AND FOOD SCIENCE
(2023)
Article
Food Science & Technology
Razanamanana H. G. Rarison, Van-Long Truong, Byoung-Hoon Yoon, Ji-Won Park, Woo-Sik Jeong
Summary: This study investigated the antioxidant and anti-inflammatory properties of lipophilic extracts from Polyscias fruticosa leaf (PFL). The results showed that the key active compounds in PFL, mainly phytosterols and sesquiterpenes, regulated core target genes in oxidative stress and inflammation-related pathways. The lipophilic extracts exhibited strong antioxidant capacities and protected against oxidative stress in cells. Additionally, they showed anti-inflammatory potential by reducing pro-inflammatory factors in treated cells.
Article
Food Science & Technology
Boon-Kiat Lee, Pei Xu, Uma-Mageswary Mageswaran, Woo-Sik Jeong, Engku Ismail Engku-Husna, Kadir Muhammad-Nashriq, Svetoslav Dimitrov Todorov, Guoxia Liu, Yong-Ha Park, Siti Nurma Hanim Hadie, Min-Tze Liong
Summary: This study suggests that Limosilactobacillus fermentum USM 4189 (LF 4189) exhibits antioxidative properties and may prevent skin aging. Rats administered LF 4189 showed increased antioxidative activity, lipid peroxidation capacity, and skin elasticity compared to untreated aged rats. LF 4189 also prevented telomere length shortening and reduced the expression of antioxidative enzyme genes in old rats.
PREVENTIVE NUTRITION AND FOOD SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Van-Long Truong, Yeon-Ji Bae, Razanamanana H. G. Rarison, Ji-Hong Bang, So-Yoon Park, Woo-Sik Jeong
Summary: This study assessed the antioxidant and anti-inflammatory potentials of the lipophilic fraction of Liriope platyphylla seeds (LLPS). The results showed that LLPS exhibited powerful antioxidant activity and attenuated inflammatory response, making it a potential antioxidant and anti-inflammatory agent for developing functional foods.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nutrition & Dietetics
Van-Long Truong, Woo-Sik Jeong
Summary: The study demonstrates that citron seed oil effectively promotes hair regrowth by inducing telogen-to-anagen transition, increasing hair follicle density and hair bulb diameter, and enhancing skin thickness. It also upregulates the expression of key proteins and enzymes related to hair growth, as well as inducing antiapoptotic and growth factor expression. These findings suggest the potential of citron seed oil in preventing and treating hair loss by promoting hair cycling and regeneration.
CURRENT TOPICS IN NUTRACEUTICAL RESEARCH
(2022)
Article
Chemistry, Medicinal
Van-Long Truong, Benya Manochai, Thu-Trang Pham, Woo-Sik Jeong
Summary: Zingiber montanum oil (ZMO) extracted by supercritical CO2 fluid system demonstrates potent antioxidant and anti-inflammatory properties by inhibiting pro-inflammatory markers formation and regulating various signaling pathways, suggesting its potential as a candidate for prevention and treatment of inflammatory and oxidative conditions.
JOURNAL OF MEDICINAL FOOD
(2021)